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  1. Article: Pneumaturia and faecaluria: Symptoms leading to a life-saving diagnosis.

    Wynn, Aye Aye / Yin, Khine San / Mya, Nang Khin / Azizan, Nornazirah / Zakaria, Andee Dzulkarnaen / Hayati, Firdaus

    Annals of medicine and surgery (2012)

    2022  Volume 79, Page(s) 103967

    Abstract: Background: Colonic diverticulosis is often asymptomatic, but it can complicate bleeding, abscess and stricture. Pneumaturia and faecaluria are unexpected manifestations of colonic diverticulitis complicated by colovesical fistula formation.: Case ... ...

    Abstract Background: Colonic diverticulosis is often asymptomatic, but it can complicate bleeding, abscess and stricture. Pneumaturia and faecaluria are unexpected manifestations of colonic diverticulitis complicated by colovesical fistula formation.
    Case presentation: This case report highlighted a 57-year-old man who presented with lower abdominal pain which was associated with pneumaturia and fecaluria. He was diagnosed with colovesical fistula after being misdiagnosed with other diseases from various clinic visits. Direct fluoroscopy was performed and a diverticular fistula of the sigmoid colon was confirmed by computed tomography of the abdomen. Hartmann's procedure and resection of the posterior wall of the bladder were resected.
    Conclusion: Pneumaturia and faecaluria are common but distinct manifestations of complicated diverticular diseases. Attention should be paid to general practitioners to achieve proper referral, hence early treatment and prevention of disease-related complications.
    Language English
    Publishing date 2022-06-11
    Publishing country England
    Document type Case Reports
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Possible correlation between iron deposition and enhanced proliferating activity in hepatitis C virus-positive hepatocellular carcinoma in Myanmar (Burma).

    Soe, Kyaw / Hishikawa, Yoshitaka / Fukuzawa, Yoshitaka / Win, Ne / Yin, Khine San / Win, Khin Maung / Myint, Aye Aye / Koji, Takehiko

    Journal of gastroenterology

    2007  Volume 42, Issue 3, Page(s) 225–235

    Abstract: Background: The aim of this study was to survey the effect of deposited iron on the cell kinetics of hepatitis C virus (HCV)-positive hepatocellular carcinoma (HCC) in Myanmar (Burmese) patients.: Methods: Formalin-fixed and paraffin-embedded liver ... ...

    Abstract Background: The aim of this study was to survey the effect of deposited iron on the cell kinetics of hepatitis C virus (HCV)-positive hepatocellular carcinoma (HCC) in Myanmar (Burmese) patients.
    Methods: Formalin-fixed and paraffin-embedded liver tissues from 34 Myanmar patients with HCC were used. To detect iron deposition, Prussian blue staining was performed. Cell proliferation and apoptosis were assessed by Ki-67 staining and by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) assay, respectively. HCV RNA was detected by in situ hybridization, and HCV protein, Fas and Fas ligand (FasL) were localized by immunohistochemistry. To identify the subtype of lymphocytes, CD8 was used as a surface marker.
    Results: Iron deposition was found in 43% of the HCC cases, and was heavier in moderately differentiated HCC than in well-differentiated HCC. The Ki-67 labeling index (LI) in cancer cells was higher in Prussian blue-positive-HCC than in -negative HCC (3.8 +/- 2.2 vs 1.5 +/- 1.7, mean +/- SD; P=0.0067), whereas there was no significant difference between these groups in TUNEL LI. HCV protein was localized in cancer cells, and was found in 89% of the patients. In addition, Fas was expressed in HCC cells, and FasL was localized in HCC cells as well as in infiltrating CD8+ T lymphocytes. The frequency of apoptosis of HCC cells was correlated significantly with the population density of infiltrating CD8+ T lymphocytes.
    Conclusions: Our results indicated that, in Myanmar patients with HCC, iron deposition might accelerate hepatocarcinogenesis, by promoting cancer cell proliferation, without affecting the Fas/FasL apoptotic system.
    MeSH term(s) Adult ; Aged ; Apoptosis ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/virology ; Cell Proliferation ; Fas Ligand Protein/metabolism ; Female ; Hepatitis C/complications ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Iron/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/virology ; Male ; Middle Aged ; Myanmar
    Chemical Substances Fas Ligand Protein ; Iron (E1UOL152H7)
    Language English
    Publishing date 2007-03
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186495-3
    ISSN 0944-1174
    ISSN 0944-1174
    DOI 10.1007/s00535-006-1993-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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