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  1. Article ; Online: Role of surgery in neuroblastoma.

    Yoneda, Akihiro

    Pediatric surgery international

    2023  Volume 39, Issue 1, Page(s) 177

    Abstract: Neuroblastoma is the most common malignant solid tumor handled by pediatric surgeons. It is well-known that neuroblastoma shows variable biological and clinical behaviors. In this review article, surgical strategy in neuroblastoma was described by risk ... ...

    Abstract Neuroblastoma is the most common malignant solid tumor handled by pediatric surgeons. It is well-known that neuroblastoma shows variable biological and clinical behaviors. In this review article, surgical strategy in neuroblastoma was described by risk stratification. Also, strategy of biopsy and clinical conditions that require special considerations such as neuroblastoma detected by mass screening, relapsed neuroblastoma, patients with stage MS and dumbbell type tumors was mentioned. As multimodal systemic treatments have been expanding, the role of surgery in neuroblastoma has become relatively less significant but requisite. We surgeons should decide therapeutic strategy based on the correct understanding of biology of neuroblastoma thinking of the better future of children.
    MeSH term(s) Child ; Humans ; Neoplasm Recurrence, Local ; Neuroblastoma/pathology ; Biopsy
    Language English
    Publishing date 2023-04-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-023-05459-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2138: Show issues Location:
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  2. Article ; Online: Comparison of Postoperative Respiratory Function Between Patients After Thoracoscopic and Open Lobectomy.

    Ishimaru, Tetsuya / Kanamori, Yutaka / Fujino, Akihiro / Yoneda, Akihiro / Fujiogi, Michimasa / Yamamoto, Yuki / Kano, Motohiro / Koinuma, Goro / Deie, Kyoichi / Kawashima, Hiroshi

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2024  Volume 34, Issue 4, Page(s) 376–379

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Infant ; Child ; Lung/surgery ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Retrospective Studies ; Forced Expiratory Volume ; Vital Capacity ; Thoracotomy/adverse effects ; Thoracotomy/methods ; Lung Neoplasms/surgery ; Treatment Outcome ; Thoracic Surgery, Video-Assisted
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0244
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3246: Show issues Location:
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  3. Article ; Online: Heat shock protein 47 confers chemoresistance on pancreatic cancer cells by interacting with calreticulin and IRE1α.

    Yoneda, Akihiro / Minomi, Kenjiro / Tamura, Yasuaki

    Cancer science

    2021  Volume 112, Issue 7, Page(s) 2803–2820

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemoresistant cancers. An understanding of the molecular mechanism by which PDAC cells have a high chemoresistant potential is important for improvement of the poor prognosis of patients with ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemoresistant cancers. An understanding of the molecular mechanism by which PDAC cells have a high chemoresistant potential is important for improvement of the poor prognosis of patients with PDAC. Here we show for the first time that disruption of heat shock protein 47 (HSP47) enhances the efficacy of the therapeutic agent gemcitabine for PDAC cells and that the efficacy is suppressed by reconstituting HSP47 expression. HSP47 interacts with calreticulin (CALR) and the unfolded protein response transducer IRE1α in PDAC cells. Ablation of HSP47 promotes both the interaction of CALR with sarcoplasmic/endoplasmic reticulum Ca
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/therapeutic use ; Calcium/metabolism ; Calreticulin/metabolism ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Caspases/metabolism ; Cell Line, Tumor ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Drug Resistance, Neoplasm ; Endoribonucleases/metabolism ; Gene Knockout Techniques ; Gene Silencing ; HSP47 Heat-Shock Proteins/genetics ; HSP47 Heat-Shock Proteins/metabolism ; Heterografts ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mice ; NADPH Oxidases/metabolism ; Neoplasm Transplantation ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Unfolded Protein Response ; Gemcitabine
    Chemical Substances Antimetabolites, Antineoplastic ; Calreticulin ; HSP47 Heat-Shock Proteins ; Inositol 1,4,5-Trisphosphate Receptors ; Reactive Oxygen Species ; Deoxycytidine (0W860991D6) ; NADPH Oxidases (EC 1.6.3.-) ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-) ; Caspases (EC 3.4.22.-) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Calcium (SY7Q814VUP) ; Gemcitabine
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.14976
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  4. Article: Outcomes of nonrejection in weakly fluorescent intestine detected by indocyanine green fluorescence angiography: a case series of infants.

    Hashizume, Naoki / Yoneda, Akihiro / Ozeki, Genta / Saito, Takeshi / Fujiogi, Michimasa / Kano, Motohiro / Yamamoto, Yuki / Ishimaru, Tetsuya / Kanamori, Yutaka / Fujino, Akihiro

    Surgical case reports

    2024  Volume 10, Issue 1, Page(s) 97

    Abstract: Background: Indocyanine green fluorescence angiography, a validated noninvasive imaging technique, is used to assess tissue vascularization. Here, we report three infant patients who underwent intraoperative indocyanine green fluorescence angiography ... ...

    Abstract Background: Indocyanine green fluorescence angiography, a validated noninvasive imaging technique, is used to assess tissue vascularization. Here, we report three infant patients who underwent intraoperative indocyanine green fluorescence angiography and suffered from postoperative complications caused by the lack of weak fluorescent intestinal resection and assessed residual intestinal perfusion.
    Case presentation: We observed the clinical characteristics and operative findings of patients treated from January 2022 to December 2022. Indocyanine green (0.5 mg/kg) was intravenously injected. The first patient was a 29-day-old girl with surgical necrotizing enterocolitis who underwent intraoperative indocyanine green fluorescence angiography at the first- and second-look operations. The proximal jejunum was difficult to diagnose to detect blood flow during the second-look operation. The second patient was a 32-day-old boy with surgical necrotizing enterocolitis. A part of the antimesenteric mucosa of the patient that exhibited weak fluorescence was preserved; however, it formed postoperative hematomas. The third patient was a 30-day-old boy with midgut volvulus. Weak fluorescence in the intestinal wall was observed 5 cm of the small intestine from the ileocecal valve was preserved, but it formed a stricture, and the patient underwent ileocecal resection after 30 days.
    Conclusions: Weak fluorescence in the intestine in infants by performing indocyanine green fluorescence angiography is associated with a high risk of non-recovering ischemic lesions and postoperative complications.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-024-01885-y
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  5. Article ; Online: Inclusion of thymic Langerhans cell histiocytosis in the "5 Ts" of the differential diagnosis of anterior mediastinal mass.

    Sakamoto, Kenichi / Fujimori, Kentaro / Miyazaki, Osamu / Yoshioka, Takako / Yoneda, Akihiro / Matsumoto, Kimikazu / Shioda, Yoko

    International journal of hematology

    2023  Volume 117, Issue 3, Page(s) 311–313

    MeSH term(s) Humans ; Diagnosis, Differential ; Thymus Gland ; Histiocytosis, Langerhans-Cell/diagnosis
    Language English
    Publishing date 2023-02-04
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-023-03554-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 269: Show issues Location:
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  6. Article: Liver resection for a congenital intrahepatic portosystemic shunt in a child with hyperammonemia and hypermanganesemia: a case report.

    Takama, Yuichi / Nakamura, Tetsuro / Santo, Kenji / Yoneda, Akihiro

    Surgical case reports

    2020  Volume 6, Issue 1, Page(s) 73

    Abstract: Background: Congenital portosystemic shunt (CPSS) is a rare malformation that leads to hyperammonemia, hypermanganesemia, and various symptoms. CPSSs are divided into intrahepatic and extrahepatic shunts. In patients with persistent CPSS including an ... ...

    Abstract Background: Congenital portosystemic shunt (CPSS) is a rare malformation that leads to hyperammonemia, hypermanganesemia, and various symptoms. CPSSs are divided into intrahepatic and extrahepatic shunts. In patients with persistent CPSS including an intrahepatic portosystemic shunt (IPSS), early intervention to occlude the shunt reverses the associated complications.
    Case presentation: The patient was a 1-year-and-7-month-old girl. She presented with hypergalactosemia and elevation of blood ammonia level (75 μg/dL) and total bile acid levels (68.2 μmol/L) during the neonatal period. Two IPSSs were detected using ultrasound and enhanced computerized tomography. Magnetic resonance imaging (MRI) at 1 year and 3 months of age showed abnormally high signal intensity in the pallidum of her brain. Spontaneous closure was not observed. We performed a right hepatectomy at 1 year and 7 months of age. The portal vein pressure was 16 mmHg after temporary occlusion of the right portal vein. Blood ammonia and serum manganese levels decreased immediately after the operation. The abnormal signal on brain MRI disappeared. She had a favorable course with no sign of recurrence of IPSS 5 years postoperatively.
    Conclusion: Liver resection for an IPSS to control the symptoms of a portosystemic shunt is reasonable in a child for whom interventional radiological treatment is not indicated.
    Language English
    Publishing date 2020-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-020-00838-5
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  7. Article ; Online: HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α.

    Yoneda, Akihiro / Minomi, Kenjiro / Tamura, Yasuaki

    Oncogene

    2020  Volume 39, Issue 23, Page(s) 4519–4537

    Abstract: Breast cancer (BC) is an aggressive cancer that is a leading cause of cancer-associated death in women worldwide. Although increased expression of heat shock protein 47 (HSP47), a collagen-specific chaperone, is associated with the high malignancy of BC, ...

    Abstract Breast cancer (BC) is an aggressive cancer that is a leading cause of cancer-associated death in women worldwide. Although increased expression of heat shock protein 47 (HSP47), a collagen-specific chaperone, is associated with the high malignancy of BC, its role in BC remains largely unclear. Here we show that a small population of high-invasive BC cells expresses HSP47 and that HSP47-positive high-invasive BC cells have a high metastatic potential that is completely abolished by disruption of HSP47. HSP47 interacts with non-muscle myosin IIA (NMIIA) via the unfolded protein response transducer IRE1α, resulting in enhancement of the metastatic potential of high-invasive BC cells by augmenting the contractile force of actin filaments. Ablation of NMIIA abrogates the metastatic potential of HSP47-positive high-invasive BC cells. We further show that forced expression of NMIIA confers a high metastatic potential on low-invasive BC cells in which HSP47 but not NMIIA is expressed. Overall, our study indicates that HSP47 acts as a stimulator for metastasis of BC cells and suggest that HSP47 may be a candidate for a therapeutic target against BC.
    MeSH term(s) Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Endoribonucleases/metabolism ; Extracellular Matrix/metabolism ; Female ; HSP47 Heat-Shock Proteins/genetics ; HSP47 Heat-Shock Proteins/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Metastasis/pathology ; Nonmuscle Myosin Type IIA/genetics ; Nonmuscle Myosin Type IIA/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Signal Transduction ; Tumor Microenvironment/physiology ; Unfolded Protein Response/physiology
    Chemical Substances HSP47 Heat-Shock Proteins ; RNA, Small Interfering ; SERPINH1 protein, human ; ERN1 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-) ; Nonmuscle Myosin Type IIA (EC 3.6.1.-)
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-020-1311-7
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    Zs.A 2218: Show issues Location:
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  8. Article ; Online: Uncapsulized sacrococcygeal teratoma in a neonate.

    Nakamura, Kyoko / Yamada, Hiroto / Kamiyama, Masafumi / Inoue, Takeshi / Yoneda, Akihiro

    Pediatrics international : official journal of the Japan Pediatric Society

    2021  Volume 63, Issue 10, Page(s) 1266–1267

    MeSH term(s) Humans ; Infant, Newborn ; Pelvic Neoplasms ; Sacrococcygeal Region ; Spinal Neoplasms ; Teratoma/diagnosis ; Teratoma/surgery
    Language English
    Publishing date 2021-10-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.14689
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    Zs.A 848: Show issues Location:
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  9. Article: Factors Associated With Adverse Outcomes Following Duodenal Atresia Surgery in Neonates: A Retrospective Study.

    Deguchi, Koichi / Tazuke, Yuko / Matsuura, Rei / Nomura, Motonari / Yamanaka, Hiroaki / Soh, Hideki / Yoneda, Akihiro

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22349

    Abstract: Objectives There is limited evidence on the infants' postoperative complications who have undergone surgical repair of duodenal atresia and stenosis. This study aimed to identify the factors associated with poor surgical outcomes after the initial repair. ...

    Abstract Objectives There is limited evidence on the infants' postoperative complications who have undergone surgical repair of duodenal atresia and stenosis. This study aimed to identify the factors associated with poor surgical outcomes after the initial repair. Methods We retrospectively reviewed the data of 82 patients who underwent surgery for duodenal atresia and stenosis between January 1994 and December 2013 at our institution. Gestational age, birth weight, fetal growth, and other associated anomalies were recorded. Multivariate regression analyses were used to identify the factors associated with surgical outcomes, including postoperative complications and time to full oral intake. Results The median gestational age was 37.6 weeks, with 30 (37%) preterm (<37 weeks) and 11 (13%) early preterm (<34 weeks) infants. The median birth weight was 2531 g, with 27 (33%) patients < 2000 g and 10 (12%) patients < 1500 g. Postoperative surgical complications were identified in 18 (22%) cases, of which 12 (15%) required additional operations. Multivariate regression analysis revealed that a combination of very low birth weight (<1500 g) and early preterm was significantly associated with both surgical and non-surgical postoperative complications (p = 0.0028 and 0.021, respectively) and a prolonged time to full oral intake postoperatively (p = 0.013). Conclusion Very low birth weight and early preterm were significantly associated with postoperative complications and a prolonged time to full oral intake.
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22349
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  10. Article ; Online: A case of enormous congenital cervicofacial immature teratoma.

    Hashizume, Naoki / Yoneda, Akihiro / Kano, Motohiro / Yoshii, Saori / Uehara, Yohji / Fujino, Akihiro / Kanamori, Yutaka

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15394

    MeSH term(s) Humans ; Teratoma/diagnosis ; Teratoma/surgery
    Language English
    Publishing date 2022-10-22
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15394
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