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  1. Article ; Online: A urinary biomarker for monitoring exposures to 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate in rats.

    Yoshida, Toshiaki

    Archives of toxicology

    2023  Volume 97, Issue 10, Page(s) 2687–2695

    Abstract: 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate (TMPD-MB) and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TMPD-DB) are widely used primarily as surface stabilizers for water-based paints and plasticizers, respectively. Exposure to these compounds has ... ...

    Abstract 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate (TMPD-MB) and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TMPD-DB) are widely used primarily as surface stabilizers for water-based paints and plasticizers, respectively. Exposure to these compounds has been suspected as being associated with sick building syndrome and allergic diseases such as asthma in general populations. Therefore, it is very important to be able to know the amounts of these compounds absorbed into the body in order to evaluate its adverse effects on humans in living environments. In the present study, the urinary excretion kinetics of TMPD-MB and TMPD-DB were studied in animals to establish for urinary metabolites suitable as biomarkers for monitoring exposure. A single dose (48-750 mg/kg body weight) of TMPD-MB or TMPD-DB was administered intraperitoneally to male Sprague-Dawley rats, and their urine was collected periodically for a week. Two major metabolites, 2,2,4-trimethyl-1,3-pentanediol (TMPD) and 3-hydroxy-2,2,4-trimethylvaleric acid (HTMV), were measured in the urine samples. Their kinetics were evaluated by moment analysis of the urinary excretion rates of the metabolites versus time curves. The urinary excretion amounts of HTMV were suggested to be proportional to the absorption amounts over a wide exposure range of both TMPD-MB and TMPD-DB. The amounts of HTMV accounted for almost the same level, i.e., 4-5% of the dose at the lowest dosage, in rats tested for both TMPD-MB and TMPD-DB. Urinary HTMV was considered to be an optimal biomarker for monitoring exposure to mixtures of these compounds.
    MeSH term(s) Humans ; Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Glycols/analysis ; Biomarkers/urine
    Chemical Substances 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (4KZA479DWQ) ; Texanol (ID6ZZH846Y) ; Glycols ; Biomarkers
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-023-03570-9
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  2. Article ; Online: A method for approximating weave diagrams under heald frame constraint

    Yoshida, Tetsuya

    Textile Research Journal. 2023 Aug., v. 93, no. 15-16 p.3527-3537

    2023  

    Abstract: Woven fabric is produced by interlacing the warp yarn and the weft yarn, and their relationship on woven fabric is represented as a weave diagram. In order to produce woven fabric with looms, the necessary number of heald frames can be calculated based ... ...

    Abstract Woven fabric is produced by interlacing the warp yarn and the weft yarn, and their relationship on woven fabric is represented as a weave diagram. In order to produce woven fabric with looms, the necessary number of heald frames can be calculated based on the weave diagram for the woven fabric. However, when the number of available heald frames is limited, it is difficult to produce complex woven fabric. To alleviate this problem, this article proposes a method for approximating weave diagrams under heald frame constraint in terms of the alternating optimization in machine learning. By defining the objective function based on the matrix representation of weave diagram, an alternating optimization method is proposed to generate an approximate weave diagram under the specified number of heald frames. The proposed method is implemented with R language, and evaluated in terms of the performance of the proposed algorithm and woven fabric. Experimental results indicate that the proposed method is effective in generating approximate weave diagrams so that they can be fabricated using looms with a limited number of heald frames.
    Keywords algorithms ; research ; system optimization ; woven fabrics ; Number of heald frames ; loom ; weave diagram ; alternating optimization ; approximation
    Language English
    Dates of publication 2023-08
    Size p. 3527-3537.
    Publishing place SAGE Publications
    Document type Article ; Online
    ZDB-ID 2209596-2
    ISSN 1746-7748 ; 0040-5175
    ISSN (online) 1746-7748
    ISSN 0040-5175
    DOI 10.1177/00405175221149684
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Leaf trichome-mediated predator effects on the distribution of herbivorous mites within a kidney bean plant.

    Yoshida, Tatsuya / Choh, Yasuyuki

    Experimental & applied acarology

    2024  

    Abstract: Some predators prefer to settle on leaf patches with microstructures (e.g., trichomes and domatia), leaving traces on the patches. Herbivorous arthropods, in turn, select leaf patches in response to these traces left by predators. It remains unclear ... ...

    Abstract Some predators prefer to settle on leaf patches with microstructures (e.g., trichomes and domatia), leaving traces on the patches. Herbivorous arthropods, in turn, select leaf patches in response to these traces left by predators. It remains unclear whether traces of predators on leaf patches affect the distribution of herbivorous prey within plants through plant microstructure. Therefore, we examined the distribution of herbivorous mite (Tetranychus urticae) and predatory mite (Phytoseiulus persimilis) by investigating their oviposition pattern. We used a kidney bean plant (Phaseolus vulgaris) with two expanded primary leaves and the first trifoliate leaf, focusing on leaf trichomes as the microstructure. The density of trichomes was higher on the first trifoliate leaf than on the primary leaves and on the abaxial surface of the leaves than on the adaxial surface. Adult female P. persimilis laid more eggs on the first trifoliate leaf to the primary leaves. Although adult female T. urticae preferred to oviposit on the abaxial surface of primary leaves, previous exposure of plants to predators diminished this preference. The altered egg distribution would be a response to the traces of P. persimilis rather than eggs of P. persimilis. Our findings indicate that T. urticae reproduces on leaf patches with traces of predators without altering their oviposition preference. Given that the presence of predator traces is known to reduce the reproduction of T. urticae, it may have a substantial effect on the population of T. urticae in the next generations on kidney bean plants.
    Language English
    Publishing date 2024-04-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 11320-7
    ISSN 1572-9702 ; 0168-8162
    ISSN (online) 1572-9702
    ISSN 0168-8162
    DOI 10.1007/s10493-024-00915-6
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  4. Article ; Online: Protect the kidneys against contrast medium.

    Yoshida, Tadashi

    Renal failure

    2021  Volume 44, Issue 1, Page(s) 1632–1633

    MeSH term(s) Contrast Media/adverse effects ; Kidney/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2022.2130803
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  5. Article ; Online: Future directions of lung-protective ventilation strategies in acute respiratory distress syndrome.

    Hoshino, Taiki / Yoshida, Takeshi

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e918

    Abstract: Acute respiratory distress syndrome (ARDS) is characterized by the heterogeneous distribution of lung aeration along a gravitational direction due to increased lung density. Therefore, the lung available for ventilation is usually limited to ventral, ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is characterized by the heterogeneous distribution of lung aeration along a gravitational direction due to increased lung density. Therefore, the lung available for ventilation is usually limited to ventral, nondependent lung regions and has been called the "baby" lung. In ARDS, ventilator-induced lung injury is known to occur in nondependent "baby" lungs, as ventilation is shifted to ventral, nondependent lung regions, increasing stress and strain. To protect this nondependent "baby" lung, the clinician targets and limits global parameters such as tidal volume and plateau pressure. In addition, positive end-expiratory pressure (PEEP) is used to prevent dorsal, dependent atelectasis and, if successful, increases the size of the baby lung and lessens its susceptibility to injury from inspiratory stretch. Although many clinical trials have been performed in patients with ARDS over the last two decades, there are few successfully showing benefits on mortality (ie, prone positioning and neuromuscular blocking agents). These disappointing results contrast with other medical disciplines, especially in oncology, where the heterogeneity of diseases is recognized widely and precision medicine has been promoted. Thus, lung-protective ventilation strategies need to take an innovative approach that accounts for the heterogeneity of injured lungs. This article summarizes ventilator-induced lung injury and ARDS and discusses how to implement precision medicine in the field of ARDS. Potentially useful methods to individualize PEEP with esophageal balloon manometry, lung recruitability, and electrical impedance tomography were discussed.
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.918
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  6. Book ; Online: Continuous Functions on Final Comodels of Free Algebraic Theories

    Yoshida, Tomoya

    2022  

    Abstract: In 2009, Ghani, Hancock and Pattinson gave a tree-like representation of stream processors $A^{\mathbb{N}} \rightarrow B^{\mathbb{N}}$. In 2021, Garner showed that this representation can be established in terms of algebraic theory and comodels: the set ... ...

    Abstract In 2009, Ghani, Hancock and Pattinson gave a tree-like representation of stream processors $A^{\mathbb{N}} \rightarrow B^{\mathbb{N}}$. In 2021, Garner showed that this representation can be established in terms of algebraic theory and comodels: the set of infinite streams $A^{\mathbb{N}}$ is the final comodel of the algebraic theory of $A$-valued input $\mathbb{T}_A$ and the set of stream processors $\mathit{Top}(A^{\mathbb{N}},B^{\mathbb{N}})$ can be seen as the final $\mathbb{T}_A$-$\mathbb{T}_B$-bimodel. In this paper, we generalize Garner's results to the case of free algebraic theories.

    Comment: 17 pages
    Keywords Computer Science - Logic in Computer Science ; Mathematics - Category Theory
    Publishing date 2022-11-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Clinical characteristics of Alexander disease.

    Yoshida, Tomokatsu

    Neurodegenerative disease management

    2020  Volume 10, Issue 5, Page(s) 325–333

    Abstract: Alexander disease (ALXDRD) is a primary astrocyte disease caused by GFAP gene mutation. The clinical features of ALXDRD vary from infantile-onset cerebral white matter involvement to adult-onset brainstem involvement. Several studies revealed that the ... ...

    Abstract Alexander disease (ALXDRD) is a primary astrocyte disease caused by GFAP gene mutation. The clinical features of ALXDRD vary from infantile-onset cerebral white matter involvement to adult-onset brainstem involvement. Several studies revealed that the level of GFAP overexpression is correlated with disease severity, and basic research on therapies to reduce abnormal GFAP accumulation has recently been published. Therefore, the accumulation of clinical data to advance understanding of the natural history is essential for clinical trials expected in the future. This review focuses on the clinical characteristics of ALXDRD including the clinical symptoms, imaging findings and genetics to provide diagnostic information useful in daily clinical practice.
    MeSH term(s) Alexander Disease/diagnosis ; Humans ; Magnetic Resonance Imaging ; Mutation
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1758-2032
    ISSN (online) 1758-2032
    DOI 10.2217/nmt-2020-0022
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  8. Article ; Online: The Dark Side of Spontaneous Breathing during Noninvasive Ventilation. From Hypothesis to Theory.

    Yoshida, Takeshi

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 4, Page(s) 482–484

    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202005-1612ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [Clinical characteristics and diagnostic criteria on Alexander disease].

    Yoshida, Tomokatsu

    Rinsho shinkeigaku = Clinical neurology

    2020  Volume 60, Issue 9, Page(s) 581–588

    Abstract: Alexander disease (ALXDRD) is a primary astrocyte disease caused by glial fibrillary acidic protein (GFAP) gene mutation. ALXDRD had been clinically regarded as a cerebral white matter disease that affects only children for about 50 years since the ... ...

    Abstract Alexander disease (ALXDRD) is a primary astrocyte disease caused by glial fibrillary acidic protein (GFAP) gene mutation. ALXDRD had been clinically regarded as a cerebral white matter disease that affects only children for about 50 years since the initial report in 1949; however, in the early part of the 21st century, case reports of adult-onset ALXDRD with medulla and spinal cord lesions increased. Basic research on therapies to reduce abnormal GFAP accumulation, such as drug-repositioning and antisense oligonucleotide suppression, has recently been published. The accumulation of clinical data to advance understanding of natural history is essential for clinical trials expected in the future. In this review, I classified ALXDRD into two subtypes: early-onset and late-onset, and detail the clinical symptoms, imaging findings, and genetic characteristics as well as the epidemiology and historical changes in the clinical classification described in the literature. The diagnostic criteria based on Japanese ALXDRD patients that are useful in daily clinical practice are also mentioned.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Alexander Disease/diagnosis ; Alexander Disease/drug therapy ; Alexander Disease/genetics ; Alexander Disease/physiopathology ; Animals ; Child ; Diffusion Magnetic Resonance Imaging ; Drug Repositioning ; Glial Fibrillary Acidic Protein/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Humans ; Mice ; Middle Aged ; Molecular Targeted Therapy ; Mutation ; Oligonucleotides, Antisense ; Young Adult
    Chemical Substances GFAP protein, human ; Glial Fibrillary Acidic Protein ; Oligonucleotides, Antisense
    Language Japanese
    Publishing date 2020-08-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.cn-001442
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  10. Article ; Online: Long noncoding RNAs: new players regulating vascular calcification?

    Yoshida, Tadashi

    Renal failure

    2020  Volume 42, Issue 1, Page(s) 570–571

    MeSH term(s) Humans ; MicroRNAs ; RNA, Long Noncoding ; Vascular Calcification
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2020.1776734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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