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  1. AU="Yin, Yatao"
  2. AU="Daniel Amirault"
  3. AU="Lipson, Laurette"
  4. AU=Wang Yuyi
  5. AU="Toledano-Fonseca, Marta"
  6. AU="Nazarenko, Tatiana A"
  7. AU=Boff Daiane
  8. AU="Michaels, Zachary"
  9. AU="Sovel, Mindy"
  10. AU="Lukyanov, Sergey"
  11. AU="Baptistella, Amanda"
  12. AU="Dichter, Gabriel S"
  13. AU="D Urbano, Vanessa"
  14. AU="Farhad Shirini"
  15. AU="Wu, Wenming"
  16. AU="Wiedermann, Christian J"
  17. AU="Corradin, Giampietro"
  18. AU="Guan, Xiaodong"
  19. AU=Burmester Gerd R.
  20. AU="Mańczak, Rafał"
  21. AU="Cristina Ceron"
  22. AU=Scardapane Arnaldo
  23. AU="Taylor, Daniel J"
  24. AU="Sabanadzovic, Sead"
  25. AU=Lee Yangsoon AU=Lee Yangsoon
  26. AU="Sahoo, Aditi"
  27. AU="Reyes, Peter Andrew C"
  28. AU="Collobert, Géromine"
  29. AU="Guevara, Katterine"
  30. AU=Ahmadivand Arash

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  1. Artikel: COLQ

    Yin, Yatao / Cao, Jing / Fan, Yuanteng / Xu, Yan

    Heliyon

    2023  Band 9, Heft 9, Seite(n) e19980

    Abstract: Congenital myasthenia syndromes (CMS) are a heterogeneous group of hereditary disorders of the neuromuscular junction. The symptoms include fatigue, muscle weakness, ptosis, mastication or swallowing problem, respiratory distress. We present a 42-year- ... ...

    Abstract Congenital myasthenia syndromes (CMS) are a heterogeneous group of hereditary disorders of the neuromuscular junction. The symptoms include fatigue, muscle weakness, ptosis, mastication or swallowing problem, respiratory distress. We present a 42-year-old male patient who was admitted with complaints of paroxysmal limb weakness for 25 years and got repeated apnea crisis due to using AchE inhibitors. We considered this patient to be
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19980
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Effect of Transcranial Direct Current Stimulation on Patients With Disorders of Consciousness: A Systematic Review and Meta-analysis.

    Fan, Wei / Fan, Yuanteng / Liao, Zhenjun / Yin, Yatao

    American journal of physical medicine & rehabilitation

    2023  Band 102, Heft 12, Seite(n) 1102–1110

    Abstract: Objectives: The aims of this study are to evaluate the efficacy of transcranial direct current stimulation for improving disorders of consciousness and to compare efficacy of the different etiologies of disorders of consciousness.: Design: Randomized ...

    Abstract Objectives: The aims of this study are to evaluate the efficacy of transcranial direct current stimulation for improving disorders of consciousness and to compare efficacy of the different etiologies of disorders of consciousness.
    Design: Randomized controlled trials or crossover trials examining effects of transcranial direct current stimulation in patients with disorders of consciousness were searched in PubMed, Embase, Cochrane Library, and Web of Science. The sample characteristics, etiology, transcranial direct current stimulation treatment characteristics, and outcomes were extracted. Meta-analysis was performed using the RevMan software.
    Results: We included nine trials providing data with 331 participants and found that transcranial direct current stimulation improved the Coma Recovery Scale-Revised score of disorders of consciousness patients. We found a significant improvement of Coma Recovery Scale-Revised score in the minimally conscious state group (weighted mean difference = 0.77, 95% confidence interval = 0.30-1.23, P = 0.001), but not in the vegetative state or unresponsive wakefulness syndrome group. The effects of transcranial direct current stimulation are related to etiology, as the Coma Recovery Scale-Revised score was improved in the traumatic brain injury group (weighted mean difference = 1.18, 95% confidence interval = 0.60-1.75, P < 0.001), but not in vascular accident and anoxia groups.
    Conclusions: This meta-analysis revealed the evidence for positive effects of transcranial direct current stimulation on disorders of consciousness without adverse effects observed in minimally conscious state patients. In particular, transcranial direct current stimulation may be an effective treatment in rehabilitating cognitive functions in people with traumatic brain injury.
    Mesh-Begriff(e) Humans ; Transcranial Direct Current Stimulation ; Persistent Vegetative State/therapy ; Coma/therapy ; Consciousness Disorders/therapy ; Brain Injuries, Traumatic
    Sprache Englisch
    Erscheinungsdatum 2023-05-16
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002290
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Functional roles of enhancer of zeste homolog 2 in gliomas

    Yin, Yatao / Shuwei Qiu / Ying Peng

    Gene. 2016 Jan. 15, v. 576, no. 1

    2016  

    Abstract: Gliomas are the most common and lethal type of primary malignant brain tumor. Due to the infiltrative nature and high resistance to standard first line treatment with combinations of radiation and chemotherapy, the prognosis of patient is very poor. ... ...

    Abstract Gliomas are the most common and lethal type of primary malignant brain tumor. Due to the infiltrative nature and high resistance to standard first line treatment with combinations of radiation and chemotherapy, the prognosis of patient is very poor. Recently, accumulated evidence suggests that enhancer of zeste homolog 2 (EZH2) serves as an oncogene and is involved in multiple glioma cell processes, including cell cycle, invasion, glioma stem cell maintenance, drug and radiotherapy resistance and so on. In this review, we will focus on updating current knowledge of EZH2 in gliomas. Moreover, the regulation of EZH2 by microRNAs and long non-coding RNAs and the therapeutic strategies targeting EZH2 for gliomas will also be discussed.
    Schlagwörter brain ; cell cycle ; drug therapy ; drugs ; microRNA ; non-coding RNA ; oncogenes ; patients ; prognosis ; radiotherapy ; stem cells
    Sprache Englisch
    Erscheinungsverlauf 2016-0115
    Umfang p. 189-194.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2015.09.080
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

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  4. Artikel ; Online: Functional roles of enhancer of zeste homolog 2 in gliomas.

    Yin, Yatao / Qiu, Shuwei / Peng, Ying

    Gene

    2016  Band 576, Heft 1 Pt 2, Seite(n) 189–194

    Abstract: Gliomas are the most common and lethal type of primary malignant brain tumor. Due to the infiltrative nature and high resistance to standard first line treatment with combinations of radiation and chemotherapy, the prognosis of patient is very poor. ... ...

    Abstract Gliomas are the most common and lethal type of primary malignant brain tumor. Due to the infiltrative nature and high resistance to standard first line treatment with combinations of radiation and chemotherapy, the prognosis of patient is very poor. Recently, accumulated evidence suggests that enhancer of zeste homolog 2 (EZH2) serves as an oncogene and is involved in multiple glioma cell processes, including cell cycle, invasion, glioma stem cell maintenance, drug and radiotherapy resistance and so on. In this review, we will focus on updating current knowledge of EZH2 in gliomas. Moreover, the regulation of EZH2 by microRNAs and long non-coding RNAs and the therapeutic strategies targeting EZH2 for gliomas will also be discussed.
    Mesh-Begriff(e) Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Cell Cycle/genetics ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/metabolism ; Central Nervous System Neoplasms/pathology ; Central Nervous System Neoplasms/therapy ; Drug Resistance, Neoplasm ; Enhancer of Zeste Homolog 2 Protein ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Glioma/therapy ; Humans ; MicroRNAs ; Oncogenes ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; RNA, Long Noncoding
    Chemische Substanzen MicroRNAs ; RNA, Long Noncoding ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Polycomb Repressive Complex 2 (EC 2.1.1.43)
    Sprache Englisch
    Erscheinungsdatum 2016-01-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2015.09.080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1357: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Artikel ; Online: EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment.

    Yin, Yatao / Qiu, Shuwei / Li, Xiangpen / Huang, Bo / Xu, Yun / Peng, Ying

    Journal of neuroinflammation

    2017  Band 14, Heft 1, Seite(n) 220

    Abstract: Background: Glioblastoma multiforme (GBM) induces tumor immunosuppression through interacting with tumor-infiltrating microglia or macrophages (TAMs) with an unclear pathogenesis. Enhancer of zeste homolog 2 (EZH2) is abundant in GBM samples and cell ... ...

    Abstract Background: Glioblastoma multiforme (GBM) induces tumor immunosuppression through interacting with tumor-infiltrating microglia or macrophages (TAMs) with an unclear pathogenesis. Enhancer of zeste homolog 2 (EZH2) is abundant in GBM samples and cell lines and is involved in GBM proliferation, cell cycle, and invasion, whereas its association with innate immune response is not yet reported. Herein, the aim of this study was to investigate the role of EZH2 in GBM immune.
    Methods: Co-culturing models of human/murine GBM cells with PBMC-derived macrophages/primary microglia were employed. EZH2 mRNAs and function were suppressed by siEZH2 and DZNep. Real-time PCR and flow cytometry were used to determine levels of microglia/macrophages markers. The fluorescence-labeled latex beads and flow cytometry were utilized to evaluate phagocytic abilities of microglia. CCK8 assay was performed to assess microglia proliferation.
    Results: EZH2 inhibition led to significant reduction of TGFβ1-3 and IL10 and elevation of IL1β and IL6 in human and murine GBM cells. More importantly, EZH2 suppression in GBM cells resulted in significant increase of M1 markers (TNFα and iNOS) and decrease of a pool of M2 markers in murine microglia. The proportion of CD206
    Conclusions: Our data demonstrates that EZH2 participates in GBM-induced immune deficient and EZH2 suppression in GBM can remodel microglia immune functions, which is beneficial for understanding GBM pathogenesis and suggests potential targets for therapeutic approaches.
    Mesh-Begriff(e) Animals ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Coculture Techniques ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Microglia/pathology ; Phenotype ; Tumor Microenvironment/physiology
    Chemische Substanzen Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
    Sprache Englisch
    Erscheinungsdatum 2017-11-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1742-2094
    ISSN (online) 1742-2094
    DOI 10.1186/s12974-017-0993-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury.

    Gong, ChenZi / Zheng, Xiaolong / Guo, FangLiang / Wang, YaNan / Zhang, Song / Chen, Jing / Sun, XueJiao / Shah, Sayed Zulfiqar Ali / Zheng, YiFeng / Li, Xiao / Yin, Yatao / Li, Qian / Huang, XiaoLin / Guo, Tiecheng / Han, Xiaohua / Zhang, Su-Chun / Wang, Wei / Chen, Hong

    Cell reports

    2021  Band 34, Heft 12, Seite(n) 108889

    Abstract: Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem cells from spinal GABA neurons. After transplantation into the ... ...

    Abstract Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem cells from spinal GABA neurons. After transplantation into the injured rat spinal cord, the DREADD (designer receptors exclusively activated by designer drug)-expressing spinal progenitors differentiate into GABA neurons, mitigating spasticity-like response of the rat hindlimbs and locomotion deficits in 3 months. Administering clozapine-N-oxide, which activates the grafted GABA neurons, further alleviates spasticity-like response, suggesting an integration of grafted GABA neurons into the local neural circuit. These results highlight the therapeutic potential of the spinal GABA neurons for SCI.
    Mesh-Begriff(e) Action Potentials/physiology ; Animals ; Cell Differentiation ; Cell Survival ; GABAergic Neurons/pathology ; Humans ; Locomotion ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/physiopathology ; Male ; Motor Neurons/pathology ; Motor Neurons/ultrastructure ; Muscle Spasticity/complications ; Muscle Spasticity/pathology ; Muscle Spasticity/physiopathology ; Neural Inhibition ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/transplantation ; Rats, Sprague-Dawley ; Spinal Cord/pathology ; Spinal Cord/physiopathology ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/therapy ; Synapses/metabolism ; Synapses/ultrastructure ; Rats
    Sprache Englisch
    Erscheinungsdatum 2021-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.108889
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment.

    Yin, Yatao / Fu, Chaoping / Li, Mei / Li, Xiangpen / Wang, Mengying / He, Lei / Zhang, Li-Ming / Peng, Ying

    Materials science & engineering. C, Materials for biological applications

    2016  Band 67, Seite(n) 159–169

    Abstract: Gliomas are the most common and lethal type of primary malignant brain tumor. But the existence of blood brain barrier (BBB) and blood-tumor barrier (BTB) hinder drug from reaching the tumor site. To address this problem, we developed a novel prodrug (Lf- ...

    Abstract Gliomas are the most common and lethal type of primary malignant brain tumor. But the existence of blood brain barrier (BBB) and blood-tumor barrier (BTB) hinder drug from reaching the tumor site. To address this problem, we developed a novel prodrug (Lf-HA-DOX) by conjugating hyaluronic acid with doxorubicin (HA-DOX) by an acid-labile hydrazone linkage, which is released in an acidic environment and accumulates in tumor tissues. Lactoferrin (Lf) was coupled for transporting across the BBB. In vitro, the release of DOX from Lf-HA-DOX was pH-dependent. At lower pH (5.0 and 6.0), the release of DOX was much quicker than that at pH7.4. In the cellular uptake studies, flow cytometry analyses and confocal laser scanning microscopy results showed significantly enhanced cellular uptake of Lf-HA-DOX and HA-DOX in C6 cells compared to DOX. In BALB/C mice bearing C6 glioma, enhanced accumulation of Lf-HA-DOX in the glioma was observed by real time fluorescence image. Correspondingly, glioma-bearing mice treated with Lf-HA-DOX displayed the longest median survival time, which was 2-fold longer than that of saline group. In conclusion, Lf-HA-DOX was able to significantly increase drug delivery to the glioma, which might provide a promising strategy for antiglioma therapy.
    Mesh-Begriff(e) Animals ; Cell Line, Tumor ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Doxorubicin/pharmacology ; Glioma/drug therapy ; Glioma/metabolism ; Glioma/pathology ; Humans ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/pharmacokinetics ; Hyaluronic Acid/pharmacology ; Hydrogen-Ion Concentration ; Lactoferrin/chemistry ; Lactoferrin/pharmacokinetics ; Lactoferrin/pharmacology ; Mice ; Mice, Nude ; Prodrugs/chemistry ; Prodrugs/pharmacokinetics ; Prodrugs/pharmacology ; Rats ; Xenograft Model Antitumor Assays
    Chemische Substanzen Delayed-Action Preparations ; Prodrugs ; Doxorubicin (80168379AG) ; Hyaluronic Acid (9004-61-9) ; Lactoferrin (EC 3.4.21.-)
    Sprache Englisch
    Erscheinungsdatum 2016-10-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2016.05.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Functional roles of enhancer of zeste homolog 2 in gliomas

    Yin, Yatao / Shuwei QiuauthorDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China / Ying PengauthorDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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