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  1. Article ; Online: P 2 FEViT

    Guanqun Wang / He Chen / Liang Chen / Yin Zhuang / Shanghang Zhang / Tong Zhang / Hao Dong / Peng Gao

    Remote Sensing, Vol 15, Iss 1773, p

    Plug-and-Play CNN Feature Embedded Hybrid Vision Transformer for Remote Sensing Image Classification

    2023  Volume 1773

    Abstract: Remote sensing image classification (RSIC) is a classical and fundamental task in the intelligent interpretation of remote sensing imagery, which can provide unique labeling information for each acquired remote sensing image. Thanks to the potent global ... ...

    Abstract Remote sensing image classification (RSIC) is a classical and fundamental task in the intelligent interpretation of remote sensing imagery, which can provide unique labeling information for each acquired remote sensing image. Thanks to the potent global context information extraction ability of the multi-head self-attention (MSA) mechanism, visual transformer (ViT)-based architectures have shown excellent capability in natural scene image classification. However, in order to achieve powerful RSIC performance, it is insufficient to capture global spatial information alone. Specifically, for fine-grained target recognition tasks with high inter-class similarity, discriminative and effective local feature representations are key to correct classification. In addition, due to the lack of inductive biases, the powerful global spatial context representation capability of ViT requires lengthy training procedures and large-scale pre-training data volume. To solve the above problems, a hybrid architecture of convolution neural network (CNN) and ViT is proposed to improve the RSIC ability, called <semantics> P 2 </semantics> FEViT, which integrates plug-and-play CNN features with ViT. In this paper, the feature representation capabilities of CNN and ViT applying for RSIC are first analyzed. Second, aiming to integrate the advantages of CNN and ViT, a novel approach embedding CNN features into the ViT architecture is proposed, which can make the model synchronously capture and fuse global context and local multimodal information to further improve the classification capability of ViT. Third, based on the hybrid structure, only a simple cross-entropy loss is employed for model training. The model can also have rapid and comfortable convergence with relatively less training data than the original ViT. Finally, extensive experiments are conducted on the public and challenging remote sensing scene classification dataset of NWPU-RESISC45 (NWPU-R45) and the self-built fine-grained target classification dataset called ...
    Keywords remote sensing image classification ; vision transformer ; plug-and-play ; feature embedded ; Science ; Q
    Subject code 004
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Association of environmental volatile organic compounds with depression in adults

    Yin Zhuang / Xiaochen Zhang / Xiangying Sun / Zhaofeng Liu / Qiurun Yu / Chao Dong / Quanquan Guan / Qiujin Xu

    Hygiene and Environmental Health Advances, Vol 6, Iss , Pp 100058- (2023)

    NHANES 2013-2018

    2023  

    Abstract: Volatile organic compounds (VOCs) exposure has been found to be associated with neurological dysfunction, with depression often being one of the classic symptoms of the disease, and indoor environments are more likely to be enriched with concentrations ... ...

    Abstract Volatile organic compounds (VOCs) exposure has been found to be associated with neurological dysfunction, with depression often being one of the classic symptoms of the disease, and indoor environments are more likely to be enriched with concentrations of VOCs. This cross-sectional study measured VOCs levels in whole blood, and estimated level of depression with the Patient Health Questionnaire in adults from NHANES 2013–2018. We found benzene (β = 0.40, 95%CI: 0.19, 0.61) and ethylbenzene (β = 0.22, 95%CI: 0.05, 0.39) were associated with depression adjusted for covariates in general linear regression models (GLM), and remained the consistent trend in quantile regression models. In indoor subgroup with higher VOCs level, benzene (β = 0.71, 95%CI: 0.21, 1.22), ethylbenzene (β = 0.47, 95%CI: 0.15, 0.78), and m-/p-xylene (β = 0.41, 95%CI: 0.15, 0.68) showed significant association with depression adjusted for covariates including cotinine in GLMs. Weighted quantile sum (WQS) model was used to assess the contribution of each VOC in mixed exposure. Results from WQS analyses revealed significantly positive associations between the mixed exposure and depression (β = 1.70, 95%CI: 1.18, 2.47), in which, benzene and ethylbenzene contributed 56% and 26%. We found statistically association between mixed exposure and depression before cotinine adjustment (β = 3.53, 95%CI: 2.78, 4.47). Our founding indicated a positive association between benzene and ethylbenzene exposure and depression, also with the most important effect in the mixture. Additionally, indoor VOCs sources of environmental pollution still cannot be ignored given the higher exposure level and health risk.
    Keywords Volatile organic compounds ; Depression ; Indoor ; Mixed exposure ; Weighted quantile sum (WQS) model ; Public aspects of medicine ; RA1-1270 ; Environmental sciences ; GE1-350
    Subject code 310
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice

    Wen-jin Chen / Yin Zhuang / Wei Peng / Wei Cui / Shu-jun Zhang / Jian-wei Wang

    Chinese Medicine, Vol 18, Iss 1, Pp 1-

    2023  Volume 15

    Abstract: Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism ... ...

    Abstract Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism for treating KOA has not been revealed. In our previous study, we confirmed that DHJST inhibited the activation of NLRP3 signaling in rats and humans. In the current study, we aimed to determine how DHJST inhibits NLRP3 to alleviate knee cartilage damage. Methods Mice were injected with NLRP3 shRNA or Notch1-overexpressing adenovirus into the tail vein to construct systemic NLRP3 low-expressing or Notch1 high-expressing mice. Mice were injected with papain into the knee joint to replicate the KOA model. DHJST was used to treat KOA model mice with different backgrounds. The thickness of the right paw was measured to evaluate toe swelling. The pathohistological changes and the levels of IL-1β, MMP2, NLRP3, Notch1, collagen 2, collagen 4, HES1, HEY1, and Caspase3 were detected by HE staining, ELISA, immunohistochemical staining, western blotting, or real-time qPCR. Results DHJST reduced tissue swelling and serum and knee cartilage IL-1β levels, inhibited cartilage MMP2 expression, increased collagen 2 and collagen 4 levels, decreased Notch1 and NLRP3 positive expression rates in cartilage, and decreased HES1 and HEY1 mRNA levels in KOA model mice. In addition, NLRP3 interference decreased cartilage MMP2 expression and increased collagen 2 and collagen 4 levels without affecting the expression levels of notch1, HES1 and HEY1 mRNA levels in the synovium of KOA mice. In KOA mice with NLRP interference, DHJST further reduced tissue swelling and knee cartilage damage in mice. Finally, Notch1-overexpressing mice not only showed more severe tissue swelling and knee cartilage degradation but also abolished the therapeutic effect of DHJST on KOA mice. Importantly, the inhibitory effects of DHJST on the mRNA expression of NLRP3, Caspase3 and IL-1β in the knee joint of KOA ...
    Keywords Osteoarthritis ; DHJST ; NLRP3 ; Notch1 ; Mice ; Inflammation ; Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Transcriptome and physiological analyses reveal the mechanism of the liver injury and pathological alterations in northern snakehead (Channa argus) after dietary exposure to aflatoxin B1

    Li, Min / Kong, Yidi / Zou, Jixing / Wu, Xueqin / Yin, Zhuang / Niu, Xiaotian / Wang, Guiqin

    Aquaculture. 2022 Dec. 15, v. 561

    2022  

    Abstract: Aflatoxin B₁ (AFB₁) is the most toxic naturally occurring mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus, has been regarded as a critical food contaminant in aquafeed. Furthermore, previous studies indicated that dietary AFB₁ ... ...

    Abstract Aflatoxin B₁ (AFB₁) is the most toxic naturally occurring mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus, has been regarded as a critical food contaminant in aquafeed. Furthermore, previous studies indicated that dietary AFB₁ exposure could cause liver tissues injury in mammals and fish. However, the mechanism of dietary AFB₁-induced liver injury of fish has not been fully elucidated. The aim of this study was to investigate the effects of dietary AFB₁ exposure on the liver of northern snakehead (Channa argus) (7.52 ± 0.02 g) through hematological parameters, liver histopathology, and ultrastructural analysis and revealed the possible mechanism of AFB₁-induced northern snakehead liver injury through RNA-Seq analysis. The results of serum biochemical indicators demonstrated that the aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) as the biomarkers of liver damage, increased significantly at AFB₁ exposure concentrations above 200 μg/kg. Liver histopathology and ultrastructural analysis demonstrated that different degrees of lesions were found in 100, 200, and 400 μg/kg groups. Liver transcriptomic analyses demonstrated that a total of 1307 differentially expressed genes (DEGs) were significantly expressed induced in response to the dietary AFB₁ exposure, of which 540 were up- and 767 were down-regulated genes. Furthermore, Gene Ontology (GO) analysis showed that the ribosome biogenesis, ribonucleoprotein complex biogenesis, negative regulation of cellular process, and metabolic process were highly enriched in the biological process category. Meanwhile, 310 enriched pathways were identified in the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database analysis, of which the metabolism of xenobiotics by cytochrome P450, glutathione metabolism, protein processing in endoplasmic reticulum, and PI3K-Akt signaling pathway were the vital metabolic mechanisms related to dietary AFB₁ exposure-induced liver injury in northern snakehead and were confirmed by qPCR. Overall, the findings provide more valuable information for further studies on the latent toxicity mechanisms of AFB₁ in fish.
    Keywords Aspergillus flavus ; Aspergillus parasiticus ; Channa argus ; aflatoxin B1 ; alanine transaminase ; alkaline phosphatase ; aquaculture ; aquaculture feeds ; aspartate transaminase ; biogenesis ; biomarkers ; blood serum ; cytochrome P-450 ; dietary exposure ; endoplasmic reticulum ; fish ; food contamination ; gene expression regulation ; gene ontology ; glutathione ; histopathology ; lactate dehydrogenase ; liver ; metabolism ; ribonucleoproteins ; ribosomes ; sequence analysis ; toxicity ; transcriptome ; transcriptomics ; xenobiotics
    Language English
    Dates of publication 2022-1215
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 185380-6
    ISSN 0044-8486 ; 0044-8516
    ISSN 0044-8486 ; 0044-8516
    DOI 10.1016/j.aquaculture.2022.738727
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Hierarchical Disentangling Network for Building Extraction from Very High Resolution Optical Remote Sensing Imagery

    Jianhao Li / Yin Zhuang / Shan Dong / Peng Gao / Hao Dong / He Chen / Liang Chen / Lianlin Li

    Remote Sensing, Vol 14, Iss 1767, p

    2022  Volume 1767

    Abstract: Building extraction using very high resolution (VHR) optical remote sensing imagery is an essential interpretation task that impacts human life. However, buildings in different environments exhibit various scales, complicated spatial distributions, and ... ...

    Abstract Building extraction using very high resolution (VHR) optical remote sensing imagery is an essential interpretation task that impacts human life. However, buildings in different environments exhibit various scales, complicated spatial distributions, and different imaging conditions. Additionally, with the spatial resolution of images increasing, there are diverse interior details and redundant context information present in building and background areas. Thus, the above-mentioned situations would create large intra-class variances and poor inter-class discrimination, leading to uncertain feature descriptions for building extraction, which would result in over- or under-extraction phenomena. In this article, a novel hierarchical disentangling network with an encoder–decoder architecture called HDNet is proposed to consider both the stable and uncertain feature description in a convolution neural network (CNN). Next, a hierarchical disentangling strategy is set up to individually generate strong and weak semantic zones using a newly designed feature disentangling module (FDM). Here, the strong and weak semantic zones set up the stable and uncertain description individually to determine a more stable semantic main body and uncertain semantic boundary of buildings. Next, a dual-stream semantic feature description is built to gradually integrate strong and weak semantic zones by the designed component feature fusion module (CFFM), which is able to generate a powerful semantic description for more complete and refined building extraction. Finally, extensive experiments are carried out on three published datasets (i.e., WHU satellite, WHU aerial, and INRIA), and the comparison results show that the proposed HDNet outperforms other state-of-the-art (SOTA) methods.
    Keywords building extraction ; convolution neural networks ; encoding–decoding method ; hierarchical disentangling ; optical remote sensing imagery ; very high resolution ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Exosomes Secreted by Nucleus Pulposus Stem Cells Derived From Degenerative Intervertebral Disc Exacerbate Annulus Fibrosus Cell Degradation via Let-7b-5p

    Yin Zhuang / Sheng Song / Dan Xiao / Xueguang Liu / Xiaofei Han / Shihao Du / Yuan Li / Yanming He / Shujun Zhang

    Frontiers in Molecular Biosciences, Vol

    2022  Volume 8

    Abstract: The pathogenesis of intervertebral disc degeneration (IDD) is complex and remains unclear. Nucleus pulposus stem cells (NPSCs) and annulus fibrosus cells (AFCs) play a critical role in the maintenance of intervertebral disc structure and function. ... ...

    Abstract The pathogenesis of intervertebral disc degeneration (IDD) is complex and remains unclear. Nucleus pulposus stem cells (NPSCs) and annulus fibrosus cells (AFCs) play a critical role in the maintenance of intervertebral disc structure and function. Exosome-mediated miRNAs regulate cell proliferation, differentiation, apoptosis, and degradation. However, it is not clear whether the degenerative intervertebral disc-derived nucleus pulposus stem cells (D-NPSCs) can regulate the function of AFCs by delivering exosomes. Here, we show that exosomes secreted by nucleus pulposus stem cells derived from degenerative intervertebral disc (D-DPSC-exo) can exacerbate AFC degeneration via inhibiting cell proliferation, migration, matrix synthesis, and promoting apoptosis. Specifically, let-7b-5p was highly expressed in D-DPSC-exo. Transfection of let-7b-5p mimic was found to promote apoptosis and inhibit proliferation migration and matrix synthesis of AFCs. In addition, transfection with let-7b-5p inhibitor caused the effect of D-DPSC-exo on AFCs to be reversed. Furthermore, we found that D-DPSC-exo and let-7b-5p inhibited IGF1R expression and blocked the activation of the PI3K–Akt pathway. Results suggested that NPSC-exo exacerbated cell degeneration of AFCs via let-7b-5p, accompanied by inhibition of IGF1R expression, and PI3K–Akt pathway activation. Therefore, insights from this work may provide a clue for targeted molecular therapy of intervertebral disc degeneration.
    Keywords intervertebral disc degeneration ; nucleus pulposus stem cells ; annulus fibrosus cell ; proliferation ; apoptosis ; miRNA ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus

    Li, Min / Kong, Yidi / Wu, Xueqin / Yin, Zhuang / Niu, Xiaotian / Wang, Guiqin

    Fish & shellfish immunology. 2021 Dec., v. 119

    2021  

    Abstract: This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure. A total of 300 fish were divided into five groups: the first group ...

    Abstract This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure. A total of 300 fish were divided into five groups: the first group was the control group and the other four groups were exposed to waterborne Pb (800 ppb) and fed α-LA diets supplemented with 0, 300, 600, and 900 mg/kg. The results demonstrated that dietary α-LA effectively reduced the Pb accumulation in the liver, kidney, gill, intestine, and muscle of C. argus after exposure to Pb. Meanwhile, dietary α-LA reversed alterations in the biochemical parameters (Alanine aminotransferase (ALT), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), blood urea nitrogen (BUN), cortisol (COR), and creatinine (CRE)) and immunity parameters (myeloperoxidase (MPO), complement 3 (C3), lysozyme (LYS), complement 4 (C4), C-reactive protein (CRP), and immunoglobulin M (IgM)) in the serum of fish caused by Pb. Pb-induced reduction of antioxidant enzyme activities (Catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px)) was inhibited by dietary α-LA. And malondialdehyde (MDA) and protein carbonyl (PC) content exhibited an opposite trend. Meanwhile, dietary supplemented with α-LA was found to relieve Pb-induced oxidative stress by downregulating Keap1 mRNA expression levels and upregulating the expression levels of CAT, nuclear factor erythroid 2-related factor 2 (Nrf2), GSH-Px, and Cu/Zn SOD. Furthermore, α-LA supplementation reversed Pb-induced upregulation of pro-inflammatory genes (interleukin (IL)-6, IL-1β, tumor necrosis factor α (TNF-α), and nuclear factor kappa B (NF-κB)), Pro-apoptotic genes (Bcl-2-associated X (Bax), caspase (Cas)-3, and tumor protein p53 (p53)) and Hsp70, and downregulation of anti-inflammatory genes (IL-10, inhibitor of κBα (IκBα), and transforming growth factor β (TGF-β)) and anti-apoptosis gene (B-cell lymphoma-2 (Bcl-2)). Overall, dietary α-LA supplementation could enhance the innate immunity and antioxidant capacity of fish, attenuating the Pb accumulation, and cell apoptosis after being exposed to Pb. Furthermore, dietary α-LA could relieve Pb-induced inflammatory response and oxidative stress of fish via regulating NF-κB and Nrf2 signaling, respectively.
    Keywords B-lymphocytes ; C-reactive protein ; Channa argus ; alanine transaminase ; antioxidant activity ; antioxidant enzymes ; apoptosis ; aspartate transaminase ; bioaccumulation ; blood serum ; caspases ; catalase ; complement ; cortisol ; creatinine ; fish ; gene expression ; genes ; glutathione ; glutathione peroxidase ; glutathione-disulfide reductase ; inflammation ; innate immunity ; interleukin-10 ; intestines ; kidneys ; lactate dehydrogenase ; lead ; liver ; lysozyme ; malondialdehyde ; muscles ; myeloperoxidase ; neoplasms ; oxidative stress ; shellfish ; superoxide dismutase ; transcription factor NF-kappa B ; urea nitrogen
    Language English
    Dates of publication 2021-12
    Size p. 249-261.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2021.10.010
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Fusion Feature Multi-Scale Pooling for Water Body Extraction from Optical Panchromatic Images

    Baogui Qi / Yin Zhuang / He Chen / Shan Dong / Lianlin Li

    Remote Sensing, Vol 11, Iss 3, p

    2019  Volume 245

    Abstract: Water body extraction is a hot research topic in remote sensing applications. Using panchromatic optical remote sensing images to extract water bodies is a challenging task, because these images have one level of gray information, variable imaging ... ...

    Abstract Water body extraction is a hot research topic in remote sensing applications. Using panchromatic optical remote sensing images to extract water bodies is a challenging task, because these images have one level of gray information, variable imaging conditions, and complex scene information. Refined water body extraction from optical panchromatic images often experiences serious under- or over- segmentation problems. In this paper, for producing refined water body extraction results from optical panchromatic images, we propose a fusion feature multi-scale pooling for Markov modeling method. Markov modeling includes two aspects: label field initialization and feature field establishment. These two aspects are jointly created by the fusion feature multi-scale pooling process, and this process is proposed to enhance the feature difference between water bodies and land cover. Then, the greedy algorithm in the iteration conditional method is used to extract refined water bodies according to the rebuilt Markov initial label and feature fields. Finally, to prove the effectiveness of proposed method, extensive experiments were used with collected 2.5m SPOT 5 and 1m GF-2 optical panchromatic images and evaluation indexes (precision, recall, overall accuracy, kappa coefficient and boundary detection ratios) to demonstrate that our proposed method can produce more refined water body extraction results than the state-of-the-art methods. The global and local refined indexes are improved by about 7% and 10%, respectively.
    Keywords fusion feature ; multi-scale pooling ; Markov modeling ; panchromatic optical images ; remote sensing ; water body extraction ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus.

    Li, Min / Kong, Yidi / Wu, Xueqin / Yin, Zhuang / Niu, Xiaotian / Wang, Guiqin

    Fish & shellfish immunology

    2021  Volume 119, Page(s) 249–261

    Abstract: This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure. A total of 300 fish were divided into five groups: the first group ...

    Abstract This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure. A total of 300 fish were divided into five groups: the first group was the control group and the other four groups were exposed to waterborne Pb (800 ppb) and fed α-LA diets supplemented with 0, 300, 600, and 900 mg/kg. The results demonstrated that dietary α-LA effectively reduced the Pb accumulation in the liver, kidney, gill, intestine, and muscle of C. argus after exposure to Pb. Meanwhile, dietary α-LA reversed alterations in the biochemical parameters (Alanine aminotransferase (ALT), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), blood urea nitrogen (BUN), cortisol (COR), and creatinine (CRE)) and immunity parameters (myeloperoxidase (MPO), complement 3 (C3), lysozyme (LYS), complement 4 (C4), C-reactive protein (CRP), and immunoglobulin M (IgM)) in the serum of fish caused by Pb. Pb-induced reduction of antioxidant enzyme activities (Catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px)) was inhibited by dietary α-LA. And malondialdehyde (MDA) and protein carbonyl (PC) content exhibited an opposite trend. Meanwhile, dietary supplemented with α-LA was found to relieve Pb-induced oxidative stress by downregulating Keap1 mRNA expression levels and upregulating the expression levels of CAT, nuclear factor erythroid 2-related factor 2 (Nrf2), GSH-Px, and Cu/Zn SOD. Furthermore, α-LA supplementation reversed Pb-induced upregulation of pro-inflammatory genes (interleukin (IL)-6, IL-1β, tumor necrosis factor α (TNF-α), and nuclear factor kappa B (NF-κB)), Pro-apoptotic genes (Bcl-2-associated X (Bax), caspase (Cas)-3, and tumor protein p53 (p53)) and Hsp70, and downregulation of anti-inflammatory genes (IL-10, inhibitor of κBα (IκBα), and transforming growth factor β (TGF-β)) and anti-apoptosis gene (B-cell lymphoma-2 (Bcl-2)). Overall, dietary α-LA supplementation could enhance the innate immunity and antioxidant capacity of fish, attenuating the Pb accumulation, and cell apoptosis after being exposed to Pb. Furthermore, dietary α-LA could relieve Pb-induced inflammatory response and oxidative stress of fish via regulating NF-κB and Nrf2 signaling, respectively.
    MeSH term(s) Animal Feed/analysis ; Animals ; Antioxidants/metabolism ; Apoptosis ; Bioaccumulation ; Diet/veterinary ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Inflammation/chemically induced ; Inflammation/veterinary ; Kelch-Like ECH-Associated Protein 1 ; Lead/toxicity ; NF-E2-Related Factor 2 ; NF-kappa B/metabolism ; Oxidative Stress ; Proto-Oncogene Proteins c-bcl-2 ; Superoxide Dismutase ; Thioctic Acid ; Tumor Suppressor Protein p53
    Chemical Substances Antioxidants ; Fish Proteins ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NF-kappa B ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Protein p53 ; Lead (2P299V784P) ; Thioctic Acid (73Y7P0K73Y) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2021.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clinical use of azelnidipine in the treatment of hypertension in Chinese patients.

    Chen, Bi-Lian / Zhang, Yin-Zhuang / Luo, Jian-Quan / Zhang, Wei

    Therapeutics and clinical risk management

    2015  Volume 11, Page(s) 309–318

    Abstract: Background: Hypertension is the most common chronic disease and the calcium channel antagonist is the most popularly used antihypertensive drug in Chinese patients. Azelnidipine is a third generation and long-acting dihydropyridine calcium channel ... ...

    Abstract Background: Hypertension is the most common chronic disease and the calcium channel antagonist is the most popularly used antihypertensive drug in Chinese patients. Azelnidipine is a third generation and long-acting dihydropyridine calcium channel antagonist. A series of research has demonstrated that azelnidipine produced an effective antihypertensive effect in patients with essential hypertension. Now it is need to summarize clinical use of azelnidipine in the treatment of hypertension in Chinese patients.
    Methods: Relevant literature was identified by performing searches in PubMed and CNKI (China National Knowledge Infrastructure), covering the period from January 2003 (the year azelnidipine was launched) to July 2014. We included studies that described pharmacology of azelnidipine, especially the pharmacokinetics, clinical efficacy, and safety and tolerability of azelnidipine in a Chinese population. The full text of each article was strictly reviewed, and data interpretation was performed.
    Results: In Chinese healthy volunteers, a single-dose oral administration of azelnidipine 8-16 mg had a peak plasma concentration of 1.66-23.06 ng/mL and time to peak plasma concentration was 2.6-4.0 hours and the area under the plasma concentration versus time curve from time 0 hour to 96 hours was 17.9-429 ng/mL·h and elimination half-life was 16.0-28.0 hours. A number of clinical trials have demonstrated that azelnidipine produced a significant reduction in blood pressure in Chinese patients with mild-to-moderate hypertension, which was similar to that of other effective antihypertensive drugs such as amlodipine, zofenopril, and nifedipine. In addition to its antihypertensive effect, azelnidipine had other cardiovascular protective effects as well, like anti-oxidative action, decreasing heart rate, and improving systolic and diastolic function. Azelnidipine was generally well tolerated in Chinese patients and no severe adverse events were observed.
    Conclusion: Azelnidipine is effective and safe in the treatment of hypertension in Chinese patients.
    Language English
    Publishing date 2015-02-24
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S64288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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