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  1. Article ; Online: Quantifying the shear modulus of the adductor longus muscle during hip joint motion using shear wave elastography.

    Kato, Takuya / Taniguchi, Keigo / Kodesho, Taiki / Nakao, Gakuto / Yokoyama, Yu / Saito, Yuhei / Katayose, Masaki

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9510

    Abstract: The present study aims to assess the effect of the hip flexion angle on the shear modulus of the adductor longus (AL) muscle associated with passive hip abduction and rotation. Sixteen men participated in the study. For the hip abduction task, the hip ... ...

    Abstract The present study aims to assess the effect of the hip flexion angle on the shear modulus of the adductor longus (AL) muscle associated with passive hip abduction and rotation. Sixteen men participated in the study. For the hip abduction task, the hip flexion angles used were - 20, 0, 20, 40, 60, and 80°, and the hip abduction angles were 0, 10, 20, 30, and 40°. For the hip rotation task, the hip flexion angles used were - 20, 0, 20, 40, 60, and 80°, hip abduction angles were 0 and 40°, and hip rotation angles were 20° internal rotation, 0° rotation, and 20° external rotation. The shear modulus at 20° extension was significantly higher than that at 80° flexion for the 10, 20, 30 and 40° hip abduction (i.e., P < 0.05). The shear modulus at 20° internal rotation and 20° extension was significantly higher than that at 0° rotation and 20° external rotation, regardless of the hip abduction angle (i.e., P < 0.05). The mechanical stress of the AL muscle associated with hip abduction was higher in the extended position. Furthermore, the mechanical stress could increase with internal rotation only at the hip-extended position.
    MeSH term(s) Male ; Animals ; Humans ; Elasticity Imaging Techniques ; Hip Joint ; Rotation ; Gastropoda ; Muscles
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36698-w
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  2. Article ; Online: DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway.

    Yoshida, Masaaki / Kokubun, Taiki / Sato, Kota / Tsuda, Satoru / Yokoyama, Yu / Himori, Noriko / Nakazawa, Toru

    Investigative ophthalmology & visual science

    2023  Volume 64, Issue 10, Page(s) 2

    Abstract: Purpose: This study investigated the effect of dipeptidyl peptidase-4 inhibitors (DPP-4is) on fibrosis after glaucoma filtering surgery with clinical data and an in vitro model that used transforming growth factor-β (TGF-β) to induce human Tenon's ... ...

    Abstract Purpose: This study investigated the effect of dipeptidyl peptidase-4 inhibitors (DPP-4is) on fibrosis after glaucoma filtering surgery with clinical data and an in vitro model that used transforming growth factor-β (TGF-β) to induce human Tenon's fibroblast (HTF) fibrosis.
    Methods: The medical records of 41 eyes of 35 patients with diabetes with neovascular glaucoma (NVG) who received initial trabeculectomy were retrospectively reviewed. The surgical success rate was compared between cases that received (n = 23) and did not receive (n = 18) DPP-4i treatment for diabetes. The antifibrotic effects of linagliptin (a DPP-4i) were evaluated with quantitative real-time PCR for fibrosis markers (α-smooth muscle actin, collagen Iα, and fibronectin), a scratch assay, and a collagen gel contraction assay of primary cultured HTFs treated with TGF-β1 and linagliptin. Western blotting analysis was performed to evaluate the levels of phosphorylated Smad2 and Smad3 in the presence of linagliptin.
    Results: The Kaplan-Meier curve for bleb survival was higher in patients who received DPP-4is (P = 0.017, log-rank test). The in vitro experiments demonstrated that treatment with linagliptin attenuated the elevated levels of fibrosis markers induced by TGF-β1 in HTFs. Linagliptin treatment also prevented the migration and gel contraction of HTFs. Linagliptin inhibited the phosphorylation of Smad2 and Smad3, which is the canonical pathway of TGF-β signaling.
    Conclusions: The current study indicates the potential effect of DPP-4is for maintaining bleb function after glaucoma filtering surgery in patients with diabetes with NVG. Our results demonstrate that linagliptin attenuates fibrotic change in HTFs by inhibiting TGF-β/Smad signaling.
    MeSH term(s) Humans ; Transforming Growth Factor beta1/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Linagliptin/pharmacology ; Linagliptin/therapeutic use ; Linagliptin/metabolism ; Retrospective Studies ; Glaucoma/drug therapy ; Glaucoma/surgery ; Glaucoma/metabolism ; Fibrosis ; Fibroblasts/metabolism ; Trabeculectomy ; Transforming Growth Factor beta/metabolism ; Signal Transduction ; Collagen/metabolism ; Cells, Cultured
    Chemical Substances Transforming Growth Factor beta1 ; Dipeptidyl-Peptidase IV Inhibitors ; Linagliptin (3X29ZEJ4R2) ; Transforming Growth Factor beta ; Collagen (9007-34-5)
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.64.10.2
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  3. Article ; Online: The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study.

    Kiyota, Naoki / Shiga, Yukihiro / Ninomiya, Takahiro / Tsuda, Satoru / Omodaka, Kazuko / Himori, Noriko / Yokoyama, Yu / Pak, Kyongsun / Nakazawa, Toru

    Advances in therapy

    2024  Volume 41, Issue 2, Page(s) 730–743

    Abstract: Introduction: Our study was conducted to determine factors associated with the effectiveness of a β-blocker eye drop add-on in altering pulse rate (PR) in glaucoma patients.: Methods: This retrospective study examined 236 eyes of 138 patients who ... ...

    Abstract Introduction: Our study was conducted to determine factors associated with the effectiveness of a β-blocker eye drop add-on in altering pulse rate (PR) in glaucoma patients.
    Methods: This retrospective study examined 236 eyes of 138 patients who received a β-blocker eye drop add-on during follow-up. Patients were included if at least one PR measurement was available both before and after the add-on was started. We collected data on ophthalmic parameters: longitudinal PR; longitudinal choroidal blood flow, represented by laser speckle flowgraphy-measured mean blur rate (MBR); and diacron-reactive oxygen metabolites (d-ROMs). We used a multivariable linear mixed-effects model to investigate the effectiveness of the β-blocker eye drop add-on in altering PR and examined factors contributing to a larger PR alteration after the add-on was started by analyzing the effect on PR of the interaction term between the add-on and clinical factors. We used the k-means method to classify the patients.
    Results: The β-blocker eye drop add-on reduced PR (- 7.61 bpm, P < 0.001). Female gender, higher PR when the add-on was started, lower central corneal thickness, and a higher d-ROM level were associated with greater reduction in PR (P < 0.05). In a cluster of patients with these clinical features, choroidal MBR increased by + 3.42% when we adjusted for change over time; MD slope, which represents the speed of glaucoma progression, improved by + 0.64 dB/year (P < 0.05).
    Conclusions: We identified a glaucoma subgroup in which PR decreased, choroidal blood flow increased, and glaucoma progression slowed after a β-blocker eye drop add-on was started.
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Heart Rate ; Longitudinal Studies ; Ophthalmic Solutions/therapeutic use ; Intraocular Pressure ; Glaucoma/drug therapy ; Adrenergic beta-Antagonists/therapeutic use
    Chemical Substances Ophthalmic Solutions ; Adrenergic beta-Antagonists
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02762-0
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  4. Article ; Online: Correction: Relationship between shear elastic modulus and passive muscle force in human hamstring muscles using a Thiel soft-embalmed cadaver.

    Nakao, Gakuto / Kodesho, Taiki / Kato, Takuya / Yokoyama, Yu / Saito, Yuhei / Ohsaki, Yuki / Watanabe, Kota / Katayose, Masaki / Taniguchi, Keigo

    Journal of medical ultrasonics (2001)

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01436-w
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  5. Article ; Online: Sector-specific Association of Intraocular Pressure Dynamics in Dark-room Prone Testing and Visual Field Defect Progression in Glaucoma.

    Sato, Masataka / Kiyota, Naoki / Yabana, Takeshi / Maekawa, Shigeto / Tsuda, Satoru / Omodaka, Kazuko / Himori, Noriko / Yokoyama, Yu / Nakazawa, Toru

    Ophthalmology. Glaucoma

    2024  

    Abstract: Purpose: To investigate sectoral differences in the relationship between intraocular pressure (IOP) dynamics during dark-room prone testing (DRPT) and visual field (VF) defect progression in primary open-angle glaucoma (POAG) patients.: Design: ... ...

    Abstract Purpose: To investigate sectoral differences in the relationship between intraocular pressure (IOP) dynamics during dark-room prone testing (DRPT) and visual field (VF) defect progression in primary open-angle glaucoma (POAG) patients.
    Design: Retrospective, longitudinal study.
    Participants: This retrospective study included 116 eyes of 84 POAG patients who underwent DRPT and had at least 5 reliable VF tests conducted over a more than 2-year follow-up period. We excluded eyes with mean deviation worse than -20 dB or a history of intraocular surgery or laser treatment.
    Methods: Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 or 30-2 program. During DRPT, IOP was measured in the sitting position, and after 60 minutes in the prone position in a dark room, IOP was measured again. The relationship between IOP change during DRPT, IOP after DRPT, and TD slope in each quadrant was analyzed with a linear mixed-effects model, adjusting for other potential confounding factors.
    Main outcome measures: Total deviation slope in each quadrant, IOP change during DRPT, and IOP after DRPT.
    Results: Intraocular pressure after DRPT and IOP change during DRPT were 18.16 ± 3.42 mmHg and 4.92 ± 3.12 mmHg, respectively. Superior TD slope was significantly associated with both IOP after DRPT (β = -0.28, P = 0.003) and IOP change during DRPT (β = -0.21, P = 0.029), while central (β = -0.05, P = 0.595; β = -0.05; P = 0.622) and inferior (β = 0.05, P = 0.611; β = 0.01, P = 0.938) TD slopes were not.
    Conclusion: Dark-room prone testing might be a useful test to predict the risk of superior VF defect progression in eyes with POAG.
    Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2589-4196
    ISSN (online) 2589-4196
    DOI 10.1016/j.ogla.2024.03.007
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  6. Article ; Online: Effect of chest mobilization on intercostal muscle stiffness.

    Yokoyama, Yu / Kodesho, Taiki / Kato, Takuya / Nakao, Gakuto / Saito, Yuhei / Taniguchi, Keigo

    Current research in physiology

    2022  Volume 5, Page(s) 429–435

    Abstract: This study examined the effect of chest mobilization on intercostal (IC) muscle stiffness using the IC muscle shear modulus. Sixteen healthy young men participated on two days with a minimum of 24 h between the stretching and control conditions (SC and ... ...

    Abstract This study examined the effect of chest mobilization on intercostal (IC) muscle stiffness using the IC muscle shear modulus. Sixteen healthy young men participated on two days with a minimum of 24 h between the stretching and control conditions (SC and CC). The tasks were resting breathing and deep breathing. The IC muscle shear modulus and muscle activity and rib cage circumference were measured before and after each condition. In the SC, IC stretching was performed for 1 min x 5 sets. In the CC, resting breathing, in a sitting position, was performed for 5 min. In the SC, the IC muscle shear modulus decreased significantly (p < 0.05) at maximum inspiration in the deep breathing task, but there was no significant difference in the CC pre- and post-intervention. The results suggest that IC muscle stretching decreases IC muscle stiffness and improves muscle flexibility and that the IC muscle shear modulus may measure the effectiveness of chest mobilization.
    Language English
    Publishing date 2022-10-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9441
    ISSN (online) 2665-9441
    DOI 10.1016/j.crphys.2022.10.002
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  7. Article ; Online: Adductor longus: An anatomical study to better understand groin pain.

    Kato, Takuya / Taniguchi, Keigo / Kodesho, Taiki / Nakao, Gakuto / Yokoyama, Yu / Saito, Yuhei / Katayose, Masaki

    Clinical anatomy (New York, N.Y.)

    2022  Volume 35, Issue 7, Page(s) 867–872

    Abstract: We investigated the shear modulus-passive force relationship in the hip adductor longus (AL) muscles of human cadavers and explored the effect of muscle architecture on the elastic properties of the AL muscle using shear wave elastography (SWE). Nine AL ... ...

    Abstract We investigated the shear modulus-passive force relationship in the hip adductor longus (AL) muscles of human cadavers and explored the effect of muscle architecture on the elastic properties of the AL muscle using shear wave elastography (SWE). Nine AL muscles were harvested from a soft, embalmed cadaver. The AL muscles were affixed to a custom-built device comprising two clamps, a pulley, and a cable to provide passive loads, which were increased from 0 to 600 g in 60-g increments. The shear modulus of the AL muscle was measured in the proximal (Pro), middle (Mid), and distal (Dis) regions. The masses and anatomical cross-sectional areas (ACSAs) of the AL muscles were measured. The shear modulus-passive load relationship of each tested muscle region was analyzed by fitting a least-squares regression line. Moreover, the rate of increase in the shear modulus per unit load (s) was calculated. The shear modulus and passive force were linearly correlated for all AL muscles in each region (p < 0.01). The mean coefficients of determination (R
    MeSH term(s) Elastic Modulus ; Elasticity Imaging Techniques ; Groin/diagnostic imaging ; Humans ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiology ; Pain
    Language English
    Publishing date 2022-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.23881
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  8. Article ; Online: Predictive potential of optical coherence tomography parameters for the prognosis of decreased visual acuity after trabeculectomy in open-angle glaucoma patients with good vision.

    Takeda, Yoko / Takahashi, Naoki / Kiyota, Naoki / Kokubun, Taiki / Tsuda, Satoru / Omodaka, Kazuko / Yokoyama, Yu / Nakazawa, Toru

    BMC ophthalmology

    2023  Volume 23, Issue 1, Page(s) 399

    Abstract: Background: Trabeculectomy (trab) is the most effective surgical procedure for lowering IOP and preventing glaucoma progression. However, decline in best-corrected visual acuity (BCVA) is one of the most serious postoperative complications of trab. Here, ...

    Abstract Background: Trabeculectomy (trab) is the most effective surgical procedure for lowering IOP and preventing glaucoma progression. However, decline in best-corrected visual acuity (BCVA) is one of the most serious postoperative complications of trab. Here, we investigated methods to predict decreased BCVA after trab in glaucoma patients with good preoperative BCVA.
    Methods: This study included 35 eyes of 35 open-angle glaucoma (OAG) patients (male / female: 21 / 14, age: 64.0 ± 9.7 years old, preoperative intraocular pressure: 15.9 ± 5.4 mmHg, mean deviation: -18.1 ± 5.6 dB) with preoperative BCVA of 0.7 or better who underwent trab and were observed for more than 12 months. As a preoperative analysis, we measured temporal quadrant circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and ganglion cell complex thickness in a central strip between the disc and fovea (csGCCT), an area that corresponds to the location of the papillomacular bundle (PMB) in swept-source optical coherence tomography (OCT). We defined BCVA decline as a loss of more than 3 lines of BCVA after 12 months. Measurement parameters were compared between the BCVA-decline group and the non-BCVA-decline group.
    Results: BCVA decline was detected in 11 cases (31.4%) 12 months after trab. There was a statistically significant difference in axial length (P = 0.049). A single logistic analysis showed that the BCVA-decline group had significantly lower cpRNFLT than the non-BCVA-decline group (27.7 ± 8.0 μm vs. 45.1 ± 5.3 μm, P < 0.001, cut-off value: 33.4 μm), as well as lower csGCCT (72.4 ± 7.7 μm vs. 87.5 ± 5.1 μm, P = 0.002, cut-off value: 82.3 μm). Multivariable logistic analysis showed that the BCVA-decline group had significantly lower temporal quadrant cpRNFLT (P < 0.001) and lower middle csGCCT (P < 0.001) compared to the non-BCVA-decline group.
    Conclusions: Lower temporal quadrant cpRNFLT and middle csGCCT, OCT scan areas that correspond to the location of the PMB, might be biomarkers that predict BCVA decline after trab in OAG patients with good vision.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Aged ; Glaucoma, Open-Angle/surgery ; Trabeculectomy ; Tomography, Optical Coherence/methods ; Glaucoma/surgery ; Intraocular Pressure ; Visual Acuity ; Prognosis
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-023-03145-3
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  9. Article ; Online: Effects of superficial tissue and intermuscular connections on rectus femoris muscle shear modulus heterogeneity.

    Kodesho, Taiki / Kato, Takuya / Nakao, Gakuto / Yokoyama, Yu / Saito, Yuhei / Watanabe, Kota / Ohsaki, Yuki / Katayose, Masaki / Taniguchi, Keigo

    Journal of ultrasound

    2023  

    Abstract: Introduction: Intramuscular heterogeneity exists in the shear modulus of the rectus femoris (RF) muscle. However, the underlying heterogeneity mechanisms are not entirely understood. Previous research has reported that detachment of superficial tissues ... ...

    Abstract Introduction: Intramuscular heterogeneity exists in the shear modulus of the rectus femoris (RF) muscle. However, the underlying heterogeneity mechanisms are not entirely understood. Previous research has reported that detachment of superficial tissues reduces the shear modulus by 50%. The aim of this study was to examine the effects of the skin, deep fascia, and intermuscular connections on the shear modulus of the RF at multiple sites.
    Materials and methods: Eleven donors were fixed using the Thiel method. Measurements were performed at 0°, 60°, and 120° knee flexion in a neutral hip position. Tissue processing was performed under four conditions: superficial tissue (CONT), skin off (SKIN), deep fascia detachment (FASC), and intermuscular connections detachment (ALL). The shear modulus at the proximal, central, and distal regions were measured using ultrasound shear wave elastography. The study was approved by the Sapporo Medical University Ethical Committee.
    Results: Three-way ANOVA revealed no significant interaction between treatment, site, and angle (P = 0.156), treatment and angle (P = 0.067), or site and angle (P = 0.441). There was a significant effect of treatment (P < 0.001), site (P = 0.010), and angle (P < 0.001) and interaction between treatment and site (P < 0.001). The proximal shear modulus was greater than the central for CONT. There were no significant differences between the measurement sites for SKIN. The distal shear modulus was greater than the proximal for FASC. The distal shear modulus was also greater than the proximal and central for ALL.
    Conclusions: Intramuscular regional differences that influence superficial tissue and intermuscular connections of RF elasticity heterogeneity were observed.
    Language English
    Publishing date 2023-02-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-022-00769-x
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  10. Article ; Online: The association between intraocular pressure dynamics during dark-room prone testing and intraocular pressure over a relatively long-term follow-up period in primary open-glaucoma patients.

    Sato, Masataka / Kiyota, Naoki / Yabana, Takeshi / Maekawa, Shigeto / Tsuda, Satoru / Omodaka, Kazuko / Himori, Noriko / Yokoyama, Yu / Nakazawa, Toru

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2023  Volume 262, Issue 3, Page(s) 949–956

    Abstract: Purpose: To investigate the relationship between the dynamics of intraocular pressure (IOP) during dark-room prone testing (DRPT) and IOP over a relatively long-term follow-up period.: Methods: This retrospective study enrolled 84 eyes of 51 primary ... ...

    Abstract Purpose: To investigate the relationship between the dynamics of intraocular pressure (IOP) during dark-room prone testing (DRPT) and IOP over a relatively long-term follow-up period.
    Methods: This retrospective study enrolled 84 eyes of 51 primary open-angle glaucoma patients who underwent DRPT for whom at least three IOP measurements made using Goldmann applanation tonometry were available over a maximum follow-up period of two years. We excluded eyes with a history of intraocular surgery or laser treatment and those with changes in topical anti-glaucoma medication during the follow-up period. In DRPT, IOP was measured in the sitting position, and after 60 min in the prone position in a dark room, IOP was measured again. In this study, IOP fluctuation refers to the standard deviation (SD) of IOP, and IOP max indicates the maximum value of IOP during the follow-up. The relationship between these parameters was analyzed with a linear mixed-effects model, adjusting for clinical parameters including age, gender, and axial length.
    Results: IOP increased after DRPT with a mean of 6.13 ± 3.55 mmHg. IOP max was significantly associated with IOP after DRPT (β = 0.38; p < 0.001). IOP fluctuation was significantly associated with IOP change in DRPT (β = 0.29; p = 0.007).
    Conclusion: Our findings suggest that short-term and relatively long-term IOP dynamics are associated. Long-term IOP dynamics can be predicted by DRPT to some extent.
    MeSH term(s) Humans ; Intraocular Pressure ; Follow-Up Studies ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/surgery ; Retrospective Studies ; Glaucoma
    Language English
    Publishing date 2023-10-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06257-0
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