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  1. Article: Progress on functional mechanisms of colorectal cancer causal SNPs in post-GWAS.

    Yige, Li / Dandan, Zhang

    Yi chuan = Hereditas

    2021  Volume 43, Issue 3, Page(s) 203–214

    Abstract: Colorectal cancer (CRC) is caused by genetic and environmental factors, and the genetic component plays a significant role in CRC development. Currently, genome-wide association studies (GWAS) have identified a large number of genetic loci associated ... ...

    Abstract Colorectal cancer (CRC) is caused by genetic and environmental factors, and the genetic component plays a significant role in CRC development. Currently, genome-wide association studies (GWAS) have identified a large number of genetic loci associated with CRC risk. In the post-GWAS era, more and more efforts focus on deciphering the biological mechanisms behind these potential causal variants by using multi-omics data and functional experiments. Many analyses have revealed that most risk single nucleotide polymorphisms (SNPs) are located in non-coding regions and these variants may regulate the expression of target genes by altering the transcription factor-binding motif, epigenetic modification, chromatin accessibility or 3D genome conformation. Results obtained from post-GWAS era have highlighted the possibility of moving from association to function. In this review, we summarize the current status of CRC post-GWAS studies and discusses the clinical application as well as future directions of CRC GWAS, in order to better gain insight into the molecular basis of CRC and provide evidence for prevention.
    MeSH term(s) Colorectal Neoplasms/genetics ; Genetic Predisposition to Disease/genetics ; Genome ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2021-03-16
    Publishing country China
    Document type Journal Article ; Review
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.20-320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Quaternary Tectonic Transformation of the Helan Shan

    Yige Li / Wenjun Zheng / Jingjun Yang / Dongli Zhang / Haoyu Zhou / Ting Liu

    Frontiers in Earth Science, Vol

    Constraints Due To Quantitative Geomorphology

    2022  Volume 10

    Abstract: The Helan Shan is located on the front edge of the expanding Tibetan Plateau. However, how the topography here responds to this propagation and its precise time constraints remain unknown. Based on the response process of fluvial landforms and tectonic ... ...

    Abstract The Helan Shan is located on the front edge of the expanding Tibetan Plateau. However, how the topography here responds to this propagation and its precise time constraints remain unknown. Based on the response process of fluvial landforms and tectonic evolution, we conducted a quantitative landform analysis of the Helan Shan region. Here, the spatial distribution features of various geomorphic indices were coupled, demonstrating that the mountain is tilting toward the west and north. The steeper downstream and gentle upper reaches indicate that the fluvial landforms have experienced an accelerated incision event, which can be attributed to the tectonic activity along the East Helan Shan Fault. Furthermore, the response time of the tectonic knickpoints ranges from 0.1 to 1.4 Ma based on the paleochannel reconstruction method. Combined with previous studies on low temperature thermochronology and active tectonics, we proposed a tectonic transformation model where the Helan Shan shifted the tilting model from the southwest to the northwest, as induced by the northeast expansion of the Tibetan Plateau from 0.1 to 1.4 Ma.
    Keywords Helan Shan ; tectonic transformation ; fluvial landforms ; tectonic geomorphology ; Tibetan Plateau ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea

    Yan Chen / Yuyan Gu / Yige Li / Geng-Lin Li / Renjie Chai / Wenyan Li / Huawei Li

    Cell Reports, Vol 35, Iss 3, Pp 109016- (2021)

    2021  

    Abstract: Summary: The mammalian cochlea cannot regenerate functional hair cells (HCs) spontaneously. Atoh1 overexpression as well as other strategies are unable to generate functional HCs. Here, we simultaneously upregulated the expression of Gfi1, Pou4f3, and ... ...

    Abstract Summary: The mammalian cochlea cannot regenerate functional hair cells (HCs) spontaneously. Atoh1 overexpression as well as other strategies are unable to generate functional HCs. Here, we simultaneously upregulated the expression of Gfi1, Pou4f3, and Atoh1 in postnatal cochlear supporting cells (SCs) in vivo, which efficiently converted SCs into HCs. The newly regenerated HCs expressed HC markers Myo7a, Calbindin, Parvalbumin, and Ctbp2 and were innervated by neurites. Importantly, many new HCs expressed the mature and terminal marker Prestin or vesicular glutamate transporter 3 (vGlut3), depending on the subtypes of the source SCs. Finally, our patch-clamp analysis showed that the new HCs in the medial region acquired a large K+ current, fired spikes transiently, and exhibited signature refinement of ribbon synapse functions, in close resemblance to native wild-type inner HCs. We demonstrated that co-upregulating Gfi1, Pou4f3, and Atoh1 enhances the efficiency of HC generation and promotes the functional maturation of new HCs.
    Keywords cochlea ; hair cell regeneration ; Atoh1 ; Gfi1 ; Pou4f3 ; functional maturation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Deletion of Kcnj16 in Mice Does Not Alter Auditory Function

    Jun Lv / Xiaolong Fu / Yige Li / Guodong Hong / Peipei Li / Jing Lin / Youfang Xun / Lucheng Fang / Weibin Weng / Rongyu Yue / Geng-Lin Li / Bing Guan / He Li / Yideng Huang / Renjie Chai

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Endolymphatic potential (EP) is the main driving force behind the sensory transduction of hearing, and K+ is the main charge carrier. Kir5.1 is a K+ transporter that plays a significant role in maintaining EP homeostasis, but the expression pattern and ... ...

    Abstract Endolymphatic potential (EP) is the main driving force behind the sensory transduction of hearing, and K+ is the main charge carrier. Kir5.1 is a K+ transporter that plays a significant role in maintaining EP homeostasis, but the expression pattern and role of Kir5.1 (which is encoded by the Kcnj16 gene) in the mouse auditory system has remained unclear. In this study, we found that Kir5.1 was expressed in the mouse cochlea. We checked the inner ear morphology and measured auditory function in Kcnj16–/– mice and found that loss of Kcnj16 did not appear to affect the development of hair cells. There was no significant difference in auditory function between Kcnj16–/– mice and wild-type littermates, although the expression of Kcnma1, Kcnq4, and Kcne1 were significantly decreased in the Kcnj16–/– mice. Additionally, no significant differences were found in the number or distribution of ribbon synapses between the Kcnj16–/– and wild-type mice. In summary, our results suggest that the Kcnj16 gene is not essential for auditory function in mice.
    Keywords Kir5.1 ; hair cell ; endolymphatic potential ; cochlea ; hearing loss ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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