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Article ; Online: Refund: a defense of luck egalitarian policy in healthcare.

Yoshida, Masahiro / Inoue, Akira

2023 Volume 45, Issue 1, Page(s) 25–40

Abstract: Luck egalitarianism assigns a central role to personal responsibility in egalitarian justice. In the context of healthcare, luck egalitarianism is the view that the distribution of medical and healthcare resources-or common resources in general-should ... ...

Abstract	Luck egalitarianism assigns a central role to personal responsibility in egalitarian justice. In the context of healthcare, luck egalitarianism is the view that the distribution of medical and healthcare resources-or common resources in general-should respond to the (im)prudence of individuals. Recently, Joar Björk, Gert Helgesson, and Niklas Juth have argued that it is impractical to use luck egalitarianism as a normative framework in healthcare because it has no reasonable way of dealing with the imprudent. In response to their argument, this paper first suggests that the epistemic problems of applying luck egalitarianism to the healthcare context raised by Björk et al. can be circumvented by using the exemption system as a policy application of luck egalitarian healthcare justice. This paper then shows that an ex ante policy, a tax system with refunds, can reasonably be adopted as a luck egalitarian institutional design of healthcare policy. We argue that the proposed conception of luck egalitarianism can deal with the problem of differential option luck. Finally, we show that the threshold problem for the definition of imprudence does not refute the proposed ex ante policy.
MeSH term(s)	Humans ; Delivery of Health Care ; Health Policy ; Social Justice
Language	English
Publishing date	2023-10-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1418481-3
ISSN	1573-0980 ; 1573-1200 ; 1386-7415
ISSN (online)	1573-0980 ; 1573-1200
ISSN	1386-7415
DOI	10.1007/s11017-023-09649-9
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Article ; Online: Critical swallowing functions contributing to dysphagia in patients with recurrent laryngeal nerve paralysis after esophagectomy.

Takatsu, Jun / Higaki, Eiji / Abe, Tetsuya / Fujieda, Hironori / Yoshida, Masahiro / Yamamoto, Masahiko / Shimizu, Yasuhiro

Esophagus : official journal of the Japan Esophageal Society

2024 Volume 21, Issue 2, Page(s) 111–119

Abstract: Background: Recurrent laryngeal nerve paralysis (RLNP) after esophagectomy can cause aspiration because of incomplete glottis closure, leading to pneumonia. However, patients with RLNP often have preserved swallowing function. This study investigated ... ...

Abstract	Background: Recurrent laryngeal nerve paralysis (RLNP) after esophagectomy can cause aspiration because of incomplete glottis closure, leading to pneumonia. However, patients with RLNP often have preserved swallowing function. This study investigated factors that determine swallowing function in patients with RLNP. Methods: Patients with esophageal cancer who underwent esophagectomy and cervical esophagogastric anastomosis were enrolled between 2017 and 2020. Videofluoroscopic examination of swallowing study (VFSS) and acoustic voice analysis were performed on patients with suspected dysphagia including RLNP. Dysphagia in VFSS was defined as score ≥ 3 of the 8-point penetration-aspiration scale VFSS and acoustic analysis results related to dysphagia were compared between patients with and without RLNP. Results: Among 312 patients who underwent esophagectomy, 74 developed RLNP. The incidence of late-onset pneumonia was significantly higher in the RLNP group than in the non-RLNP (18.9 vs. 8.0%, P = .008). Detailed swallowing function was assessed by VFSS in 84 patients, and patients with RLNP and dysphagia showed significantly shorter maximum diagonal hyoid bone elevation (10.62 vs. 16.75 mm; P = .003), which was a specific finding not seen in patients without RLNP. For acoustic voice analysis, the degree of hoarseness was not closely related to dysphagia. The length of oral intake rehabilitation for patients with and without RLNP was comparable if they did not present with dysphagia (8.5 vs. 9.0 days). Conclusions: Impaired hyoid bone elevation is a specific dysphagia factor in patients with RLNP, suggesting compensatory epiglottis inversion by hyoid bone elevation is important for incomplete glottis closure caused by RLNP.
MeSH term(s)	Humans ; Deglutition Disorders/epidemiology ; Deglutition Disorders/etiology ; Deglutition/physiology ; Esophagectomy/adverse effects ; Recurrent Laryngeal Nerve ; Vocal Cord Paralysis/epidemiology ; Vocal Cord Paralysis/etiology ; Pneumonia ; Respiratory Aspiration
Language	English
Publishing date	2024-01-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2133367-1
ISSN	1612-9067 ; 1612-9059
ISSN (online)	1612-9067
ISSN	1612-9059
DOI	10.1007/s10388-023-01041-9
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Article: [Overview of the JPN practice guidelines for management of acute pancreatitis 2021].

Mayumi, Toshihiko / Takada, Tadahiro / Yoshida, Masahiro

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

2022 Volume 119, Issue 8, Page(s) 697–703

MeSH term(s)	Acute Disease ; Humans ; Pancreatitis/diagnosis ; Pancreatitis/therapy ; Practice Guidelines as Topic
Language	Japanese
Publishing date	2022-08-06
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.119.697
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Article ; Online: Gold-Catalyzed Nucleophilic Ring-Opening Reaction of 2-Alkynylazetidines with Alcohols.

Hirokane, Tsukasa / Kariya, Touya / Takata, Misa / Matsumoto, Kenji / Yoshida, Masahiro

The Journal of organic chemistry

2022 Volume 87, Issue 18, Page(s) 12455–12459

Abstract: The reaction of 2-alkynylazetidines and alcohols with a gold catalyst is described. A variety of substituted δ-amino-α,β-unsaturated ketones were synthesized via gold-promoted nucleophilic attack of alcohols followed by ring-opening of azetidine ring. ...

Abstract	The reaction of 2-alkynylazetidines and alcohols with a gold catalyst is described. A variety of substituted δ-amino-α,β-unsaturated ketones were synthesized via gold-promoted nucleophilic attack of alcohols followed by ring-opening of azetidine ring.
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c01325
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Article ; Online: Factors Affecting Delay in Initial Treatment of Patients with Soft Tissue Sarcomas.

Fujihara, Nasa / Hamada, Shunsuke / Yoshida, Masahiro / Tsukushi, Satoshi / Fujihara, Yuki

The journal of hand surgery Asian-Pacific volume

2022 Volume 27, Issue 1, Page(s) 135–140

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Female ; Humans ; Liposarcoma ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/epidemiology ; Sarcoma/therapy ; Soft Tissue Neoplasms/epidemiology ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/therapy
Language	English
Publishing date	2022-02-09
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2848651-1
ISSN	2424-8363 ; 2424-8355
ISSN (online)	2424-8363
ISSN	2424-8355
DOI	10.1142/S2424835522500163
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Article ; Online: Novel hydrophobically modified agarose cryogels fabricated using dimethyl sulfoxide.

Evans, Courtney / Morimitsu, Yuto / Nishi, Rikako / Yoshida, Masahiro / Takei, Takayuki

Journal of bioscience and bioengineering

2022 Volume 133, Issue 4, Page(s) 390–395

Abstract: Drug delivery systems (DDS) are devices able to adsorb therapeutic drugs in vitro before being either injected or surgically implanted into the body before releasing the drugs in vivo. Hydrogels are interesting for DDS researchers as they mimic soft ... ...

Abstract	Drug delivery systems (DDS) are devices able to adsorb therapeutic drugs in vitro before being either injected or surgically implanted into the body before releasing the drugs in vivo. Hydrogels are interesting for DDS researchers as they mimic soft tissue and can absorb large quantities of liquid. This research reported the successful fabrication of hydrophobically modified agarose (HMA) as well as the creation of a novel approach to the formation of hydrophobically modified agarose cryogels. By activating the hydroxyl groups in agarose, hydrophobic modification could occur through the bonding of the activated hydroxyl groups and the amines in fatty aldehydes. It was found that HMA was insoluble in water, and as such a new method of cryogel creation was produced using dimethyl sulfoxide. Further testing of HMA cryogels showed that cell adhesiveness and cytotoxicity were low. Adsorption tests showed that HMA cryogels had the ability to adsorb larger amounts of hydrophobic dye than unmodified agarose cryogels and that the release of the hydrophobic dye from HMA cryogels could be controlled. These results showed that the HMA cryogels made using this novel approach have the potential to be used as drug delivery systems.
MeSH term(s)	Cryogels/chemistry ; Dimethyl Sulfoxide ; Drug Delivery Systems ; Hydrophobic and Hydrophilic Interactions ; Sepharose
Chemical Substances	Cryogels ; Sepharose (9012-36-6) ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2022-01-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2021.12.009
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Article ; Online: Autoclaving-Triggered Hydrogelation of Chitosan-Gluconic acid Conjugate Aqueous Solution for Wound Healing.

Yamashita, Yusuke / Ohzuno, Yoshihiro / Saito, Yoichi / Fujiwara, Yukio / Yoshida, Masahiro / Takei, Takayuki

Gels (Basel, Switzerland)

2023 Volume 9, Issue 4

Abstract: Moist wound healing is known to heal wounds faster than dry wound healing. Hydrogel wound dressings are suitable for moist wound healing because of their hyperhydrous structure. Chitosan, a natural polymer, promotes wound healing by stimulating ... ...

Abstract	Moist wound healing is known to heal wounds faster than dry wound healing. Hydrogel wound dressings are suitable for moist wound healing because of their hyperhydrous structure. Chitosan, a natural polymer, promotes wound healing by stimulating inflammatory cells and releasing bioactive compounds. Therefore, chitosan hydrogel has great potential as a wound dressing. In our previous study, physically crosslinked chitosan hydrogels were successfully prepared solely by freeze-thawing of chitosan-gluconic acid conjugate (CG) aqueous solution without using any toxic additives. Furthermore, the CG hydrogels could be sterilized by autoclaving (steam sterilization). In this study, we showed that autoclaving (121 °C, 20 min) of a CG aqueous solution simultaneously achieved gelation of the solution and sterilization of the hydrogel. Hydrogelation of CG aqueous solution by autoclaving is also physically crosslinking without any toxic additives. Further, we showed that the CG hydrogels retained favorable biological properties of the CG hydrogels prepared by freeze-thawing and subsequent autoclaving. These results indicated that CG hydrogels prepared by autoclaving were promising as wound dressings.
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9040280
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Article ; Online: Recurrent giant cell tumour of the distal ulna after en bloc resection with preoperative denosumab use.

Fujihara, Nasa / Hamada, Shunsuke / Yoshida, Masahiro / Tsukushi, Satoshi

BMJ case reports

2021 Volume 14, Issue 11

Abstract: In recent years, denosumab has been used to treat giant cell tumour of bone (GCTB) not only in cases where surgery is complicated but also preoperatively to decrease the preoperative grade or to facilitate surgery for Campanacci grade II and III cases. ... ...

Abstract	In recent years, denosumab has been used to treat giant cell tumour of bone (GCTB) not only in cases where surgery is complicated but also preoperatively to decrease the preoperative grade or to facilitate surgery for Campanacci grade II and III cases. However, there are no clear protocols regarding the preoperative use of denosumab before en bloc resection. There are a few reports of recurrent cases after en bloc resection; however, the association with the use of denosumab is unknown. We present the clinical, radiological and histopathological findings of a case of Campanacci grade III GCTB at the distal end of the ulna, which resulted in soft tissue recurrence after en bloc resection with the preoperative use of denosumab.
MeSH term(s)	Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/drug therapy ; Bone Neoplasms/surgery ; Denosumab/therapeutic use ; Giant Cell Tumor of Bone/diagnostic imaging ; Giant Cell Tumor of Bone/drug therapy ; Giant Cell Tumor of Bone/surgery ; Humans ; Neoplasm Recurrence, Local ; Retrospective Studies ; Ulna/diagnostic imaging ; Ulna/surgery
Chemical Substances	Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
Language	English
Publishing date	2021-11-11
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-245022
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Article ; Online: Early prediction of cytokine release syndrome by measuring phosphate and magnesium levels following chimeric antigen receptor T cell therapy.

Yoshida, Masahiro / Matsuoka, Yoshinori / Mitsuyuki, Satoshi / Yonetani, Noboru / Kawai, Junichi / Kondo, Tadakazu / Ishikawa, Takayuki

Blood cell therapy

2023 Volume 6, Issue 4, Page(s) 129–134

Abstract: Introduction: Cytokine release syndrome (CRS) is a life-threatening side effect of chimeric antigen receptor T (CAR-T) cell therapy. This study investigated whether serum inorganic phosphate (IP) and magnesium (Mg) levels are predictive markers of CRS ... ...

Abstract	Introduction: Cytokine release syndrome (CRS) is a life-threatening side effect of chimeric antigen receptor T (CAR-T) cell therapy. This study investigated whether serum inorganic phosphate (IP) and magnesium (Mg) levels are predictive markers of CRS development. Methods: This single-center retrospective cohort study enrolled 16 consecutive patients with diffuse large B-cell lymphoma who had received CAR-T cell therapy. Logistic regression models with generalized estimating equations were used to evaluate whether changes in IP and Mg levels from their baseline values were associated with the development of CRS within 48 hours. Results: Decreased IP and Mg levels from baseline (per 10% change) were associated with an increased CRS incidence (adjusted odds ratio 2.18 [95% confidence interval (CI), 1.31-3.62], 3.18 [95% CI, 1.57-6.44], respectively). Conclusions: Changes in IP and Mg concentrations within 48 hours may be useful predictive markers of CRS onset.
Language	English
Publishing date	2023-11-25
Publishing country	Japan
Document type	Journal Article
ISSN	2432-7026
ISSN (online)	2432-7026
DOI	10.31547/bct-2023-021
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Article: Usefulness of High-resolution Computed Tomography for Macrolide Therapy of Idiopathic Bronchiectasis.

Saito, Zenya / Yoshida, Masahiro / Uchiyama, Shota / Nishioka, Saiko / Tamura, Kentaro / Tamura, Nobumasa

The open respiratory medicine journal

2023 Volume 17, Page(s) e187430642307250

Abstract: Background: High-resolution computed tomography (HRCT) correlates with clinical symptoms, respiratory function, and quality of life in bronchiectasis.: Objective: We aimed to investigate the relationship between macrolide and acute exacerbation (AE) ... ...

Abstract	Background: High-resolution computed tomography (HRCT) correlates with clinical symptoms, respiratory function, and quality of life in bronchiectasis. Objective: We aimed to investigate the relationship between macrolide and acute exacerbation (AE) in idiopathic bronchiectasis classified by the Bronchiectasis Radiologically Indexed CT Score (BRICS). Methods: We retrospectively reviewed the medical records of patients diagnosed with idiopathic bronchiectasis between April 2014 and December 2020 at a single hospital. Overall, 115 patients with idiopathic bronchiectasis were selected and divided into three groups, according to the BRICS. Each group was divided into subgroups with and without macrolide therapy, and the number of patients with AE in each group was retrospectively compared. Results: About 45, 48, and 22 patients were included in the mild, moderate, and severe groups, respectively. In the mild group, the subgroup with macrolide therapy had significantly fewer patients with single AE than those without macrolide ( Conclusion: HRCT severity assessment might be useful in predicting treatment efficacy in patients with idiopathic bronchiectasis without previous AEs. Further large-scale clinical trials are required on the usefulness of HRCT in the future.
Language	English
Publishing date	2023-08-29
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2395996-4
ISSN	1874-3064
ISSN	1874-3064
DOI	10.2174/18743064-v17-230822-2022-27
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