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  1. Article ; Online: PEG

    Yi Wen Kong / Erik C Dreaden

    Frontiers in Bioengineering and Biotechnology, Vol

    Will It Come Back to You? Polyethelyne Glycol Immunogenicity, COVID Vaccines, and the Case for New PEG Derivatives and Alternatives

    2022  Volume 10

    Keywords polymer chemistry ; drug delivery ; nanotechnology ; nanomaterials ; PEG ; Biotechnology ; TP248.13-248.65
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage

    Justine R. Stehn / Scott R. Floyd / Erik W. Wilker / H. Christian Reinhardt / Scott M. Clarke / Qiuying Huang / Roberto D. Polakiewicz / Nahum Sonenberg / Yi Wen Kong / Michael B. Yaffe

    Frontiers in Molecular Biosciences, Vol

    A combined kinase and protein array approach

    2023  Volume 10

    Abstract: 14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrates of ...

    Abstract 14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrates of basophilic protein kinases following their phosphorylation on specific serine/threonine residues. Although over 200 mammalian proteins that bind to 14-3-3 have been identified, largely through proteomic studies, in many cases the relevant protein kinase responsible for conferring 14-3-3-binding to these proteins is not known. To facilitate the identification of kinase-specific 14-3-3 clients, we developed a biochemical approach using high-density protein filter arrays and identified the translational regulatory molecule PABPC1 as a substrate for Chk1 and MAPKAP Kinase-2 (MK2) in vitro, and for MK2 in vivo, whose phosphorylation results in 14-3-3-binding. We identify Ser-470 on PABPC1 within the linker region connecting the RRM domains to the PABC domain as the critical 14-3-3-binding site, and demonstrate that loss of PABPC1 binding to 14-3-3 results in increased cell proliferation and decreased cell death in response to UV-induced DNA damage.
    Keywords 14-3-3 ; polyA-binding protein ; MAPKAP Kinase-2 ; signal transduction ; DNA damage ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Transite

    Konstantin Krismer / Molly A. Bird / Shohreh Varmeh / Erika D. Handly / Anna Gattinger / Thomas Bernwinkler / Daniel A. Anderson / Andreas Heinzel / Brian A. Joughin / Yi Wen Kong / Ian G. Cannell / Michael B. Yaffe

    Cell Reports, Vol 32, Iss 8, Pp 108064- (2020)

    A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression

    2020  

    Abstract: Summary: RNA-binding proteins (RBPs) play critical roles in regulating gene expression by modulating splicing, RNA stability, and protein translation. Stimulus-induced alterations in RBP function contribute to global changes in gene expression, but ... ...

    Abstract Summary: RNA-binding proteins (RBPs) play critical roles in regulating gene expression by modulating splicing, RNA stability, and protein translation. Stimulus-induced alterations in RBP function contribute to global changes in gene expression, but identifying which RBPs are responsible for the observed changes remains an unmet need. Here, we present Transite, a computational approach that systematically infers RBPs influencing gene expression through changes in RNA stability and degradation. As a proof of principle, we apply Transite to RNA expression data from human patients with non-small-cell lung cancer whose tumors were sampled at diagnosis or after recurrence following treatment with platinum-based chemotherapy. Transite implicates known RBP regulators of the DNA damage response and identifies hnRNPC as a new modulator of chemotherapeutic resistance, which we subsequently validated experimentally. Transite serves as a framework for the identification of RBPs that drive cell-state transitions and adds additional value to the vast collection of publicly available gene expression datasets.
    Keywords RNA-binding proteins ; post-transcriptional regulation ; sequence motifs ; chemotherapy ; DNA damage response ; Biology (General) ; QH301-705.5
    Subject code 612 ; 570
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

    Fred C. Lam / Yi Wen Kong / Qiuying Huang / Tu-Lan Vu Han / Amanda D. Maffa / Ekkehard M. Kasper / Michael B. Yaffe

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 20

    Abstract: In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage ... ...

    Abstract In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

    Fred C. Lam / Yi Wen Kong / Qiuying Huang / Tu-Lan Vu Han / Amanda D. Maffa / Ekkehard M. Kasper / Michael B. Yaffe

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 20

    Abstract: In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage ... ...

    Abstract In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

    Yi Wen Kong / Erik C. Dreaden / Sandra Morandell / Wen Zhou / Sanjeev S. Dhara / Ganapathy Sriram / Fred C. Lam / Jesse C. Patterson / Mohiuddin Quadir / Anh Dinh / Kevin E. Shopsowitz / Shohreh Varmeh / Ömer H. Yilmaz / Stephen J. Lippard / H. Christian Reinhardt / Michael T. Hemann / Paula T. Hammond / Michael B. Yaffe

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to ... ...

    Abstract Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to cisplatin in p53-deficient tumours.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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