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  1. Article ; Online: Direct-to-Consumer Telemedicine.

    Elliott, Tania / Yopes, Margot C

    The journal of allergy and clinical immunology. In practice

    2019  Volume 7, Issue 8, Page(s) 2546–2552

    Abstract: The telemedicine industry and adoption of services have grown exponentially in the last 5 years, and the market is expected to reach more than $130 billion by 2025. Most US health institutions and hospital systems are currently using some form of ... ...

    Abstract The telemedicine industry and adoption of services have grown exponentially in the last 5 years, and the market is expected to reach more than $130 billion by 2025. Most US health institutions and hospital systems are currently using some form of telehealth, and more than 90% of health care executives surveyed across the United States have virtual care on their roadmap for growth. Telemedicine has been proposed as a way to expand the reach of allergy services and allow more patients to manage their disease with an allergy specialist. Technology can help address fragmentation of allergy care, which is currently provided in multiple clinical settings beyond the allergist's office including in primary care, pulmonary, dermatology, ear, nose, and throat, urgent care, and the emergency room. Remote monitoring, specialist second opinions, and synchronous and asynchronous encounters offer opportunities to streamline routine care, especially as smart hardware such as digital inhalers hit the market and reimbursement for telehealth services evolve. To date, allergy care has been a significant area of interest for direct-to-consumer telemedicine solutions, although the care has mainly been offered by nonallergists. Quality assurance and adherence to evidence-based standards, particularly in the self-pay direct-to-consumer space, warrant attention.
    MeSH term(s) Delivery of Health Care/statistics & numerical data ; Evidence-Based Practice ; Humans ; Hypersensitivity/epidemiology ; Monitoring, Physiologic ; Quality Assurance, Health Care ; Telemedicine/statistics & numerical data ; United States/epidemiology
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.06.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Kounis Syndrome After Administration of Ultrasound Enhancing Agent.

    Yopes, Margot C / Larnard, Emily A / Liu, Spencer D / Stout, Jessica L / Matos, Jason D / Osborn, Eric A / Strom, Jordan B

    Circulation. Cardiovascular imaging

    2024  Volume 17, Issue 3, Page(s) e016362

    MeSH term(s) Humans ; Kounis Syndrome ; Myocardial Infarction ; Ultrasonography
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.123.016362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Analysis of 5 Years of Randomized Trials in Gastroenterology and Hepatology Reveals 52 Medical Reversals.

    Yopes, Margot C / Mozeika, Alexander M / Liebling, Simon / Haslam, Alyson / Prasad, Vinay / Lebwohl, Benjamin

    Digestive diseases and sciences

    2021  Volume 67, Issue 6, Page(s) 2011–2018

    Abstract: Background and aims: One manifestation of low-value medical practice is the medical reversal, a practice in widespread use that, once subjected to a randomized controlled trial (RCT), is found to be no better-or worse-than a prior established standard ... ...

    Abstract Background and aims: One manifestation of low-value medical practice is the medical reversal, a practice in widespread use that, once subjected to a randomized controlled trial (RCT), is found to be no better-or worse-than a prior established standard of care. We aimed to determine the prevalence of medical reversals in gastroenterology (GI) journals and characterize these reversals.
    Methods: We searched the American Journal of Gastroenterology, Clinical Gastroenterology and Hepatology, Gastroenterology, Gut, Hepatology, and the Journal of Hepatology, reviewing studies published in 2015-2019. We identified RCTs that tested an established clinical practice and produced negative results, considered tentative reversals. Any systematic review or meta-analysis that included the article was categorized as confirming the reversal, refuting the reversal, or providing insufficient data.
    Results: During the 5-year period, we identified 5,898 original articles, of which 212 tested an established practice and 52 were categorized as unrefuted medical reversals (25% of articles testing standard of care). Of the reversals, 21 (40%) tested procedures and devices, 15 (29%) tested medications, and 8 (15%) tested vitamins/supplements/diet. Twenty-three (44%) considered the alimentary tract, 12 (23%) considered the liver, pancreas, or biliary tract, and 17 (33%) considered endoscopy. Thirty-eight (73%) were funded exclusively by non-industry sources.
    Conclusion: This review reveals a total of 52 reversals across all subfields of GI and medical, procedural, screening, and diagnostic interventions, occurring in 25% of randomized trials testing an established practice. More research is needed to determine the optimal way to engage stakeholders and remove reversed practices from medical care.
    MeSH term(s) Gastroenterology ; Humans ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07199-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection.

    Connors, Thomas J / Baird, J Scott / Yopes, Margot C / Zens, Kyra D / Pethe, Kalpana / Ravindranath, Thyyar M / Ho, Siu-Hong / Farber, Donna L

    Journal of immunology (Baltimore, Md. : 1950)

    2018  Volume 201, Issue 2, Page(s) 432–439

    Abstract: Viral respiratory tract infections (VRTI) remain a leading cause of morbidity and mortality among infants and young children. In mice, optimal protection to VRTI is mediated by recruitment of effector T cells to the lungs and respiratory tract, and ... ...

    Abstract Viral respiratory tract infections (VRTI) remain a leading cause of morbidity and mortality among infants and young children. In mice, optimal protection to VRTI is mediated by recruitment of effector T cells to the lungs and respiratory tract, and subsequent establishment of tissue resident memory T cells (Trm), which provide long-term protection. These critical processes of T cell recruitment to the respiratory tract, their role in disease pathogenesis, and establishment of local protective immunity remain undefined in pediatric VRTI. In this study, we investigated T cell responses in the upper respiratory tract (URT) and lower respiratory tract (LRT) of infants and young children with VRTI, revealing developmental regulation of T cell differentiation and Trm generation in situ. We show a direct concurrence between T cell responses in the URT and LRT, including a preponderance of effector CD8
    MeSH term(s) Adult ; CD8-Positive T-Lymphocytes/immunology ; Child ; Child, Preschool ; Female ; Humans ; Immunologic Memory/immunology ; Infant ; Infant, Newborn ; Lung/immunology ; Lung/virology ; Lymphocyte Activation/immunology ; Male ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/virology ; Transcription Factors/immunology ; Virus Diseases/immunology
    Chemical Substances Transcription Factors
    Keywords covid19
    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1800396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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