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  1. Article: The Impact of Chronic Comorbidities on Outcomes in Acute Exacerbations of Idiopathic Pulmonary Fibrosis.

    Baig, Saqib H / Yoo, Erika J

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: Introduction: Idiopathic pulmonary fibrosis is a chronic progressive lung disease of unknown cause with a high associated mortality. We aimed to compare the impact of chronic medical conditions on hospital outcomes of patients with acute exacerbations ... ...

    Abstract Introduction: Idiopathic pulmonary fibrosis is a chronic progressive lung disease of unknown cause with a high associated mortality. We aimed to compare the impact of chronic medical conditions on hospital outcomes of patients with acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF).
    Methods: This was a retrospective cohort study using the NIS database from 2016 to 2018. We included patients aged 60 and older hospitalized in academic medical centers with the diagnoses of IPF and acute respiratory failure. We examined factors associated with hospital mortality and length of stay (LOS) using survey-weighted multivariate logistic and negative binomial regression.
    Results: Out of 4975 patients with AE-IPF, 665 (13.4%) did not survive hospitalization. There was no difference in the mean age between survivors and non-survivors. Patients were more likely to be male, predominantly white, and have Medicare coverage. Most non-survivors were from households with higher median income. Hospital LOS was longer among non-survivors than survivors (9.4 days vs. 9.8 days;
    Conclusions: Our results suggest that CKD is a significant contributor to hospital mortality in AE-IPF, and diabetes mellitus may be protective. Obesity and hypothyroidism are linked with shorter hospital LOS among patients hospitalized with AE-IPF in US academic medical centers.
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010156
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  2. Article ; Online: Trust in the ICU: What every clinician should know.

    Kazi, Abdul W / Yoo, Erika J / Oxman, David

    Journal of critical care

    2024  , Page(s) 154540

    Abstract: Trust is an essential element in the relationship between patients and intensive care unit (ICU) clinicians. Without a foundation of trust, communication is difficult, conflict is more likely, and even clinical outcomes can be affected. The ICU is a ... ...

    Abstract Trust is an essential element in the relationship between patients and intensive care unit (ICU) clinicians. Without a foundation of trust, communication is difficult, conflict is more likely, and even clinical outcomes can be affected. The ICU is a particularly challenging environment for trust to flourish. Illness occurs suddenly, emotions can be charged, the environment is impersonal, and there is rarely a prior relationship between patients and their caregivers. Therefore, intensivists must have some understanding of the factors that impact patient and family trust, as well as the actions they can take to improve it.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2024.154540
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    Zs.A 2152: Show issues Location:
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  3. Article ; Online: Improving Asthma Outcomes During Pregnancy in Underserved Communities.

    Gandler, Alan / Schulman, Edward S / Yoo, Erika J

    Immunology and allergy clinics of North America

    2022  Volume 43, Issue 1, Page(s) 199–208

    Abstract: It is known that poor asthma control is common in pregnancy, and asthma in general disproportionally affects underserved communities. However, there is a paucity of data examining strategies to improve asthma control specifically among pregnant women ... ...

    Abstract It is known that poor asthma control is common in pregnancy, and asthma in general disproportionally affects underserved communities. However, there is a paucity of data examining strategies to improve asthma control specifically among pregnant women from vulnerable populations. Identified barriers to optimal asthma care in other underserved groups include health literacy, financial constraints, cultural differences, and poor environmental controls. These deficiencies may also be targets for multimodal interventions geared toward improving asthma outcomes for underserved women during pregnancy.
    MeSH term(s) Pregnancy ; Humans ; Female ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2022.07.002
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  4. Article ; Online: Diaphragmatic Eventration and Positive Pressure Ventilation.

    Selzer, Evan B / Biblowitz, Kathleen / Yoo, Erika J

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 3, Page(s) 347–348

    MeSH term(s) Diaphragm ; Diaphragmatic Eventration ; Humans ; Intermittent Positive-Pressure Ventilation ; Positive-Pressure Respiration ; Thoracoscopy
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202109-2110IM
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  5. Article ; Online: The Impact of Chronic Medical Conditions on Mortality in Acute Respiratory Distress Syndrome.

    Baig, Saqib H / Vaid, Urvashi / Yoo, Erika J

    Journal of intensive care medicine

    2022  Volume 38, Issue 1, Page(s) 78–85

    Abstract: Purpose: To examine the impact of chronic comorbidities on mortality in Acute Respiratory Distress Syndrome (ARDS).: Materials and methods: Retrospective cohort study of adults with ARDS (ICD-10-CM code J80) from the National Inpatient Sample between ...

    Abstract Purpose: To examine the impact of chronic comorbidities on mortality in Acute Respiratory Distress Syndrome (ARDS).
    Materials and methods: Retrospective cohort study of adults with ARDS (ICD-10-CM code J80) from the National Inpatient Sample between January, 2016 and December, 2018. For the primary outcome of mortality, we conducted weighted logistic regression adjusting for factors identified on univariate analysis as potentially significant or differing between the two groups at baseline. We used negative binomial regression adjusting for the same comorbidities to identify risk factors for longer length of stay (LOS) among ARDS survivors.
    Results: After exclusions, 1046 records were analyzed (3355 ARDS survivors and 1875 non-survivors.) The comorbidities examined included hypertension, diabetes mellitus, obesity, hypothyroidism, alcohol and drug use, chronic kidney disease (CKD), cardiovascular disease, chronic liver disease, chronic pulmonary disease and malignancy. In multivariate analysis, we found that malignancy (OR 2.26, 95% CI 1.84-2.78, p < 0.001), cardiovascular disease (OR 1.54, 95% CI 1.23-1.92, p < 0.001), and CKD (OR 1.75, 95% CI 1.22-2.50, p  =  0.002) increased the risk of death. In interaction analyses, cardiovascular disease combined with either malignancy or CKD conferred higher odds of death compared to either risk factor alone.
    Conclusions: The comorbidity of malignancy confers the most reliable risk of poor outcomes in ARDS with higher odds of hospital death and a simultaneous association with longer hospital LOS among survivors.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Cardiovascular Diseases ; Respiratory Distress Syndrome ; Chronic Disease ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2022-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666221108079
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  6. Article ; Online: Weekend Admission Does Not Confer an Increased Risk of Mortality in Septic Shock.

    Baig, Saqib H / Oxman, David A / Yoo, Erika J

    Journal of intensive care medicine

    2021  Volume 37, Issue 6, Page(s) 810–816

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Adult ; Hospital Mortality ; Hospitalization ; Humans ; Patient Admission ; Retrospective Studies ; Shock, Septic ; Time Factors
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666211038549
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  7. Article ; Online: Critical Care Utilization and Outcomes of Interhospital Medical Transfers at Lower Risk of Death.

    Baig, Saqib H / Gorth, Deborah J / Yoo, Erika J

    Journal of intensive care medicine

    2021  Volume 37, Issue 5, Page(s) 679–685

    Abstract: Purpose: To evaluate utilization and mortality outcomes of interhospital transferred critically-ill medical patients with lower predicted risk of hospital mortality.: Materials & methods: Multisite retrospective cohort analysis of patients with Acute ...

    Abstract Purpose: To evaluate utilization and mortality outcomes of interhospital transferred critically-ill medical patients with lower predicted risk of hospital mortality.
    Materials & methods: Multisite retrospective cohort analysis of patients with Acute Physiology and Chronic Health Evaluation (APACHE) IV-a predicted mortality of ≤20% from 335 ICUs in 208 hospitals in the Philips eICU database between 2014-2015. Differences in length-of-stay (LOS) and mortality between transferred and local patients were evaluated using negative binomial logistic regression and logistic regression, respectively. Stratified analyses were conducted for subgroups of predicted mortality: 0%-5%, 6%-10%, 11%-15%, and 16%-20%.
    Results: Transfers had a higher risk of longer ICU and hospital LOS across all risk strata (IRR 1.12; 95% CI 1.09-1.16,
    Conclusions: Interhospital transfer of critically-ill medical patients with lower illness severity is associated with higher ICU and hospital utilization and increased mortality. Better understanding of factors driving patient selection for and characteristics of interhospital transfer for this population will have an impact on ICU resource utilization, care efficiency, and hospital quality.
    MeSH term(s) APACHE ; Critical Care ; Critical Illness/therapy ; Hospital Mortality ; Humans ; Intensive Care Units ; Length of Stay ; Patient Transfer ; Retrospective Studies
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666211022613
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  8. Article: Recurrent Acute Neurogenic Pulmonary Edema after Uncontrolled Seizures.

    Sacher, Daniel C / Yoo, Erika J

    Case reports in pulmonology

    2018  Volume 2018, Page(s) 3483282

    Abstract: Acute pulmonary edema following significant injury to the central nervous system is known as neurogenic pulmonary edema (NPE). Commonly seen after significant neurological trauma, NPE has also been described after seizure. While many pathogenic theories ... ...

    Abstract Acute pulmonary edema following significant injury to the central nervous system is known as neurogenic pulmonary edema (NPE). Commonly seen after significant neurological trauma, NPE has also been described after seizure. While many pathogenic theories have been proposed, the exact mechanism remains unclear. We present a 31-year-old man who developed recurrent acute NPE on two consecutive admissions after experiencing witnessed generalized tonic-clonic (GTC) seizures. Chest radiographs obtained after seizure during both admissions showed bilateral infiltrates which rapidly resolved within 24 hours. He required intubation on each occasion, was placed on lung protective ventilation, and was successfully extubated within 72 hours. There was no identified source of infection, and no cardiac pathology was thought to be contributory.
    Language English
    Publishing date 2018-08-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2666707-1
    ISSN 2090-6854 ; 2090-6846
    ISSN (online) 2090-6854
    ISSN 2090-6846
    DOI 10.1155/2018/3483282
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  9. Article ; Online: Improving the Quality of Visualization Dashboards in Critical Care: A Mixed-Methods Study.

    Williams, Asia A / Jallo, Jack / Yoo, Erika J

    American journal of medical quality : the official journal of the American College of Medical Quality

    2020  Volume 36, Issue 4, Page(s) 215–220

    Abstract: Intensive care units (ICUs) lack both standardized performance indicators to better understand the effectiveness of interventions and uniform platforms to present these indicators. The goal of this study was to identify ICU metrics meaningful to ... ...

    Abstract Intensive care units (ICUs) lack both standardized performance indicators to better understand the effectiveness of interventions and uniform platforms to present these indicators. The goal of this study was to identify ICU metrics meaningful to stakeholders to help guide the development of a local visualization dashboard. Individual ICU directors were interviewed to collate their input on metrics important to their units. These qualitative data were used to develop a dashboard draft, after which the authors surveyed 20 stakeholders from different hospital departments for feedback on its content and structure. The varied survey results reinforced the inherent difficulties of adapting previously developed measurement tools while also selecting ICU performance measures that are simultaneously widely accepted yet relevant to local practice. These results also call attention to the importance of interdisciplinary input in quality dashboard development, thereby enabling more successful implementation and utilization for ICU quality improvement.
    MeSH term(s) Benchmarking ; Critical Care ; Feedback ; Humans ; Intensive Care Units ; Quality Improvement
    Language English
    Publishing date 2020-08-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1177/1062860620946109
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  10. Article: A retrospective cohort study of short-stay admissions to the medical intensive care unit: Defining patient characteristics and critical care resource utilization.

    Pandit, Pooja N / Mallozzi, Mark / Mohammed, Rahed / McDonough, Gregory / Treacy, Taylor / Zahustecher, Nathaniel / Yoo, Erika J

    International journal of critical illness and injury science

    2022  Volume 12, Issue 3, Page(s) 127–132

    Abstract: Background: Little is known about the mortality and utilization outcomes of short-stay intensive care unit (ICU) patients who require <24 h of critical care. We aimed to define characteristics and outcomes of short-stay ICU patients whose need for ICU ... ...

    Abstract Background: Little is known about the mortality and utilization outcomes of short-stay intensive care unit (ICU) patients who require <24 h of critical care. We aimed to define characteristics and outcomes of short-stay ICU patients whose need for ICU level-of-care is ≤24 h compared to nonshort-stay patients.
    Methods: Single-center retrospective cohort study of patients admitted to the medical ICU at an academic tertiary care center in 2019. Fisher's exact test or Chi-square for descriptive categorical variables,
    Results: Of 819 patients, 206 (25.2%) were short-stay compared to 613 (74.8%) nonshort-stay. The severity of illness as measured by the Mortality Probability Model-III was significantly lower among short-stay compared to nonshort-stay patients (
    Conclusions: Despite their lower illness severity and fewer ICU-level care needs, short-stay patients spend an equally substantial amount of time occupying an ICU bed while waiting for a floor bed as nonshort-stay patients. Further investigation into the factors influencing ICU triage of these subacute patients and contributors to system inefficiencies prohibiting their timely transfer may improve ICU resource allocation, hospital throughput, and patient outcomes.
    Language English
    Publishing date 2022-09-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/ijciis.ijciis_6_22
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