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Article ; Online: Inflammatory auxo-action in the stem cell division theory of cancer

Yi Luo / Jian-Hui Xiao

PeerJ, Vol 11, p e

2023 Volume 15444

Abstract: Acute inflammation is a beneficial response to the changes caused by pathogens or injuries that can eliminate the source of damage and restore homeostasis in damaged tissues. However, chronic inflammation causes malignant transformation and carcinogenic ... ...

Abstract	Acute inflammation is a beneficial response to the changes caused by pathogens or injuries that can eliminate the source of damage and restore homeostasis in damaged tissues. However, chronic inflammation causes malignant transformation and carcinogenic effects of cells through continuous exposure to pro-inflammatory cytokines and activation of inflammatory signaling pathways. According to the theory of stem cell division, the essential properties of stem cells, including long life span and self-renewal, make them vulnerable to accumulating genetic changes that can lead to cancer. Inflammation drives quiescent stem cells to enter the cell cycle and perform tissue repair functions. However, as cancer likely originates from DNA mutations that accumulate over time via normal stem cell division, inflammation may promote cancer development, even before the stem cells become cancerous. Numerous studies have reported that the mechanisms of inflammation in cancer formation and metastasis are diverse and complex; however, few studies have reviewed how inflammation affects cancer formation from the stem cell source. Based on the stem cell division theory of cancer, this review summarizes how inflammation affects normal stem cells, cancer stem cells, and cancer cells. We conclude that chronic inflammation leads to persistent stem cells activation, which can accumulate DNA damage and ultimately promote cancer. Additionally, inflammation not only facilitates the progression of stem cells into cancer cells, but also plays a positive role in cancer metastasis.
Keywords	Stem cell division theory ; Quiescent stem cells ; Cancer stem cells ; Carcinogenesis ; Cancer metastasis ; Inflammation ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	571 ; 610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of and reflections on ecological anthropology in China

Shaocong Zeng / Yi Luo

International Journal of Anthropology and Ethnology, Vol 6, Iss 1, Pp 1-

2022 Volume 19

Abstract: Abstract Ecological anthropology in China has a history of more than 70 years, and can be divided into four stages. The first stage was in the 1950s, which began with China’s identification of minzu and socio-historical surveys of ethnic minorities. This ...

Abstract	Abstract Ecological anthropology in China has a history of more than 70 years, and can be divided into four stages. The first stage was in the 1950s, which began with China’s identification of minzu and socio-historical surveys of ethnic minorities. This stage was characterized by refinement and application of the Economic-Cultural Type theory from Soviet ethnography. The second stage took place in the 1980s and 1990s, when China’s ecological anthropology research focused on explaining the relationship between local group culture and the environment, and how this changed in the process of modernization. Studies in this phase mainly concentrated on China’s southwestern and northwestern regions, and the theoretical trends of the “adaptation model” and “the cost of development” were formed, becoming central topics. The third stage was in the first decade of the twenty-first century, when Chinese ecological anthropologists focused on the natural and social consequences of changes in the ecological environment, and stressed the importance of exploring, protecting and transforming local ecological knowledge. Ecological anthropology research flourished in Hunan, Guizhou, and Guangxi as well as in the Daxing’anling and Xiaoxing’anling mountainous regions of Northeast China. The fourth stage was in the most recent decade, when ecological anthropologists expanded their research to cover disasters, biodiversity, local social vulnerability and promotion of ecological progress, and their research areas expanded to the southeastern coast, inland river basins and traditional farming areas in the Central Plains. This paper argues that the development of ecological anthropology in China has been driven by academic consciousness rooted in local field experience, accurate understanding of the research target and changes in social situations of the era, and in-depth dialogue with Western ecological anthropological theories. At present, China’s economic and social development patterns and the relationship between local people and ...
Keywords	China ; Ecological anthropology ; Development and reflection ; Promoting ecological progress ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674
Subject code	950
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic correction of induced pluripotent stem cells from a DFNA36 patient results in morphologic and functional recovery of derived hair cell-like cells

Yi Luo / Kaiwen Wu / Xiaolong Zhang / Hongyang Wang / Qiuju Wang

Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-

2024 Volume 13

Abstract: Abstract Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. ... ...

Abstract	Abstract Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. Here, we investigated the differentiation, morphology and electrophysiological properties of hair cell-like cells (HC-like cells) derived from DFNA36 patient. Methods Inner ear HC-like cells were induced from iPSCs derived from DFNA36 (TMC1 p.M418K) patient (M+/−), normal control (M+/+) and genetic corrected iPSCs (M+/C). Immunofluorescence, scanning electron microscopy and whole-cell patch-clamp were used to study the mechanism and influence of TMC1 p.M418K mutation. Results In this study we successfully generated HC-like cells from iPSCs with three different genotypes. HC-like cells from M+/− showed defected morphology of microvilli and physiological properties compared to M+/+. HC-like cells from M+/C showed recovery in morphology of microvilli and physiological properties. Conclusions Our results indicate that TMC1 p.M418K mutation didn’t influence inner ear hair cell differentiation but the morphology of microvilli and electrophysiological properties and gene correction induced recovery. CRISPR/Cas9 gene therapy is feasible in human patient with TMC1 p.M418K mutation.
Keywords	Induced pluripotent stem cells ; TMC1 ; Hair cells ; Differentiation ; Whole-cell patch-clamp ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between cultural capital and health literacy during the COVID-19 pandemic among community residents in China

Yi Luo / Hang Zhao / Huayong Chen / Mimi Xiao

Frontiers in Public Health, Vol

the mediating effect of social capital

2023 Volume 11

Abstract: BackgroundHealth literacy is crucial for managing pandemics such as COVID-19 and maintaining the health of the population; our goal was to investigate the impact of cultural capital on health literacy during the COVID-19 pandemic among community ... ...

Abstract	BackgroundHealth literacy is crucial for managing pandemics such as COVID-19 and maintaining the health of the population; our goal was to investigate the impact of cultural capital on health literacy during the COVID-19 pandemic among community residents and to further examine the mediating role of social capital in the relationship between cultural capital and health literacy.MethodsA cross-sectional study was conducted among 1,600 community residents selected in Chongqing, China using a stratified random sampling method. Data were gathered through a questionnaire survey, including sociodemographic characteristics, cultural capital, social capital, and health literacy. Chi-square analysis, one-way ANOVA, t-test, and hierarchical linear regression were used to analyze the level of health literacy among community residents and the related elements; the structural equation model (SEM) was used to explore the influential mechanisms of health literacy and explore whether social capital acted as a mediator in the relationship between cultural capital and health literacy.ResultsCultural capital, community participation, community trust, reciprocity, and cognitive social capital had a significant positive effect on health literacy. In addition, the results of SEM indicated that cultural capital not only directly influences health literacy (β = 0.383, 95% CI = 0.265–0.648), but also indirectly influences health literacy through three types of social capital (β = 0.175, 95% CI = 0.117–0.465; β = 0.191, 95% CI = 0.111–0.406; β = 0.028, 95% CI = 0.031–0.174); its mediating effect accounting for 50.7% of the overall effect.ConclusionsOur results highlight the empirical link between cultural capital and health literacy, and suggest that social capital mediates this connection. These findings suggest that governments and communities should focus on the construction of community cultural capital and provide residents with better social capital to improve their health literacy to prepare for future pandemics.
Keywords	community residents ; cultural capital ; social capital ; health literacy ; mediation effect ; COVID-19 ; Public aspects of medicine ; RA1-1270
Subject code	302
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Linking Informative and Factual CSR Communication to Reputation

Yi Luo / Hua Jiang / Linzhi Zeng

Sustainability, Vol 15, Iss 5136, p

Understanding CSR Motives and Organizational Identification

2023 Volume 5136

Abstract: The way corporate social responsibility (CSR) communication relates to corporate reputation has attracted an increasing amount of attention from communication and business researchers and practitioners. To place our study in the context of CSR and ... ...

Abstract	The way corporate social responsibility (CSR) communication relates to corporate reputation has attracted an increasing amount of attention from communication and business researchers and practitioners. To place our study in the context of CSR and employee communication, we proposed a CSR communication—motives—organizational identification—corporate reputation model. Data collected from an online Qualtrics survey (n = 811) supported all the proposed hypotheses linking informativeness and factual tone in CSR communication, employee-perceived intrinsic/other-serving motives of their organizations’ CSR activities, organizational identification, and corporate reputation. Specifically, informativeness and a factual tone in CSR communication were positively related to employee-perceived intrinsic/other-serving motives of their organizations’ CSR activities. Employee-perceived intrinsic/other-serving motives of their organizations’ CSR activities were positively associated with employee organizational identification. Employee organizational identification was positively related to corporate reputation. In addition, employee-perceived intrinsic/other-serving motives of their organizations’ CSR activities and employee organizational identification turned out to be two significant mediators in the proposed model between CSR communication and corporate reputation. We conducted a two-step structural equation modeling (SEM) analysis to analyze the collected data. The theoretical and practical implications of the study were discussed.
Keywords	CSR communication ; informativeness ; factual tone ; CSR motives ; organizational identification ; corporate reputation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving Laio’s model for investigating soil water response to vegetation restoration in the middle Yellow River Basin, China

Wei Wang / Yi Luo / Xiaolei Wang / Lin Sun

Ecological Indicators, Vol 157, Iss , Pp 111260- (2023)

2023

Abstract: Over the last few decades, vegetation–soil water interactions in the semiarid middle Yellow River basin have been a topic of interest for many researchers, especially since the implementation of the Grain-to-Green Project (GTGP) in 1999. The ... ...

Abstract	Over the last few decades, vegetation–soil water interactions in the semiarid middle Yellow River basin have been a topic of interest for many researchers, especially since the implementation of the Grain-to-Green Project (GTGP) in 1999. The probabilistic states of soil water and water stress on vegetation development provide interactions from a perspective that is different from process-based modelling approaches. The Laio’s model, a widely used probabilistic soil water model was applied in the study. To include the infiltration-excess runoff, co-exist with the saturation-excess runoff, or even be dominant in the study region, a parameter Δ2 was incorporated to reflect mean surface runoff of a rainfall event under current theoretical framework of Laio’s model. The modified model was evaluated against the observations, and the effectiveness of the modification was proved in the study region. Based on the modified model, the soil water response to vegetation restoration was studied with remote-sensing based land use and leaf area index in the 2000 s and 2010 s. Vegetation was restored in most parts of the region, resulting in soil water reduction in approximately 83 % of the area, and the soil water stress increased by 49 % on average. The reduction in soil water and increase in soil water stress were more serious in areas that had converted vegetation and loess soil than those had non-converted vegetation and non-loess soil. These findings might imply that vegetation greening will reach an upper limit due to the negative soil water balance and increased water stress on plant growth, which is meaningful for a better understanding of vegetation–soil water interactions and ecosystem management in semi-arid regions.
Keywords	Vegetation–soil water interactions ; Probabilistic soil water model ; Infiltration-excess runoff ; Saturation-excess runoff ; Yellow River basin ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Long-Term Impact of Famine Experience on Harvest Losses

Kunyang Zhang / Yi Luo / Yan Han

Agriculture, Vol 13, Iss 1128, p

2023 Volume 1128

Abstract: Approximately one-third of the global food supply is lost or wasted each year. Given that the harvesting process is the initial stage following food production, minimizing losses in this crucial phase holds paramount significance in augmenting the food ... ...

Abstract	Approximately one-third of the global food supply is lost or wasted each year. Given that the harvesting process is the initial stage following food production, minimizing losses in this crucial phase holds paramount significance in augmenting the food supply and ensuring food security. The 1959–1961 famine in China was one of the most catastrophic events in history and had long-term effects on human beings, particularly farmers. This paper aims to provide a new perspective on the variations in harvest losses across age cohorts by examining the impact of famine experiences. Using survey data from the 2016 Postproduction Food Loss and Waste Survey conducted by China Agricultural University and the Rural Economic Research Center, which involved 3538 farming households across 28 provinces, we construct a cohort difference-in-difference (DID) model to investigate the impact of famine experience on household harvest losses. The standard cohort DID estimation results indicate that in areas with severe famine, a 1% increase in excess mortality would reduce the rate of harvest loss by 3%, suggesting that farmers who have experienced extreme famine have a deeper memory of the event, which subsequently helps them reduce harvest losses. Moreover, the results of the heterogeneity test reveal that the more serious the famine that the household head experienced in early life was, the less harvest losses there were, particularly for those who were adolescents during the famine. The findings elucidate the importance of historical events in shaping current behaviors and contribute to a better understanding of the variation in harvest losses across age cohorts.
Keywords	famine experience ; harvest losses ; age cohorts ; Agriculture (General) ; S1-972
Subject code	950
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Climate and Land-Use Change on the Supply and Demand Relationship of Water Provision Services in the Yellow River Basin

Fei Gao / Yi Luo / Congju Zhao

Land, Vol 12, Iss 12, p

2023 Volume 2089

Abstract: The Yellow River Basin (YRB) has undergone profound climate and land-use change. These transformations are anticipated to affect the availability of water resources, potentially causing substantial perturbations to the equilibrium between water ... ...

Abstract	The Yellow River Basin (YRB) has undergone profound climate and land-use change. These transformations are anticipated to affect the availability of water resources, potentially causing substantial perturbations to the equilibrium between water availability and societal needs. Consequently, research is warranted to explore the ramifications of climate and land-use change on the water provision service, particularly their impacts on the delicate equilibrium between supply and demand. To quantify the water supply–demand relationship, this study introduces the water supply and demand index (WSDR). This study examines the impacts of climate and land-use change on the actual evapotranspiration, water yield, and WSDR in the YRB from 1995 to 2019. According to the results, the YRB experienced an increase in forest land by 4.72%, grassland by 1.71%, and a substantial surge of 595.36% in construction land; however, cropland witnessed a decrease of 5.95%. The climate exhibited a discernible wetting trend (3.38 mm/year, p < 0.01). The actual evapotranspiration significantly increased by 2.45 mm/year ( p < 0.01), but this increase was not substantial enough to result in a decline in the water yield, since precipitation also increased. The annual water demand depth demonstrated a statistically significant increasing trend (0.13 mm/year, p < 0.01), but this increase was not sufficient to cause a decrease in the WSDR, since the water yield also increased (0.94 mm/year). Land use had a significantly negative effect on the water yield and WSDR, but this negative effect was offset by the positive effects of climate variability. At the basin scale, there exists a surplus of water resources (WSDR > 0). Nevertheless, regions grappling with water resource deficits (WSDR < 0) have witnessed an increase from 18% in 1995 to 26% in 2019. This indicates that the primary water resource problem in the YRB is the uneven spatial distribution of water resources. Hence, implementing spatial management strategies at larger scales ...
Keywords	Yellow River basin ; water provision services ; climate change ; land use ; supply–demand relationship ; Agriculture ; S
Subject code	550
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Editorial-special issue of “Lake water quality processes and impacts”

Senlin Zhu / Yi Luo / Patrick Willems

Journal of Hydrology: Regional Studies, Vol 50, Iss , Pp 101591- (2023)

2023

Keywords	Physical geography ; GB3-5030 ; Geology ; QE1-996.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A DFT Study of the Copolymerization of Methyl Vinyl Sulfone and Ethylene Catalyzed by Phosphine–Sulfonate and α-Diimine Palladium Complexes

Ling Zhu / Shuang Li / Xiaohui Kang / Wenzhen Zhang / Yi Luo

Catalysts, Vol 13, Iss 1026, p

2023 Volume 1026

Abstract: Density functional theory (DFT) calculations were comparatively carried out to reveal the origins of different catalytic performances from phosphine–benzene sulfonate ( A , [{P^O}PdMe(L)] (P^O = Κ 2 -P,O-Ar 2 PC 6 H 4 SO 3 with Ar = 2-MeOC 6 H 4 )) and α ...

Abstract	Density functional theory (DFT) calculations were comparatively carried out to reveal the origins of different catalytic performances from phosphine–benzene sulfonate ( A , [{P^O}PdMe(L)] (P^O = Κ 2 -P,O-Ar 2 PC 6 H 4 SO 3 with Ar = 2-MeOC 6 H 4 )) and α -diimine ( B , [{N^N}PdMe(Cl)] (N^N = (ArN=C(Me)-C(Me)=NAr) with Ar = 2,6- i Pr 2 C 6 H 3 )) palladium complexes toward the copolymerization of ethylene and methyl vinyl sulfone (MVS). Having achieved agreement between theory and experiment, it was found that the favorable 2,1-selective insertion of MVS into phosphine–sulfonate palladium complex A was due to there being less structural deformations in the catalyst and monomer. Both the MVS and ethylene insertions were calculated, and the former was found to be more favorable for chain initiation and chain propagation. In the case of α -diimine palladium system B , the resulting product of the first MVS insertion was quite stable, and the stronger O-backbiting interaction hampered the insertion of the incoming ethylene molecule. These computational results are expected to provide some hints for the design of transition metal copolymerization catalysts.
Keywords	density functional theory ; phosphine–benzene sulfonate ; α-diimine ; palladium ; methyl vinyl sulfone ; copolymerization ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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