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  1. Article ; Online: Vulnerability assessment of the eco-geo-environment of mining cities in arid and semi-arid areas

    Peixian Li / Bing Wang / Peng Chen / Yongliang Zhang / Sihai Zhao

    Ecological Indicators, Vol 152, Iss , Pp 110364- (2023)

    A case study from Zhungeer, China

    2023  

    Abstract: Assessing the ecological and geological environment vulnerability (EGEV) of cities arid and semi-arid regions is important for urban planning, development, and ecological protection. This study investigated the ecological and geological environmental ... ...

    Abstract Assessing the ecological and geological environment vulnerability (EGEV) of cities arid and semi-arid regions is important for urban planning, development, and ecological protection. This study investigated the ecological and geological environmental problems and possible potential risk factors in Zhungeer City and constructed an EGEV assessment index system covering the geological environment, human activities, coal mining, and hydrological conditions. We proposed a linear weighted model to calculate the comprehensive weight of each indicator using the Analytical Hierarchy Process (AHP) and Entropy method based on distance function optimization (AELW), and frequency ratio accuracy is then introduced to compare the remarkable classification performance between AELW and other models. The frequency ratio accuracy results show that AELW model has the highest accuracy for EGEV assessment (62.77 %), followed by Multiplicative Integrated Normalization Model (MINM, 61.46 %), AHP (60.98 %), Ideal Point Model (IPM, 60.30 %) and Entropy (53.55 %). The EGEV of Zhungeer was classified as I-V from lowest into highest, among which the EGEV of I-II-III accounted for 78.15 %, EGEV of IV accounted for 16.42 %, and the EGEV of V risk area accounted for 5.43 %, with a good overall ecological and geological environment quality. These results can provide tangible management suggestions for reducing EGEV in Zhungeer city, and the AELW model provides direction for EGEV assessment in other similar areas.
    Keywords Eco-geo-environment vulnerability ; Assessment index system ; Mining city ; AHP-entropy linear weighted model ; Geospatial techniques ; Ecology ; QH540-549.5
    Subject code 710
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Synergism of fermented feed and ginseng polysaccharide on growth performance, intestinal development, and immunity of Xuefeng black-bone chickens

    Jie Liu / Huan Wang / Junyi Luo / Ting Chen / Qianyun Xi / Jiajie Sun / Limin Wei / Yongliang Zhang

    BMC Veterinary Research, Vol 20, Iss 1, Pp 1-

    2024  Volume 9

    Abstract: Abstract Microbial fermented feed (MF) is considered a valuable strategy to bring advantages to livestock and is widely practiced. Oral supplementation of Ginseng polysaccharide (Gps) eliminated weight loss in chickens following vaccination. This study ... ...

    Abstract Abstract Microbial fermented feed (MF) is considered a valuable strategy to bring advantages to livestock and is widely practiced. Oral supplementation of Ginseng polysaccharide (Gps) eliminated weight loss in chickens following vaccination. This study investigated the effects of the combined use of Gps and MF on growth performance and immune indices in Xuefeng black-bone chickens. A total of 400 Xuefeng black-bone chickens at the age of 1 day were randomly assigned to four groups. Normal feed group (Control group), ginseng polysaccharide (200 mg/kg) group (Gps group), microbially fermented feed (completely replace the normal feed) group (MF group), and microbially fermented feed and add ginseng polysaccharide just before use (MF + Gps group). Each group contained 5 pens per treatment and 20 birds per pen. The body weight and average daily gain in the Gps, MF, and MF + Gps groups increased significantly (P < 0.01), while the feed conversion ratio decreased significantly (P < 0.01). The combined use of MF and Gps showed a synergistic effect. There was no significant difference in villus height (cecal) between the experimental group and the Con group. The crypt depth of the three experimental groups exhibited a significantly lower value compared to the Control group (P < 0.05). The V/C ratio of the Gps group and MF + Gps was significantly increased (P < 0.05), but there was no significant difference in the MF group. Moreover, the diarrhea rate of the Gps and the MF + Gps groups was lower than that of the Con group, while that of the MF + Gps group decreased the mortality rate (P < 0.05). The serum tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) levels in the MF, Gps, and MF + Gps groups decreased significantly (P < 0.01), the serum immunoglobulin G (IgG) levels increased significantly (P < 0.01), while the combination of MF and Gps had a synergistic effect. The combined use of Gps and MF not only further improved growth performance and immune parameters, but also reduced the ...
    Keywords Ginseng polysaccharide ; Growth performance ; Immune parameters ; Microbial fermented feed ; Synergistic effect ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Experimental Study of Yield Surface in Polypropylene Considering Rate Effect

    Hang Zheng / Xiaofei Yi / Zhiping Tang / Kai Zhao / Yongliang Zhang

    Polymers, Vol 14, Iss 3225, p

    Stress Path Dependence

    2022  Volume 3225

    Abstract: In order to investigate the yield surface evolution of polypropylene (PP) under dynamic impact and the relationship between yield surface parameters and the strain rate, five shear-compression specimens (SCSs) with different inclination angles are ... ...

    Abstract In order to investigate the yield surface evolution of polypropylene (PP) under dynamic impact and the relationship between yield surface parameters and the strain rate, five shear-compression specimens (SCSs) with different inclination angles are designed and produced to explore the yield behavior of PP under dynamic loading. Dynamic combined stress loading paths with different compression-shear ratios are achieved by the split Hopkinson pressure bar (SHPB). The evolution laws of the compressive stress and shear stress in the measurement region during the PP SCS compressive deformation process are analyzed. In terms of mechanical response, PP under combined compression-shear loading is of visco-elasticity plasticity and its deformation undergoes a three-stage transition, namely “unyield→yield→failure”. The yield characteristics of PP are found to be affected not only by the hydrostatic pressure but also by the stress path. According to the Hu–Pae yield criterion, the dynamic yield surface and model parameters of PP are obtained, and the relationship between the yield surface and the strain rate is ascertained. These findings contribute to deepening the research on the mechanical response characteristics of PP-based materials.
    Keywords polypropylene ; shear-compression ; strain-rate effect ; stress path ; yield surface ; Organic chemistry ; QD241-441
    Subject code 670
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Flow and Noise Characteristics of Centrifugal Fan in Low Pressure Environment

    Xilong Zhang / Yongliang Zhang / Chenggang Lu

    Processes, Vol 8, Iss 985, p

    2020  Volume 985

    Abstract: The influence of low pressure environment on centrifugal fan’s flow and noise characteristics was studied experimentally and numerically. A testbed was established to conduct the experimental test on the performance of a centrifugal fan, and the ... ...

    Abstract The influence of low pressure environment on centrifugal fan’s flow and noise characteristics was studied experimentally and numerically. A testbed was established to conduct the experimental test on the performance of a centrifugal fan, and the characteristic curve and power consumption curve of the fan under different pressure were obtained. Then the simulation model of the centrifugal fan was established, which was used to simulate the working process of centrifugal fan under different negative pressures. The results showed that the total pressure and static pressure of the fan decrease with the decrease of the ambient pressure. The total and static pressures of the fan under 60 kPa pressure condition decreased by 42.3% and 38.3%, respectively, compared with those of fan under the normal pressure. The main reason for this phenomenon is that the decrease of the environmental pressure leads to the decrease of air density. Besides, with the drop of environmental pressure, the sound pressure and sound power of the fan noise decreases.
    Keywords centrifugal fan ; noise characteristics ; power consumption ; negative pressure ; sound pressure ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Alterations in co-abundant bacteriome in colorectal cancer and its persistence after surgery

    Chin-Wen Png / Yong-Kang Chua / Jia-Hao Law / Yongliang Zhang / Ker-Kan Tan

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    a pilot study

    2022  Volume 13

    Abstract: Abstract There is growing interest in the role of gut microbiome in colorectal cancer (CRC), ranging from screening to disease recurrence. Our study aims to identify microbial markers characteristic of CRC and to examine if changes in bacteriome persist ... ...

    Abstract Abstract There is growing interest in the role of gut microbiome in colorectal cancer (CRC), ranging from screening to disease recurrence. Our study aims to identify microbial markers characteristic of CRC and to examine if changes in bacteriome persist after surgery. Forty-nine fecal samples from 25 non-cancer (NC) individuals and 12 CRC patients, before and 6-months after surgery, were collected for analysis by bacterial 16S rRNA gene sequencing. Bacterial richness and diversity were reduced, while pro-carcinogenic bacteria such as Bacteroides fragilis and Odoribacter splanchnicus were increased in CRC patients compared to NC group. These differences were no longer observed after surgery. Comparison between pre-op and post-op CRC showed increased abundance of probiotic bacteria after surgery. Concomitantly, bacteria associated with CRC progression were observed to have increased after surgery, implying persistent dysbiosis. In addition, functional pathway predictions based on the bacterial 16S rRNA gene data showed that various pathways were differentially enriched in CRC compared to NC. Microbiome signatures characteristic of CRC comprise altered bacterial composition. Elements of these dysbiotic signatures persists even after surgery, suggesting possible field-change in remnant non-diseased colon. Future studies should involve a larger sample size with microbiome data collected at multiple time points after surgery to examine if these dysbiotic patterns truly persist and also correlate with disease outcomes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)

    Jiabo Yu / Xiang Sun / Jian Yi Gerald Goie / Yongliang Zhang

    Microorganisms, Vol 8, Iss 1067, p

    2020  Volume 1067

    Abstract: Influenza is a major respiratory viral disease caused by infections from the influenza A virus (IAV) that persists across various seasonal outbreaks globally each year. Host immune response is a key factor determining disease severity of influenza ... ...

    Abstract Influenza is a major respiratory viral disease caused by infections from the influenza A virus (IAV) that persists across various seasonal outbreaks globally each year. Host immune response is a key factor determining disease severity of influenza infection, presenting an attractive target for the development of novel therapies for treatments. Among the multiple signal transduction pathways regulating the host immune activation and function in response to IAV infections, the mitogen-activated protein kinase (MAPK) pathways are important signalling axes, downstream of various pattern recognition receptors (PRRs), activated by IAVs that regulate various cellular processes in immune cells of both innate and adaptive immunity. Moreover, aberrant MAPK activation underpins overexuberant production of inflammatory mediators, promoting the development of the “cytokine storm”, a characteristic of severe respiratory viral diseases. Therefore, elucidation of the regulatory roles of MAPK in immune responses against IAVs is not only essential for understanding the pathogenesis of severe influenza, but also critical for developing MAPK-dependent therapies for treatment of respiratory viral diseases. In this review, we will summarise the current understanding of MAPK functions in both innate and adaptive immune response against IAVs and discuss their contributions towards the cytokine storm caused by highly pathogenic influenza viruses.
    Keywords influenza ; MAPK ; respiratory viral diseases ; pattern recognition receptors ; inflammatory cytokines ; innate immunity ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A tris-spiro metalla-aromatic system featuring Craig-Möbius aromaticity

    Zhe Huang / Yongliang Zhang / Wen-Xiong Zhang / Junnian Wei / Shengfa Ye / Zhenfeng Xi

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Spiroaromatic compounds are advantageous platforms for designing expanded aromatic systems. Herein, the authors present a tris‐spiro metalla‐aromatic Vanadium compound which forms a 40π Craig‐Möbius aromatic system. ...

    Abstract Spiroaromatic compounds are advantageous platforms for designing expanded aromatic systems. Herein, the authors present a tris‐spiro metalla‐aromatic Vanadium compound which forms a 40π Craig‐Möbius aromatic system.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Exploration of the Effect on Genome-Wide DNA Methylation by miR-143 Knock-Out in Mice Liver

    Xingping Chen / Junyi Luo / Jie Liu / Ting Chen / Jiajie Sun / Yongliang Zhang / Qianyun Xi

    International Journal of Molecular Sciences, Vol 22, Iss 13075, p

    2021  Volume 13075

    Abstract: MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting hepatoma cell proliferation. DNA methyltransferase 3 alpha ( DNMT3a ), as a target of miR-143 , regulates the development of primary organic solid tumors through ...

    Abstract MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting hepatoma cell proliferation. DNA methyltransferase 3 alpha ( DNMT3a ), as a target of miR-143 , regulates the development of primary organic solid tumors through DNA methylation mechanisms. However, the effect of miR-143 on DNA methylation profiles in liver is unclear. In this study, we used Whole-Genome Bisulfite Sequencing (WGBS) to detect the differentially methylated regions (DMRs), and investigated DMR-related genes and their enriched pathways by miR-143 . We found that methylated cytosines increased 0.19% in the miR-143 knock-out (KO) liver fed with high-fat diet (HFD), compared with the wild type (WT). Furthermore, compared with the WT group, the CG methylation patterns of the KO group showed lower CG methylation levels in CG islands (CGIs), promoters and hypermethylation in CGI shores, 5′UTRs, exons, introns, 3′UTRs, and repeat regions. A total of 984 DMRs were identified between the WT and KO groups consisting of 559 hypermethylation and 425 hypomethylation DMRs. Furthermore, DMR-related genes were enriched in metabolism pathways such as carbon metabolism ( serine hydroxymethyltransferase 2 ( Shmt2 ) , acyl-Coenzyme A dehydrogenase medium chain ( Acadm) ), arginine and proline metabolism ( spermine synthase ( Sms ), proline dehydrogenase ( Prodh2 )) and purine metabolism ( phosphoribosyl pyrophosphate synthetase 2 ( Prps2) ). In summary, we are the first to report the change in whole-genome methylation levels by miR-143 -null through WGBS in mice liver, and provide an experimental basis for clinical diagnosis and treatment in liver diseases, indicating that miR-143 may be a potential therapeutic target and biomarker for liver damage-associated diseases and hepatocellular carcinoma.
    Keywords DNA methylation ; miR-143 ; Whole-Genome Bisulfite Sequencing ; liver diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Epididymal research one generation on

    Yongliang Zhang / Trevor G Cooper

    Asian Journal of Andrology, Vol 17, Iss 5, Pp 691-

    2015  Volume 692

    Keywords Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants

    Zongyu Gao / Dingliang Zhang / Xiaoling Wang / Xin Zhang / Zhiyan Wen / Qianshen Zhang / Dawei Li / Savithramma P. Dinesh-Kumar / Yongliang Zhang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 20

    Abstract: MAPK cascades play an important role in innate immunity. Here, the authors show that that beet black scorch virus activates MAPK signaling in Nicotiana benthamiana and the viral coat protein counteracts MAPK-mediated defence by competitively binding to a ...

    Abstract MAPK cascades play an important role in innate immunity. Here, the authors show that that beet black scorch virus activates MAPK signaling in Nicotiana benthamiana and the viral coat protein counteracts MAPK-mediated defence by competitively binding to a MAPKKKα interactor.
    Keywords Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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