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  1. Article ; Online: Synthesis of a Cyclic Hexaamide Consisting of a Brominated m-Phenylene Repeating Unit.

    Yokoyama, Akihiro / Chino, Ayaka / Rakumitsu, Kenta

    Chemical & pharmaceutical bulletin

    2024  Volume 72, Issue 3, Page(s) 294–297

    Abstract: Aiming to synthesize a cyclic hexaamide, 4-bromo-3-(isobutylamino)benzoic acid was subjected to self-condensation reactions in the presence of either dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane or tetrachlorosilane in pyridine. However, ... ...

    Abstract Aiming to synthesize a cyclic hexaamide, 4-bromo-3-(isobutylamino)benzoic acid was subjected to self-condensation reactions in the presence of either dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane or tetrachlorosilane in pyridine. However, instead of the targeted cyclic hexaamide, the cyclic triamide and the cyclic tetraamide were obtained. The cyclic hexaamide was successfully synthesized via the self-condensation of the dimer, which was synthesized in five steps from 4-bromo-3-(isobutylamino)benzoic acid. A thorough screening of the self-condensation conditions was performed to improve the yield of the target macrocycle. In addition, the linear hexamer was synthesized by stepwise deprotection and condensation, and its cyclization afforded the cyclic hexaamide in good yield.
    MeSH term(s) Benzoic Acid ; Cyclization ; Amides/chemistry ; Benzoates/chemistry
    Chemical Substances Benzoic Acid (8SKN0B0MIM) ; Amides ; Benzoates
    Language English
    Publishing date 2024-03-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c24-00023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 770: Show issues Location:
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  2. Article ; Online: Optimal hyperparameters for random forest to predict leakage current alarm on premises

    Yokoyama Akihiro / Yamaguchi Nobuyuki

    E3S Web of Conferences, Vol 152, p

    2020  Volume 03003

    Abstract: While the number of private electrical facilities is increasing, there are not enough security personnel to perform the security work. In this paper, we propose a random forest model for predicting leakage current alarms in order to improve the ... ...

    Abstract While the number of private electrical facilities is increasing, there are not enough security personnel to perform the security work. In this paper, we propose a random forest model for predicting leakage current alarms in order to improve the efficiency of electrical safety operations. A random forest was created using periodic inspection data, alarm data, and meteorological data as explanatory variables, and generalization performance was evaluated by OOB-based F-measure. In order to obtain the highest performance, a grid search was performed to optimize the hyperparameters. As a result, it was possible to achieve alarm prediction with a certain level of performance. In addition, the optimal hyperparameters were found by grid search, and the F-measure was improved.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Comparison of Impressions of COVID-19 Vaccinations Stratified by the Number of Vaccinations Among Japanese Healthcare Professional University Students.

    Yokoyama, Akihiro / Suzuki, Hiromi / Kataoka, Hiroaki / Mori, Yoshiro / Watanabe, Yuji / Miyatake, Nobuyuki

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55861

    Abstract: Objective: Coronavirus infectious disease, that emerged in 2019 (COVID-19) has been a major public health issue not only in Japan, but also worldwide, and the implementation of a proper vaccination strategy has been important. To promote vaccination, ... ...

    Abstract Objective: Coronavirus infectious disease, that emerged in 2019 (COVID-19) has been a major public health issue not only in Japan, but also worldwide, and the implementation of a proper vaccination strategy has been important. To promote vaccination, the present study compared impressions of COVID-19 vaccinations stratified by the number of vaccinations among healthcare professional university students in Okayama, Japan, and suggests better vaccination strategies.
    Method: A total of 212 Japanese healthcare professional university students were enrolled in this clinical qualitative study using the text mining method. A self-reported questionnaire, including questions such as "What do you think about COVID-19 vaccinations?" was performed. We also examined the number of vaccinations, sex, history of COVID-19 infection, and daily mask use.
    Results: A total of 5,935 words were obtained and "Think" (169 times) was the most frequently used followed by "Inject" (108 times), "Inoculation" (97 times), "Vaccine" (83 times), "Corona" (66 times) and "Side effects" (49 times). Characteristic words were "Safety" in non-vaccinated subjects and "Side effects" and "Necessary" in vaccinated subjects. In addition, "Safety" in non-vaccinated men and "Frightening" in non-vaccinated women were characteristic and fundamental features.
    Conclusion: Impressions of COVID-19 vaccinations stratified by the number of vaccinations differed among healthcare professional university students. The provision of appropriate information on safety to non-vaccinated subjects and side effects to vaccinated subjects appears to be necessary. In addition, sex-specific information may be required for non-vaccinated subjects.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mucosa-associated lymphoid tissue lymphoma mimicking mucoid impaction.

    Kaji, Masanori / Mochimaru, Takao / Yokoyama, Akihiro / Oyamada, Yoshitaka

    Oxford medical case reports

    2022  Volume 2022, Issue 6, Page(s) omac065

    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omac065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Remimazolam and low-dose flumazenil for awake craniotomy.

    Murata, Hiroaki / Yokoyama, Akihiro / Hara, Tetsuya

    Journal of anesthesia

    2022  Volume 36, Issue 6, Page(s) 789–790

    MeSH term(s) Flumazenil/therapeutic use ; Wakefulness ; Benzodiazepines ; Craniotomy
    Chemical Substances Flumazenil (40P7XK9392) ; remimazolam (7V4A8U16MB) ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2022-09-12
    Publishing country Japan
    Document type Letter
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-022-03103-1
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  6. Article ; Online: Titration of flumazenil during awake craniotomy.

    Murata, Hiroaki / Yokoyama, Akihiro / Hara, Tetsuya

    Journal of anesthesia

    2022  Volume 37, Issue 1, Page(s) 166–167

    MeSH term(s) Humans ; Flumazenil ; Wakefulness ; Craniotomy ; Brain Neoplasms/surgery
    Chemical Substances Flumazenil (40P7XK9392)
    Language English
    Publishing date 2022-10-29
    Publishing country Japan
    Document type Letter
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-022-03128-6
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  7. Article: [Discordant lymphoma of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified in a human T-cell leukemia virus type-I carrier].

    Sumiya, Chieko / Kagoo, Toshiya / Yokoyama, Akihiro / Yano, Takahiro / Ueno, Hironori

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2021  Volume 62, Issue 9, Page(s) 1400–1405

    Abstract: A 69-year-old man was diagnosed with diffuse large B-cell lymphoma (DLBCL) negative for Epstein-Barr virus-encoded small nuclear RNA 1 (EBER-1) in October 2011, when he was also diagnosed as having a human T-cell leukemia virus type-I (HTLV-1) carrier. ... ...

    Abstract A 69-year-old man was diagnosed with diffuse large B-cell lymphoma (DLBCL) negative for Epstein-Barr virus-encoded small nuclear RNA 1 (EBER-1) in October 2011, when he was also diagnosed as having a human T-cell leukemia virus type-I (HTLV-1) carrier. He achieved complete response after six courses of R-CHOP therapy. In February 2015, the patient had high fever and markedly elevated serum lactate dehydrogenase (LDH) level. Bone marrow examination revealed infiltration of CD4-positive T-cell malignancy. Based on the tentative diagnosis of adult T-cell leukemia/lymphoma, modified LSG15 therapy was initiated. His symptoms and serum LDH level quickly improved after the start of treatment. During the treatment, HTLV-1 proviral DNA integration was reported negative, allowing his final diagnosis to be peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Despite discontinuation of chemotherapy in the middle of the second course due to the patient's preference, complete remission was reached. He remains in clinical remission at 28 months after the treatment discontinuation. Discordant lymphoma of DLBCL and PTCL-NOS in HTLV-1 carrier has not been well characterized and will be discussed with a literature review.
    MeSH term(s) Aged ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Human T-lymphotropic virus 1 ; Humans ; Leukemia, T-Cell ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, T-Cell, Peripheral/diagnosis ; Lymphoma, T-Cell, Peripheral/drug therapy ; Male
    Language Japanese
    Publishing date 2021-07-01
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.62.1400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 535: Show issues

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  8. Article ; Online: Synthesis, crystal structure, and properties of methyl-substituted coronene amide analogue.

    Rakumitsu, Kenta / Fujii, Miho / Kusumoto, Sotaro / Kikkawa, Shoko / Azumaya, Isao / Yokoyama, Akihiro

    RSC advances

    2022  Volume 12, Issue 40, Page(s) 26411–26417

    Abstract: A coronene amide analogue was synthesized in six steps using an improved method at the final biarylation step. The key to the progress of palladium-mediated biarylation involved the introduction of three methyl groups to suppress the undesired reaction ... ...

    Abstract A coronene amide analogue was synthesized in six steps using an improved method at the final biarylation step. The key to the progress of palladium-mediated biarylation involved the introduction of three methyl groups to suppress the undesired reaction and the use of tri-
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra04035b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Synthesis of a coronene analogue containing an amide bond by Pd-mediated intramolecular C[sbnd]C bond formation of 2-halogenated 4-(alkylamino)benzoic acid cyclic trimer

    Yokoyama, Akihiro / Ishii, Arisa / Ohishi, Tomoyuki / Kikkawa, Shoko / Azumaya, Isao

    Tetrahedron letters. 2021 Jan. 05, v. 62

    2021  

    Abstract: A coronene analogue containing amide linkage was synthesized from a halogenated cyclic triamide by palladium-mediated intramolecular CC bond formation. The cyclic triamide was formed from the condensation of 2-chloro-4-(isobutylamino)benzoic acid in the ... ...

    Abstract A coronene analogue containing amide linkage was synthesized from a halogenated cyclic triamide by palladium-mediated intramolecular CC bond formation. The cyclic triamide was formed from the condensation of 2-chloro-4-(isobutylamino)benzoic acid in the presence of dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane. By contrast, the condensation of 2-bromo counterpart required silicon tetrachloride in pyridine. The intramolecular CC bond formation, which yielded the target coronene analogue, occurred during the reaction of bromo-substituted cyclic triamide with palladium(II) acetate, triphenylphosphine, and potassium carbonate in N,N-dimethylformamide.
    Keywords acetates ; benzoic acid ; palladium ; potassium carbonate ; pyridines ; silicon ; synthesis
    Language English
    Dates of publication 2021-0105
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2020.152704
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  10. Article ; Online: Synthesis and characterization of cyclobutenedione-bithiophene π-conjugated polymers: acetal-protecting strategy for Kumada-Tamao-Corriu coupling polymerization between aryl bromide and Grignard reagents.

    Ohishi, Tomoyuki / Sone, Takuma / Oda, Kohei / Yokoyama, Akihiro

    RSC advances

    2019  Volume 9, Issue 70, Page(s) 40863–40872

    Abstract: Cyclobutenedione is an aromatic ring that exhibits strong electron-withdrawing properties but is susceptible to undesired reactions with nucleophiles. Herein, Kumada-Tamao-Corriu coupling polymerization of a cyclobutenedione monomer whose carbonyl groups ...

    Abstract Cyclobutenedione is an aromatic ring that exhibits strong electron-withdrawing properties but is susceptible to undesired reactions with nucleophiles. Herein, Kumada-Tamao-Corriu coupling polymerization of a cyclobutenedione monomer whose carbonyl groups are protected as acetals was achieved. Hydrolysis of the acetals afforded donor-acceptor type π-conjugated polymers consisting of cyclobutenedione as an acceptor unit and bithiophene as a donor unit. The acetal-protected monomer was also subjected to Suzuki-Miyaura coupling polymerization. The absorption and emission spectra of the deprotected polymers shifted to the longer wavelength compared with the acetal-protected polymers.
    Language English
    Publishing date 2019-12-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra08275a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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