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Book ; Conference proceedings: Special double issue Theoretical advances and empirical lessons on emissions trading schemes

Fan, Ying

(the Symposium on Theoretical Advances and Empirical Lessons of Emissions Trading Scheme (ETS) was held at IPM on October 10 and 11 ... 2013)

(Energy & environment ; 25,3/4)

2014

Title variant	Theoretical advances and empirical lessons on emissions trading schemes
Event/congress	Symposium on Theoretical Advances and Empirical Lessons of Emissions Trading Scheme (ETS) (2013, Peking)
Author's details	guest ed.: Y. Fan
Series title	Energy & environment ; 25,3/4
Collection
Language	English
Size	S. 519 - 862 : graph. Darst.
Publisher	Multi-Science Publ
Publishing place	Brentwood
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT018291701
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
Z 5965 (25,3/4)	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: A special issue of Essays in Biochemistry on cancer stem cells.

Ying, Fan / Lee, Terence Kin Wah

Essays in biochemistry

2022 Volume 66, Issue 4, Page(s) 287–289

Abstract: Cancer stem cells (CSCs) are subpopulation of cells within the tumor bulk, which leads to tumor recurrence and therapeutic resistance. Identification of specific CSC targets for detection and efficient cancer therapy are the major hurdles in this ... ...

Abstract	Cancer stem cells (CSCs) are subpopulation of cells within the tumor bulk, which leads to tumor recurrence and therapeutic resistance. Identification of specific CSC targets for detection and efficient cancer therapy are the major hurdles in this research field. In this decade, basic researchers and clinicians made every effort to overcome these challenges to target CSCs using different approaches. This special issue includes a varied collection of review articles with comprehensive discussion on the complexity of CSC heterogeneity, signaling pathways regulating the behaviors of CSCs, the therapeutic resistance mechanism of CSCs, and therapeutic targets against CSCs. These review articles shed light on current advances in understanding of CSC biology.
MeSH term(s)	Humans ; Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Signal Transduction
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1744-1358 ; 0071-1365
ISSN (online)	1744-1358
ISSN	0071-1365
DOI	10.1042/EBC20220049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease.

Cho, Sungji / Ying, Fan / Sweeney, Gary

Biomedical journal

2023 Volume 46, Issue 5, Page(s) 100624

Abstract: Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ... ...

Abstract	Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with development and progression of cardiometabolic diseases. The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is well-established as a major player in sterile inflammatory responses. It is a multimeric cytosolic protein complex which regulates the activation of caspase-1 and subsequently promotes cleavage and release of interleukin (IL)-1 family cytokines, which have a deleterious impact on the development of cardiometabolic diseases. Therefore, targeting NLRP3 itself or the downstream consequences of NLRP3 activation represent excellent potential therapeutic targets in inflammatory cardiometabolic diseases. Here, we review our current understanding of the role which NLRP3 inflammasome regulation plays in cardiometabolic diseases such as obesity, diabetes, non-alcoholic steatohepatitis (NASH), atherosclerosis, ischemic heart disease and cardiomyopathy. Finally, we highlight the potential of targeting NLPR3 or related signaling molecules as a therapeutic approach.
MeSH term(s)	Humans ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammation/metabolism ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/metabolism ; Cardiovascular Diseases
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2023.100624
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma.

Ying, Fan / Chan, Mandy Sze Man / Lee, Terence Kin Wah

Cellular and molecular gastroenterology and hepatology

2023 Volume 15, Issue 4, Page(s) 985–999

Abstract: Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis. PLC is characterized by an abundant stromal reaction in which cancer-associated ... ...

Abstract	Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis. PLC is characterized by an abundant stromal reaction in which cancer-associated fibroblasts (CAFs) are one of the major stromal components. Solid evidence has demonstrated the crucial role of CAFs in tumor progression, and CAF abundance is often correlated with poor clinical outcomes. Although CAFs are regarded as an attractive and promising target for PLC treatment, a poor understanding of CAF origins and heterogeneity and a lack of specific CAF markers are the major hurdles to efficient CAF-specific therapy. In this review, we examine recent advances in the understanding of CAF diversity in the context of biomarkers, subtypes, and functions in PLC. The regulatory roles of CAFs in extracellular matrix remodeling, metastasis, cancer stemness, and therapeutic resistance are summarized. With an increasing link between CAF abundance and reduced antitumor immune responses, we provide updated knowledge on the crosstalk between CAFs and immune cells within the tumor microenvironment, which leads to immune resistance. In addition, we present current CAF-targeted therapies and describe some future perspectives. A better understanding of CAF biology will shed light on a novel therapeutic strategy against PLC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Cancer-Associated Fibroblasts/pathology ; Liver Neoplasms/pathology ; Cholangiocarcinoma ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Tumor Microenvironment
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2819778-1
ISSN	2352-345X ; 2352-345X
ISSN (online)	2352-345X
ISSN	2352-345X
DOI	10.1016/j.jcmgh.2023.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair

Robert J. Lake / Rabeya Bilkis / Hua-Ying Fan

Biomedicines, Vol 10, Iss 361, p

2022 Volume 361

Abstract: Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair. DNA ... ...

Abstract	Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair. DNA breaks activate PARP1, leading to the synthesis of poly(ADP-ribose) (PAR) on itself and neighboring proteins, which is crucial for the recruitment of DNA repair machinery. CSB and PARP1 interact; however, how CSB mechanistically participates in oxidative DNA damage repair mediated by PARP1 remains unclear. Using chromatin immunoprecipitation followed by quantitative PCR, we found that CSB and PARP1 facilitate each other’s chromatin association during the onset of oxidative stress, and that CSB facilitates PARP1 removal when the level of chromatin-bound CSB increases. Furthermore, by monitoring chromatin PAR levels using Western blot analysis, we found that CSB sustains the DNA damage signal initiated by PARP1, and may prevent PARP1 overactivation by facilitating DNA repair. By assaying cell viability in response to oxidative stress, we further demonstrate that PARP1 regulation by CSB is a major CSB function in oxidatively-stressed cells. Together, our study uncovers a dynamic interplay between CSB and PARP1 that is critical for oxidative stress relief.
Keywords	Cockayne syndrome group B protein (CSB) ; poly(ADP-ribose) polymerase 1 (PARP1) ; oxidative stress ; PARylation ; Cockayne syndrome ; ATP-dependent chromatin remodeler ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Economics of planning electricity transmission considering environmental and health externalities

Bowen Yi / Shaohui Zhang / Ying Fan

iScience, Vol 25, Iss 8, Pp 104815- (2022)

2022

Abstract: Summary: Long-distance electricity transmission can achieve environmental benefits through the transfer of air pollutants. However, current electricity transmission investment decisions do not take enough environmental factors into account. This study ... ...

Abstract	Summary: Long-distance electricity transmission can achieve environmental benefits through the transfer of air pollutants. However, current electricity transmission investment decisions do not take enough environmental factors into account. This study combines Greenhouse Gas–Air Pollution Interactions and Synergies model with power system planning to reveal how regional differences in environmental and health losses affect the allocation of electricity at the spatial level. Based on the analysis of inter-provincial electricity interconnection in China, we find that the regional differences in environmental and health external costs of power generation are significant. Considering external costs in investment decisions will largely improve the economy of long-distance inter-regional electricity transfer dominated by ultra-high voltage lines, thus replacing a portion of intra-regional electricity transfer dominated by high voltage lines. Meanwhile, the increases in local health losses in major electricity exporting provinces are not significant, which can alleviate the regional equity issues caused by pollutant transfer.
Keywords	Health sciences ; Energy policy ; Electrical system ; Energy sustainability ; Economics ; Science ; Q
Subject code	660
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Semi‐Analytical Solution for Slug Test by Considering Near‐Well Formation Damage and Nonlinear Flow

Lin, Ying‐Fan / Yeh, Hund‐Der

Water resources research. 2022 Mar., v. 58, no. 3

2022

Abstract: This study proposes a new analytical slug test model describing confined flow considering the effects of the formation damage and non‐Darcy flow near the wellbore. The former, primarily caused by drilling fluid invasion, introduces an extra wellbore head ...

Abstract	This study proposes a new analytical slug test model describing confined flow considering the effects of the formation damage and non‐Darcy flow near the wellbore. The former, primarily caused by drilling fluid invasion, introduces an extra wellbore head loss near the well screen. The latter, mainly resulting from the relatively high‐velocity flow across the gravel‐pack screen, adopts the Forchheimer equation to consider the joint effects of the laminar flow and non‐Darcy flow. The proposed model is nonlinear due to the quadratic term for non‐Darcy flow in the Forchheimer equation. The new solutions for head responses in the well and formation are derived using the Laplace transform method and integration by parts formula. Furthermore, the present solution is applied to estimate the aquifer parameters via analyzing the water level data from field slug tests conducted in the Minnelusa aquifer near Spearfish, South Dakota. We found that the present solution provides very good fit to the field data from tests in fractured aquifers, notably the data exhibits a rapid decline at late times on the normalized head vs. logarithmic time plots.
Keywords	aquifers ; equations ; head ; laminar flow ; models ; research ; water ; South Dakota
Language	English
Dates of publication	2022-03
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2021WR031368
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effectiveness and safety of acupuncture for insulin resistance in women with polycystic ovary syndrome

Yu Liu / Hua-Ying Fan / Jin-Qun Hu / Tian-Yu Wu / Jiao Chen

Heliyon, Vol 9, Iss 3, Pp e13991- (2023)

A systematic review and meta-analysis

2023

Abstract: Objective: To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate acupuncture's clinical effect on insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). Methods: PubMed, Cochrane Library, ... ...

Abstract	Objective: To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate acupuncture's clinical effect on insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). Methods: PubMed, Cochrane Library, Embase databases, and Chinese databases, including China National Knowledge Infrastructure, Technology Journal Database, and Wanfang Database, were searched without language restrictions from inception to December 20, 2021. Only RCTs in which acupuncture had been examined as the sole or adjunctive PCOS-IR treatment were included. Our primary endpoint was the homeostasis model assessment of insulin resistance (HOMA-IR). The secondary outcomes were fasting blood glucose (FBG), fasting insulin (FINS), body mass index (BMI), and adverse events. Results: Our analysis included 17 eligible RCTs (N = 1511 participants). Compared with other treatments, acupuncture therapy yielded a greater mean reduction in HOMA-IR (MD = −0.15; 95% CI, −0.27 to −0.03; P = 0.01) and BMI (MD = −1.47; 95% CI, −2.46 to −0.47; P = 0.004). Besides acupuncture was associated with a lower risk of adverse events than other treatments (RR, 0.15; 95% CI, 0.10 to 0.22; P < 0.01). Additionally, the combination treatment of acupuncture and medicine is more effective in improving HOMA-IR (MD = −0.91; 95% CI, −1.11 to −0.71; P < 0.01), FBG (MD = −0.30; 95% CI, −0.56 to −0.04; P = 0.02), FINS (MD = −2.33; 95% CI, −2.60 to −2.06; P < 0.01) and BMI (MD = −1.63; 95% CI, −1.94 to −1.33; P < 0.01) than medicine alone. Conclusions: Acupuncture is relatively effective in improving HOMA-IR and BMI in PCOS-IR. Besides, it's safer than other treatments and could be an adjuvant strategy for improving PCOS-IR. Further large-scale, long-term RCTs with strict methodological standards are justified.
Keywords	Acupuncture ; Polycystic ovary syndrome ; Insulin resistance ; Metformin ; Meta-analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regulation of Dynamic Protein S-Acylation

Jessica J. Chen / Ying Fan / Darren Boehning

Frontiers in Molecular Biosciences, Vol

2021 Volume 8

Abstract: Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions, ... ...

Abstract	Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions, protein stability, and protein conformation. This process is regulated by palmitoyl acyltransferases that have the conserved amino acid sequence DHHC at their active site. Although they have conserved catalytic cores, DHHC enzymes vary in their protein substrate selection, lipid substrate preference, and regulatory mechanisms. Alterations in DHHC enzyme function are associated with many human diseases, including cancers and neurological conditions. The removal of fatty acids from acylated cysteine residues is catalyzed by acyl protein thioesterases. Notably, S-acylation is now known to be a highly dynamic process, and plays crucial roles in signaling transduction in various cell types. In this review, we will explore the recent findings on protein S-acylation, the enzymatic regulation of this process, and discuss examples of dynamic S-acylation.
Keywords	S-acylation ; DHHC enzymes ; APT ; ABHD ; cell signaling ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Understanding the Anticontagion Process and Reopening of China during COVID-19 via Coevolution Network of Epidemic and Awareness

Lingbo Li / Ying Fan / An Zeng / Zengru Di

Complexity, Vol

2021 Volume 2021

Abstract: The novel coronavirus (COVID-19) pandemic is intensifying all over the world, but some countries, including China, have developed extensive and successful experience in controlling this pandemic. In this context, some questions arise naturally: What can ... ...

Abstract	The novel coronavirus (COVID-19) pandemic is intensifying all over the world, but some countries, including China, have developed extensive and successful experience in controlling this pandemic. In this context, some questions arise naturally: What can countries caught up in the epidemic learn from China’s experience? In regions where the outbreak is under control, what would lead to a resurgence of the epidemic? To address these issues, we investigate China’s experience in anticontagion interventions and reopening process, focusing on the coevolution of epidemic and awareness during COVID-19 outbreak. Through an empirical analysis based on large-scale data and simulation based on a metapopulation and multilayer network model, we ascertain the impact of human movements and awareness diffusion on the epidemic, elucidate the inherent patterns and effective interventions of different epidemic prevention methods, and highlight the crunch time of each measure. The results are also employed to analyze COVID-19 evolution in other countries so as to find unified rules in complex situations around the world and provide advice on anticontagion and reopening policies. Our findings explain some key mechanisms of epidemic prevention and may help the epidemic analysis and decision-making in various countries suffering from COVID-19.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Subject code	612
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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