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Article: Case report: Isolated eyelid metastasis of ccRCC 5 years after receiving radical nephrectomy.

Yin, Huaqi / Du, Zheng / Zhang, Jiuwen / Ma, Yongkang / Zhao, Shiming / Yang, Tiejun

2024 Volume 14, Page(s) 1321919

Abstract: Introduction: The most common sites of clear cell renal cell carcinoma(ccRCC) metastasis are the lung, bones, liver and brain; eyelid metastasis is a rare occurrence.: Case presentation: We report a case of ccRCC metastasis to the left eyelid after ... ...

Abstract	Introduction: The most common sites of clear cell renal cell carcinoma(ccRCC) metastasis are the lung, bones, liver and brain; eyelid metastasis is a rare occurrence. Case presentation: We report a case of ccRCC metastasis to the left eyelid after radical nephrectomy, and remission after sunitinib treatment. Conclusions: Although the probability of eyelid metastasis rate is very low, tumor metastasis to the eyelid skin is possible after radical nephrectomy. Therefore, any rash like changes on the skin during the review procedure cannot be ignored by the physician.
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1321919
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Article: [Immunotherapy Based on Tumor Microenvironment in Renal Cell Carcinoma].

Han, Song-Chen / Yin, Hua-Qi / Xu, Tao

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2022 Volume 44, Issue 2, Page(s) 305–312

Abstract: Renal cell carcinoma (RCC) is a common lethal urological cancer,the distant metastasis of which is the leading cause of death.Although targeted agents have remarkably improved the overall prognosis of RCC patients,nearly all the patients eventually ... ...

Abstract	Renal cell carcinoma (RCC) is a common lethal urological cancer,the distant metastasis of which is the leading cause of death.Although targeted agents have remarkably improved the overall prognosis of RCC patients,nearly all the patients eventually acquire therapeutic resistance.With the advent of immune checkpoint inhibitors,immunotherapy based on tumor microenvironment (TME) has shown a broad scope in clinical application.The deepening understanding of TME leads to the changes of therapeutic strategies for advanced RCC,and the combination of targeted therapy and immunotherapy is exhibiting a promising prospect.Herein,we reviewed the TME characteristics,candidate predictive biomarkers,and possible targets for future development of drugs against RCC.
MeSH term(s)	Carcinoma, Renal Cell/therapy ; Female ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Male ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Inhibitors
Language	Chinese
Publishing date	2022-05-11
Publishing country	China
Document type	Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.13013
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Article ; Online: Penile cancer with bilateral inguinal lymph node metastases surviving for more than 4 years: A case report.

Zhu, Mingkai / Yin, Huaqi / Dong, Bingqi / Yang, Tiejun

Asian journal of surgery

2022 Volume 46, Issue 4, Page(s) 1590–1591

MeSH term(s)	Male ; Humans ; Lymphatic Metastasis/pathology ; Penile Neoplasms/surgery ; Penile Neoplasms/pathology ; Lymph Nodes/pathology ; Lymph Node Excision ; Lower Extremity ; Neoplasm Staging ; Sentinel Lymph Node Biopsy ; Inguinal Canal/pathology
Language	English
Publishing date	2022-10-26
Publishing country	China
Document type	Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.10.015
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Article ; Online: Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma.

Han, Songchen / Yang, Wenbo / Qin, Caipeng / Du, Yiqing / Ding, Mengting / Yin, Huaqi / Xu, Tao

BMC cancer

2022 Volume 22, Issue 1, Page(s) 661

Abstract: Background: Intratumoral fibrosis was positively correlated with histological grade of renal clear cell carcinoma (ccRCC) and intratumoral inflammation. However, the association of intratumoral fibrosis with the immune infiltration of ccRCC was few ... ...

Abstract	Background: Intratumoral fibrosis was positively correlated with histological grade of renal clear cell carcinoma (ccRCC) and intratumoral inflammation. However, the association of intratumoral fibrosis with the immune infiltration of ccRCC was few evaluated. Methods: We used the second harmonic generation (SHG)-based imaging technology and evaluated the intratumoral fibrosis in ccRCC, and then divided the patients into the high fibrosis group (HF) and the low fibrosis group (LF). Meanwhile, the Kaplan-Meier survival curve analysis was performed to analyze the relationship between intratumoral fibrosis and the disease-free survival rate. Antibody arrays were used for seeking difference in cytokines and immune infiltration between the HF group (N = 11) and LF group (N = 11). The selected immune infiltration marker was then verified by immunohistochemistry (IHC) staining in 45 ccRCC samples. Results: Out of 640 cytokines and immune infiltration markers, we identified 115 proteins that were significantly different in quantity between ccRCC and adjacent normal tissues. In addition, the Venn diagram indicated that six proteins, including Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4), were significantly associated with intratumoral fibrosis (p < 0.05). The GO/KEGG enrichment analysis indicated that the proteins associated with intratumoral fibrosis were involved in the immunity and tumor-infiltrating lymphocytes. The expression of the CTLA4 was negatively correlated with collagen level, confirmed by IHC staining of CTLA4 (p < 0.05). Conclusions: The study indicated that the intratumoral fibrosis level was negatively correlated with the expression of CTLA4 in the tumor immune microenvironment of the ccRCC, which posed the potential value of targeting the stroma of the tumor, a supplement to immunotherapy. However, the specific mechanism of this association is still unclear and needs further investigation.
MeSH term(s)	Biomarkers, Tumor/metabolism ; CTLA-4 Antigen ; Carcinoma, Renal Cell/pathology ; Cytokines ; Fibrosis ; Humans ; Kidney Neoplasms/pathology ; Prognosis ; Tumor Microenvironment
Chemical Substances	Biomarkers, Tumor ; CTLA-4 Antigen ; Cytokines
Language	English
Publishing date	2022-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09765-0
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Article ; Online: PD-1 inhibitor toripalimab with gemcitabine as a neoadjuvant therapy for muscle-invasive bladder urothelial carcinoma: A case report.

Yin, Huaqi / Yongkang, Ma / Bao, Guan / Shiming, Zhao / Chaohong, He / Tiejun, Yang

Medicine

2022 Volume 101, Issue 2, Page(s) e28591

Abstract: Rationale: Routine neoadjuvant therapy for muscle-invasive bladder urothelial carcinoma prior to radical surgery is curative. With the increase in cancer immunotherapy, neoadjuvant immunotherapy has been used as an important complement to neoadjuvant ... ...

Abstract	Rationale: Routine neoadjuvant therapy for muscle-invasive bladder urothelial carcinoma prior to radical surgery is curative. With the increase in cancer immunotherapy, neoadjuvant immunotherapy has been used as an important complement to neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma. Toripalimab is a recombinant, humanized IgG4 monoclonal antibody directed against programmed cell death protein 1 and received the first global approval for the treatment of unresectable or metastatic melanoma in China on December 17, 2018. Patient concerns and diagnosis: A 57-year-old man was admitted to our hospital because of hematuria for 1 week. The patient was diagnosed pathologically with muscle-invasive bladder urothelial carcinoma. Interventions and outcomes: The patient received neoadjuvant toripalimab combined with gemcitabine therapy. The patient showed partial response. Subsequently, radical cystectomy was performed. Lessons: Toripalimab combined with gemcitabine exhibited accurate antitumor activity and may be a promising novel neoadjuvant therapy for muscle-invasive urothelial carcinoma.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/surgery ; Cystectomy ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Muscles/pathology ; Neoadjuvant Therapy ; Treatment Outcome ; Urinary Bladder ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery
Chemical Substances	Antibodies, Monoclonal, Humanized ; Immune Checkpoint Inhibitors ; Deoxycytidine (0W860991D6) ; toripalimab (8JXN261VVA) ; gemcitabine (B76N6SBZ8R)
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028591
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Article: Clinical study of renal artery cold perfusion combined with laparoscopic nephron retention in the treatment of complex renal angiomyolipoma.

Zhu, ChaoShuai / Yin, HuaQi / Zhao, ShiMing / Ma, YongKang / Sun, ZhengHui / Zhu, MingKai / Du, Zheng / Yang, Tiejun

Frontiers in oncology

2023 Volume 13, Page(s) 1220380

Abstract: Objective: The aim of this study is to summarize the surgical experience of renal artery cold perfusion combined with laparoscopic nephron preserving surgery for the treatment of complex renal angiomyolipoma and to evaluate the safety and feasibility of ...

Abstract	Objective: The aim of this study is to summarize the surgical experience of renal artery cold perfusion combined with laparoscopic nephron preserving surgery for the treatment of complex renal angiomyolipoma and to evaluate the safety and feasibility of this surgical protocol. Materials and methods: Clinical data of nine patients who received renal artery cold perfusion combined with laparoscopic nephron preserving surgery for complex renal angiomyolipoma in our hospital from February 2017 to August 2020 were retrospectively analyzed. The study parameters included imaging findings, total renal function before and after surgery, glomerular filtration rate (GFR) of affected kidney before and after surgery, and related complications. Results: Eight of the nine patients successfully completed the operation, one patient was intolerant to renal artery balloon implantation, and the success rate of the operation was 88.89%. The mean maximum tumor diameter was 6.8 cm, and RENAL score was 7 points. Postoperative total renal function and GFR of the affected kidney had no significant changes compared with that before surgery, and imaging examination showed no tumor residue or recurrence. Conclusion: This surgical procedure is safe and feasible for complex renal angiomyolipoma and can be used as a surgical option for renal hamartoma. The long-term effect needs to be confirmed by further studies.
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1220380
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Article ; Online: Correction

Yin Huaqi / Du Zheng / Ma Yongkang / Zhao Shiming / Sun Zhenghui / Wang Zhiwei / Li Congyu / Li Qian / Dong Bingqi / Zhu Mingkai / Zhu Chaoshuai / Peng Jiangshan / Yang Tiejun

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

The significance of transrectal ultrasound and urologist_dually guided pelvic floor muscle exercise in improving urinary continence after radical prostatectomy

2023 Volume 1

Keywords	Medicine ; R
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The significance of transrectal ultrasound and urologist_dually guided pelvic floor muscle exercise in improving urinary continence after radical prostatectomy

Yin Huaqi / Du Zheng / Ma Yongkang / Zhao Shiming / Sun Zhenghui / Wang Zhiwei / Li Congyu / Li Qian / Dong Bingqi / Zhu Mingkai / Zhu Chaoshuai / Peng Jiangshan / Yang Tiejun

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Background To determine whether transrectal ultrasound and urologist_dually guided pelvic floor muscle exercise is associated with immediate, early and long-term urinary continence after radical prostatectomy. Materials and methods Data from 114 ...

Abstract	Abstract Background To determine whether transrectal ultrasound and urologist_dually guided pelvic floor muscle exercise is associated with immediate, early and long-term urinary continence after radical prostatectomy. Materials and methods Data from 114 patients with localized prostate cancer (PC) who underwent RP at Henan Cancer Hospital from November 2018 to April 2021 were included in the retrospective study. Of the 114 patients, 50 patients in the observation group underwent transrectal ultrasound and urologist_dually guided PFME, and 64 patients in the control group underwent verbally_guided PFME. Contractile function of the external urinary sphincter was in the observation group was evaluated. The immediate, early and long-term urinary continence rates were assessed in both groups, and the factors affecting urinary continence were analyzed. Results The urinary continence rate at 2 weeks and 1, 3, 6 and 12 months in the observation group after RP was significantly higher than that in the control group (52.0% vs. 29.7%, 70.0% vs. 39.1%, 82% vs. 57.8, 88% vs. 70.3%, 98.0 vs. 84.4%, p < 0.05). The contractile function of the external urinary sphincter was obviously correlated with urinary continence at multiple visits after RP, except for the 12-month visit. Transrectal ultrasound and urologist-dually guided PFME was verified to be an independent positive factor for urinary continence at 2 weeks and 1, 3, 6 and 12 months using logistic regression analysis. However, TURP was a negative factor for postoperative urinary continence at different times. Conclusions Transrectal ultrasound and urologist_dually guided PFME had a significant role in improving immediate, early and long-term urinary continence after RP and acted as an independent prognostic factor.
Keywords	Prostate cancer ; Urinary continence ; Transrectal ultrasound ; PFME ; Radical prostatectomy ; Medicine ; R
Subject code	610 ; 796
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predicting ureteral status below the ureteral calculi in patients undergoing ureteroscopic lithotomy.

Qin, Caipeng / Yin, Huaqi / Du, Yiqing / Li, Qing / Liu, Hijun / Xu, Tao

Acta radiologica (Stockholm, Sweden : 1987)

2021 Volume 63, Issue 1, Page(s) 127–132

Abstract: Background: During ureteroscopy, severe ureter straightness or contortion may occur before the stone is passed.: Purpose: To identify clinical factors associated with distal ureteral status below the ureteral calculi in patients before surgery.: ... ...

Abstract	Background: During ureteroscopy, severe ureter straightness or contortion may occur before the stone is passed. Purpose: To identify clinical factors associated with distal ureteral status below the ureteral calculi in patients before surgery. Material and methods: From October 2016 to March 2017, 101 patients with ureteral calculi who underwent ureteroscopic lithotripsy were reviewed. Patients who lacked clinical data and underwent preoperative indwelling ureteral stent placement were excluded. Univariate and multivariate analyses were performed to determine the clinical factors associated with intraoperative findings. Results: A total of 101 patients were enrolled in the study (mean age = 54 years; mean stone size = 7.9 ± 4.5 mm). Overall, 25 of the 101 patients (24.7%) were diagnosed with poor distal ureteral status defined as intraoperative ureterostenosis or contortion resulting in a ureteroscope being unable to pass during the initial attempt. Univariate analysis showed significant differences in renal parenchyma thickness, ureteral wall thickening on imaging, and stone location (all, Conclusion: In conclusion, renal parenchyma thickness and ureteral wall thickening on imaging were associated with poor distal ureteral status. Therefore, patients with these predictive factors should undergo more intensive preparation before surgery.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China ; Female ; Humans ; Lithotripsy/methods ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Ureteral Calculi/diagnostic imaging ; Ureteral Calculi/surgery ; Ureteroscopy
Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185120988092
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Article ; Online: A laparoscopic radical inguinal lymphadenectomy approach partly preserving great saphenous vein branches can benefit for patients with penile carcinoma.

Ma, Yongkang / Hao, Jianwei / Yin, Huaqi / Zhu, Mingkai / Guan, Bao / Zhu, Chaoshuai / Dong, Bingqi / Zhao, Shiming / He, Zhaohong / Yang, Tiejun

BMC surgery

2022 Volume 22, Issue 1, Page(s) 138

Abstract: Background: Inguinal lymphadenectomy (iLAD) is effective for penile carcinoma treatment, but usually results in many complications. This study aims to clinically evaluate the feasibility and clinical significance of a laparoscopic radical iLAD approach ... ...

Abstract	Background: Inguinal lymphadenectomy (iLAD) is effective for penile carcinoma treatment, but usually results in many complications. This study aims to clinically evaluate the feasibility and clinical significance of a laparoscopic radical iLAD approach partly preserving great saphenous vein branches for penile carcinoma patients. Methods: A total of 48 patients with penile cancer who underwent laparoscopic radical iLAD with retention of the great saphenous vein in Henan Cancer Hospital from 2012 Jan to 2020 Dec were included in this study. Sixteen penile carcinoma patients who underwent laparoscopic radical iLAD preserving parts of superficial branches of the great saphenous vein were identified as the sparing group, and the matched 32 patients who incised those branches were identified as control group. This new procedure was performed by laparoscopy, preserving parts of superficial branches of the great saphenous vein, superficial lateral and medial femoral veins. Clinicopathological features and perioperative variables were recorded. Postoperative complications, including skin flap necrosis, lymphorrhagia, and lower extremity edema were analyzed retrospectively. Results: We found that the operative time of the sparing group is significantly longer than the control group (p = 0.011). There was no statistical difference in intraoperative blood loss, the lymph node number per side, average time to remove the drainage tube and postoperative hospital stay between the two groups. Compared to the control group, the sparing group showed a significantly decreased incidence of lower extremity edema (p = 0.018). The preservation of parts of superficial branches of the great saphenous vein was mainly decreased the incidence of edema below ankle (p = 0.034). Conclusions: This study demonstrated that the iLAD with preserving parts of superficial branches of the great saphenous vein, with a decreased incidence of postoperative complications, is a safe and feasible approach for penile cancer.
MeSH term(s)	Carcinoma/surgery ; Femoral Vein/pathology ; Humans ; Laparoscopy/methods ; Lymph Node Excision/methods ; Male ; Penile Neoplasms/surgery ; Postoperative Complications/epidemiology ; Retrospective Studies ; Saphenous Vein/pathology ; Saphenous Vein/surgery
Language	English
Publishing date	2022-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-022-01582-3
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