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  1. Article: NK Cells and ILC1s in Cancer Biology.

    Sliz, Anna / Yokoyama, Wayne M

    Advances in experimental medicine and biology

    2022  Volume 1365, Page(s) 41–55

    Abstract: Natural killer (NK) cells are cytotoxic innate lymphocytes that can kill tumor cells. While a majority of the early studies on the role of NK cells in cancer focused on hematopoietic tumors, there has been a growing interest in the role of NK cells in ... ...

    Abstract Natural killer (NK) cells are cytotoxic innate lymphocytes that can kill tumor cells. While a majority of the early studies on the role of NK cells in cancer focused on hematopoietic tumors, there has been a growing interest in the role of NK cells in solid tumors. NK cells are grouped with innate lymphoid cells (ILCs) that include ILC1, a closely related but distinct cell whose role in antitumor immunity is incompletely understood. In this review we focus primarily on the role of NK cells in solid tumors and review the limited data available on the role of ILC1s in cancer.
    MeSH term(s) Biology ; Humans ; Immunity, Innate ; Killer Cells, Natural ; Lymphocytes ; Neoplasms
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-16-8387-9_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fifty Years (Well, Almost!) in Immunology.

    Yokoyama, Wayne M

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 202, Issue 11, Page(s) 3115–3122

    MeSH term(s) Allergy and Immunology/history ; Biomedical Research ; Congresses as Topic ; Cytotoxicity, Immunologic ; History, 20th Century ; History, 21st Century ; Humans ; Information Dissemination ; Killer Cells, Natural/immunology ; Receptors, Natural Killer Cell/metabolism ; Serial Publications ; Societies, Scientific
    Chemical Substances Receptors, Natural Killer Cell
    Language English
    Publishing date 2019-05-18
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article ; Portrait ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1990007
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  3. Article ; Online: Emil R. Unanue (1934-2022).

    Yokoyama, Wayne M / Murphy, Kenneth M / Schreiber, Robert D / Colonna, Marco

    Immunity

    2023  Volume 56, Issue 2, Page(s) 225–226

    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.006
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  4. Article ; Online: Immunology Lessons from the SARS-CoV-2 Pandemic.

    Yokoyama, Wayne M / Hogquist, Kristin A / O'Shea, John J

    Annual review of immunology

    2021  Volume 39, Page(s) v–vii

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Disease Management ; Disease Susceptibility/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Pandemics ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Editorial ; Letter
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-iy-39-030121-100001
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  5. Article ; Online: Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis.

    Bigley, Tarin M / Yang, Liping / Kang, Liang-I / Saenz, Jose B / Victorino, Francisco / Yokoyama, Wayne M

    The Journal of experimental medicine

    2022  Volume 219, Issue 3

    Abstract: Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity ... ...

    Abstract Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity long after acute infection. Murine roseolovirus (MRV) is highly related to human roseoloviruses. Herein we show that neonatal MRV infection induced autoimmune gastritis (AIG) in adult mice in the absence of ongoing infection. MRV-induced AIG was dependent on replication during the neonatal period and was CD4+ T cell and IL-17 dependent. Moreover, neonatal MRV infection was associated with development of a wide array of autoantibodies in adult mice. Finally, neonatal MRV infection reduced medullary thymic epithelial cell numbers, thymic dendritic cell numbers, and thymic expression of AIRE and tissue-restricted antigens, in addition to increasing thymocyte apoptosis at the stage of negative selection. These findings strongly suggest that infection with a roseolovirus early in life results in disruption of central tolerance and development of autoimmune disease.
    MeSH term(s) Animals ; Autoimmune Diseases ; CD4-Positive T-Lymphocytes ; Central Tolerance ; Gastritis ; Mice ; Roseolovirus ; Thymus Gland
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20211403
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  6. Article ; Online: Reply to "Murine Roseolovirus, Historically Known as Murine Thymic Lymphotropic Virus".

    Patel, Swapneel J / Yokoyama, Wayne M

    Journal of virology

    2017  Volume 91, Issue 18

    MeSH term(s) Animals ; DNA Viruses ; Human T-lymphotropic virus 1 ; Humans ; Mice ; Roseolovirus
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00956-17
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  7. Article ; Online: CD8

    Patel, Swapneel J / Yokoyama, Wayne M

    Journal of immunology (Baltimore, Md. : 1950)

    2017  Volume 199, Issue 9, Page(s) 3212–3221

    Abstract: A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic ... ...

    Abstract A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Mice ; Mice, Knockout ; Roseolovirus/immunology ; Roseolovirus Infections/genetics ; Roseolovirus Infections/immunology ; Roseolovirus Infections/pathology ; Thymus Gland/immunology ; Thymus Gland/pathology
    Language English
    Publishing date 2017-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1700982
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  8. Article ; Online: Uterine Natural Killer Cells.

    Sojka, Dorothy K / Yang, Liping / Yokoyama, Wayne M

    Frontiers in immunology

    2019  Volume 10, Page(s) 960

    Abstract: Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK ( ... ...

    Abstract Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK (trNK) cells in many tissues that resemble group 1 ILCs (ILC1s). During pregnancy, NK cells are the most abundant lymphocytes in the uterus at the maternal-fetal interface and are involved in placental vascular remodeling. Prior studies suggested that these uterine NK (uNK) cells are mostly derived from circulating NK cells. However, the murine virgin uterus contains mostly trNK cells and it has been challenging to determine their contribution to uNK cells in pregnancy as well as other potential function(s) of uNK cells due to the dynamic microenvironment in the pregnant uterus. This review focuses on the origins and functions of the heterogeneous populations of uNK cells during the course of murine pregnancy.
    MeSH term(s) Animals ; Female ; Humans ; Killer Cells, Natural/immunology ; Mice ; Uterus/cytology ; Uterus/immunology
    Language English
    Publishing date 2019-05-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00960
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  9. Article ; Online: Uterine natural killer cells: To protect and to nurture.

    Sojka, Dorothy K / Yang, Liping / Yokoyama, Wayne M

    Birth defects research

    2018  Volume 110, Issue 20, Page(s) 1531–1538

    Abstract: During the course of pregnancy, the maternal-fetal interface is tightly regulated and undergoes dynamic changes that promote the successful development of the semi-allogeneic fetus. In response to embryo implantation, the uterus remodels with maternal ... ...

    Abstract During the course of pregnancy, the maternal-fetal interface is tightly regulated and undergoes dynamic changes that promote the successful development of the semi-allogeneic fetus. In response to embryo implantation, the uterus remodels with maternal immune cells occupying the maternal-fetal interface and uterine natural killer (uNK) cells becoming the most prominent leukocyte. Recently, uNK cells have been discovered to be heterogeneous, including conventional NK and tissue-resident NK cells. Here, we will review the recent advances in uNK cell biology and discuss their functional mechanisms which protect and nurture the growing fetus.
    MeSH term(s) Animals ; Female ; Fetal Development/immunology ; Fetus/immunology ; Humans ; Killer Cells, Natural/physiology ; Maternal-Fetal Exchange/physiology ; Pregnancy/immunology ; Uterus/immunology
    Language English
    Publishing date 2018-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2104792-3
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.1419
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  10. Article ; Online: Human NK cells confer protection against HIV-1 infection in humanized mice.

    Sungur, Can M / Wang, Qiankun / Ozantürk, Ayşe N / Gao, Hongbo / Schmitz, Aaron J / Cella, Marina / Yokoyama, Wayne M / Shan, Liang

    The Journal of clinical investigation

    2022  Volume 132, Issue 24

    Abstract: The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could be used to directly evaluate human NK cell responses during HIV-1 infection, improved functional development of human NK cells ... ...

    Abstract The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could be used to directly evaluate human NK cell responses during HIV-1 infection, improved functional development of human NK cells in these hosts is needed. Here, we report the humanized MISTRG-6-15 mouse model, in which NK cells were quick to expand and exhibit degranulation, cytotoxicity, and proinflammatory cytokine production in nonlymphoid organs upon HIV-1 infection but had reduced functionality in lymphoid organs. Although HIV-1 infection induced functional impairment of NK cells, antiretroviral therapy reinvigorated NK cells in response to HIV-1 rebound after analytic treatment interruption. Moreover, a broadly neutralizing antibody, PGT121, enhanced NK cell function in vivo, consistent with antibody-dependent cellular cytotoxicity. Monoclonal antibody depletion of NK cells resulted in higher viral loads in multiple nonlymphoid organs. Overall, our results in humanized MISTRG-6-15 mice demonstrated that NK cells provided direct anti-HIV-1 responses in vivo but were limited in their responses in lymphoid organs.
    MeSH term(s) Humans ; Mice ; Animals ; HIV Infections ; HIV-1 ; Antibody-Dependent Cell Cytotoxicity ; Viral Load ; Killer Cells, Natural
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI162694
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