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  1. Article ; Online: Therapeutic observation of electroacupuncture treatment for primary dysmenorrhea

    Tiantian Hu / Lihua Shen / Yijie Du

    Traditional Medicine and Modern Medicine, Vol 2, Iss 4, Pp 193-

    2019  Volume 196

    Abstract: Objective: To observe the clinical efficacy of electroacupuncture treatment for primary dysmenorrhea. Methods: In total 75 patients with primary dysmenorrhea were randomized into electroacupuncture with point injection group (37 patients), and ... ...

    Abstract Objective: To observe the clinical efficacy of electroacupuncture treatment for primary dysmenorrhea. Methods: In total 75 patients with primary dysmenorrhea were randomized into electroacupuncture with point injection group (37 patients), and electroacupuncture group (38 patients). Cox Menstrual Symptom Scale (CMSS) and Visual Analogue Scale (VAS) were observed before and after three treatment interventions, and the clinical efficacies were compared. Results: The total effective rates were 91.9% and 86.8%, and the difference was not significant (P>0.05). Conclusions: Electroacupuncture with point injection and electroacupuncture are effective methods in treating primary dysmenorrhea, and the difference between the two groups is not statistically significant.
    Keywords primary dysmenorrhea ; electroacupuncture ; point injection ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher World Scientific Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

    Wenyi Zhu / Yijie Du / Hong Meng / Yinmao Dong / Li Li

    Chemistry Central Journal, Vol 11, Iss 1, Pp 1-

    2017  Volume 16

    Abstract: Abstract Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a ... ...

    Abstract Abstract Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.
    Keywords Tribulus terrestris ; Traditional uses ; Phytochemical ; Pharmacological activities ; Chemistry ; QD1-999
    Language English
    Publishing date 2017-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD

    Qing Kong / Yuxue Cao / Zhen Gao / Jing Sun / Hongying Zhang / Yijie Du / Yubao Lv / Sihan Zhou / Zihui Tang / Baojun Liu / Jingcheng Dong

    Trials, Vol 23, Iss 1, Pp 1-

    study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial

    2022  Volume 12

    Abstract: Abstract Background Inhaled glucocorticoid corticosteroid (ICS), long-acting β2-adrenoceptor agonist (LABA), and other drugs have limited therapeutic effects on COPD with significant individual differences. Traditional Chinese medicine (TCM)-modified ... ...

    Abstract Abstract Background Inhaled glucocorticoid corticosteroid (ICS), long-acting β2-adrenoceptor agonist (LABA), and other drugs have limited therapeutic effects on COPD with significant individual differences. Traditional Chinese medicine (TCM)-modified Bushen Yiqi formula (MBYF) demonstrates advantages in COPD management in China. This study aims to evaluate the efficacy and safety of MBYF as an add-on to budesonide/formoterol in COPD patients and confirm the related genes affecting the therapeutic effect in the treatment of COPD. Methods In this multicentre, randomised, double-blind, placebo-controlled, parallel-group study, eligible patients with COPD will randomly receive a 360-day placebo or MBYF as an adjuvant to budesonide/formoterol in a 1:1 ratio and be followed up with every 2 months. The primary outcomes will be the frequency, times, and severity of acute exacerbation of COPD (AECOPD), COPD assessment test (CAT) score, and pulmonary function tests (PFTs). The secondary outcomes will include the modified Medical Research Council (mMRC) dyspnoea scale, 6-min walking test (6MWT), BODE index, quantitative scores of syndromes classified in TCM, inflammation indices, and hypothalamic-pituitary-adrenaline (HPA) axis function. We will also test the genotype to determine the relationship between drugs and efficacy. All the data will be recorded in case report forms (CRFs) and analysed by SPSS V.20.0. Discussion A randomized clinical trial design to evaluate the efficacy and safety of MBYF in COPD is described. The results will provide evidence for the combination therapy of modern medicine and TCM medicine, and individual therapy for COPD.Trial registration. Trial registration ID: ChiCTR1900026124 , Prospective registration.
    Keywords Randomised clinical trial ; Design and method ; COPD ; Traditional Chinese medicine formula ; Formoterol and budesonide ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD

    Qing Kong / Shuming Mo / Wenqian Wang / Zihui Tang / Ying Wei / Yijie Du / Baojun Liu / Lingwen Kong / Yubao Lv / Jingcheng Dong

    Trials, Vol 21, Iss 1, Pp 1-

    study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial

    2020  Volume 16

    Abstract: Abstract Background Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these ... ...

    Abstract Abstract Background Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient’s next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
    Keywords Randomized clinical trial ; Design and method ; Acute exacerbation of COPD ; Traditional Chinese medicine ; Systemic glucocorticoids duration ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effects of progressive Orff vocal therapy on BODE index and quality of life in patients with low lung function after non-small cell lung cancer surgery

    Yijie Du / Mingyue Su / Hongli Xue / Mengyu Ma / Xilong Wu / Hanyu Xue / Tao Yi / Zhao Tang / Qing Kong / Yizhe Xu / Yuxue Cao

    Traditional Medicine and Modern Medicine, Vol 3, Iss 2, Pp 109-

    2020  Volume 115

    Abstract: Objective: To explore the effect of Orff vocal therapy on BODE index and quality of life of patients with low lung function after non-small cell lung cancer surgery. Methods: From March 2014 to March 2019, 231 patients with NSCLC postoperative (their ... ...

    Abstract Objective: To explore the effect of Orff vocal therapy on BODE index and quality of life of patients with low lung function after non-small cell lung cancer surgery. Methods: From March 2014 to March 2019, 231 patients with NSCLC postoperative (their pulmonary functions FEV1 ≤50% of the expected value) in the Huashan Hospital, Fudan University were selected and randomly divided into observation groups and control group. On the basis of conventional treatment of NSCLC, the control group used lung rehabilitation training, and the observation group used the Orff music therapy. They carry out vocal and breath training step by step, using a combination of online and offline methods, 1h per day online interactive training, 2h of offline group vocal therapy once a week, continuous intervention for 12 months. The patient’s BODE index and FACT-L scores were monthly follow-up. Results: Compared with the control group, the BODE index and FACT-L scores improved more significantly in the vocal therapy group (P<0.05). Especially in the FEV1pred, family/society module and functional status module, the improvement was most significant, compared with the control group (P<0.05). And the loss of follow-up rate in the vocal therapy group was lower than that in the lung rehabilitation group (P<0.01). Conclusion: Orff vocal therapy can improve the BODE index and quality of life of patients with low lung function after non-small cell lung cancer surgery, and its compliance and intervention effects are better than ordinary lung rehabilitation training.
    Keywords non-small cell lung cancer ; music therapy ; lung function ; bode index ; cancer treatment function evaluation ; quality of life ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher World Scientific Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Anti-Inflammatory Effects of Invigorating Kidney and Supplementing Qi Chinese Herbal Formulae in Asthma Patients

    Lingwen Kong / Hongying Zhang / Yuxue Cao / Jingjing Le / Jinfeng Wu / Baojun Liu / Meixia Chen / Yijie Du / Jia Wang / Genfa Wang / Tao Yi / Xianmei Zhou / Gang Wang / Qing Miao / Suyun Li / Naiqing Zhao / Jingcheng Dong

    Evidence-Based Complementary and Alternative Medicine, Vol

    2017  Volume 2017

    Abstract: Background. The theories of Shen-reinforcement and Qi-supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney and Supplementing Qi herbal formulae, Bu Shen Fang ... ...

    Abstract Background. The theories of Shen-reinforcement and Qi-supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney and Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) and Bu Shen Yi Qi (BSYQ), conveyed promising results in asthma treatment. However, the efficacy and safety of the formulae need to be further investigated by a randomized double-blind clinical trial. Methods. 328 eligible patients were randomly sent to BSFC, BSYQ, and placebo group. The two formulae were received as add-on therapy. The primary endpoints were rate of asthma exacerbation and Hamilton Rating Scale for Depression (HAM-D) score. The secondary endpoints included HPA axis function and inflammatory cytokine production profile. All indexes were measured before and after treatment. Results. The primary endpoints were not improved in both groups; however, the depression levels of subgroup patients with HAM-D score > 5 were improved in BSFC group. HPA axis functions and inflammatory cytokines level were also improved by two formulae. The incidences of adverse events were similar among groups. Conclusions. The two formulae had multiple advantage effects on neuroendocrine-immune system. They are worth used as a replacement therapy in asthma. Trial Registration. This trial is registered with clinical trial number ChiCTR-PRC-09000529.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correction

    Genfa Wang / Baojun Liu / Yuxue Cao / Yijie Du / Hongying Zhang / Qingli Luo / Bei Li / Jinfeng Wu / Yubao Lv / Jing Sun / Hualiang Jin / Kai Wei / Zhengxiao Zhao / Lingwen Kong / Xianmei Zhou / Qing Miao / Gang Wang / Qingwei Zhou / Jingcheng Dong

    PLoS ONE, Vol 11, Iss 3, p e

    Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial.

    2016  Volume 0152379

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of two Chinese herbal formulae for the treatment of moderate to severe stable chronic obstructive pulmonary disease

    Genfa Wang / Baojun Liu / Yuxue Cao / Yijie Du / Hongying Zhang / Qingli Luo / Bei Li / Jinfeng Wu / Yubao Lv / Jing Sun / Hualiang Jin / Kai Wei / Zhengxiao Zhao / Lingwen Kong / Xianmei Zhou / Qing Miao / Gang Wang / Qingwei Zhou / Jingcheng Dong

    PLoS ONE, Vol 9, Iss 8, p e

    a multicenter, double-blind, randomized controlled trial.

    2014  Volume 103168

    Abstract: The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD.A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional ... ...

    Abstract The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD.A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol.A total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY) granule group, n = 109; Bushen Fangchuan (BF) tablet group, n = 109) and a placebo group (n = 113). Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (%) and FEV1/FVC (%), compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067), BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01). Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219). BY granule obviously descended IL-17(P<0.05), IL-1β (P = 0.05), IL-6, compared with placebo. They improved the level of IL-10 and cortisol. BY granule raised cortisol (P = 0.07) and decreased TNF-α. Both treatments slightly descended TGF-β1. In terms of safety, subject compliance and drug combination, there were no differences (P>0.05) among three groups.BY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general.Chinese Clinical Trial Register center ChiCTR-TRC-09000530.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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