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  1. Article ; Online: Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications.

    Yingrui, Wang / Zheng, Liu / Guoyan, Liu / Hongjie, Wang

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 148, Page(s) 112690

    Abstract: Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term hyperglycemia can lead to a variety of serious chronic complications, such as diabetic nephropathy, diabetic retinopathy, diabetes cardiovascular disease, and so on, ... ...

    Abstract Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term hyperglycemia can lead to a variety of serious chronic complications, such as diabetic nephropathy, diabetic retinopathy, diabetes cardiovascular disease, and so on, threatening human life, health and safety. Scutellaria baicalensis Georgi is one of the most commonly used traditional Chinese medicine. Flavonoids are the main effective components of Scutellaria baicalensis Georgi. The flavonoids are mainly baicalin, baicalein, wogonoside and wogonin. The four have the effects of improving the renal function, insulin resistance and retinopathy of type 2 diabetic patients. The aim of this review is to summarize the pathogenesis and clinical research progress of baicalin, baicalein, wogonoside and wogonin in Scutellaria baicalensis Georgi in the treatment of type 2 diabetes mellitus and its complications.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Flavanones ; Flavonoids ; Humans ; Medicine, Chinese Traditional ; Scutellaria baicalensis
    Chemical Substances Flavanones ; Flavonoids
    Language English
    Publishing date 2022-02-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Integrating Network Pharmacology and Experimental Validation to Elucidate the Mechanism of Yiqi Yangyin Decoction in Suppressing Non-Small-Cell Lung Cancer

    Pengfei Jiao / Yingrui Wang / Gaofei Ren / Dan Chu / Yameng Li / Tianqing Sang

    BioMed Research International, Vol

    2023  Volume 2023

    Abstract: Yiqi Yangyin Decoction (YYD) is a classic traditional Chinese medicine (TCM) formulation to treat lung cancer in clinic. Nevertheless, the active ingredients, key targets, and molecular mechanisms for YYD are still poorly understood. This study is ... ...

    Abstract Yiqi Yangyin Decoction (YYD) is a classic traditional Chinese medicine (TCM) formulation to treat lung cancer in clinic. Nevertheless, the active ingredients, key targets, and molecular mechanisms for YYD are still poorly understood. This study is focused on elucidating the pharmacological mechanism of YYD in non-small-cell lung cancer (NSCLC) by using a combined network pharmacology approach and biological experiment validation. Online bioinformatics tools showed that 40 bioactive compounds and 229 putative targets of YYD were associated with anti-NSCLC activity. Protein-Protein Interaction (PPI) network demonstrated AKT1, SRC, JUN, TP53, and EGFR as the top five key targets for YYD against NSCLC. Through enrichment analysis, YYD was found to affect cell proliferation and apoptosis in NSCLC possibly by PI3K-AKT signaling. Molecular docking confirmed a strong binding between the main compounds (quercetin or luteolin) and EGFR. As demonstrated by CCK-8, EdU, and colony formation assays, we found a significant inhibition of YYD on cell proliferation. Moreover, YYD treatment induced cell cycle arrest by affecting p53, p21, and cyclin D1 expression. YYD administration enhanced apoptosis by changing the expression of cleaved caspase-3, Bax, and Bcl-2. Mechanistically, YYD resulted in a significant inactivation of EGFR-PI3K-AKT signaling. Furthermore, EGFR activator significantly reversed YYD-mediated proliferation inhibition and apoptosis. YYD also showed an inhibitory effect on tumor growth in mice. Together, YYD might target the EGFR-PI3K-AKT pathway to repress NSCLC progression.
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Thesis: Nitric oxide-cGMP signal transduction in the injury, matrix expansion and progression of anti-thy1-induced renal disease of the rat

    Wang-Rosenke, Yingrui

    2005  

    Author's details von Yingrui Wang
    Language German
    Size V, 108 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Univ., Diss., 2005
    HBZ-ID HT014424498
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 E 858 order for loan Magazin

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  4. Article ; Online: Operating Strategy for Local-Area Energy Systems Integration Considering Uncertainty of Supply-Side and Demand-Side under Conditional Value-At-Risk Assessment

    Jiaqi Shi / Yingrui Wang / Ruibin Fu / Jianhua Zhang

    Sustainability, Vol 9, Iss 9, p

    2017  Volume 1655

    Abstract: To alleviate environmental pollution and improve the energy usage efficiency of terminals, energy systems integration (ESI) has become an important paradigm in the energy structure evolution. Power, gas and heat systems are becoming tightly interlinked ... ...

    Abstract To alleviate environmental pollution and improve the energy usage efficiency of terminals, energy systems integration (ESI) has become an important paradigm in the energy structure evolution. Power, gas and heat systems are becoming tightly interlinked with each other in ESI. The dispatching strategy of local-area ESI has significant impact on its operation. In this paper, a local-area ESI operational scheduling model based on conditional value-at-risk (CVaR) is proposed to minimize expected operational cost, which considers the uncertainty of energy supply-side and demand-side as well as multi-energy network constraints, including electrical network, thermal network and gas network. The risk cost is analyzed comprehensively under the condition of under- or overestimated cost. On this basis, a hybrid method combining particle swarm optimization with interior point algorithm is executed to compute the optimal solutions of two-stage multi-period mixed-integer convex model. Finally, a case study is performed on ESI to demonstrate the effectiveness of the proposed method.
    Keywords energy systems integration (ESI) ; conditional value-at-risk (CVaR) ; risk cost ; multi-energy network constraints ; bi-level optimization ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A novel role of Krüppel-like factor 4 in Zhikong scallop Chlamys farreri during spermatogenesis.

    Dandan Yang / Zhifeng Zhang / Shaoshuai Liang / Qiankun Yang / Yingrui Wang / Zhenkui Qin

    PLoS ONE, Vol 12, Iss 6, p e

    2017  Volume 0180351

    Abstract: Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals. In the present study, we ... ...

    Abstract Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals. In the present study, we identified a full-length cDNA of Klf4 in Zhikong scallop Chamys farreri (Cf-Klf4) and found that Cf-Klf4 presented a sexual dimorphic expression characteristic in C. farreri gonads. Cf-Klf4 expression was significantly higher in testes than in ovaries from growing stage to mature stage detected by quantitative real-time PCR, and was located in male gametes, except for spermatozoa during spermatogenesis through in situ hybridization and immunohistochemistry, while no positive signal was visible in female gametes during oogenesis. Furthermore, the knockdown of Cf-Klf4 in testes by means of in vivo RNA interference led to an obviously developmental retardance, lower gonadosomatic index, less male gametes and more apoptotic spermatocytes. Interestingly, we found that two out of eight scallops showed a hermaphroditic phenotype characteristic of male-to-female sex reversal when the Klf4 mRNA and protein levels were knocked down in males. These results verified that Klf4 plays an important role in testis functional maintenance and is necessary in spermatogenesis of C. farreri.
    Keywords Medicine ; R ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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