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Article: Impact of family history of cancer on development of lung cancer among the Korean population: a prospective cohort study using KoGES data.

Kim, Sang Hyuk / Lee, Hyun / Kim, Bo-Guen / Kim, Sang-Heon / Sohn, Jang Won / Yoon, Ho Joo / Park, Dong Won

2024 Volume 16, Issue 2, Page(s) 1741–1744

Language	English
Publishing date	2024-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1077
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Article ; Online: Both quality of life and exacerbation are important outcomes of work-related asthma.

Jang, Jong Geol / Lee, Hyun / Min, Kyung Hoon / Kim, Sang-Heon / Yoon, Ho Joo / Moon, Ji-Yong

The journal of allergy and clinical immunology. In practice

2024 Volume 12, Issue 3, Page(s) 803–804

MeSH term(s)	Humans ; Quality of Life ; Asthma/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Letter
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2023.12.044
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Article: Intermittent to mild asthma: the need for continued treatment.

Yoon, Ho Joo

Allergy, asthma & immunology research

2013 Volume 5, Issue 6, Page(s) 341–342

Language	English
Publishing date	2013-10-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2545725-1
ISSN	2092-7363 ; 2092-7355
ISSN (online)	2092-7363
ISSN	2092-7355
DOI	10.4168/aair.2013.5.6.341
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Article ; Online: COVID-19 Vaccine-Induced Multisystem Inflammatory Syndrome With Polyserositis Detected by FDG PET/CT.

Lee, Soo Jin / Park, Dong Won / Sohn, Jang Won / Yoon, Ho Joo / Kim, Sang-Heon

Clinical nuclear medicine

2022 Volume 47, Issue 5, Page(s) e397–e398

Abstract: Abstract: Of the various adverse reactions to COVID-19 vaccines, fever is a common systemic symptom that often resolves spontaneously without treatment. However, rare vaccine-induced conditions that present with fever and systemic inflammation have been ...

Abstract	Abstract: Of the various adverse reactions to COVID-19 vaccines, fever is a common systemic symptom that often resolves spontaneously without treatment. However, rare vaccine-induced conditions that present with fever and systemic inflammation have been reported. In this case, a 65-year-old man with BNT162b2 mRNA COVID-19 vaccination underwent 18F-FDG PET/CT to evaluate prolonged fever and elevated serum C-reactive protein. PET/CT showed hypermetabolic infiltration in the pericardium and peritoneum suggesting immune-mediated pericarditis and peritonitis. After administration of high-dose corticosteroids, the patient's symptom resolved. This case suggests that multisystem inflammatory syndrome and polyserositis can be induced by the COVID-19 vaccine.
MeSH term(s)	Aged ; BNT162 Vaccine ; COVID-19/complications ; COVID-19 Vaccines/adverse effects ; Fluorodeoxyglucose F18 ; Humans ; Inflammation ; Male ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004094
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Article ; Online: Impacts of regular physical activity on hospitalisation in chronic obstructive pulmonary disease: a nationwide population-based study.

Yang, Bumhee / Lee, Hyun / Ryu, Jiin / Park, Dong Won / Park, Tai Sun / Chung, Jee-Eun / Kim, Tae-Hyung / Sohn, Jang Won / Kim, Eung-Gook / Choe, Kang Hyeon / Yoon, Ho Joo / Moon, Ji-Yong

BMJ open respiratory research

2024 Volume 11, Issue 1

Abstract: Introduction: Studies that comprehensively evaluate the association between physical activity (PA) levels, particularly by quantifying PA intensity, and healthcare use requiring emergency department (ED) visit or hospitalisation in patients with chronic ...

Abstract	Introduction: Studies that comprehensively evaluate the association between physical activity (PA) levels, particularly by quantifying PA intensity, and healthcare use requiring emergency department (ED) visit or hospitalisation in patients with chronic obstructive pulmonary disease (COPD) are limited in Korea. Methods: The risk of all-cause and respiratory ED visit or hospitalisation according to the presence or absence of COPD and the level of PA was evaluated in a retrospective nationwide cohort comprising 3308 subjects with COPD (COPD cohort) and 293 358 subjects without COPD (non-COPD cohort) from 2009 to 2017. Results: The COPD group exhibited a higher relative risk of all-cause and respiratory ED visit or hospitalisation across all levels of PA compared with the highly active control group (≥1500 metabolic equivalents (METs)-min/week). Specifically, the highest risk was observed in the sedentary group (adjusted HR (aHR) (95% CI) = 1.70 (1.59 to 1.81) for all-cause ED visit or hospitalisation, 5.45 (4.86 to 6.12) for respiratory ED visit or hospitalisation). A 500 MET-min/week increase in PA was associated with reductions in all-cause and respiratory ED visit or hospitalisation in the COPD cohort (aHR (95% CI) = 0.92 (0.88 to 0.96) for all-cause, 0.87 (0.82 to 0.93) for respiratory cause). Conclusions: Compared with the presumed healthiest cohort, the control group with PA>1500 METs-min/week, the COPD group with reduced PA has a higher risk of ED visit or hospitalisation.
MeSH term(s)	Humans ; Retrospective Studies ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Pulmonary Disease, Chronic Obstructive/complications ; Hospitalization ; Risk ; Exercise
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2023-001789
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Article: Impact of adjuvant chemotherapy on patients with stage IB non-small cell lung cancer with visceral pleural invasion.

Kim, Bo-Guen / Choi, Juwhan / Lee, Sun-Kyung / Choi, Sue In / Park, Chan Kwon / Sim, Jae Kyeom / Lee, Hyun / Kim, Sang-Heon / Sohn, Jang Won / Yoon, Ho Joo / Lee, Sung Yong / Park, Dong Won

Journal of thoracic disease

2024 Volume 16, Issue 2, Page(s) 875–883

Abstract: Background: Adjuvant chemotherapy has reduced the risk of recurrence and death in stage IB non-small cell lung cancer (NSCLC) with high-risk factors; however, the impact of visceral pleural invasion (VPI) on outcomes in stage IB NSCLC treated with ... ...

Abstract	Background: Adjuvant chemotherapy has reduced the risk of recurrence and death in stage IB non-small cell lung cancer (NSCLC) with high-risk factors; however, the impact of visceral pleural invasion (VPI) on outcomes in stage IB NSCLC treated with adjuvant chemotherapy remains controversial. The aim of this study was to explore the clinical and prognostic significance of adjuvant chemotherapy for stage IB (1-4 cm) NSCLC with VPI. Methods: This retrospective study included 251 patients admitted between January 2008 and May 2018 from four hospitals who underwent complete resection for Tumor-Node-Metastasis (TNM) 8th edition stage IB NSCLC with VPI. The relationship between adjuvant chemotherapy and overall survival (OS) or recurrence-free survival (RFS) was analyzed using the Kaplan-Meier method and Cox proportional hazards model. Results: Of 251 patients with stage IB NSCLC with VPI, 122 (48.6%) received adjuvant chemotherapy after surgical resection and 129 (51.4%) were placed under observation. Multivariable analysis showed that adjuvant chemotherapy was an independent predictor of RFS [adjusted hazard ratio (aHR), 0.57; 95% confidence interval (CI): 0.33-0.96; P=0.036]. A micropapillary pattern (aHR, 2.46; 95% CI: 1.33-4.55; P=0.004) and lymphovascular invasion (aHR, 2.86; 95% CI: 1.49-5.48; P=0.002) were associated with a higher risk of recurrence. Multivariable analysis also showed that adjuvant chemotherapy was an independent predictor of OS (aHR, 0.22; 95% CI: 0.09-0.58; P=0.002). In a subgroup analysis of patients with a tumor size of 1-3 cm, adjuvant chemotherapy was associated with improved RFS and OS, and this association was maintained even when patients with VPI had additional risk factors. Conclusions: Our study shows that adjuvant chemotherapy is appropriate for patients with stage IB (1-4 cm) NSCLC with VPI, and even those with smaller tumors (1-3 cm).
Language	English
Publishing date	2024-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-936
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Article ; Online: Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: a nationwide population-based cohort study.

Kim, Bo-Guen / Lee, Hyun / Jeong, Cho Yun / Yeom, Sang Woo / Park, Dong Won / Park, Tai Sun / Moon, Ji-Yong / Kim, Tae-Hyung / Sohn, Jang Won / Yoon, Ho Joo / Kim, Jong Seung / Kim, Sang-Heon

Frontiers in public health

2024 Volume 11, Page(s) 1295457

Abstract: Objectives: Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung disease (ILD) after COVID-19 is unclear. We aimed to determine whether COVID-19 ... ...

Abstract	Objectives: Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung disease (ILD) after COVID-19 is unclear. We aimed to determine whether COVID-19 increases the risk of newly diagnosed ILD and whether vaccination against COVID-19 can reduce this risk. Methods: This retrospective cohort study used data from the Korean National Health Insurance claim-based database. Two study groups and propensity score (PS)-matched control groups were constructed: Study 1: participants diagnosed with COVID-19 (COVID-19 cohort) and their PS-matched controls; Study 2: COVID-19 vaccinated participants (vaccination cohort) and their PS-matched controls. Results: In Study 1, during a median 6 months of follow-up, 0.50% of the COVID-19 cohort (300/60,518) and 0.04% of controls (27/60,518) developed newly diagnosed ILD, with an incidence of 9.76 and 0.88 per 1,000 person-years, respectively. The COVID-19 cohort had a higher risk of ILD [adjusted hazard ratio (aHR), 11.01; 95% confidence interval (CI), 7.42-16.32] than controls. In Study 2, the vaccination cohort had a lower risk of newly diagnosed ILD than controls (aHR, 0.44; 95% CI, 0.34-0.57). Conclusion: Using nationwide data, we demonstrated that COVID-19 was associated with a higher incidence rate of newly diagnosed ILD, but that this risk could be mitigated by COVID-19 vaccination.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Cohort Studies ; Retrospective Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1295457
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Article ; Online: Long-Term Impacts of COVID-19 on Severe Exacerbation and Mortality in Adult Asthma: A Nationwide Population-Based Cohort Study.

Lee, Hyun / Kim, Bo-Guen / Jeong, Cho Yun / Park, Dong Won / Park, Tai Sun / Moon, Ji-Yong / Kim, Tae-Hyung / Sohn, Jang Won / Yoon, Ho Joo / Kim, Jong Seung / Kim, Sang-Heon

The journal of allergy and clinical immunology. In practice

2024

Abstract: Background: In adults with asthma, the long-term impact of previous coronavirus disease 2019 (COVID-19) on severe exacerbations and mortality is unclear.: Objective: We evaluated the long-term risk of severe exacerbation and mortality in adults with ... ...

Abstract	Background: In adults with asthma, the long-term impact of previous coronavirus disease 2019 (COVID-19) on severe exacerbations and mortality is unclear. Objective: We evaluated the long-term risk of severe exacerbation and mortality in adults with asthma who recovered from COVID-19. Methods: Using the Korean National Health Insurance claim-based database, we compared the risk of severe exacerbations (emergency room visits or hospitalization) and mortality in adults with asthma aged greater than 20 years who had recovered from COVID-19 between October 8, 2020, and December 16, 2021 (COVID-19 cohort, n = 10,739) with 1:1 propensity score-matched controls (n = 10,739). Results: During a median follow-up of 87 days (range, 15-448 days), the incidence rate of severe exacerbations in the COVID-19 cohort and the matched cohort was 187.3 and 119.3 per 10,000 person-years, respectively. The COVID-19 cohort had a higher risk of severe exacerbation compared with the matched cohort (hazard ratio = 1.57; 95% CI, 1.06-2.32). During a median follow-up of 360 days (range, 15-721 days), the incidence rate of death in the COVID-19 and matched cohorts was 128.3 and 73.5 per 10,000 person-years, respectively. The COVID-19 cohort had a higher risk of death (hazard ratio = 1.76; 95% CI, 1.33-2.30) compared with the matched cohort. When further analyzed by COVID-19 severity, severe COVID-19 was associated with a 5.12-fold (95% CI, 3.27-8.01) and 7.31-fold (95% CI, 5.41-9.88) increased risk of severe exacerbation and death, respectively, but non-severe COVID-19 was not. Conclusions: Our study shows that severe COVID-19 is associated with an increased long-term risk of severe exacerbation and mortality among individuals with asthma.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2024.03.035
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Article ; Online: Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study.

Kim, Taehee / Choi, Hayoung / Kim, Sang Hyuk / Yang, Bumhee / Han, Kyungdo / Jung, Jin-Hyung / Kim, Bo-Guen / Park, Dong Won / Moon, Ji Yong / Kim, Sang-Heon / Kim, Tae-Hyung / Yoon, Ho Joo / Shin, Dong Wook / Lee, Hyun

Journal of Korean medical science

2024 Volume 39, Issue 11, Page(s) e105

Abstract: Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.: Methods! ...

Abstract	Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
MeSH term(s)	Humans ; Cohort Studies ; Risk Factors ; Tuberculosis/complications ; Tuberculosis/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Incidence ; Hospitalization
Language	English
Publishing date	2024-03-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2024.39.e105
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Article: Impact of air pollution on healthcare utilization in patients with bronchiectasis.

Lee, Hyun / Kim, Sang Hyuk / Lee, Sun-Kyung / Choi, Hayoung / Chung, Sung Jun / Park, Dong Won / Park, Tai Sun / Moon, Ji-Yong / Kim, Tae-Hyung / Kim, Sang-Heon / Sohn, Jang Won / Yoon, Ho Joo

Frontiers in medicine

2023 Volume 10, Page(s) 1233516

Abstract: Introduction: Air pollutants are increasingly recognized to affect long-term outcomes in patients with bronchiectasis. We aimed to figure out the association between air pollutants and the risk of healthcare utilization in patients with bronchiectasis.!# ...

Abstract	Introduction: Air pollutants are increasingly recognized to affect long-term outcomes in patients with bronchiectasis. We aimed to figure out the association between air pollutants and the risk of healthcare utilization in patients with bronchiectasis. Methods: Data for 1,029 subjects with bronchiectasis in Seoul were extracted. The air pollutants included particulate matter of 10 μm or less in diameter (PM Results: There were significant correlations between air pollutant concentrations and the risk of healthcare utilization, particularly for PM Discussion: Increased concentrations of PM
Language	English
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1233516
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