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  1. AU="Yoon, Jong Hyun"
  2. AU="Ningaraj, Nagendra S"
  3. AU="Deegan, Patrick"
  4. AU="Jo, Doo Sin"
  5. AU="Adgey, A J"
  6. AU=Liu Hejun
  7. AU="Ferreira, Filipa C"
  8. AU="Losurdo, G"
  9. AU="Dorjsuren, Bilguujin"
  10. AU="Kilgore, Henry R"
  11. AU="Magee, Toni"
  12. AU="Jiang Gui"

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  1. Artikel ; Online: The novel HLA-B allele, HLA-B*15:656, first identified in a Korean individual by next-generation sequencing.

    Shin, Sue / Kim, Yumi / Park, Hyunwoong / Yoon, Jong Hyun / Roh, Eun Youn

    HLA

    2023  Band 102, Heft 3, Seite(n) 354–355

    Abstract: HLA-B*15:656 differs from B*15:27:01:01 by two nucleotide substitutions in codon 163 (CTG > GAG). ...

    Abstract HLA-B*15:656 differs from B*15:27:01:01 by two nucleotide substitutions in codon 163 (CTG > GAG).
    Mesh-Begriff(e) Humans ; Alleles ; HLA-B Antigens/genetics ; Genes, MHC Class I ; High-Throughput Nucleotide Sequencing ; Republic of Korea
    Chemische Substanzen HLA-B Antigens
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15121
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  2. Artikel ; Online: The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first identified in Korean individuals by next-generation sequencing.

    Roh, Eun Youn / Lim, Sori / Shin, Sue / Yoon, Jong Hyun

    HLA

    2022  Band 101, Heft 1, Seite(n) 96–97

    Abstract: HLA-DPB1*1344:01 has one non-synonymous nucleotide change from DPB1*02:01:02:01 in codon 117. ...

    Abstract HLA-DPB1*1344:01 has one non-synonymous nucleotide change from DPB1*02:01:02:01 in codon 117.
    Mesh-Begriff(e) Humans ; Alleles
    Chemische Substanzen HLA-DPB1 antigen
    Sprache Englisch
    Erscheinungsdatum 2022-09-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14806
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  3. Artikel ; Online: Identification of the novel HLA-DPA1*01:106 allele by next-generation sequencing in a Korean cord blood donor.

    Roh, Eun Youn / Lim, Sori / Shin, Sue / Yoon, Jong Hyun

    HLA

    2022  Band 101, Heft 1, Seite(n) 93–94

    Abstract: HLA-DPA1*01:106 differs from DPA1*01:03:01:01 by a single substitution at nucleotide 5 (G/A) in exon 1. ...

    Abstract HLA-DPA1*01:106 differs from DPA1*01:03:01:01 by a single substitution at nucleotide 5 (G/A) in exon 1.
    Mesh-Begriff(e) Humans ; Blood Donors ; Alleles
    Chemische Substanzen HLA-DPA1 antigen
    Sprache Englisch
    Erscheinungsdatum 2022-10-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14807
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  4. Artikel ; Online: Effects of multi-species probiotic supplementation on alcohol metabolism in rats.

    Lim, Tae-Joong / Lim, Sanghyun / Yoon, Jong Hyun / Chung, Myung Jun

    Journal of microbiology (Seoul, Korea)

    2021  Band 59, Heft 4, Seite(n) 417–425

    Abstract: Probiotics are known to protect against liver damage induced by the alcohol and acetaldehyde accumulation associated with alcohol intake. However, there have been few studies of the direct effect of probiotics on alcohol metabolism, and the types of ... ...

    Abstract Probiotics are known to protect against liver damage induced by the alcohol and acetaldehyde accumulation associated with alcohol intake. However, there have been few studies of the direct effect of probiotics on alcohol metabolism, and the types of probiotics that were previously analyzed were few in number. Here, we investigated the effects of 19 probiotic species on alcohol and acetaldehyde metabolism. Four probiotic species that had a relatively high tolerance to alcohol and metabolized alcohol and acetaldehyde effectively were identified: Lactobacillus gasseri CBT LGA1, Lactobacillus casei CBT LC5, Bifidobacterium lactis CBT BL3, and Bifidobacterium breve CBT BR3. These species also demonstrated high mRNA expression of alcohol and acetaldehyde dehydrogenases. ProAP4, a mixture of these four probiotics species and excipient, was then administered to rats for 2 weeks in advance of acute alcohol administration. The serum alcohol and acetaldehyde concentrations were significantly lower in the ProAP4-administered group than in the control and excipient groups. Thus, the administration of ProAP4, containing four probiotic species, quickly lowers blood alcohol and acetaldehyde concentrations in an alcohol and acetaldehyde dehydrogenasedependent manner. Furthermore, the serum alanine aminotransferase activity, which is indicative of liver damage, was significantly lower in the ProAP4 group than in the control group. The present findings suggest that ProAP4 may be an effective means of limiting alcohol-induced liver damage.
    Mesh-Begriff(e) Acetaldehyde/blood ; Alanine Transaminase/blood ; Alcohol Dehydrogenase/genetics ; Alcohol Dehydrogenase/metabolism ; Alcohol Drinking/metabolism ; Aldehyde Oxidoreductases/genetics ; Aldehyde Oxidoreductases/metabolism ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bifidobacterium animalis/genetics ; Bifidobacterium animalis/metabolism ; Bifidobacterium breve/genetics ; Bifidobacterium breve/metabolism ; Dietary Supplements ; Ethanol/blood ; Lactobacillus casei/genetics ; Lactobacillus casei/metabolism ; Lactobacillus gasseri/genetics ; Lactobacillus gasseri/metabolism ; Male ; Probiotics/administration & dosage ; RNA, Bacterial ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction
    Chemische Substanzen Bacterial Proteins ; RNA, Bacterial ; Ethanol (3K9958V90M) ; Alcohol Dehydrogenase (EC 1.1.1.1) ; Aldehyde Oxidoreductases (EC 1.2.-) ; aldehyde dehydrogenase (NAD(P)+) (EC 1.2.1.5) ; Alanine Transaminase (EC 2.6.1.2) ; Acetaldehyde (GO1N1ZPR3B)
    Sprache Englisch
    Erscheinungsdatum 2021-03-29
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-021-0573-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Erratum to: Effects of multi-species probiotic supplementation on alcohol metabolism in rats.

    Lim, Tae-Joong / Lim, Sanghyun / Yoon, Jong Hyun / Chung, Myung Jun

    Journal of microbiology (Seoul, Korea)

    2021  Band 59, Heft 5, Seite(n) 534

    Sprache Englisch
    Erscheinungsdatum 2021-04-28
    Erscheinungsland Korea (South)
    Dokumenttyp Published Erratum
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-021-0699-2
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  6. Artikel ; Online: Differences in the diagnosis and treatment of hematologic malignancies attributable to health insurance coverage.

    Song, Eun Young / Shin, Sue / Park, Hyunwoong / Kim, Namhee / Yoon, Jong Hyun / Roh, Eun Youn

    Medicine

    2022  Band 101, Heft 9, Seite(n) e29020

    Abstract: Abstract: Medical care should be equally provided to the public regardless of their financial capability. In the real world, expenditures directly out from the patient sector decide the medical journey, even in a country with national health insurance. ... ...

    Abstract Abstract: Medical care should be equally provided to the public regardless of their financial capability. In the real world, expenditures directly out from the patient sector decide the medical journey, even in a country with national health insurance. The aim of this study was to investigate whether there are differences in the diagnostic and treatment processes in hematologic malignancies based on patient characteristics, such as health insurance status.Through the review of 5614 "CBCs with differential count" results with abnormal cells from 358 patients from January 2010 to June 2017, 238 patients without past medical histories of hematologic malignancies were enrolled. Excluding reactive cases, 206 patients with hematologic malignancy were classified into 8 disease categories: acute leukemia, myelodysplastic syndrome, myeloproliferative neoplasm (MPN), myelodysplastic syndrome/MPN, lymphoid neoplasm, plasma cell neoplasm, r/o hematologic malignancy, and cancer.The patients' age, sex, disease categories and follow-up durations showed associations with the clinical course. The "refusal of treatment" group was the oldest and had a relatively higher percentage of females, whereas those who decided to transfer to a tertiary hospital were younger. The age, clinical course, and follow-up durations were different across health insurance statuses. The medical aid group was the oldest, and the group whose status changed from a medical insurance subscriber to a medical aid beneficiary during treatment was the youngest. The majority of patients who refused treatment or wished to be transferred to a tertiary hospital were medical insurance subscribers. The percentage of patients who were treated in this secondary municipal hospital was higher in the medical-aid beneficiaries group than in the medical insurance group. Follow-up durations were longest in the status change group and shortest in the medical insurance group.Almost all medical aid beneficiaries with hematologic malignancies opted to continue treatment at this secondary/municipal hospitals, indicating that this category of medical institutions provides adequate levels and qualified healthcare services to those patients. The secondary municipal hospital provides qualified healthcare services for medical aid beneficiaries with hematologic malignancies.
    Mesh-Begriff(e) Age Factors ; Female ; Health Expenditures ; Health Services Accessibility/economics ; Health Services Accessibility/statistics & numerical data ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/economics ; Hematologic Neoplasms/therapy ; Humans ; Insurance Coverage/statistics & numerical data ; Insurance, Health/economics ; Insurance, Health/statistics & numerical data ; National Health Programs ; Sex Factors
    Sprache Englisch
    Erscheinungsdatum 2022-03-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Characteristics of Korean BCR-ABL1-Negative Myeloproliferative Neoplasms Related to the 2016 WHO Criteria Revision.

    Kim, Namhee / Park, Hyunwoong / Shin, Sue / Yoon, Jong-Hyun / Roh, Eun-Youn

    Clinical laboratory

    2022  Band 68, Heft 9

    Abstract: Background: We aimed to identify changes in the diagnosis and subtype classification of Korean patients with BCR-ABL1-negative MPN related to the revision of the WHO classification in 2016.: Methods: We evaluated 76 Korean patients with BCR-ABL1- ... ...

    Abstract Background: We aimed to identify changes in the diagnosis and subtype classification of Korean patients with BCR-ABL1-negative MPN related to the revision of the WHO classification in 2016.
    Methods: We evaluated 76 Korean patients with BCR-ABL1-negative MPN who underwent diagnostic work-ups, including bone marrow (BM) examinations and JAK2 V617F mutation analysis, from January 2013 to June 2018. Additionally, we reclassified the subtype of 43 patients who were diagnosed based on the WHO 2008 classification.
    Results: From January 2013 to April 2016, 43 patients were diagnosed with BCR-ABL1-negative MPN (12 PV, 17 ET, 14 PMF) according to the 2008 WHO classification, and from May 2016 to June 2018, 33 patients were diagnosed according to the 2016 classification (15 PV, 11 ET, 7 PMF). With the application of 2016 classification, 3 cases of ET were reclassified as pre-PMF, and the proportion of PV increased from 27.9% to 45.5%. There were significant differences in CBC between pre-PMF and overt PMF, between ET and overt-PMF, but no difference between ET and pre-PMF.
    Conclusions: The overall characteristics of BCR-ABL1-negative MPN patients were not significantly different from those of previous reports. 'Masked PV', which could not be diagnosed according to the WHO 2008 classification, may have been diagnosed as PV since 2016 due to the increase in the diagnostic value of the BM findings and the lowering of the hemoglobin (Hb) threshold.
    Mesh-Begriff(e) Fusion Proteins, bcr-abl/genetics ; Humans ; Janus Kinase 2/genetics ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Neoplasms ; Republic of Korea ; World Health Organization
    Chemische Substanzen Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Sprache Englisch
    Erscheinungsdatum 2022-09-20
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2021.220113
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Machine Learning Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy for ER+HER2- Breast Cancer: Integrating Tumoral and Peritumoral MRI Radiomic Features.

    Park, Jiwoo / Kim, Min Jung / Yoon, Jong-Hyun / Han, Kyunghwa / Kim, Eun-Kyung / Sohn, Joo Hyuk / Lee, Young Han / Yoo, Yangmo

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 19

    Abstract: Background: This study aimed to predict pathologic complete response (pCR) in neoadjuvant chemotherapy for ER+HER2- locally advanced breast cancer (LABC), a subtype with limited treatment response.: Methods: We included 265 ER+HER2- LABC patients ( ... ...

    Abstract Background: This study aimed to predict pathologic complete response (pCR) in neoadjuvant chemotherapy for ER+HER2- locally advanced breast cancer (LABC), a subtype with limited treatment response.
    Methods: We included 265 ER+HER2- LABC patients (2010-2020) with pre-treatment MRI, neoadjuvant chemotherapy, and confirmed pathology. Using data from January 2016, we divided them into training and validation cohorts. Volumes of interest (VOI) for the tumoral and peritumoral regions were segmented on preoperative MRI from three sequences: T1-weighted early and delayed contrast-enhanced sequences and T2-weighted fat-suppressed sequence (T2FS). We constructed seven machine learning models using tumoral, peritumoral, and combined texture features within and across the sequences, and evaluated their pCR prediction performance using AUC values.
    Results: The best single sequence model was SVM using a 1 mm tumor-to-peritumor VOI in the early contrast-enhanced phase (AUC = 0.9447). Among the combinations, the top-performing model was K-Nearest Neighbor, using 1 mm tumor-to-peritumor VOI in the early contrast-enhanced phase and 3 mm peritumoral VOI in T2FS (AUC = 0.9631).
    Conclusions: We suggest that a combined machine learning model that integrates tumoral and peritumoral radiomic features across different MRI sequences can provide a more accurate pretreatment pCR prediction for neoadjuvant chemotherapy in ER+HER2- LABC.
    Sprache Englisch
    Erscheinungsdatum 2023-09-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13193031
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  9. Artikel: Effects of multi-species probiotic supplementation on alcohol metabolism in rats

    Lim, Tae-Joong / Lim, Sanghyun / Yoon, Jong Hyun / Chung, Myung Jun

    journal of microbiology. 2021 Apr., v. 59, no. 4

    2021  

    Abstract: Probiotics are known to protect against liver damage induced by the alcohol and acetaldehyde accumulation associated with alcohol intake. However, there have been few studies of the direct effect of probiotics on alcohol metabolism, and the types of ... ...

    Abstract Probiotics are known to protect against liver damage induced by the alcohol and acetaldehyde accumulation associated with alcohol intake. However, there have been few studies of the direct effect of probiotics on alcohol metabolism, and the types of probiotics that were previously analyzed were few in number. Here, we investigated the effects of 19 probiotic species on alcohol and acetaldehyde metabolism. Four probiotic species that had a relatively high tolerance to alcohol and metabolized alcohol and acetaldehyde effectively were identified: Lactobacillus gasseri CBT LGA1, Lactobacillus casei CBT LC5, Bifidobacterium lactis CBT BL3, and Bifidobacterium breve CBT BR3. These species also demonstrated high mRNA expression of alcohol and acetaldehyde dehydrogenases. ProAP4, a mixture of these four probiotics species and excipient, was then administered to rats for 2 weeks in advance of acute alcohol administration. The serum alcohol and acetaldehyde concentrations were significantly lower in the ProAP4-administered group than in the control and excipient groups. Thus, the administration of ProAP4, containing four probiotic species, quickly lowers blood alcohol and acetaldehyde concentrations in an alcohol and acetaldehyde dehydrogenasedependent manner. Furthermore, the serum alanine aminotransferase activity, which is indicative of liver damage, was significantly lower in the ProAP4 group than in the control group. The present findings suggest that ProAP4 may be an effective means of limiting alcohol-induced liver damage.
    Schlagwörter Bifidobacterium animalis subsp. lactis ; Bifidobacterium breve ; Lactobacillus casei ; Lactobacillus gasseri ; acetaldehyde ; alanine transaminase ; alcohol drinking ; alcohols ; blood serum ; gene expression ; liver ; metabolism ; oxidoreductases ; probiotics
    Sprache Englisch
    Erscheinungsverlauf 2021-04
    Umfang p. 417-425.
    Erscheinungsort The Microbiological Society of Korea
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2012399-1
    ISSN 1225-8873
    ISSN 1225-8873
    DOI 10.1007/s12275-021-0573-2
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Coagulation Testing in Real-World Setting: Insights From a Comprehensive Survey.

    Bang, Hae In / Lee, Ja Young / Kim, Hyun-Young / Shin, Saeam / Nam, Myung Hyun / Kim, In-Suk / Kim, Ji Myung / Yoon, Jong-Hyun / Shin, Myung-Geun / Hwang, Sang Mee / Kong, Sun-Young

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2024  Band 30, Seite(n) 10760296241228239

    Abstract: The objective of this survey was to gain a real-world perspective on coagulation testing by evaluating the availability of various coagulation laboratory tests, assessing specific analytic and postanalytic steps in clinical laboratories in Korea ... ...

    Abstract The objective of this survey was to gain a real-world perspective on coagulation testing by evaluating the availability of various coagulation laboratory tests, assessing specific analytic and postanalytic steps in clinical laboratories in Korea.Participants were surveyed using a 65-question questionnaire specifically focused on their coagulation testing practices related to prothrombin time (PT), activated partial thromboplastin time (aPTT), plasma-mixing studies, lupus anticoagulant (LA) tests, platelet function tests, coagulation factor assays, and the composition of hemostasis and thrombosis test panels. The survey was performed between July and September 2022.The survey achieved a 77.9% (81 of 104) response rate. PT or aPTT tests were performed directly at all participating institutions, followed by D-dimer and fibrinogen tests, platelet function test, and plasma-mixing studies in order of frequency. Variations existed in the performance of mixing test and LA assessment. Patterns of coagulating testing differed depending on the size of the hospital. The survey revealed that most laboratories conducted coagulation tests following the international guidelines such as Clinical Laboratory Standards Institute guidelines and the Korean Laboratory Certification system. However, some coagulation tests, including mixing test and LA tests, are yet to be standardized in Korea.Continuous education on coagulation test methods and internal and external quality control are required to encourage laboratories to enhance the performance of coagulation testing.
    Mesh-Begriff(e) Humans ; Blood Coagulation Tests/methods ; Prothrombin Time ; Blood Coagulation ; Partial Thromboplastin Time ; Surveys and Questionnaires ; Lupus Coagulation Inhibitor
    Chemische Substanzen Lupus Coagulation Inhibitor
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296241228239
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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