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Article: Intervention Effect of a Soybean-Based Complementary Food Supplement on Anemic Infants in a Poor Rural Region in China: Evidence from Quasi-RCT.

Yin, Jiyong / Liu, Tingting / Sun, Jing / Huo, Junsheng / Huang, Jian

2023 Volume 11, Issue 1

Abstract: The soybean-based Yingyang Bao complementary food supplement represents a special nutritional improvement method for anemic infants in many intervention projects across China, while its benefits lack rigorous evidence. Using a quasi-randomized controlled ...

Abstract	The soybean-based Yingyang Bao complementary food supplement represents a special nutritional improvement method for anemic infants in many intervention projects across China, while its benefits lack rigorous evidence. Using a quasi-randomized controlled trial design, which adhered to randomization and control except for the blinding method, 248 anemic infants were divided randomly into an intervention group (128 cases received the Yingyang Bao intervention based on routine feeding) and a control group (120 cases only received routine feeding). Anthropometric indicators and 16 blood indicators were measured at baseline and 1 year after intervention. The levels of hemoglobin, 1,25-dihydroxy vitamin D, homocysteine, retinol, vitamin D
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11010013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Construction and Evaluation of a Novel MAP Immunoassay for 9 Nutrition-and-Health-Related Protein Markers Based on Multiplex Liquid Protein Chip Technique.

Yin, Jiyong / Niu, Jiangping / Huo, Junsheng / Sun, Jing / Huang, Jian / Sun, Chaoqun

Nutrients

2023 Volume 15, Issue 6

Abstract: We attempted to construct and evaluate a novel detection method to realize simultaneous detection based on a multiplex liquid protein chip technique for nine nutrition-and-health-related protein markers to meet the requirement of an accurate, ... ...

Abstract	We attempted to construct and evaluate a novel detection method to realize simultaneous detection based on a multiplex liquid protein chip technique for nine nutrition-and-health-related protein markers to meet the requirement of an accurate, simultaneous and comprehensive analysis of the proteomics of nutrition and health. The lower limits of detection, biological limits of detection and regression equations of serum ferritin (SF), soluble transferrin receptor (sTfR), c-reactive protein (CRP), retinol-binding protein4 (RBP4), apolipoprotein B (ApoB), alpha-fetoprotein (AFP), prealbumin (PA), carcino-embryonic antigen (CEA) and D-Dimmer (D-D) were determined after a series of optimal experiments. Then, the results of the methodological evaluation for this novel method indicated that the accuracies were between 70.12% and 127.07%, the within-run precisions were between 0.85% and 7.31%, the between-run precisions were between 3.53% and 19.07%, the correlation coefficients between this method and other methods were above 0.504 (
MeSH term(s)	Protein Array Analysis ; Immunoassay/methods ; C-Reactive Protein/metabolism ; Bilirubin
Chemical Substances	C-Reactive Protein (9007-41-4) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061522
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Article: [Conditional optimization and methodological evaluation of liquid protein microarray in detecting cystatin C].

Sun, Chaoqun / Niu, Jiangping / Yin, Jiyong / Huo, Junsheng / Sun, Jing / Huang, Jian / Li, Tiantong / Liu, Yuhe / Liu, Ailing

Wei sheng yan jiu = Journal of hygiene research

2023 Volume 52, Issue 3, Page(s) 460–464

Abstract: Objective: To optimize the detection conditions and evaluate of cystatin C(CysC) by liquid protein microarray.: Methods: CysC was detected by double antibody sandwich method using liquid protein microarray. On the basis of determining the optimal ... ...

Abstract	Objective: To optimize the detection conditions and evaluate of cystatin C(CysC) by liquid protein microarray. Methods: CysC was detected by double antibody sandwich method using liquid protein microarray. On the basis of determining the optimal concentration combination of captured antibody and detected antibody, the detection conditions were optimized by determining the biological detection limit and lower detection limit, drawing the S-shaped curve and judging the linear range, and establishing the standard curve and regression equation. Methodsologically evaluate the accuracy, precision, reportable range and analytical specificity of the detection method. Results: The optimal concentration combinations of CycC trapping-detection antibodies were 26.6 μg/mL-1∶800. The lower limits of detection and biologic limits of detection of the CysC were 0.037 and 0.237 ng/mL, respectively. Regression equation were as followes: y=-3.315x~2+283.04x+160.89, R~2=0.9921. The relative bias of CysC which was detected on the liquid protein microarry was 5.81%. The dilution recovery and recovery were 70.35%-84.91%(n=3)and 79.94%-122.41%(n=3)respectively. The correlation coefficient of method ology comparison experiment was r=0.616, P<0.05, and there was no significant difference between the two method(t=0.948, P=0.358); The within-run precision range from 3.54% to 4.03%(n=10); The between-run precision range from 12.07% to 15.05%(D=5, n=3); The reportable range was 0.26-3784.04 ng/mL. The analysis of interference test result showed that the both concentrations of hemoglobin(160.00, 71.11 g/L) had interference to the result of CysC detected on the chip. Conclusion: This study completed the optimization of conditions and methodological evaluation of liquid protein microarray in detecting CysC.
MeSH term(s)	Cystatin C ; Protein Array Analysis ; Antibodies ; Creatinine ; Biomarkers
Chemical Substances	Cystatin C ; Antibodies ; Creatinine (AYI8EX34EU) ; Biomarkers
Language	Chinese
Publishing date	2023-07-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
DOI	10.19813/j.cnki.weishengyanjiu.2023.03.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Serum metabolomics of iron deficiency anemia in infants based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry].

Shen, Shi / Sun, Jing / Yin, Jiyong / Liu, Tingting / Chen, Xi / Gong, Zhaolong / Zhuo, Qin / Huo, Junsheng

Wei sheng yan jiu = Journal of hygiene research

2023 Volume 52, Issue 1, Page(s) 123–128

Abstract: Objective: To explore the differential metabolites in the serum of infants with iron deficiency anemia(IDA) and non iron deficiency anemia, and to explore the potential biomarkers.: Methods: Non-targeted metabolomics of 30 infants with iron ... ...

Abstract	Objective: To explore the differential metabolites in the serum of infants with iron deficiency anemia(IDA) and non iron deficiency anemia, and to explore the potential biomarkers. Methods: Non-targeted metabolomics of 30 infants with iron deficiency anemia aged 6-11 months and 30 infants with non iron deficiency anemia aged 6-11 months were analyzed by ultra-high performance liquid chromatography with time of flight mass spectrometry using Acquity UPLC BEH C_(18) column(100 mm×2.1 mm, 1.8 μm). The differences of metabolites between the two groups were analyzed by principal component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA). Differential metabolites were screened according to OPLS-DA variable importance projection(VIP) >1. The related metabolic pathways involved in the markers were analyzed based on the KEGG database. Results: Differences in serum metabolic profiles between iron deficiency anemia group and non iron deficiency anemia group were observed. The 44 potential biomarkers were mainly lipids. Combined with pathway analysis, the metabolic pathways related to different metabolites included glycerophosphingolipid metabolism and sphingolipid metabolism. Conclusion: There are differences in lipid metabolites between infants with non iron deficiency anemia and iron deficiency anemia, suggesting that the occurrence and progress of iron deficiency anemia are related to lipid metabolism.
MeSH term(s)	Humans ; Infant ; Metabolomics/methods ; Chromatography, Liquid ; Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods ; Biomarkers/metabolism ; Anemia
Chemical Substances	Biomarkers
Language	Chinese
Publishing date	2023-02-07
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
DOI	10.19813/j.cnki.weishengyanjiu.2023.01.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Construction and Application of Hepatocyte Model Based on Microfluidic Chip Technique in Evaluating Emodin

Chen, Di / Yin, Jiyong / Yang, Zhuo / Qin, Wen / Huo, Junsheng / Huang, Jian / Sun, Jing / Piao, Wei

Nutrients. 2022 July 05, v. 14, no. 13

2022

Abstract: The current cytological evaluation technique of health food raw materials does not entirely meet the needs of evaluating health food. Our study adopted the microfluidic chip technique for the first time to construct a hepatocyte model of evaluating ... ...

Abstract	The current cytological evaluation technique of health food raw materials does not entirely meet the needs of evaluating health food. Our study adopted the microfluidic chip technique for the first time to construct a hepatocyte model of evaluating emodin, which was composed of a human hepatocellular carcinoma cell (HepG2) and microfluidic chip. The mixed glue of a model with rat tail collagen type I (1.3 mg/mL) + gelatin (7.5%) was used to simulate the microenvironment of a cell. The validity of this model was evaluated by cell proliferation activity and cell staining, and the toxicity of emodin was evaluated by a series of metabolic indicators on this model. The results indicated that the repeatability of the constructed hepatocyte model was favorable, with a coefficient of variation (CV) of 2.8%. After emodin continuously was exposed for 48 h, the cell inhibition was obvious at 100 and 200 μM, and the number of dead cells gradually increased with the increasing of emodin concentration, and the difference of BUN was significant between the emodin group and blank group (p < 0.05). The constructed model has a favorable applicability in evaluating emodin. This study provides an important platform and a potential in vitro alternative model for assessing and predicting the health effects of health food.
Keywords	cell proliferation ; collagen ; emodin ; gelatin ; health foods ; hepatoma ; humans ; models ; neoplasm cells ; organ-on-a-chip ; rats ; tail ; toxicity
Language	English
Dates of publication	2022-0705
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132768
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Construction and Application of Hepatocyte Model Based on Microfluidic Chip Technique in Evaluating Emodin.

Chen, Di / Yin, Jiyong / Yang, Zhuo / Qin, Wen / Huo, Junsheng / Huang, Jian / Sun, Jing / Piao, Wei

Nutrients

2022 Volume 14, Issue 13

Abstract	The current cytological evaluation technique of health food raw materials does not entirely meet the needs of evaluating health food. Our study adopted the microfluidic chip technique for the first time to construct a hepatocyte model of evaluating emodin, which was composed of a human hepatocellular carcinoma cell (HepG2) and microfluidic chip. The mixed glue of a model with rat tail collagen type I (1.3 mg/mL) + gelatin (7.5%) was used to simulate the microenvironment of a cell. The validity of this model was evaluated by cell proliferation activity and cell staining, and the toxicity of emodin was evaluated by a series of metabolic indicators on this model. The results indicated that the repeatability of the constructed hepatocyte model was favorable, with a coefficient of variation (CV) of 2.8%. After emodin continuously was exposed for 48 h, the cell inhibition was obvious at 100 and 200 μM, and the number of dead cells gradually increased with the increasing of emodin concentration, and the difference of BUN was significant between the emodin group and blank group (p < 0.05). The constructed model has a favorable applicability in evaluating emodin. This study provides an important platform and a potential in vitro alternative model for assessing and predicting the health effects of health food.
MeSH term(s)	Animals ; Cell Line ; Emodin/pharmacology ; Hepatocytes ; Microfluidics ; Rats
Chemical Substances	Emodin (KA46RNI6HN)
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132768
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Article ; Online: Optimization and Application of A Bionic System of Dynamic Co-Culture with Hepatocytes and Renal Cells Based on Microfluidic Chip Technique in Evaluating Materials of Health Food.

Chen, Di / Yin, Jiyong / Huo, Junsheng / Sun, Jing / Huang, Jian / Li, Tiantong / Sun, Chaoqun / Yang, Zhuo / Qin, Wen

Nutrients

2022 Volume 14, Issue 22

Abstract: We aimed to explore the optimization and application of a bionic system of dynamic co-culture with hepatocytes and renal cells based on the microfluidic chip technique in evaluating emodin, which might replace the conventionally cytological evaluation ... ...

Abstract	We aimed to explore the optimization and application of a bionic system of dynamic co-culture with hepatocytes and renal cells based on the microfluidic chip technique in evaluating emodin, which might replace the conventionally cytological evaluation technique of health food. After optimal experiments, the improved bionic system was composed of human hepatocellular carcinoma cells (HepG2), human renal glomerular endothelial cells (HRGECs), rat tail collagen type I, and gelatin with optimized concentrations (1.3 mg/mL + 7.5%). The applicability of the bionic system indicated that the growth stability was appropriate (CV: 7.36%), and the cell viability of that gradually decreased with the increasing of emodin concentration from 0−100 μM, which statistic significances were at 50 and 100 μM (p < 0.05), and the stained results of dead/live cells also showed the same trend. The LDH level appeared rising trend after decline between 0 μM and 100 μM emodi, and the level of that at 100 μM emodin was significantly higher than that at 25 μM and 50 μM emodin, respectively. The BUN level continuously and significantly declined with the increasing of emodin concentration (p < 0.05). Our research realized the application of this optimized bionic system in evaluating emodin, and provided a useful platform and reference for further in vitro alternative research with regard to evaluating the efficacies of health food in the future.
MeSH term(s)	Rats ; Humans ; Animals ; Coculture Techniques ; Microfluidics/methods ; Emodin ; Endothelial Cells ; Bionics ; Hepatocytes
Chemical Substances	Emodin (KA46RNI6HN)
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14224728
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect Assessment of Aurantio-Obtusin on Novel Human Renal Glomerular Endothelial Cells Model Using a Microfluidic Chip.

Qin, Wen / Yang, Zhuo / Yin, Jiyong / Chen, Di / Huo, Junsheng / Wang, Jingbo / Wang, Liyuan / Zhuo, Qin

Nutrients

2022 Volume 14, Issue 21

Abstract: Cassiae semen is widely used as a raw material of health food. Anthraquinone compounds, the main components in cassiae semen, have been reported to show nephrotoxicity. Aurantio-obtusin (AO) is a major anthraquinone compound extracted from cassiae semen. ...

Abstract	Cassiae semen is widely used as a raw material of health food. Anthraquinone compounds, the main components in cassiae semen, have been reported to show nephrotoxicity. Aurantio-obtusin (AO) is a major anthraquinone compound extracted from cassiae semen. This study investigates the effects of AO on the morphology and physiological function of human renal glomerular endothelial cells (HRGECs) on a microfluidic chip device for the first time. HRGECs were cultured on a microfluidic plate and exposed to a series of AO concentrations. Compared with traditional 96-well culture, HRGECs cultured on the microfluidic chip appeared to better mimic the glomerular microenvironment in vivo. AO induced different degrees of damage to cellular morphology and physiological function. The leakage of lactate dehydrogenase (LDH), as well as the secretion of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β
MeSH term(s)	Humans ; Cassia ; Endothelial Cells ; Microfluidics ; Anthraquinones/pharmacology
Chemical Substances	aurantio-obtusin ; Anthraquinones
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14214615
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A New Method of Extracting

Sun, Chaoqun / Wang, Guodong / Sun, Jing / Yin, Jiyong / Huang, Jian / Li, Zizi / Mu, Di / He, Menglu / Liu, Tingting / Cheng, Jiali / Du, Hanchen / Chen, Yan / Qu, Wenjie

Foods (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: Polygonatum ... ...

Abstract	Polygonatum sibiricum
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12183438
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Evaluation of iron fortified soy sauce on changes of anemia prevalence in 2004-2013].

Wei, Yanli / Huo, Junsheng / Yin, Jiyong / Sun, Jing / Huang, Jian

Wei sheng yan jiu = Journal of hygiene research

2018 Volume 46, Issue 1, Page(s) 136–142

Abstract: Objective: To understand the role of iron fortified soy sauce( IFSS) on the decrease of anemia prevalence in Chinese population in 2004- 2013.: Methods: Meta analysis was used to analyze the effect of IFSS on anemia through published randomcontrol ... ...

Abstract	Objective: To understand the role of iron fortified soy sauce( IFSS) on the decrease of anemia prevalence in Chinese population in 2004- 2013. Methods: Meta analysis was used to analyze the effect of IFSS on anemia through published randomcontrol studies on the population intervention with IFSS. Integrated with other data from IFSS statistic on IFSS production and consumption, the recovered population from IFSS was identified and anemia decrease determined, therefore, IFSS contribution to anemia change could be estimated. Results: By Meta analysis, the anemia rate of the population consumed IFSS was 27% compared with the anemia rate of the population non-consumed IFSS. In the past 10 years, IFSS had covered more than 186 millions population with effect validity time. A total of 28. 49 millions anemic population recovered from anemia. To recover one anemic with IFSS, the cost was 0. 12 RMB. Conclusion: IFSS has showed effect on the decline of anemia prevalence in last decade, 23. 2% of the decrease was estimated owe to IFSS project, but there are unidentified factors which may bring bias to the result.
MeSH term(s)	Anemia/epidemiology ; Anemia, Iron-Deficiency/diet therapy ; Anemia, Iron-Deficiency/epidemiology ; China/epidemiology ; Female ; Food, Fortified ; Hemoglobins ; Humans ; Iron/blood ; Iron, Dietary/administration & dosage ; Prevalence ; Soy Foods
Chemical Substances	Hemoglobins ; Iron, Dietary ; Iron (E1UOL152H7)
Language	Chinese
Publishing date	2018-08-02
Publishing country	China
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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