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Article ; Online: Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control

Byongsun Lee / Seungjae Lee / Younggwang Lee / Yongjin Park / Jaekyung Shim

International Journal of Molecular Sciences, Vol 22, Iss 6669, p

2021 Volume 6669

Abstract: Emerin is the inner nuclear membrane protein involved in maintaining the mechanical integrity of the nuclear membrane. Mutations in EMD encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Evidence is accumulating that emerin regulation of ... ...

Abstract	Emerin is the inner nuclear membrane protein involved in maintaining the mechanical integrity of the nuclear membrane. Mutations in EMD encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Evidence is accumulating that emerin regulation of specific gene expression is associated with this disease, but the exact function of emerin has not been fully elucidated. Here, we show that emerin downregulates Signal transducer and activators of transcription 3 (STAT3) signaling, activated exclusively by Janus kinase (JAK). Deletion mutation experiments show that the lamin-binding domain of emerin is essential for the inhibition of STAT3 signaling. Emerin interacts directly and co-localizes with STAT3 in the nuclear membrane. Emerin knockdown induces STAT3 target genes Bcl2 and Survivin to increase cell survival signals and suppress hydrogen peroxide-induced cell death in HeLa cells. Specifically, downregulation of BAF or lamin A/C increases STAT3 signaling, suggesting that correct-localized emerin, by assembling with BAF and lamin A/C, acts as an intrinsic inhibitor against STAT3 signaling. In C2C12 cells, emerin knockdown induces STAT3 target gene, Pax7, and activated abnormal myoblast proliferation associated with muscle wasting in skeletal muscle homeostasis. Our results indicate that emerin downregulates STAT3 signaling by inducing retention of STAT3 and delaying STAT3 signaling in the nuclear membrane. This mechanism provides clues to the etiology of emerin-related muscular dystrophy and may be a new therapeutic target for treatment.
Keywords	JAK ; STAT3 ; emerin ; muscular dystrophy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heteroleptic Ir(III)-based near-infrared organic light-emitting diodes with high radiance capacity

Yongjin Park / Gyeong Seok Lee / Woochan Lee / Seunghyup Yoo / Yun-Hi Kim / Kyung-Cheol Choi

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract Near-infrared organic light-emitting diodes (NIR OLEDs) with heavy metals are regularly reported due to the advantages of their various applications in healthcare services, veil authentication, and night vision displays. For commercial ... ...

Abstract	Abstract Near-infrared organic light-emitting diodes (NIR OLEDs) with heavy metals are regularly reported due to the advantages of their various applications in healthcare services, veil authentication, and night vision displays. For commercial applications, it is necessary to look at radiance capacity (RC) instead of radiance because of power consumption. However, recent papers still reported only simple high radiance performance and do not look at device from the point of view of RC. To overcome this hurdle, we designed Ir(III)-based heteroleptic NIR materials with two types of auxiliary ligand. The proposed emitters achieve a highly oriented horizontal dipole ratio (Ir(mCPDTiq)2tmd, complex 1: 80%, Ir(mCPDTiq)2acac, complex 2: 81%) with a short radiative lifetime (1: 386 ns, 2: 323 ns). The device also shows an extremely low turn-on voltage (Von) of 2.2 V and a high RC of 720 mW/sr/m2/V. The results on the Von and RC of the device is demonstrated an outstanding performance among the Ir(III)-based NIR OLEDs with a similar emission peak.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High‐Performance and Reliable White Organic Light‐Emitting Fibers for Truly Wearable Textile Displays

Yong Ha Hwang / Byeongju Noh / Junwoo Lee / Ho Seung Lee / Yongjin Park / Kyung Cheol Choi

Advanced Science, Vol 9, Iss 11, Pp n/a-n/a (2022)

2022

Abstract: Abstract Light‐emitting fibers have been intensively developed for the realization of textile displays and various lighting applications, as promising free‐form electronics with outstanding interconnectivity. These advances in the fiber displays have ... ...

Abstract	Abstract Light‐emitting fibers have been intensively developed for the realization of textile displays and various lighting applications, as promising free‐form electronics with outstanding interconnectivity. These advances in the fiber displays have been made possible by the successful implementation of the core technologies of conventional displays, including high optoelectronic performance and essential elements, in the fiber form‐factor. However, although white organic light‐emitting diodes (WOLEDs), as a fundamental core technology of displays, are essential for realizing full‐color displays and solid‐state lighting, fiber‐based WOLEDs are still challenging due to structural issues and the lack of approaches to implementing WOLEDs on fiber. Herein, the first fiber WOLED is reported, exhibiting high optoelectronic performance and a reliable color index, comparable to those of conventional planar WOLEDs. As key features, it is found that WOLEDs can be successfully introduced on a cylindrical fiber using a dip‐coatable single white‐emission layer based on simulation and optimization of the white spectra. Furthermore, to ensure durability from usage, the fiber WOLED is encapsulated by an Al2O3/elastomer bilayer, showing stable operation under repetitive bending and pressure, and in water. This pioneering work is believed to provide building blocks for realizing complete textile display technologies by complementing the lack of the core technology.
Keywords	fiber OLED ; fiber WOLED ; textile displays ; wearable displays ; Science ; Q
Subject code	621
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Contributing Factors Affecting Number of Vehicles Involved in Crashes Using Machine Learning Techniques in Rural Roads of Cosenza, Italy

Giuseppe Guido / Sina Shaffiee Haghshenas / Sami Shaffiee Haghshenas / Alessandro Vitale / Vittorio Astarita / Yongjin Park / Zong Woo Geem

Safety, Vol 8, Iss 28, p

2022 Volume 28

Abstract: The evaluation of road safety is a critical issue having to be conducted for successful safety management in road transport systems, whereas safety management is considered in road transportation systems as a challenging task according to the dynamic of ... ...

Abstract	The evaluation of road safety is a critical issue having to be conducted for successful safety management in road transport systems, whereas safety management is considered in road transportation systems as a challenging task according to the dynamic of this issue and the presence of a large number of effective parameters on road safety. Therefore, the evaluation and analysis of important contributing factors affecting the number of vehicles involved in crashes play a key role in increasing the efficiency of road safety. For this purpose, in this research work, two machine learning algorithms, including the group method of data handling (GMDH)-type neural network and a combination of support vector machine (SVM) and the grasshopper optimization algorithm (GOA), are employed. Hence, the number of vehicles involved in an accident is considered to be the output, and the seven factors affecting transport safety, including Daylight (DL), Weekday (W), Type of accident (TA), Location (L), Speed limit (SL), Average speed (AS), and Annual average daily traffic (AADT) of rural roads in Cosenza, southern Italy, are selected as the inputs. In this study, 564 data sets from rural areas were investigated, and the relevant, effective parameters were measured. In the next stage, several models were developed to investigate the parameters affecting the safety management of road transportation in rural areas. The results obtained demonstrated that the “Type of accident” has the highest level and “Location” has the lowest importance in the investigated rural area. Finally, although the results of both algorithms were the same, the GOA-SVM model showed a better degree of accuracy and robustness than the GMDH model.
Keywords	road safety ; safety management ; road transportation ; GMDH ; GOA-SVM ; machine learning ; Industrial safety. Industrial accident prevention ; T55-55.3 ; Medicine (General) ; R5-920
Subject code	380
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads

Yongjin Park / Amin Espah Borujeni / Thomas E Gorochowski / Jonghyeon Shin / Christopher A Voigt

Molecular Systems Biology, Vol 16, Iss 8, Pp n/a-n/a (2020)

2020

Abstract: Abstract Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically stable and not hinder the host. Encoding circuits in the genome reduces burden, but this ... ...

Abstract	Abstract Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically stable and not hinder the host. Encoding circuits in the genome reduces burden, but this decreases performance and can interfere with native transcription. We have designed genomic landing pads in Escherichia coli at high‐expression sites, flanked by ultrastrong double terminators. DNA payloads >8 kb are targeted to the landing pads using phage integrases. One landing pad is dedicated to carrying a sensor array, and two are used to carry genetic circuits. NOT/NOR gates based on repressors are optimized for the genome and characterized in the landing pads. These data are used, in conjunction with design automation software (Cello 2.0), to design circuits that perform quantitatively as predicted. These circuits require fourfold less RNA polymerase than when carried on a plasmid and are stable for weeks in a recA+ strain without selection. This approach enables the design of synthetic regulatory networks to guide cells in environments or for applications where plasmid use is infeasible.
Keywords	gene regulatory network ; genetic circuit design automation ; genome editing ; synthetic biology ; systems biology ; Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation.

Tae Hyuk Kang / Yongjin Park / Joel S Bader / Theodore Friedmann

PLoS ONE, Vol 8, Iss 10, p e

2013 Volume 74967

Abstract: The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood. The best recognized neural consequences of ... ...

Abstract	The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood. The best recognized neural consequences of HPRT deficiency are defective basal ganglia expression of the neurotransmitter dopamine (DA) and aberrant DA neuronal function. We have reported that HPRT deficiency leads to dysregulated expression of multiple DA-related developmental functions and cellular signaling defects in a variety of HPRT-deficient cells, including human induced pluripotent stem (iPS) cells. We now describe results of gene expression studies during neuronal differentiation of HPRT-deficient murine ESD3 embryonic stem cells and report that HPRT knockdown causes a marked switch from neuronal to glial gene expression and dysregulates expression of Sox2 and its regulator, genes vital for stem cell pluripotency and for the neuronal/glial cell fate decision. In addition, HPRT deficiency dysregulates many cellular functions controlling cell cycle and proliferation mechanisms, RNA metabolism, DNA replication and repair, replication stress, lysosome function, membrane trafficking, signaling pathway for platelet activation (SPPA) multiple neurotransmission systems and sphingolipid, sulfur and glycan metabolism. We propose that the neural aberrations of HPRT deficiency result from combinatorial effects of these multi-system metabolic errors. Since some of these aberrations are also found in forms of Alzheimer's and Huntington's disease, we predict that some of these systems defects play similar neuropathogenic roles in diverse neurodevelopmental and neurodegenerative diseases in common and may therefore provide new experimental opportunities for clarifying pathogenesis and for devising new potential therapeutic targets in developmental and genetic disease.
Keywords	Medicine ; R ; Science ; Q
Subject code	570 ; 571
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic networks from hierarchical bayesian graph clustering.

Yongjin Park / Cristopher Moore / Joel S Bader

PLoS ONE, Vol 5, Iss 1, p e

2010 Volume 8118

Abstract: Biological networks change dynamically as protein components are synthesized and degraded. Understanding the time-dependence and, in a multicellular organism, tissue-dependence of a network leads to insight beyond a view that collapses time-varying ... ...

Abstract	Biological networks change dynamically as protein components are synthesized and degraded. Understanding the time-dependence and, in a multicellular organism, tissue-dependence of a network leads to insight beyond a view that collapses time-varying interactions into a single static map. Conventional algorithms are limited to analyzing evolving networks by reducing them to a series of unrelated snapshots.Here we introduce an approach that groups proteins according to shared interaction patterns through a dynamical hierarchical stochastic block model. Protein membership in a block is permitted to evolve as interaction patterns shift over time and space, representing the spatial organization of cell types in a multicellular organism. The spatiotemporal evolution of the protein components are inferred from transcript profiles, using Arabidopsis root development (5 tissues, 3 temporal stages) as an example.The new model requires essentially no parameter tuning, out-performs existing snapshot-based methods, identifies protein modules recruited to specific cell types and developmental stages, and could have broad application to social networks and other similar dynamic systems.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does the Use of Social Network Sites and Mobile Phones Promote the Acquisition of Job- Related Information, Job Mobility and Entrepreneurship in Asia?

Marko M. Skoric / Pan Ji / Wayne Wei-Jen Fu / Clarice Chwei Lin Sim / Yongjin Park

Journal of Contemporary Eastern Asia, Vol 14, Iss 1, Pp 5-

2015 Volume 22

Abstract: This study examines how different uses of social network sites (SNS) and mobile phones (MP) to communicate with friends and business associates are related to the acquisition of job-related information, job mobility, and entrepreneurial intentions, using ...

Abstract	This study examines how different uses of social network sites (SNS) and mobile phones (MP) to communicate with friends and business associates are related to the acquisition of job-related information, job mobility, and entrepreneurial intentions, using social capital as its main theoretical lens. To this end, a nationally representative, random digit dialing (RDD) survey was conducted in Singapore. Path analyses show that SNS interactions with friends are positively related to both bonding and bridging social capital. The former is linked with greater job mobili- ty, the latter with entrepreneurship, and both are associated with more job-related information. SNS interactions with business contacts are directly positively related to job-related information and entrepreneurship. For mobile phones, interactions with friends are positively related to social capital, job information and entrepreneurship. Professional networking is associated with more bridging social capital, job information and job mobility. Bonding capital is found to be linked with greater job mobility, while bridging capital has a positive relationship with both entrepreneurship and job mobility.
Keywords	social network sites ; mobile phones ; social capital ; job mobility ; entrepreneurship ; Social sciences and state - Asia (Asian studies only) ; H53
Subject code	331
Language	English
Publishing date	2015-05-01T00:00:00Z
Publisher	World Association for Triple Helix and Future Strategy Studies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy

Su Mi Lee / Seuk Hee Chung / Yongjin Park / Mi Kyoung Park / Young Ki Son / Seong Eun Kim / Won Suk An

International Journal of Endocrinology, Vol

2014 Volume 2014

Keywords	Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contribution of cell elongation to the biofilm formation of Pseudomonas aeruginosa during anaerobic respiration.

Mi Young Yoon / Kang-Mu Lee / Yongjin Park / Sang Sun Yoon

PLoS ONE, Vol 6, Iss 1, p e

2011 Volume 16105

Abstract: Pseudomonas aeruginosa, a gram-negative bacterium of clinical importance, forms more robust biofilm during anaerobic respiration, a mode of growth presumed to occur in abnormally thickened mucus layer lining the cystic fibrosis (CF) patient airway. ... ...

Abstract	Pseudomonas aeruginosa, a gram-negative bacterium of clinical importance, forms more robust biofilm during anaerobic respiration, a mode of growth presumed to occur in abnormally thickened mucus layer lining the cystic fibrosis (CF) patient airway. However, molecular basis behind this anaerobiosis-triggered robust biofilm formation is not clearly defined yet. Here, we identified a morphological change naturally accompanied by anaerobic respiration in P. aeruginosa and investigated its effect on the biofilm formation in vitro. A standard laboratory strain, PAO1 was highly elongated during anaerobic respiration compared with bacteria grown aerobically. Microscopic analysis demonstrated that cell elongation likely occurred as a consequence of defective cell division. Cell elongation was dependent on the presence of nitrite reductase (NIR) that reduces nitrite (NO(2) (-)) to nitric oxide (NO) and was repressed in PAO1 in the presence of carboxy-PTIO, a NO antagonist, demonstrating that cell elongation involves a process to respond to NO, a spontaneous byproduct of the anaerobic respiration. Importantly, the non-elongated NIR-deficient mutant failed to form biofilm, while a mutant of nitrate reductase (NAR) and wild type PAO1, both of which were highly elongated, formed robust biofilm. Taken together, our data reveal a role of previously undescribed cell biological event in P. aeruginosa biofilm formation and suggest NIR as a key player involved in such process.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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