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Article ; Online: Distinct spatiotemporal patterns of cortical thinning in Alzheimer's disease-type cognitive impairment and subcortical vascular cognitive impairment.

Kim, Jinhee / Kim, Jonghoon / Park, Yu-Hyun / Yoo, Heejin / Kim, Jun Pyo / Jang, Hyemin / Park, Hyunjin / Seo, Sang Won

Communications biology

2024 Volume 7, Issue 1, Page(s) 198

Abstract: Previous studies on Alzheimer's disease-type cognitive impairment (ADCI) and subcortical vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct spatiotemporal cortical atrophy patterns ... ...

Abstract	Previous studies on Alzheimer's disease-type cognitive impairment (ADCI) and subcortical vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct spatiotemporal cortical atrophy patterns in ADCI and SVCI. 1,338 participants (713 ADCI, 208 SVCI, and 417 cognitively unimpaired elders) underwent brain magnetic resonance imaging (MRI), amyloid positron emission tomography, and neuropsychological tests. Using MRI, this study measures cortical thickness in five brain regions (medial temporal, inferior temporal, posterior medial parietal, lateral parietal, and frontal areas) and utilizes the Subtype and Stage Inference (SuStaIn) model to predict the most probable subtype and stage for each participant. SuStaIn identifies two distinct cortical thinning patterns in ADCI (medial temporal: 65.8%, diffuse: 34.2%) and SVCI (frontotemporal: 47.1%, parietal: 52.9%) patients. The medial temporal subtype of ADCI shows a faster decline in attention, visuospatial, visual memory, and frontal/executive domains than the diffuse subtype (p-value < 0.01). However, there are no significant differences in longitudinal cognitive outcomes between the two subtypes of SVCI. Our study provides valuable insights into the distinct spatiotemporal patterns of cortical thinning in patients with ADCI and SVCI, suggesting the potential for individualized therapeutic and preventive strategies to improve clinical outcomes.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/pathology ; Cerebral Cortical Thinning/pathology ; Cognitive Dysfunction/diagnostic imaging ; Brain/pathology ; Dizocilpine Maleate/analogs & derivatives
Chemical Substances	5-aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (124070-15-1) ; Dizocilpine Maleate (6LR8C1B66Q)
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05787-5
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Article: H

Cao, Lijun / Yoo, Heejin / Chen, Tianyuan / Mwimba, Musoki / Zhang, Xing / Dong, Xinnian

bioRxiv : the preprint server for biology

2023

Abstract: In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For 30 years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating ...

Abstract	In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For 30 years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been hotly debated. We found that, upon pathogen challenge, the cysteine residue of transcription factor CHE undergoes sulfenylation in systemic tissues, enhancing its binding to the promoter of SA-synthesis gene,
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.27.550865
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Article: Correlation analysis between subtest scores of CERAD-K and a newly developed tablet computer-based digital cognitive test (Inbrain CST).

Na, Seunghee / Seo, Sang Won / Kim, Young Ju / Yoo, Heejin / Lee, Eek-Sung

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1178324

Abstract: Introduction: The prevalence of Alzheimer's disease (AD) and other dementias is increasing; therefore, identifying individuals at risk for dementia is crucial. Traditional neuropsychological assessments are expensive and time-consuming; however, ... ...

Abstract	Introduction: The prevalence of Alzheimer's disease (AD) and other dementias is increasing; therefore, identifying individuals at risk for dementia is crucial. Traditional neuropsychological assessments are expensive and time-consuming; however, computerized cognitive testing is becoming popular in clinical and research settings, particularly during the COVID-19 pandemic. This study aimed to investigate the correlation between the computerized cognitive test, Inbrain cognitive screening test (CST), and the traditional neuropsychological battery, the consortium to establish a registry for Alzheimer's disease assessment packet (CERAD-K). Methods: We enrolled 166 participants from five districts in Republic of Korea, including cognitively unimpaired individuals and those with mild cognitive impairment (MCI) diagnosed by experienced neurologists. We used the Inbrain CST and CERAD-K to evaluate the cognitive function of the participants, and the scores of each subtest of the Inbrain CST and CERAD-K were compared. Results: A significant correlation was found between the Inbrain CST and CERAD-K subtests. Furthermore, multivariate analysis revealed a significant correlation between the Inbrain CST and the CERAD-K test pairs after adjusting for age, educational level, and sex. Discussion: In conclusion, this study demonstrates that the Inbrain CST is a reliable tool for detecting cognitive impairment in cognitively unimpaired individuals and patients with MCI, because it has a high correlation and agreement with CERAD-K. Therefore, the Inbrain CST can be a useful, time-efficient, and cost-effective computer-based cognitive test for individuals at risk for cognitive impairment.
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1178324
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Article: The rice heavy‐metal transporter OsNRAMP1 regulates disease resistance by modulating ROS homoeostasis

Chu, Chuanliang / Huang, Renyan / Liu, Liping / Tang, Guilin / Xiao, Jinghua / Yoo, Heejin / Yuan, Meng

Plant, cell and environment. 2022 Apr., v. 45, no. 4

2022

Abstract: Crop diseases threaten food security and sustainable agriculture. Consumption of crops containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation of disease‐resistant and toxic metal‐safe crops is a double‐gain strategy ...

Abstract	Crop diseases threaten food security and sustainable agriculture. Consumption of crops containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation of disease‐resistant and toxic metal‐safe crops is a double‐gain strategy that can contribute to food security. Here, we show that rice heavy‐metal transporter OsNRAMP1 plays an important role in plant immunity by modulating metal ion and reactive oxygen species (ROS) homoeostasis. OsNRAMP1 expression was induced after pathogenic bacteria and fungi infections. The osnramp1 mutants had an increased content of H₂O₂ and activity of superoxide dismutase, but decreased activity of catalase, showing enhanced broad‐spectrum resistance against bacterial and fungal pathogens. RNA‐seq analysis identified a number of differentially expressed genes that were involved in metal ion and ROS homoeostasis. Altered expression of metal ion‐dependent ROS‐scavenging enzymes genes and lower accumulation of cations such as Mn together induced compromised metal ion‐dependent enzyme‐catalysing activity and modulated ROS homoeostasis, which together contributed towards disease resistance in osnramp1 mutants. Furthermore, the osnramp1 mutants contained lower levels of toxic heavy metals Cd and Pb and micronutrients Ni and Mn in leaves and grains. Taken together, a proof of concept was achieved that broad‐spectrum disease‐resistant and toxic heavy‐metal‐safe rice was engineered by removal of the OsNRAMP1 gene.
Keywords	catalase ; disease resistance ; environment ; food security ; fungi ; gene expression regulation ; genes ; heavy metals ; immunity ; rice ; sequence analysis ; superoxide dismutase ; sustainable agriculture ; toxicity
Language	English
Dates of publication	2022-04
Size	p. 1109-1126.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14263
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Combination of ultrasound-treated 2D g-C

Jo, Wan-Kuen / Yoo, Hee-Jin

Ultrasonics sonochemistry

2018 Volume 42, Page(s) 517–525

Abstract: Herein, nanosheets of g- ... ...

Abstract	Herein, nanosheets of g-C
Language	English
Publishing date	2018-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2017.12.019
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Article ; Online: Separation of native and C106-oxidized DJ-1 proteins by using column chromatography.

Choi, Joonhyeok / Yoo, Hee-Jin / Cho, Kun / Kim, Hak Nam / Lee, Joon-Hwa / Ryu, Kyoung-Seok

Protein expression and purification

2022 Volume 195-196, Page(s) 106092

Abstract: Mutations in PARK7, the gene encoding the DJ-1 protein, are associated with early onset of Parkinson's disease. The C106 residue of DJ-1 is highly susceptible to oxidation, and its oxidation status is essential for various in vivo neuroprotective roles. ... ...

Abstract	Mutations in PARK7, the gene encoding the DJ-1 protein, are associated with early onset of Parkinson's disease. The C106 residue of DJ-1 is highly susceptible to oxidation, and its oxidation status is essential for various in vivo neuroprotective roles. Since C106 is readily oxidized to sulfinic acid that is not reduced by dithiothreitol, no method to separate native DJ-1 protein from the oxidized one creates challenges in the in vitro study of the biological relevance of C106-oxidation state. Here, we report an efficient column chromatography method to purify native, C106-sulfinic, and mixed (combination of the priors) forms of DJ-1. This method will be useful for systematic in vitro studies of DJ-1 functions by providing specific native and C106-sulfinic DJ-1 proteins.
MeSH term(s)	Chromatography ; Humans ; Oncogene Proteins/chemistry ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Protein Deglycase DJ-1/genetics ; Protein Deglycase DJ-1/metabolism
Chemical Substances	Oncogene Proteins ; PARK7 protein, human (EC 3.1.2.-) ; Protein Deglycase DJ-1 (EC 3.1.2.-)
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1055455-5
ISSN	1096-0279 ; 1046-5928
ISSN (online)	1096-0279
ISSN	1046-5928
DOI	10.1016/j.pep.2022.106092
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The rice heavy-metal transporter OsNRAMP1 regulates disease resistance by modulating ROS homoeostasis.

Chu, Chuanliang / Huang, Renyan / Liu, Liping / Tang, Guilin / Xiao, Jinghua / Yoo, Heejin / Yuan, Meng

Plant, cell & environment

2022 Volume 45, Issue 4, Page(s) 1109–1126

Abstract: Crop diseases threaten food security and sustainable agriculture. Consumption of crops containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation of disease-resistant and toxic metal-safe crops is a double-gain strategy ...

Abstract	Crop diseases threaten food security and sustainable agriculture. Consumption of crops containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation of disease-resistant and toxic metal-safe crops is a double-gain strategy that can contribute to food security. Here, we show that rice heavy-metal transporter OsNRAMP1 plays an important role in plant immunity by modulating metal ion and reactive oxygen species (ROS) homoeostasis. OsNRAMP1 expression was induced after pathogenic bacteria and fungi infections. The osnramp1 mutants had an increased content of H
MeSH term(s)	Cadmium/metabolism ; Cadmium/toxicity ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Disease Resistance ; Homeostasis ; Metals, Heavy/metabolism ; Metals, Heavy/toxicity ; Oryza/genetics ; Oryza/metabolism ; Reactive Oxygen Species/metabolism ; Soil Pollutants/metabolism
Chemical Substances	Cation Transport Proteins ; Metals, Heavy ; Reactive Oxygen Species ; Soil Pollutants ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14263
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor.

Rhu, Jinsoo / Kim, Jong Man / Kim, Kyunga / Yoo, Heejin / Choi, Gyu-Seong / Joh, Jae-Won

Scientific reports

2021 Volume 11, Issue 1, Page(s) 12909

Abstract: This study was designed to build models predicting early graft failure after liver transplantation. Cox regression model for predicting early graft failure after liver transplantation using post-transplantation aspartate aminotransferase, total bilirubin, ...

Abstract	This study was designed to build models predicting early graft failure after liver transplantation. Cox regression model for predicting early graft failure after liver transplantation using post-transplantation aspartate aminotransferase, total bilirubin, and international normalized ratio of prothrombin time was constructed based on data from both living donor (n = 1153) and deceased donor (n = 359) liver transplantation performed during 2004 to 2018. The model was compared with Model for Early Allograft Function Scoring (MEAF) and early allograft dysfunction (EAD) with their C-index and time-dependent area-under-curve (AUC). The C-index of the model for living donor (0.73, CI = 0.67-0.79) was significantly higher compared to those of both MEAF (0.69, P = 0.03) and EAD (0.66, P = 0.001) while C-index for deceased donor (0.74, CI = 0.65-0.83) was only significantly higher compared to C-index of EAD. (0.66, P = 0.002) Time-dependent AUC at 2 weeks of living donor (0.96, CI = 0.91-1.00) and deceased donor (0.98, CI = 0.96-1.00) were significantly higher compared to those of EAD. (both 0.83, P < 0.001 for living donor and deceased donor) Time-dependent AUC at 4 weeks of living donor (0.93, CI = 0.86-0.99) was significantly higher compared to those of both MEAF (0.87, P = 0.02) and EAD. (0.84, P = 0.02) Time-dependent AUC at 4 weeks of deceased donor (0.94, CI = 0.89-1.00) was significantly higher compared to both MEAF (0.82, P = 0.02) and EAD. (0.81, P < 0.001). The prediction model for early graft failure after liver transplantation showed high predictability and validity with higher predictability compared to traditional models for both living donor and deceased donor liver transplantation.
MeSH term(s)	Area Under Curve ; Aspartate Aminotransferases/blood ; Bilirubin/blood ; Biomarkers ; Blood Coagulation ; Blood Coagulation Factors/metabolism ; Blood Coagulation Tests ; Graft Rejection/blood ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Survival ; Humans ; Liver Transplantation/adverse effects ; Prognosis ; Reproducibility of Results ; Risk Factors
Chemical Substances	Biomarkers ; Blood Coagulation Factors ; Aspartate Aminotransferases (EC 2.6.1.1) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92298-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Outcome Comparison between Low-Dose Rabbit Anti-Thymocyte Globulin and Basiliximab in Low-Risk Living Donor Kidney Transplantation.

Kim, Sang Jin / Rhu, Jinsoo / Yoo, Heejin / Kim, Kyunga / Lee, Kyo Won / Park, Jae Berm

Journal of clinical medicine

2020 Volume 9, Issue 5

Abstract: The objective of this study was to compare outcomes between basiliximab and low-dose r-ATG in living donor kidney transplantation recipients with low immunological risk. Patients in the low-dose r-ATG group received 1.5 mg/kg of r-ATG for 3 days (total 4. ...

Abstract	The objective of this study was to compare outcomes between basiliximab and low-dose r-ATG in living donor kidney transplantation recipients with low immunological risk. Patients in the low-dose r-ATG group received 1.5 mg/kg of r-ATG for 3 days (total 4.5 mg/kg). Graft survival, patient survival, acute rejection,
Language	English
Publishing date	2020-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9051320
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Article ; Online: Distinct effects of cholesterol profile components on amyloid and vascular burdens.

Kang, Sung Hoon / Yoo, Heejin / Cheon, Bo Kyoung / Park, Yu Hyun / Kim, Soo-Jong / Ham, Hongki / Jang, Hyemin / Kim, Hee Jin / Oh, Kyungmi / Koh, Seong-Beom / Na, Duk L / Kim, Jun Pyo / Seo, Sang Won

Alzheimer's research & therapy

2023 Volume 15, Issue 1, Page(s) 197

Abstract: Background: Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ and cerebral small vessel disease (CSVD) burdens are not fully understood in Asians. Herein, ... ...

Abstract	Background: Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ and cerebral small vessel disease (CSVD) burdens are not fully understood in Asians. Herein, we investigated the relationships between plasma cholesterol profile components and Aβ and CSVD burdens in a large, non-demented Korean cohort. Methods: We enrolled 1,175 non-demented participants (456 with unimpaired cognition [CU] and 719 with mild cognitive impairment [MCI]) aged ≥ 45 years who underwent Aβ PET at the Samsung Medical Center in Korea. We performed linear regression analyses with each cholesterol (low-density lipoprotein cholesterol [LDL-c], high-density lipoprotein cholesterol [HDL-c], and triglyceride) level as a predictor and each image marker (Aβ uptake on PET, white matter hyperintensity [WMH] volume, and hippocampal volume) as an outcome after controlling for potential confounders. Results: Increased LDL-c levels (β = 0.014 to 0.115, p = 0.013) were associated with greater Aβ uptake, independent of the APOE e4 allele genotype and lipid-lowering medication. Decreased HDL-c levels (β = - 0.133 to - 0.006, p = 0.032) were predictive of higher WMH volumes. Increased LDL-c levels were also associated with decreased hippocampal volume (direct effect β = - 0.053, p = 0.040), which was partially mediated by Aβ uptake (indirect effect β = - 0.018, p = 0.006). Conclusions: Our findings highlight that increased LDL-c and decreased HDL-c levels are important risk factors for Aβ and CSVD burdens, respectively. Furthermore, considering that plasma cholesterol profile components are potentially modified by diet, exercise, and pharmacological agents, our results provide evidence that regulating LDL-c and HDL-c levels is a potential strategy to prevent dementia.
MeSH term(s)	Humans ; Cholesterol, LDL ; Cognitive Dysfunction/diagnostic imaging ; Cognition ; Cholesterol ; Amyloid beta-Peptides/metabolism ; Amyloid ; Cerebral Small Vessel Diseases
Chemical Substances	Cholesterol, LDL ; Cholesterol (97C5T2UQ7J) ; Amyloid beta-Peptides ; Amyloid
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-023-01342-2
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