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  1. Article ; Online: Editorial for "MRI-Characteristics of Pediatric Renal Tumors: A SIOP-RTSG Radiology Panel Delphi Study": Standardized Assessment of Pediatric Renal Tumors with MRI: A Laudable Objective That Requires Further Investigation.

    van der Pol, Christian B / Yikilmaz, Ali / Schieda, Nicola

    Journal of magnetic resonance imaging : JMRI

    2021  Volume 55, Issue 2, Page(s) 553–554

    MeSH term(s) Child ; Delphi Technique ; Humans ; Kidney Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Radiology ; Wilms Tumor
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27883
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  2. Article ; Online: Understanding the diagnosis of superior mesenteric artery syndrome: analysis of the location of duodenal impression on upper gastrointestinal studies.

    Caterine, Scott / Patil, Nikhil S / Takrouri, Heba / Issenman, Robert M / Stein, Nina R / Donnellan, John / Yikilmaz, Ali

    Pediatric radiology

    2023  Volume 53, Issue 13, Page(s) 2633–2641

    Abstract: Background: Upper gastrointestinal (GI) contrast studies are frequently requested to aid superior mesenteric artery syndrome diagnosis, a rare entity. Compression of the third duodenal part is expected to be mid-to-left of the midline where the superior ...

    Abstract Background: Upper gastrointestinal (GI) contrast studies are frequently requested to aid superior mesenteric artery syndrome diagnosis, a rare entity. Compression of the third duodenal part is expected to be mid-to-left of the midline where the superior mesenteric artery arises from the aorta; however, a duodenal impression to the right of the midline due to normal anatomic impression by the inferior vena cava (IVC) is often encountered and frequently misdiagnosed.
    Objective: The purpose of this study was to determine the frequencies of (1) normal right-of-midline duodenal impressions and (2) mid-to-left of midline compressions in upper GI studies in a tertiary pediatric referral center.
    Materials and methods: All upper GI studies performed at our institution over 2 years were retrospectively evaluated to determine whether the duodenum had vertical duodenal impression to the right of the vertebral midline, mid-to-left of the vertebral midline, or no identifiable duodenal impression at all.
    Results: In total, 538 upper GI studies were included in this analysis. A total of 275 male and 247 female patients between 0 and 17 years of age (median: 6 years, range: 1 month-17 years) were included. Of 538 total upper GI studies, there were 240 studies (44.6%) with a right-of-midline impression. There were only 10 studies (1.9%) with a mid-to-left of midline compression, and 9/10 also showed a concurrent right-sided impression sign.
    Conclusion: Right-of-midline duodenal impression is a normal anatomic finding caused by the IVC and should not be confused with superior mesenteric artery syndrome. In the presence of an appropriate clinical context, proximal duodenal dilation, "to-and-fro" motion of contrast, and duodenal impression at mid-to-left of midline, a diagnosis of superior mesenteric artery syndrome should be considered.
    MeSH term(s) Humans ; Male ; Female ; Child ; Infant ; Superior Mesenteric Artery Syndrome/diagnostic imaging ; Superior Mesenteric Artery Syndrome/etiology ; Retrospective Studies ; Duodenum/diagnostic imaging ; Mesenteric Artery, Superior
    Language English
    Publishing date 2023-10-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-023-05782-8
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  3. Article ; Online: Evaluation of Ovarian Vascularity in Children by Using the "Superb Microvascular Imaging" Ultrasound Technique in Comparison With Conventional Doppler Ultrasound Techniques.

    Ayaz, Ercan / Aslan, Ahmet / İnan, İbrahim / Yıkılmaz, Ali

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2019  Volume 38, Issue 10, Page(s) 2751–2760

    Abstract: Objectives: The aim of this study was to assess the feasibility of the novel "superb microvascular imaging" (SMI) Doppler ultrasound technique to detect ovarian vascularity in healthy children and to compare it with the conventional Doppler ultrasound ... ...

    Abstract Objectives: The aim of this study was to assess the feasibility of the novel "superb microvascular imaging" (SMI) Doppler ultrasound technique to detect ovarian vascularity in healthy children and to compare it with the conventional Doppler ultrasound techniques.
    Methods: This prospective study included 140 girls, aged 3 to 18 years, for which an abdominal ultrasound study was requested in the pediatrics outpatient clinics for suspicion of nonovarian pathologies. Nineteen individuals were excluded from the study due to incomplete ultrasound scanning. For the remaining 121 cases, gray scale ultrasound evaluation was performed followed by color Doppler imaging, power Doppler imaging, advanced dynamic flow, color SMI, and monochrome SMI to detect the presence and degree of vascularity in the ovaries. Ultrasound scanning was performed for all participants by the same doctor by using curvilinear probe via the suprapubic approach, and the images were independently evaluated by 3 different observers. The images were assessed with regard to the degree of vascularity and the presence of artifacts.
    Results: A total of 146 ovaries (42 right, 54 left, and 25 bilateral) were examined by sonography. The mean interrater agreement regarding the detection of vascularity was moderate for the color Doppler imaging, power Doppler imaging, advanced dynamic flow, and monochrome SMI techniques (κ = 0.514-0.551) and substantial for the color SMI technique (κ = 0.636) (P < .001). The techniques were found to be statistically significant for detecting vascularity: monochrome SMI > color SMI > power Doppler imaging > color Doppler imaging > advanced dynamic flow (P < .001).
    Conclusion: SMI is a promising tool that can detect ovarian vascularity more effectively than the conventional Doppler ultrasound techniques.
    MeSH term(s) Adolescent ; Artifacts ; Child ; Child, Preschool ; Feasibility Studies ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Microvessels/diagnostic imaging ; Ovary/blood supply ; Ovary/diagnostic imaging ; Prospective Studies ; Sensitivity and Specificity ; Ultrasonography, Doppler/methods
    Language English
    Publishing date 2019-03-28
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.14983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Left-sided Poland's syndrome associated with dextrocardia.

    Ozkok, Sercin / Erol, Nurdan / Onal, Canver / Yikilmaz, Ali

    Northern clinics of Istanbul

    2018  Volume 6, Issue 2, Page(s) 192–195

    Abstract: Poland's syndrome is a rare congenital anomaly accompanied by the absence of the pectoralis major, and the ipsilateral upper-limb and chest wall deformities. Hypoplasia of the breast, agenesis of the ipsilateral rib cartilage, athelia, and ipsilateral ... ...

    Abstract Poland's syndrome is a rare congenital anomaly accompanied by the absence of the pectoralis major, and the ipsilateral upper-limb and chest wall deformities. Hypoplasia of the breast, agenesis of the ipsilateral rib cartilage, athelia, and ipsilateral developmental finger anomalies such as syndactyly can also be seen. In the literature, only 56 cases of dextrocardia and left-sided Poland's syndrome have been described. Herein, a case of left-sided Poland's syndrome coexisting with dextrocardia and nasal hemangioma was presented.
    Language English
    Publishing date 2018-09-03
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 3031921-3
    ISSN 2536-4553 ; 2148-4902
    ISSN (online) 2536-4553
    ISSN 2148-4902
    DOI 10.14744/nci.2018.82698
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  5. Article ; Online: Seeing the Unseen: Evaluating Testicular Vascularity in Neonates by Using the Superb Microvascular Imaging Ultrasound Technique.

    Ayaz, Ercan / Ayaz, Muzaffer / Önal, Canver / Yıkılmaz, Ali

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2018  Volume 38, Issue 7, Page(s) 1847–1854

    Abstract: Objectives: To evaluate testicular vascularity in neonates by using the novel Superb Microvascular Imaging (SMI; Toshiba Medical Systems Corporation, Tokyo, Japan) ultrasound (US) technique and to compare this technique to conventional Doppler US ... ...

    Abstract Objectives: To evaluate testicular vascularity in neonates by using the novel Superb Microvascular Imaging (SMI; Toshiba Medical Systems Corporation, Tokyo, Japan) ultrasound (US) technique and to compare this technique to conventional Doppler US techniques.
    Methods: A total of 140 healthy neonates between 2 and 60 days old who were admitted for routine screening were included in the study. However, in 9 cases, the Doppler study could not be completed. In the remaining 131 cases, color Doppler imaging (CDI), power Doppler imaging (PDI), Advanced Dynamic Flow (ADF; Toshiba Medical Systems), and monochrome SMI (mSMI) techniques were performed on a single representative testicle. Real-time cine images were captured for 5 to 10 seconds for each technique by using a high-frequency (7.2-14-MHz) linear transducer. The images were evaluated by 3 observers using a grading system to quantify the degree of vascularity and artifact interference.
    Results: A total of 131 testicles (74 right and 57 left) were evaluated, and vascularity was shown in 110 (84%) testicles with CDI, 109 (83%) with PDI, 94 (72%) with ADF, and 128 (98%) with mSMI by the consensus of all observers. The Doppler techniques were ranked from highest to lowest in the following order based on the degree of vascularity detected: mSMI > PDI > CDI > ADF (P < .001). Based on the presence of artifacts, the Doppler techniques were ranked as follows from high to low: ADF > CDI > PDI > mSMI (P < .001).
    Conclusions: Superb Microvascular Imaging is a promising US technique that appears to detect testis vascularity better than conventional Doppler US techniques; however, further research is needed to support the results of this study.
    MeSH term(s) Artifacts ; Humans ; Infant, Newborn ; Male ; Microvessels/diagnostic imaging ; Sensitivity and Specificity ; Testis/blood supply ; Testis/diagnostic imaging ; Ultrasonography, Doppler/methods
    Language English
    Publishing date 2018-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.14882
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  6. Article ; Online: Pediatric Hepatobiliary Neoplasms: An Overview and Update.

    Yikilmaz, Ali / George, Michael / Lee, Edward Y

    Radiologic clinics of North America

    2017  Volume 55, Issue 4, Page(s) 741–766

    Abstract: Recent developments regarding the treatment of pediatric liver tumors have significantly improved patient care. Stimulated by collaboration between international pediatric groups, advances have been made in surgical techniques, transplantation options, ... ...

    Abstract Recent developments regarding the treatment of pediatric liver tumors have significantly improved patient care. Stimulated by collaboration between international pediatric groups, advances have been made in surgical techniques, transplantation options, and chemotherapy schemas. In light of this progress, clear understanding of the state-of-the-art imaging evaluation of hepatobiliary tumors has become even more integral to the effective management of children with hepatic neoplasms. The unique imaging features of hepatic neoplasms in the pediatric population, when coupled with supportive demographic data and laboratory findings, can lead to accurate diagnosis and proper treatment of hepatobiliary tumors.
    MeSH term(s) Biliary Tract Neoplasms/diagnostic imaging ; Biliary Tract Neoplasms/pathology ; Biomarkers, Tumor/analysis ; Child ; Child, Preschool ; Diagnostic Imaging/methods ; Humans ; Infant ; Infant, Newborn ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Neoplasm Metastasis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2017.02.003
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  7. Article ; Online: Desmoplastic Small Round Cell Tumor With Ascending Intraspinal Metastasis at Recurrence: Case Report and Review of the Literature.

    Cacciotti, Chantel / Samji, Nasrin / Cox, Stephanie / Yikilmaz, Ali / Hann, Crystal / Marin, Jorge A / Fowler, JoAnn / VanHouwelingen, Lisa / Athale, Uma

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 2, Page(s) e561–e566

    Abstract: Background: Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy commonly involving the abdomen and/or pelvic peritoneum. Despite aggressive therapy, the prognosis remains poor. Central nervous system relapse is rare in ... ...

    Abstract Background: Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy commonly involving the abdomen and/or pelvic peritoneum. Despite aggressive therapy, the prognosis remains poor. Central nervous system relapse is rare in abdominal/pelvic primary DSRCT.
    Observation: We report a case of a 10-year-old female with a large pelvic DSRCT and involvement of the rectosigmoid colon and liver. Following treatment with chemotherapy, and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy an initial response was noted. With progressive lower limb weakness, recurrence with perineural invasion in the lumbosacral nerve root involving the conus was noted 2.5 years from diagnosis. Cerebrospinal fluid showed tumor cells with a molecular confirmation.
    Conclusions: Perineural invasion and ascending paralysis secondary to primary abdominal DSRCT has not been previously reported to our knowledge. We recommend a high index of suspicion for early and accurate diagnosis of this rare presentation.
    MeSH term(s) Child ; Cytoreduction Surgical Procedures ; Desmoplastic Small Round Cell Tumor/pathology ; Desmoplastic Small Round Cell Tumor/therapy ; Female ; Humans ; Neoplasm Recurrence, Local/therapy ; Prognosis
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002138
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  8. Article ; Online: Pediatric Urinary System Neoplasms: An Overview and Update.

    George, Michael / Perez-Rosello, Jeannette M / Yikilmaz, Ali / Lee, Edward Y

    Radiologic clinics of North America

    2017  Volume 55, Issue 4, Page(s) 767–784

    Abstract: Pediatric urinary system neoplasms are a diverse group of tumors that frequently overlap in their clinical and radiologic features. By contrast, the histopathologic classification and treatment of these entities have become increasingly refined, ... ...

    Abstract Pediatric urinary system neoplasms are a diverse group of tumors that frequently overlap in their clinical and radiologic features. By contrast, the histopathologic classification and treatment of these entities have become increasingly refined, resulting in improved outcomes, with the overall survival of Wilms tumors now exceeding 90%. Significantly, many contemporary protocols rely on radiologic diagnosis in the absence of tissue confirmation. This review article provides up-to-date clinical, epidemiologic, and imaging findings of pediatric urinary system neoplasms and their mimics frequently encountered in daily clinical practice.
    MeSH term(s) Child ; Child, Preschool ; Diagnosis, Differential ; Diagnostic Imaging/methods ; Humans ; Infant ; Infant, Newborn ; Urologic Neoplasms/diagnostic imaging ; Urologic Neoplasms/epidemiology
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2017.02.004
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  9. Article: Silicosis due to Denim Sandblasting in Young People: MDCT Findings.

    Doganay, Selim / Gocmen, Hayrettin / Yikilmaz, Ali / Coskun, Abdulhakim

    The Eurasian journal of medicine

    2015  Volume 42, Issue 1, Page(s) 21–23

    Abstract: Objective: Occupational lung disease due to silica dust is one of the most common work-related injuries. In denim sandblasting, workers are exposed to silica that may cause immediate mortality, especially in young people. The aim of this study was to ... ...

    Abstract Objective: Occupational lung disease due to silica dust is one of the most common work-related injuries. In denim sandblasting, workers are exposed to silica that may cause immediate mortality, especially in young people. The aim of this study was to assess the multidetector computed tomography (MDCT) findings of silicosis in denim sandblasters and to better define the role of MDCT in the early detection of silicosis.
    Materials and methods: The study included 12 consecutive male patients who were admitted to a pulmonary outpatient clinic between April 2009 and December 2009. All patients had been working as sandblasters for at least one year. All patients underwent chest CT examinations for suspected silicosis. Two radiologists independently assessed the images for the presence and distribution of airspace consolidation, ground-glass opacity, nodules, interlobular septal thickening, parenchymal bands, fibrosis, masses, traction bronchiectasis, honeycombing, lobular low-attenuation areas, emphysema, pleural effusion or thickening, and mediastinal or hilar adenopathy.
    Results: MDCT detected parenchymal abnormalities in the lungs in eight (67%) of the twelve patients. The most common MDCT finding was ground glass opacity (58%). Other common findings were parencyhmal nodules and interlobular septal thickening, predominantly in the upper zones. Nodules were detected in six (50%) of the twelve patients. In four cases (67%), the nodules were numerous (>10), were predominantly smaller than 10 mm, and were centrilobular in distribution. In five (42%) of the 12 patients, interlobular septal thickening was detected. Only one (8%) patient presented with airspace consolidation; this was bilateral in the upper zones and associated with air bronchograms. In one (8%) patient there were several traction bronchiectases in the upper zones. None of the patients presented with pleural effusion, thickening, or honeycombing. Enlarged mediastinal nodes were identified in half of the patients, predominantly in the precarinal, paratracheal, and prevascular regions. No egg-shell calcification was detected. One (8%) patient presented with punctate calcification in the hilar region.
    Conclusions: Early detection of silicosis is important because it may cause immediate mortality, especially in young people. Enlarged mediastinal lymph nodes, centrilobular nodules, interlobular septal thickening, and patchy ground glass opacity may be early MDCT findings of silicosis. Thus, MDCT plays an important role in the early detection of silicosis in denim sandblasters.
    Language English
    Publishing date 2015-01-06
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2577670-8
    ISSN 1308-8742 ; 1308-8734
    ISSN (online) 1308-8742
    ISSN 1308-8734
    DOI 10.5152/eajm.2010.07
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  10. Article ; Online: Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation.

    Yikilmaz, Ali / Ngan, Bo-Yee / Navarro, Oscar M

    Pediatric radiology

    2015  Volume 45, Issue 12, Page(s) 1796–1802

    Abstract: Background: Angiomatoid fibrous histiocytoma is a rare soft-tissue tumor that more often affects children and young adults. There is little information available regarding the imaging appearance of angiomatoid fibrous histiocytoma in children.: ... ...

    Abstract Background: Angiomatoid fibrous histiocytoma is a rare soft-tissue tumor that more often affects children and young adults. There is little information available regarding the imaging appearance of angiomatoid fibrous histiocytoma in children.
    Objective: To describe the ultrasonographic (US) and magnetic resonance (MR) imaging findings of angiomatoid fibrous histiocytoma in children.
    Materials and methods: A retrospective analysis was done of US and MR imaging findings in children with angiomatoid fibrous histiocytoma. Clinical findings and histopathology with molecular analysis results were also collected.
    Results: There were 7 children with angiomatoid fibrous histiocytoma with a median age of 6 years (age range: 16 months-14 years). Patients presented clinically with a soft-tissue mass in the extremities or in the trunk. Four children had anemia, and three of them had additional systemic symptoms. Two patients had US and three had MR imaging while the remaining two had both. Lesion size ranged from 1.3 cm to 7.2 cm. In four patients, angiomatoid fibrous histiocytoma presented as a nonspecific predominantly solid mass. The other three patients had a combination of the following imaging findings: intralesional blood-filled cystic spaces with fluid-fluid levels, enhancing fibrous pseudocapsule and hemosiderin deposition. These findings correlated well with histopathology.
    Conclusion: The imaging detection of intralesional blood-filled cystic spaces with fluid-fluid levels, enhancing fibrous pseudocapsule and hemosiderin deposition in a soft-tissue tumor in a child may suggest the diagnosis of angiomatoid fibrous histiocytoma. A history of systemic symptoms and anemia in the presence of a soft-tissue mass may also be a clue for the diagnosis of angiomatoid fibrous histiocytoma.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Extremities/diagnostic imaging ; Extremities/pathology ; Female ; Histiocytoma, Malignant Fibrous/diagnostic imaging ; Histiocytoma, Malignant Fibrous/pathology ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Reproducibility of Results ; Retrospective Studies ; Thorax/diagnostic imaging ; Thorax/pathology ; Ultrasonography
    Language English
    Publishing date 2015-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-015-3404-y
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