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  1. Article ; Online: Analysis of endometrial thickness threshold and optimal thickness interval in cleavage embryo hormone replacement freeze-thawed embryo transfer (HRT-FET).

    Shaodi, Zhang / Qiuyuan, Li / Yisha, Yin / Cuilian, Zhang

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2020  Volume 36, Issue 11, Page(s) 968–972

    Abstract: To investigate the effect of endometrial thickness on the clinical outcome of cleavage embryo HRT-FET on the day of embryo transfer and analyzed the threshold and optimal thickness interval corresponding to ideal clinical pregnancy rate by statistical ... ...

    Abstract To investigate the effect of endometrial thickness on the clinical outcome of cleavage embryo HRT-FET on the day of embryo transfer and analyzed the threshold and optimal thickness interval corresponding to ideal clinical pregnancy rate by statistical method. A total of 5861 HRT-FET cycles with cleavage embryo transferred from January 2013 to December 2017 in the Reproductive Medicine Center of Henan Provincial People's Hospital were studied retrospectively.Fifth-order grouping of endometrial thickness (EMT) on embryo transfer day as a continuous variable by statistical software, they were divided into five subgroups: Q1 (EMT:4.0-7.9 mm), Q2 (EMT: 8.0-8.9 mm), Q3 (EMT: 9.0-9.5 mm), Q4 (EMT: 9. 6-10.9 mm), Q5 (EMT: 11.0-19.0 mm). After adjusting for confounding factors, the clinical pregnancy rate and live birth rate in other groups were higher than Group Q1 significantly (
    MeSH term(s) Adult ; Blastocyst/cytology ; Blastocyst/drug effects ; Cleavage Stage, Ovum/cytology ; Cleavage Stage, Ovum/drug effects ; Cryopreservation ; Drug Administration Schedule ; Embryo Implantation/drug effects ; Embryo Transfer/methods ; Endometrium/drug effects ; Endometrium/pathology ; Female ; Fertilization in Vitro/methods ; Freezing ; Hormone Replacement Therapy/methods ; Humans ; Male ; Organ Size/drug effects ; Ovulation Induction/methods ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Progesterone/administration & dosage ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Chemical Substances Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2020.1742686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect of endometrial thickness on pregnancy outcomes of frozen-thawed embryo transfer cycles which underwent hormone replacement therapy.

    Shaodi, Zhang / Qiuyuan, Li / Yisha, Yin / Cuilian, Zhang

    PloS one

    2020  Volume 15, Issue 9, Page(s) e0239120

    Abstract: Objective: To investigate the impact of endometrial thickness on the embryo transfer(ET) day on the clinical pregnancy outcomes of frozen-thawed embryo transfer cycles which have undergone hormone replacement therapy(HRT-FET).: Methods: A total of 10, ...

    Abstract Objective: To investigate the impact of endometrial thickness on the embryo transfer(ET) day on the clinical pregnancy outcomes of frozen-thawed embryo transfer cycles which have undergone hormone replacement therapy(HRT-FET).
    Methods: A total of 10,165 HRT-FET cycles performed between January 2013 to December 2017 in the Reproductive Medicine Center of Henan Provincial People's Hospital were studied retrospectively. All patients were grouped according to their endometrial thickness on the ET day (each group having an increment of 1mm between two neighboring groups). Multivariate regression analysis, curve fitting and threshold effect analysis were performed on all data.
    Results: After adjusting for the age, duration of infertility, body mass index(BMI), infertility type and number and type of embryos transferred, a significant correlation was observed to be between the endometrial thickness and implantation rates (aOR: 1.08; 95% CI: 1.06-1.10, p < 0.0001), clinical pregnancy rate(aOR: 1.10; 95% CI: 1.07-1.14, p < 0.0001)and live birth rate (aOR: 1.09; 95% CI: 1.06-1.12, p < 0.0001). The numerical value of the cut-off point for the endometrial thickness was 8.7 mm. When the endometrial thickness was less than 8.7 mm, with each additional 1 mm of endometrial thickness, the implantation rate increased by 32%, the clinical pregnancy rate increased by 36%, and the live birth rate increased by 45%.
    Conclusions: In the HRT-FET cycles, the optimal live birth rate would be obtained when the endometrial thickness remains within the range of 8.7-14.5 mm. If the endometrium is too thin or too thick, the live birth rate will be reduced.
    MeSH term(s) Adult ; China/epidemiology ; Cryopreservation ; Embryo Implantation/physiology ; Embryo Transfer/methods ; Endometrium/anatomy & histology ; Endometrium/diagnostic imaging ; Endometrium/physiology ; Endosonography ; Female ; Hormone Replacement Therapy ; Humans ; Infertility/therapy ; Live Birth/epidemiology ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0239120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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