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  1. Book: Ciliary function in mammalian development

    Yoder, Bradley K.

    (Current topics in developmental biology ; 85)

    2008  

    Author's details ed. by Bradley K. Yoder
    Series title Current topics in developmental biology ; 85
    Collection
    Keywords Basalmembran ; Flimmerbewegung ; Membranproteine ; Zilie ; Funktionsmorphologie ; Physiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion ; Funktionale Morphologie ; Funktionelle Morphologie ; Morphologie ; Wimper ; Cilia ; Cilie ; Cilium ; Flimmerhaar ; Kinocilie ; Biomembran ; Flimmern ; Ciliary action ; Basallamina
    Language English
    Size XIX, 464, [32] S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015795871
    ISBN 978-0-12-374453-1 ; 0-12-374453-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 175 -85- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Resident Macrophages in Cystic Kidney Disease.

    Li, Zhang / Zimmerman, Kurt A / Yoder, Bradley K

    Kidney360

    2021  Volume 2, Issue 1, Page(s) 167–175

    Abstract: Interstitial inflammation is an important feature of cystic kidney disease. Renal macrophages are the most well-studied inflammatory cell in the kidney, and their involvement in cyst formation has been reported in different animal models and patients ... ...

    Abstract Interstitial inflammation is an important feature of cystic kidney disease. Renal macrophages are the most well-studied inflammatory cell in the kidney, and their involvement in cyst formation has been reported in different animal models and patients with cystic kidney disease. Originally, it was believed that renal macrophages were maintained from a constant supply of bone marrow-derived circulating monocytes, and could be recruited to the kidney in response to local inflammation. However, this idea has been challenged using fate-mapping methods, by showing that at least two distinct developmental origins of macrophages are present in the adult mouse kidney. The first type, infiltrating macrophages, are recruited from circulating monocytes and gradually develop macrophage properties on entering the kidney. The second, resident macrophages, predominantly originate from embryonic precursors, colonize the kidney during its development, and proliferate
    MeSH term(s) Adult ; Animals ; Humans ; Inflammation/metabolism ; Kidney/pathology ; Macrophages/metabolism ; Mice ; Monocytes/metabolism ; Polycystic Kidney Diseases/metabolism
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0006052020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Intravital visualization of the primary cilium, tubule flow, and innate immune cells in the kidney utilizing an abdominal window imaging approach.

    Revell, Dustin Z / Yoder, Bradley K

    Methods in cell biology

    2019  Volume 154, Page(s) 67–83

    Abstract: The renal primary cilium is a small microtubule-based appendage thought to have mechano/chemosensory roles detecting changes in the fluid passing through the nephron. Mutations affecting cilium structure or function of ciliary-localized proteins result ... ...

    Abstract The renal primary cilium is a small microtubule-based appendage thought to have mechano/chemosensory roles detecting changes in the fluid passing through the nephron. Mutations affecting cilium structure or function of ciliary-localized proteins result in a spectrum of diseases termed ciliopathies, with prevalent phenotypes such as the formation of renal cysts and fibrosis. While many studies have been conducted using fixed kidney sections or live imaging of cells in culture to investigate the cilium, examination in the context of a living murine kidney remains to be conducted. Previously, our lab generated the SSTR3
    MeSH term(s) Animals ; Biosensing Techniques ; Blood Pressure/physiology ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Calcium Signaling/physiology ; Carbocyanines/chemistry ; Carbocyanines/pharmacokinetics ; Cilia/physiology ; Cilia/ultrastructure ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacokinetics ; Gene Expression ; Genes, Reporter ; Glycoconjugates/chemistry ; Glycoconjugates/pharmacokinetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Heart Rate/physiology ; Intravital Microscopy/instrumentation ; Intravital Microscopy/methods ; Kidney Tubules/physiology ; Kidney Tubules/ultrastructure ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Microscopy, Confocal/instrumentation ; Microscopy, Confocal/methods ; Receptors, CCR2/genetics ; Receptors, CCR2/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Rheology ; Red Fluorescent Protein
    Chemical Substances Alexa Fluor 647 ; CX3C Chemokine Receptor 1 ; Carbocyanines ; Ccr2 protein, mouse ; Cx3cr1 protein, mouse ; Fluorescent Dyes ; Glycoconjugates ; Luminescent Proteins ; Receptors, CCR2 ; Recombinant Fusion Proteins ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2019-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2019.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions.

    Clearman, Kelsey R / Timpratoom, Napassawon / Patel, Dharti / Rains, Addison B / Haycraft, Courtney J / Croyle, Mandy J / Reiter, Jeremy F / Yoder, Bradley K

    Journal of the American Society of Nephrology : JASN

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Functions of the primary cilium in the kidney and its connection with renal diseases.

    Clearman, Kelsey R / Haycraft, Courtney J / Croyle, Mandy J / Collawn, James F / Yoder, Bradley K

    Current topics in developmental biology

    2023  Volume 155, Page(s) 39–94

    Abstract: The nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of ... ...

    Abstract The nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), result in polycystic kidney disease (PKD), a progressive disorder causing renal functional decline and end-stage renal disease. PKD affects nearly 1 in 1000 individuals and as there is no cure for PKD, patients frequently require dialysis or renal transplantation. Pkd1, Pkd2, and Pkhd1 encode membrane proteins that all localize in the cilium. Pkd1 and Pkd2 function as a nonselective cation channel complex while Pkhd1 protein function remains uncertain. Data indicate that the cilium may act as a mechanosensor to detect fluid movement through renal tubules. Other functions proposed for the cilium and PKD proteins in cyst development involve regulation of cell cycle and oriented division, regulation of renal inflammation and repair processes, maintenance of epithelial cell differentiation, and regulation of mitochondrial structure and metabolism. However, how loss of cilia or cilia function leads to cyst development remains elusive. Studies directed at understanding the roles of Pkd1, Pkd2, and Pkhd1 in the cilium and other locations within the cell will be important for developing therapeutic strategies to slow cyst progression.
    MeSH term(s) Animals ; Humans ; Cilia/metabolism ; Kidney ; Polycystic Kidney Diseases/genetics ; Polycystic Kidney Diseases/metabolism ; Cysts/metabolism ; Mammals
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2023.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Elevated Protein Kinase A Activity in Stomach Mesenchyme Disrupts Mesenchymal-epithelial Crosstalk and Induces Preneoplasia.

    Puri, Pawan / Grimmett, Garfield / Faraj, Rawah / Gibson, Laurielle / Gilbreath, Ebony / Yoder, Bradley K

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 14, Issue 3, Page(s) 643–668.e1

    Abstract: Background & aims: Mesenchymal-epithelial crosstalk (MEC) in the stomach is executed by pathways such as bone morphogenetic protein (BMP) and extracellular signal-regulated kinase (ERK). Mis-regulation of MEC disrupts gastric homeostasis and causes ... ...

    Abstract Background & aims: Mesenchymal-epithelial crosstalk (MEC) in the stomach is executed by pathways such as bone morphogenetic protein (BMP) and extracellular signal-regulated kinase (ERK). Mis-regulation of MEC disrupts gastric homeostasis and causes tumorigenesis. Protein Kinase A (PKA) crosstalks with BMP and ERK signaling; however, PKA function(s) in stomach development and homeostasis remains undefined.
    Methods: We generated a novel Six2-Cre
    Results: Lineage tracing showed that Six2-Cre activity in the stomach is restricted to the mesenchymal compartment. CA-PKA mice showed disruption of gastric homeostasis characterized by aberrant mucosal development and epithelial hyperproliferation; ultimately developing multiple features of gastric corpus preneoplasia including decreased parietal cells, mucous cell hyperplasia, spasmolytic peptide expressing metaplasia with intestinal characteristics, and dysplastic and invasive cystic glands. Furthermore, mutant corpus showed marked chronic inflammation characterized by infiltration of lymphocytes and myeloid-derived suppressor cells along with the upregulation of innate and adaptive immune system components. Striking upregulation of inflammatory mediators and STAT3 activation was observed. Mechanistically, we determined there is an activation of ERK1/2 and downregulation of BMP/SMAD signaling characterized by marked upregulation of BMP inhibitor gremlin 1.
    Conclusions: We report a novel role of PKA signaling in gastric MEC execution and show that PKA activation in the gastric mesenchyme drives preneoplasia by creating a proinflammatory and proproliferative microenvironment associated with the downregulation of BMP/SMAD signaling and activation of ERK1/2.
    MeSH term(s) Animals ; Bone Morphogenetic Proteins/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gastric Mucosa/pathology ; Mesoderm/metabolism ; Mice ; Stomach
    Chemical Substances Bone Morphogenetic Proteins ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ly6c

    Aloria, Ernald Jules G / Song, Cheng J / Li, Zhang / Croyle, Mandy J / Mrug, Michal / Zimmerman, Kurt A / Yoder, Bradley K

    Kidney360

    2023  Volume 2, Issue 6, Page(s) 989–995

    MeSH term(s) Animals ; Cysts ; Macrophages ; Mice ; Monocytes
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000882021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions.

    Clearman, Kelsey R / Timpratoom, Napassawon / Patel, Dharti / Rains, Addison B / Haycraft, Courtney J / Croyle, Mandy J / Reiter, Jeremy F / Yoder, Bradley K

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin ... ...

    Abstract Background: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin Rab35 regulates actin organization and is required for gastrulation. In mice, loss of Rab35 in the CNS disrupts hippocampal development and neuronal organization. Outside of the CNS, the functions of mammalian Rab35
    Methods: We generated and analyzed the consequences of both congenital and conditional null
    Results: Congenital
    Conclusion: Rab35 is essential for mammalian development and the maintenance of kidney and ureter architecture. Loss of Rab35 leads to non-obstructive hydronephrosis, making the
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.11.556924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SnapShot: Sensing and Signaling by Cilia.

    Zimmerman, Kurt / Yoder, Bradley K

    Cell

    2015  Volume 161, Issue 3, Page(s) 692–692.e1

    Abstract: Primary cilia are cellular appendages that coordinate diverse sensory and signaling activities. They are important for proper mammalian development, adult tissue homeostasis, and vision and odorant detection, and their dysfunction contributes to disease ... ...

    Abstract Primary cilia are cellular appendages that coordinate diverse sensory and signaling activities. They are important for proper mammalian development, adult tissue homeostasis, and vision and odorant detection, and their dysfunction contributes to disease pathology and developmental defects.
    MeSH term(s) Animals ; Cilia/physiology ; Embryonic Development ; Humans ; Sensation ; Signal Transduction
    Language English
    Publishing date 2015-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2015.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1167: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  10. Article ; Online: Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs.

    Cevallos, Ricardo R / Edwards, Yvonne J K / Parant, John M / Yoder, Bradley K / Hu, Kejin

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19710

    Abstract: The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs). It is, however, perplexing that they can do so only for a rare population of the starting cells with a long ... ...

    Abstract The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs). It is, however, perplexing that they can do so only for a rare population of the starting cells with a long latency. Transcription factors (TFs) define identities of both the starting fibroblasts and the end product, iPSCs, and are also of paramount importance for the reprogramming process. It is critical to upregulate or activate the iPSC-enriched TFs while downregulate or silence the fibroblast-enriched TFs. This report explores the initial TF responses to OSKM as the molecular underpinnings for both the potency aspects and the limitation sides of the OSKM reprogramming. The authors first defined the TF reprogramome, i.e., the full complement of TFs to be reprogrammed. Most TFs were resistant to OSKM reprogramming at the initial stages, an observation consistent with the inefficiency and long latency of iPSC reprogramming. Surprisingly, the current analyses also revealed that most of the TFs (at least 83 genes) that did respond to OSKM induction underwent legitimate reprogramming. The initial legitimate transcriptional responses of TFs to OSKM reprogramming were also observed in the reprogramming fibroblasts from a different individual. Such early biased legitimate reprogramming of the responsive TFs aligns well with the robustness aspect of the otherwise inefficient and stochastic OSKM reprogramming.
    MeSH term(s) Cells, Cultured ; Cellular Reprogramming/drug effects ; Cellular Reprogramming Techniques/methods ; Fibroblasts/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Kruppel-Like Factor 4 ; Kruppel-Like Transcription Factors/genetics ; Lentivirus/genetics ; Octamer Transcription Factor-3/genetics ; Proto-Oncogene Proteins c-myc/genetics ; SOXB1 Transcription Factors/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transduction, Genetic
    Chemical Substances KLF4 protein, human ; Kruppel-Like Factor 4 ; Kruppel-Like Transcription Factors ; MYC protein, human ; Octamer Transcription Factor-3 ; POU5F1 protein, human ; Proto-Oncogene Proteins c-myc ; SOX2 protein, human ; SOXB1 Transcription Factors ; Transcription Factors
    Language English
    Publishing date 2020-11-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-76705-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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