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Article ; Online: Statistical analysis of ionospheric vertical total electron content anomalies before global Mw≥6.0 shallow earthquakes during 2000–2020

Yifang Ma / Xiaohui Zhou / Yilin Yang / Leyin Hu / Hongyan Dong / Rui Yan

Frontiers in Earth Science, Vol

2023 Volume 11

Abstract: To quantitatively investigate the relationship between earthquakes and ionospheric anomalies, this paper presents a statistical study of pre-earthquake vertical total electron content (VTEC) variations. A total of 1522 shallow (≤60 km) strong (Mw≥6.0) ... ...

Abstract	To quantitatively investigate the relationship between earthquakes and ionospheric anomalies, this paper presents a statistical study of pre-earthquake vertical total electron content (VTEC) variations. A total of 1522 shallow (≤60 km) strong (Mw≥6.0) earthquakes in the global area during 2000-2020 are selected, and classified according to different magnitudes, latitudes and focal depths. A quartile-based process with different lengths of sliding windows, equaling 10 days, 15 days and 27 days, respectively, has been utilized to detect VTEC anomalies. The abnormal level is first defined, and then VTEC anomalies occurrence probabilities (Po) and occurrence rates (PE) within 1-10 days before 1522 earthquakes have been calculated. Besides, VTEC anomalies occurrence rates of the background days (PN) are also calculated. The results show that the significant correlation between Po and epicentral latitudinal locations could be observed within 1-10 days before earthquakes. The values of Po increase with larger magnitudes in the equatorial and low-latitude regions, but decrease with greater magnitudes in the mid- and high-latitude regions to some degree. Within 1-5 days before earthquakes, the overall trend of PE shows an increase with larger magnitudes, but the correlation between the values of PE and magnitudes is relatively weak in the southern mid- and high-latitude regions. There is no evident causality between PN and the magnitude, and most of the values of PE/PN are larger than 1, indicating that VTEC anomalies within a few days before earthquakes are probably related with the forthcoming earthquakes. Moreover, when the abnormal level exceeds 60%, different sliding window lengths have a significant impact on the values of Po and PE in the mid- and high-latitude regions. In particular, there are obvious systematic deviations between the values of Po obtained from different sliding windows in the southern mid- and high-latitude regions. However, the selection of the optimal sliding window needs to be further studied.
Keywords	shallow strong earthquakes ; seismo-ionospheric anomaly ; VTEC ; statistical analysis ; different lengths of sliding window ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of the disease severity with infection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta and Omicron variants

Ying Qiu / Zhenghao Li / Fan Lin / Yilin Yang / Lanxuan Yang / Ting Li

MedComm – Future Medicine, Vol 2, Iss 1, Pp n/a-n/a (2023)

A meta‐analysis

2023

Abstract: Abstract The increased transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta and Omicron variants due to their complex mutations has been confirmed by many studies, but the disease severity caused by these two variants ... ...

Abstract	Abstract The increased transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta and Omicron variants due to their complex mutations has been confirmed by many studies, but the disease severity caused by these two variants and vaccine efficacy have not been clearly concluded. This meta‐analysis evaluated and compared disease severity and vaccine efficacy for infection with these two variants. Databases were searched on July 29, 2022, for original studies. Data extracted included participants, hospitalization rate, intensive care unit (ICU) admission rate, mortality rate, and vaccination status. Total 15 studies (570,713 subjects) were included. The risk of hospitalization, ICU admission and death in patients with Delta were increased compared with patients with Omicron, especially hospitalization (Log risk ratio [RR]: 1.09, 95% confidence interval [CI]: 0.65–1.53). The Delta was associated with a higher risk of death in the unvaccinated population (Log RR: 0.48, 95% CI: 0.04–0.93). No significant differences in the risk of severe illness between BA.1 and BA.2 were observed. All three risks were reduced in fully vaccinated populations infected with Delta and Omicron. The existing evidence shows that the inherent virulence and disease severity of Omicron are reduced compared with Delta, and fully vaccination is effective in preventing severe infection of both variants.
Keywords	Delta ; Omicron ; SARS‐CoV‐2 ; severity ; Medical technology ; R855-855.5 ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Deep Learning Labeling Method for Material Microstructure Image Segmentation

Xuandong Wang / Hang Su / Nan Li / Ying Chen / Yilin Yang / Huimin Meng

Processes, Vol 11, Iss 12, p

2023 Volume 3272

Abstract: In the existing deep learning modeling process for material microstructure image segmentation, the manual pixel labeling process is time-consuming and laborious. In order to achieve fast and high-accuracy modeling, this work proposes a convenient deep ... ...

Abstract	In the existing deep learning modeling process for material microstructure image segmentation, the manual pixel labeling process is time-consuming and laborious. In order to achieve fast and high-accuracy modeling, this work proposes a convenient deep learning labeling method and a workflow for generating a synthetic image data set. Firstly, a series of label templates was prepared by referring to the distribution of the material microstructure. Then, the typical textures of different microstructures were box-selected in the images to be segmented to form texture templates. The manual pixel labeling was simplified to the box-selection of the typical microstructure texture. Finally, a synthetic data set can be generated using the label and texture templates for further deep learning model training. Two image cases containing multiple types of microstructures were used to verify the labeling method and workflow. The results show that the pixel segmentation accuracy of the deep learning model for the test images reaches 95.92% and 95.40%, respectively. The modeling workflow can be completed within 20 min, and the labeling time that requires manual participation is within 10 min, significantly reducing the modeling time compared to traditional methods where the labeling process may take several hours.
Keywords	data augmentation ; synthetic microstructure image ; texture learning ; label template ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time-Dependent Toxicity and Health Effects Mechanism of Cadmium to Three Green Algae

Lingyun Mo / Yilin Yang / Danna Zhao / Litang Qin / Baikang Yuan / Nan Liang

International Journal of Environmental Research and Public Health, Vol 19, Iss 10974, p

2022 Volume 10974

Abstract: As algae are extremely sensitive to heavy-metal ions and can be critical biological indicators in the heavy-metal toxicity analyses conducted by environmental health researchers, this paper explores the sensitivity to temporal toxicity of three species ... ...

Abstract	As algae are extremely sensitive to heavy-metal ions and can be critical biological indicators in the heavy-metal toxicity analyses conducted by environmental health researchers, this paper explores the sensitivity to temporal toxicity of three species of green algae: Scenedesmus obliquus , Chlorella pyrenoidosa , and Selenastrum capricornutum . The method of time-dependent microplate toxicity analysis was used to systematically investigate the changes in the toxicities of the three green-algae species induced by different concentrations of cadmium (Cd). The chlorophyll a content, antioxidant enzyme activity, and malondialdehyde (MDA) content in the algae were analyzed to explore the mechanism of Cd toxicity after 96 h of exposure. The results showed that the toxic effects of Cd on the three algae species were time-dependent. By comparing the toxic effect of Cd, indicated by pEC 50 (the negative logarithm of EC 50 ), on the algae species at four durations of exposure (24, 48, 72, and 96 h), this study found that the indicator organisms had different sensitivities to Cd. The order of sensitivity was C. pyrenoidosa > S. obliquus > S. capricornutum . Cd exposure had significant effects on the chlorophyll a and MDA content and on the enzyme activity of superoxide dismutase (SOD) and catalase (CAT) in the algae species. The chlorophyll a content in the cells of the algae decreased with increasing Cd concentration. The enzyme activity of CAT and content of MDA increased with increasing Cd concentration, which indicated that Cd had an oxidative stress effect on the three algae species.
Keywords	cadmium ; green alga ; toxicity ; antioxidant activity ; Medicine ; R
Subject code	590
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Green and Red Thai Kratom (Mitragyna speciosa) on pancreatic digestive enzymes (alpha-glucosidase and lipase) and acetyl-carboxylase 1 activity

Atikarn Janthongkaw / Sirinthip Klaophimai / Tanaporn Khampaya / Supaporn Yimthiang / Yilin Yang / Ruixue Ma / Apirak Bumyut / Phisit Pouyfung

PLoS ONE, Vol 18, Iss

A possible therapeutic target for obesity prevention

2023 Volume 9

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Green and Red Thai Kratom (Mitragyna speciosa) on pancreatic digestive enzymes (alpha-glucosidase and lipase) and acetyl-carboxylase 1 activity

Atikarn Janthongkaw / Sirinthip Klaophimai / Tanaporn Khampaya / Supaporn Yimthiang / Yilin Yang / Ruixue Ma / Apirak Bumyut / Phisit Pouyfung

PLoS ONE, Vol 18, Iss 9, p e

A possible therapeutic target for obesity prevention.

2023 Volume 0291738

Abstract: Regular use of Thai kratom has been linked to reduced blood triglyceride levels and body mass index (BMI) in healthy individuals. We analyzed Green Thai Kratom (GTK) and Red Thai Kratom (RTK) to investigate their effects on pancreatic digestive enzymes. ... ...

Abstract	Regular use of Thai kratom has been linked to reduced blood triglyceride levels and body mass index (BMI) in healthy individuals. We analyzed Green Thai Kratom (GTK) and Red Thai Kratom (RTK) to investigate their effects on pancreatic digestive enzymes. The ethanol extracts of GTK and RTK inhibited lipase activity more strongly than alpha-glucosidase activity, suggesting the presence of lipase inhibitors. Mitragynine, the major compound in GTK, showed potent lipase inhibition and moderate alpha-glucosidase inhibition. Quercetin, found in both extracts, strongly inhibited alpha-glucosidase but had limited effects on lipase. These findings suggest that mitragynine and quercetin may hinder triglyceride and starch digestion. Combination inhibition studies revealed synergistic effects between mitragynine and quercetin on alpha-glucosidase activity. Additionally, both GTK and RTK extracts reduced fat accumulation in 3T3-L1 adipocyte cells, with quercetin specifically inhibiting Acetyl-CoA carboxylase 1 (ACC1), a key enzyme in fatty acid biosynthesis. Thus, GTK and RTK extracts, particularly mitragynine and quercetin, exhibit potential anti-obesity effects. We report the novel finding that Thai kratom inhibits de novo fatty acid synthesis by targeting ACC1, resulting in decreased fat accumulation in adipocytes. Regular use of Thai kratom in specific populations may improve blood triglyceride levels and reduce BMI by inhibiting lipase, alpha-glucosidase, and ACC1 activity. Further clinical trials are needed to determine optimal dosage, duration, toxicity levels, and potential side effects of Kratom use.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The application value of high-frequency ultrasound in the feasibility assessment of endoscopic retrograde appendicitis therapy in children with appendicitis

Xiaoya Guo / Hengli Yang / Ping Zhao / Jinghua Li / Lingchao Zeng / Chunhui Wang / Yilin Yang / Ruijing Yang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Acute appendicitis is one of the common acute abdominal diseases in pediatrics. However, the implementation of radiological examination guided endoscopic retrograde appendicitis therapy (ERAT) in adults is limited in children. Our previous ... ...

Abstract	Abstract Acute appendicitis is one of the common acute abdominal diseases in pediatrics. However, the implementation of radiological examination guided endoscopic retrograde appendicitis therapy (ERAT) in adults is limited in children. Our previous research explored the non-invasive guidance of high-frequency ultrasound (HFUS) for ERAT and achieved good therapeutic effects. This study mainly focuses on exploring the application value of HFUS in the feasibility assessment of ERAT in children with appendicitis. 163 children with appendicitis received ERAT guided by HFUS were analyzed retrospectively. According to the parameters evaluated by HFUS before and during ERAT, the results indicated that the distance between the appendix orifice and the ileocecal valve significantly affected the time required for the guidewire to enter the appendix cavity (P < 0.05). The diameter and the texture of the fecalith, the thickness of the intestinal wall of the appendiceal orifice all had significant effects on the successful removal of the fecalith (P < 0.05). The success rate, treatment time and final flushing effect of the guidewire to reach the blind end of the appendix were significantly affected by the tortuosity of the appendix and whether there was adhesion with surrounding tissues (P < 0.05). HFUS can accurately assess the feasibility of ERAT in children with appendicitis.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Tacit Knowledge Transfer Based on Fusion of Three-Way Decision and Fuzzy Rough Set

ZHANG Jianhua, LI Fangfang, LIU Yilin, YANG Lan

Jisuanji kexue yu tansuo, Vol 16, Iss 1, Pp 253-

2022 Volume 260

Abstract: In the face of increasingly abundant knowledge resources, low-cost, high-precision knowledge transfer mechanisms can support knowledge service organizations to provide good knowledge services for knowledge users, realize effective allocation of knowledge ...

Abstract	In the face of increasingly abundant knowledge resources, low-cost, high-precision knowledge transfer mechanisms can support knowledge service organizations to provide good knowledge services for knowledge users, realize effective allocation of knowledge resources, and improve the utilization of knowledge resources. This paper takes tacit knowledge as the research object, and proposes a model of tacit knowledge transfer based on three-way decision aiming at the characteristics of knowledge itself. The model mainly includes three parts: matching the user’s knowledge needs with existing knowledge resources; determining the decision threshold $\left( \alpha,\beta \right)$ based on the transfer cost; determining the region of “transfer” “non-transfer” and “delayed transfer” based on decision threshold. The empirical results show that, compared with the existing methods, the implicit knowledge transfer model based on three-way decision proposed in this paper reduces the cost of knowledge transfer due to misclassification by subdividing the transfer area. Meanwhile, the decision area is determined according to the similarity of views, improving the accuracy of knowledge transfer.
Keywords	\|knowledge service\|tacit knowledge\|knowledge transfer\|three-way decision ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	306
Language	Chinese
Publishing date	2022-01-01T00:00:00Z
Publisher	Journal of Computer Engineering and Applications Beijing Co., Ltd., Science Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of ultrasound elastography for monitoring the effects of TβR1 shRNA therapy on hepatic fibrosis in a rat model.

Xiangzhou Shi / Jinghua Li / Binying Min / Ruijing Yang / Chunxiang He / Yilin Yang

PLoS ONE, Vol 16, Iss 6, p e

2021 Volume 0253150

Abstract: Background To investigate the application of ultrasound elastography in monitoring the effects of the transforming growth factor (TGF)-β1 signaling pathway-targeted combination therapy for hepatic fibrosis. Methods 1. Short hairpin RNA (shRNA) constructs ...

Abstract	Background To investigate the application of ultrasound elastography in monitoring the effects of the transforming growth factor (TGF)-β1 signaling pathway-targeted combination therapy for hepatic fibrosis. Methods 1. Short hairpin RNA (shRNA) constructs targeted towards TβR1 were designed, synthesized, and packaged using an adeno-associated virus (AAV), and the effective target shRNA was selected based on transfection results. 2. Fifty rats were randomly allocated (n = 10 per group) to the (A) control group, (B) model group, (C) 0-week therapy group, (D) 4-week therapy group, and (E) combination therapy group. At weeks 2, 4, 6, 8, 10, and 12, acoustic radiation force impulse (ARFI) elastography was used to measure the liver stiffness, inner diameter of the portal vein diameter, and blood velocity; radio frequency ultrasound imaging was used to measure the abdominal aortic elasticity parameter and pulse wave velocity (PWV) of the rats. 3. At week 12, portal vein puncture was performed to measure the portal venous pressure, and rat liver specimens were obtained for the pathological measurement of the degree of hepatic fibrosis. Results 1. An shRNA interference sequence targeted towards TβR1 was successfully designed, screened, and packaged using an AAV, and small-animal imaging results indicated expression of the specific shRNA in the liver. 2. At week 12, the ultrasound elastography results were significantly different between the experimental groups and the control group (p < 0.01); among the experimental groups, differences were significant between the therapy groups and the model group (p < 0.01). For groups C and E, the therapeutic effects on hepatic fibrosis in rats were significant, with the pathological results indicating a significant reduction in the degree of hepatic fibrosis (p < 0.01). The therapeutic effectiveness of group D was less than that of group C (p < 0.05). Significant differences existed between the portal venous pressure of the experimental groups and of the control group (p ...
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effective natural inhibitors targeting granzyme B in rheumatoid arthritis by computational study

Xinyu Wang / Ye Jiang / Pengcheng Zhou / Liangxin Lin / Yilin Yang / Qifan Yang / Jiting Zhang / Dong Zhu

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected by clinicians and patients.ObjectivesThis study aimed to identify novel therapeutic and ... ...

Abstract	BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected by clinicians and patients.ObjectivesThis study aimed to identify novel therapeutic and prognostic targets in RA at the genomic level and to screen desirable compounds with potential inhibitory effects on GZMB.MethodsWe performed differential gene analysis on GSE55235 and GSE55457 from Gene Expression Omnibus (GEO) and then obtained the intersection of the two differentially expressed genes (DEGs) lists by drawing Venn diagrams. Then we performed protein-protein interaction (PPI) network analysis, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the DEGs of the intersection. Next, we downloaded the crystal structure of Granzyme B (GZMB). Molecular docking technology was used to screen potential inhibitors of GZMB in subsequent experiments, and we then analyzed the toxicity and water solubility of these potential inhibitors for future drug experiments. Finally, whether the docking of these small molecules with GZMB is stable is tested by molecular dynamics.ResultsA total of 352 mutual DEGs were identified. Twenty hub genes were obtained according to PPI network analysis, among which the GZMB gene attracted the attention of our research. Three potent natural compounds, ZINC000004557101, ZINC000012495776, and ZINC000038143593, bound to GZMB, show better binding affinity. Furthermore, they are predicted to own low Ames mutagenicity, developmental toxicity potential, rodent carcinogenicity, and high tolerance to cytochrome P4502D6. Molecular dynamics simulations show that ZINC000004557101 and GZMB have more advantageous potential energy and can exist stably in a natural environment. Moreover, we finally verified the inhibitory effect of ZINC000004557101 on granzyme B by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Western blotting experiment.ConclusionRA patients showed increased GZMB ...
Keywords	GZMB ; RA ; virtual screening ; drug candidate ; computer-aided technology ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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