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  1. Article: PCNA cycling dynamics during DNA replication and repair in mammals.

    Kang, Sukhyun / Yoo, Juyeong / Myung, Kyungjae

    Trends in genetics : TIG

    2024  

    Abstract: Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association ... ...

    Abstract Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp-loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C-like complex (RLC) is a PCNA-unloading clamp-loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process.

    Ryu, Eunjin / Ha, Na Young / Jung, Woojae / Yoo, Juyeong / Myung, Kyungjae / Kang, Sukhyun

    Cells

    2022  Volume 11, Issue 11

    Abstract: Proliferating cell nuclear antigen (PCNA) is a DNA clamp that functions in key roles for DNA replication and repair. After the completion of DNA synthesis, PCNA should be unloaded from DNA in a timely way. The ATAD5-RFC-Like Complex (ATAD5-RLC) unloads ... ...

    Abstract Proliferating cell nuclear antigen (PCNA) is a DNA clamp that functions in key roles for DNA replication and repair. After the completion of DNA synthesis, PCNA should be unloaded from DNA in a timely way. The ATAD5-RFC-Like Complex (ATAD5-RLC) unloads PCNA from DNA. However, the mechanism of the PCNA-unloading process remains unclear. In this study, we determined the minimal PCNA-unloading domain (ULD) of ATAD5. We identified several motifs in the ATAD5 ULD that are essential in the PCNA-unloading process. The C-terminus of ULD is required for the stable association of RFC2-5 for active RLC formation. The N-terminus of ULD participates in the opening of the PCNA ring. ATAD5-RLC was more robustly bound to open-liable PCNA compared to the wild type. These results suggest that distinct motifs of the ATAD5 ULD participate in each step of the PCNA-unloading process.
    MeSH term(s) DNA/metabolism ; DNA Damage ; DNA Replication ; DNA-Binding Proteins/metabolism ; Proliferating Cell Nuclear Antigen/metabolism
    Chemical Substances DNA-Binding Proteins ; Proliferating Cell Nuclear Antigen ; DNA (9007-49-2)
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11111832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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