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  1. Article ; Online: Call for Papers for the Special Issue on Neurotoxicology.

    Richardson, Jason / Yinsheng Wang

    Chemical research in toxicology

    2020  Volume 33, Issue 8, Page(s) 2009

    MeSH term(s) Animals ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.0c00295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Facile enzymatic synthesis of base J-containing oligodeoxyribonucleotides and an analysis of the impact of base J on DNA replication in cells.

    Debin Ji / Yinsheng Wang

    PLoS ONE, Vol 9, Iss 7, p e

    2014  Volume 103335

    Abstract: We reported here the use of T4 bacteriophage β-glucosyltransferase (T4 β-GT) for the facile synthesis of base J-containing oligodeoxyribonucleotides (ODNs). We found that the enzyme could catalyze the glucosylation of 5-hydroxymethyl-2-deoxyuridine (5hmU) ...

    Abstract We reported here the use of T4 bacteriophage β-glucosyltransferase (T4 β-GT) for the facile synthesis of base J-containing oligodeoxyribonucleotides (ODNs). We found that the enzyme could catalyze the glucosylation of 5-hydroxymethyl-2-deoxyuridine (5hmU) in both single- and double-stranded ODNs, though the latter reaction occurred only when 5hmU was mispaired with a guanine. In addition, base J blocked moderately DNA replication, but it did not induce mutations during replication in human cells.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

    Qiong Zhang / Yuqi Kang / Shaobo Wang / Gwendolyn Michelle Gonzalez / Wanyu Li / Hui Hui / Yinsheng Wang / Tariq M. Rana

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication ... ...

    Abstract m6Am is a modification of the 5′ end of mRNAs catalyzed by PCIF1. Here, Zhang et al. show that HIV infection induces a decrease in m6Am of cellular mRNAs through Vpr-mediated PCIF1 ubiquitination and degradation, resulting in increased HIV replication through regulation of host transcription factors.
    Keywords Science ; Q
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

    Weili Miao / Lin Li / Yonghui Zhao / Xiaoxia Dai / Xuemei Chen / Yinsheng Wang

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated ... ...

    Abstract Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced upregulation of DNAJB4.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

    Weili Miao / Lin Li / Yonghui Zhao / Xiaoxia Dai / Xuemei Chen / Yinsheng Wang

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated ... ...

    Abstract Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced upregulation of DNAJB4.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Dual regulation of Arabidopsis AGO2 by arginine methylation

    Po Hu / Hongwei Zhao / Pei Zhu / Yongsheng Xiao / Weili Miao / Yinsheng Wang / Hailing Jin

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: AGO2 is a core component of the RNAi machinery and contributes to plant immunity during bacterial infection. Here the authors show that AGO2 activity is suppressed by arginine methylation which not only promotes AGO2 degradation but also recruits TSN ... ...

    Abstract AGO2 is a core component of the RNAi machinery and contributes to plant immunity during bacterial infection. Here the authors show that AGO2 activity is suppressed by arginine methylation which not only promotes AGO2 degradation but also recruits TSN proteins to degrade AGO2-associated small RNAs.
    Keywords Science ; Q
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Cytotoxic and Mutagenic Properties of C3′-Epimeric Lesions of 2′-Deoxyribonucleosides in Escherichia coli Cells

    Wang, Pengcheng / Nicholas J. Amato / Yinsheng Wang

    Biochemistry. 2017 July 25, v. 56, no. 29

    2017  

    Abstract: Reactive oxygen species (ROS), resulting from endogenous metabolism and/or environmental exposure, can induce damage to the 2-deoxyribose moiety in DNA. Specifically, a hydrogen atom from each of the five carbon atoms in 2-deoxyribose can be abstracted ... ...

    Abstract Reactive oxygen species (ROS), resulting from endogenous metabolism and/or environmental exposure, can induce damage to the 2-deoxyribose moiety in DNA. Specifically, a hydrogen atom from each of the five carbon atoms in 2-deoxyribose can be abstracted by hydroxyl radical, and improper chemical repair of the ensuing radicals formed at the C1′, C3′, and C4′ positions can lead to the stereochemical inversion at these sites to yield epimeric 2-deoxyribose lesions. Although ROS-induced single-nucleobase lesions have been well studied, the biological consequences of the C3′-epimeric lesions of 2′-deoxynucleosides, i.e., 2′-deoxyxylonucleosides (dxN), have not been comprehensively investigated. Herein, we assessed the impact of dxN lesions on the efficiency and fidelity of DNA replication in Escherichia coli cells by conducting a competitive replication and adduct bypass assay with single-stranded M13 phage containing a site-specifically incorporated dxN. Our results revealed that, of the four dxN lesions, only dxG constituted a strong impediment to DNA replication, and intriguingly, dxT and dxC conferred replication bypass efficiencies higher than those of the unmodified counterparts. In addition, the three SOS-induced DNA polymerases (Pol II, Pol IV, and Pol V) did not play any appreciable role in bypassing these lesions. Among the four dxNs, only dxA directed a moderate frequency of dCMP misincorporation. These results provided important insights into the impact of the C3′-epimeric lesions on DNA replication in E. coli cells.
    Keywords bacteriophages ; carbon ; cytotoxicity ; DNA ; DNA replication ; environmental exposure ; Escherichia coli ; free radicals ; hydrogen ; hydroxyl radicals ; metabolism ; moieties ; mutagens ; stereochemistry
    Language English
    Dates of publication 2017-0725
    Size p. 3725-3732.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.7b00146
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 217: Show issues Location:
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  8. Article ; Online: Single-Nucleotide Resolution Mapping of N6‑Methyladenine in Genomic DNA

    Cheng-Jie Ma / Gaojie Li / Wen-Xuan Shao / Yi-Hao Min / Ping Wang / Jiang-Hui Ding / Neng-Bin Xie / Min Wang / Feng Tang / Yu-Qi Feng / Weimin Ci / Yinsheng Wang / Bi-Feng Yuan

    ACS Central Science, Vol 9, Iss 9, Pp 1799-

    2023  Volume 1809

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  9. Article ; Online: NT-seq

    Xuwen Li / Shiyuan Guo / Yan Cui / Zijian Zhang / Xinlong Luo / Margarita T. Angelova / Laura F. Landweber / Yinsheng Wang / Tao P. Wu

    Genome Biology, Vol 23, Iss 1, Pp 1-

    a chemical-based sequencing method for genomic methylome profiling

    2022  Volume 20

    Abstract: Abstract DNA methylation plays vital roles in both prokaryotes and eukaryotes. There are three forms of DNA methylation in prokaryotes: N 6-methyladenine (6mA), N 4-methylcytosine (4mC), and 5-methylcytosine (5mC). Although many sequencing methods have ... ...

    Abstract Abstract DNA methylation plays vital roles in both prokaryotes and eukaryotes. There are three forms of DNA methylation in prokaryotes: N 6-methyladenine (6mA), N 4-methylcytosine (4mC), and 5-methylcytosine (5mC). Although many sequencing methods have been developed to sequence specific types of methylation, few technologies can be used for efficiently mapping multiple types of methylation. Here, we present NT-seq for mapping all three types of methylation simultaneously. NT-seq reliably detects all known methylation motifs in two bacterial genomes and can be used for identifying de novo methylation motifs. NT-seq provides a simple and efficient solution for detecting multiple types of DNA methylation.
    Keywords DNA methylation ; Next-generation sequencing ; Whole-genome epigenetic profiling ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

    Chen Hu / Fengming Zou / Aoli Wang / Weili Miao / Qianmao Liang / Ellen L. Weisberg / Yinsheng Wang / Jing Liu / Wenchao Wang / Qingsong Liu

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 4

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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