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  1. Article ; Online: Deciphering the enigmatic spikelet traits: Resolving trade-offs for enhancing rice yield.

    Yoshida, Hideki / Matsuoka, Makoto

    Molecular plant

    2024  Volume 17, Issue 5, Page(s) 694–695

    MeSH term(s) Oryza/growth & development ; Oryza/genetics ; Oryza/metabolism ; Phenotype
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.04.006
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  2. Article ; Online: Locomotor Assays in Drosophila Larvae and Adult Flies.

    Tsuda, Leo / Anh, Huynh Man / Yoshida, Hideki

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2794, Page(s) 305–311

    Abstract: Brain defects often lead to motor dysfunctions in humans. Drosophila melanogaster has been one of the most useful organisms in the study of neuronal biology due to its similarities with humans and has contributed to a more detailed understanding of the ... ...

    Abstract Brain defects often lead to motor dysfunctions in humans. Drosophila melanogaster has been one of the most useful organisms in the study of neuronal biology due to its similarities with humans and has contributed to a more detailed understanding of the effects of genetic dysfunctions in the brain on behavior. We herein present modified protocols for the crawling assay with larvae and the climbing assay with adult flies that are simple to perform as well as a series of commands for ImageJ to automatically analyze data for the crawling assay.
    MeSH term(s) Adult ; Humans ; Animals ; Drosophila ; Larva ; Drosophila melanogaster ; Arthropods ; Biological Assay
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3810-1_25
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  3. Article ; Online: Two bHLH transcription factors affect sprouting by regulating the level of ABA.

    Yoshida, Hideki / Matsuoka, Makoto

    Nature genetics

    2022  Volume 54, Issue 12, Page(s) 1772–1773

    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01238-1
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  4. Article: Factors associated with improvement in impaired consciousness during the acute phase of cerebral infarction: a prospective observational study.

    Matsumoto, Koki / Takami, Akiyoshi / Makino, Misato / Yoshida, Hideki

    Journal of physical therapy science

    2023  Volume 35, Issue 10, Page(s) 678–684

    Abstract: Purpose] In this study, we investigated factors that contribute to improvement in impaired consciousness following cerebral infarction. [Participants and Methods] This prospective observational study included 186 patients with cerebral infarction. We ... ...

    Abstract [Purpose] In this study, we investigated factors that contribute to improvement in impaired consciousness following cerebral infarction. [Participants and Methods] This prospective observational study included 186 patients with cerebral infarction. We investigated 21 variables including the rehabilitation status to determine factors that contribute to improvement in impaired consciousness. [Results] Improvement in impaired consciousness was correlated with age, delirium, the Japan Coma Scale score at initiation of rehabilitation, worsening, cerebral edema, and standing practice. [Conclusion] We conclude that the aforementioned factors may serve as predictors of possible improvement and that standing practice may contribute to improvement in impaired consciousness.
    Language English
    Publishing date 2023-10-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.678
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  5. Article ; Online: Progress to Clarify How

    Mizuta, Ikuko / Nakao-Azuma, Yumiko / Yoshida, Hideki / Yamaguchi, Masamitsu / Mizuno, Toshiki

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Notch signaling is conserved ... ...

    Abstract Notch signaling is conserved in
    MeSH term(s) Adult ; Humans ; Animals ; CADASIL/genetics ; Caenorhabditis elegans ; Cerebral Small Vessel Diseases ; Signal Transduction/genetics ; Mutation ; Drosophila ; Mammals ; Receptor, Notch3/genetics
    Chemical Substances NOTCH3 protein, human ; Receptor, Notch3
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010127
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  6. Article ; Online: α-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies.

    Matsuoka, Taro / Yoshida, Hideki / Kasai, Takashi / Tozawa, Takenori / Iehara, Tomoko / Chiyonobu, Tomohiro

    Human molecular genetics

    2024  

    Abstract: Syntaxin-binding protein 1 (STXBP1) is a presynaptic protein that plays important roles in synaptic vesicle docking and fusion. STXBP1 haploinsufficiency causes STXBP1 encephalopathy (STXBP1-E), which encompasses neurological disturbances including ... ...

    Abstract Syntaxin-binding protein 1 (STXBP1) is a presynaptic protein that plays important roles in synaptic vesicle docking and fusion. STXBP1 haploinsufficiency causes STXBP1 encephalopathy (STXBP1-E), which encompasses neurological disturbances including epilepsy, neurodevelopmental disorders, and movement disorders. Most patients with STXBP1-E present with regression and movement disorders in adulthood, highlighting the importance of a deeper understanding of the neurodegenerative aspects of STXBP1-E. An in vitro study proposed an interesting new role of STXBP1 as a molecular chaperone for α-Synuclein (αSyn), a key molecule in the pathogenesis of neurodegenerative disorders. However, no studies have shown αSyn pathology in model organisms or patients with STXBP1-E. In this study, we used Drosophila models to examine the effects of STXBP1 haploinsufficiency on αSyn-induced neurotoxicity in vivo. We demonstrated that haploinsufficiency of Ras opposite (Rop), the Drosophila ortholog of STXBP1, exacerbates compound eye degeneration, locomotor dysfunction, and dopaminergic neurodegeneration in αSyn-expressing flies. This phenotypic aggravation was associated with a significant increase in detergent-insoluble αSyn levels in the head. Furthermore, we tested whether trehalose, which has neuroprotective effects in various models of neurodegenerative disorders, mitigates αSyn-induced neurotoxicity exacerbated by Rop haploinsufficiency. In flies expressing αSyn and carrying a heterozygous Rop null variant, trehalose supplementation effectively alleviates neuronal phenotypes, accompanied by a decrease in detergent-insoluble αSyn in the head. In conclusion, this study revealed that Rop haploinsufficiency exacerbates αSyn-induced neurotoxicity by altering the αSyn aggregation propensity. This study not only contributes to understanding the mechanisms of neurodegeneration in STXBP1-E patients, but also provides new insights into the pathogenesis of α-synucleinopathies.
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddae073
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3469: Show issues Location:
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  7. Article: Low mutation rate of spontaneous mutants enables detection of causative genes by comparing whole genome sequences.

    Suganami, Mao / Kojima, Soichi / Yoshida, Hideki / Mori, Masaki / Kawamura, Mayuko / Koketsu, Eriko / Matsuoka, Makoto

    Frontiers in plant science

    2024  Volume 15, Page(s) 1366413

    Abstract: In the early 1900s, mutation breeding to select varieties with desirable traits using spontaneous mutation was actively conducted around the world, including Japan. In rice, the number of fixed mutations per generation was estimated to be 1.38-2.25. ... ...

    Abstract In the early 1900s, mutation breeding to select varieties with desirable traits using spontaneous mutation was actively conducted around the world, including Japan. In rice, the number of fixed mutations per generation was estimated to be 1.38-2.25. Although this low mutation rate was a major problem for breeding in those days, in the modern era with the development of next-generation sequencing (NGS) technology, it was conversely considered to be an advantage for efficient gene identification. In this paper, we proposed an
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1366413
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  8. Article ; Online: Lipin knockdown in pan-neuron of Drosophila induces reduction of lifespan, deficient locomotive behavior, and abnormal morphology of motor neuron.

    Nguyen, Yen D H / Yoshida, Hideki / Tran, Thanh Men / Kamei, Kaeko

    Neuroreport

    2023  Volume 34, Issue 12, Page(s) 629–637

    Abstract: The Lipin family is evolutionarily conserved among insects and mammals, and its crucial roles in lipid synthesis and homeostatic control of energy balance have been well documented. This study investigated the function of Lipin in neuronal function and ... ...

    Abstract The Lipin family is evolutionarily conserved among insects and mammals, and its crucial roles in lipid synthesis and homeostatic control of energy balance have been well documented. This study investigated the function of Lipin in neuronal function and neurodegeneration. The GAL4/UAS system was used to knock down Lipin in the nervous system of Drosophila and investigate its behavioral and cellular phenotypes. The neuromuscular junction (NMJ) morphology was detected by immunostaining. Moreover, triacylglycerol and ATP levels were analyzed by using assay Kit. This study found that Lipin is localized almost in the cytoplasm of neurons in the brain lobe and ventral nerve cord, which are part of the central nervous system (CNS) of Drosophila melanogaster. Lipin knockdown larvae exhibit decreased locomotor activity, aberrant morphology of motor nerve terminals at NMJs, and reduced number and size of lipid droplets in the CNS. Furthermore, neuron-specific knockdown of Lipin leads to locomotor defects and a shortened lifespan, accompanied by a reduction in ATP levels in the adult stage. These results indicate that Lipin plays a crucial role in the CNS of Drosophila.
    MeSH term(s) Animals ; Adenosine Triphosphate ; Animals, Genetically Modified ; Drosophila/genetics ; Drosophila Proteins/genetics ; Longevity ; Motor Neurons/physiology
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Drosophila Proteins ; lipine ; Lpin protein, Drosophila
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001936
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    Zs.A 3118: Show issues Location:
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  9. Article ; Online: Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants.

    Yamaguchi, Mizuki / Huynh, Man Anh / Chiyonobu, Tomohiro / Yoshida, Hideki

    Experimental cell research

    2023  Volume 433, Issue 2, Page(s) 113827

    Abstract: Neurodevelopmental disorders (NDD) are a group of disorders that include intellectual disability. Although several genes have been implicated in NDD, the molecular mechanisms underlying its pathogenesis remain unclear. Therefore, it is important to ... ...

    Abstract Neurodevelopmental disorders (NDD) are a group of disorders that include intellectual disability. Although several genes have been implicated in NDD, the molecular mechanisms underlying its pathogenesis remain unclear. Therefore, it is important to develop novel models to analyze the functions of NDD-causing genes in vivo. Recently, rare pathogenic variants of the B-cell lymphoma/leukemia11A/B (BCL11A/B) gene have been identified in several patients with NDD. Drosophila carries the Chronophage (Cph) gene, which has been predicted to be a homolog of BCL11A/B based on the conservation of the amino acid sequence. In the present study, we investigated whether nervous system-specific knockdown of Cph mimics NDD phenotypes in Drosophila. Nervous system-specific knockdown of Cph induced learning and locomotor defects in larvae and epilepsy-like behaviors in adults. The number of synaptic branches was also elevated in the larval neuromuscular junction without a corresponding increase in the number of boutons. Furthermore, the expression levels of putative target genes that are Drosophila homologs of the mammalian BCL11 target genes were decreased in Cph knockdown flies. These results suggest that Cph knockdown flies are a promising model for investigating the pathology of NDD-induced BCL11A/B dysfunction.
    MeSH term(s) Drosophila/genetics ; Intellectual Disability/genetics ; Mammals ; Neurodevelopmental Disorders/genetics ; Repressor Proteins ; Transcription Factors/genetics ; Drosophila Proteins/genetics
    Chemical Substances BCL11A protein, human ; Repressor Proteins ; Transcription Factors ; Drosophila Proteins
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2023.113827
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    Zs.A 563: Show issues Location:
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  10. Article ; Online: The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.

    Xu, Jinghong / Hashino, Takuya / Tanaka, Reiji / Kawaguchi, Koichiro / Yoshida, Hideki / Kataoka, Takao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14041

    Abstract: The BCL-2 family protein BCL-RAMBO, also known as BCL2-like 13, anchors at the outer mitochondrial membrane and regulates apoptosis, mitochondrial fragmentation, and mitophagy. However, the mechanisms underlying the proapoptotic role of BCL-RAMBO remain ... ...

    Abstract The BCL-2 family protein BCL-RAMBO, also known as BCL2-like 13, anchors at the outer mitochondrial membrane and regulates apoptosis, mitochondrial fragmentation, and mitophagy. However, the mechanisms underlying the proapoptotic role of BCL-RAMBO remain unclear. In the present study, we demonstrated that BCL-RAMBO interacted with glucose-regulated protein 75 (GRP75), also known as heat shock protein family A member 9, and mortalin using co-immunoprecipitation and glutathione S-transferase-based pull-down assays. BCL-RAMBO interacted with GRP75 via its No BCL-2 homology domain. The interaction between BCL-RAMBO and GRP75 was confirmed by genetic interactions in Drosophila because a rough eye phenotype caused by the ectopic expression of BCL-RAMBO was partially suppressed by mutations in Hsc70-5, a mammalian GRP75 ortholog. In human embryonic kidney 293T cells, the co-expression of BCL-RAMBO and GRP75 facilitated an elevation in executioner caspase activity and poly (ADP-ribose) polymerase 1 (PARP-1) cleavage. In contrast, the knockdown of GRP75 suppressed elevated executioner caspase activity and PARP-1 cleavage in BCL-RAMBO-transfected cells. The mitochondrial release of cytochrome c induced by BCL-RAMBO was also attenuated by the knockdown of GRP75. These results indicate that GRP75 interacts with BCL-RAMBO and plays a crucial role in the BCL-RAMBO-dependent apoptosis signaling pathway.
    MeSH term(s) Humans ; Animals ; Poly(ADP-ribose) Polymerase Inhibitors ; Apoptosis ; Drosophila ; Signal Transduction ; Caspases ; Mammals
    Chemical Substances glucose-regulated proteins ; Poly(ADP-ribose) Polymerase Inhibitors ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41196-0
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