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  1. Article ; Online: Protect the kidneys against contrast medium.

    Yoshida, Tadashi

    Renal failure

    2021  Volume 44, Issue 1, Page(s) 1632–1633

    MeSH term(s) Contrast Media/adverse effects ; Kidney/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2022.2130803
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  2. Article ; Online: Long noncoding RNAs: new players regulating vascular calcification?

    Yoshida, Tadashi

    Renal failure

    2020  Volume 42, Issue 1, Page(s) 570–571

    MeSH term(s) Humans ; MicroRNAs ; RNA, Long Noncoding ; Vascular Calcification
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2020.1776734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Massive Calcification in A Nonfunctioning Transplanted Kidney.

    Morimoto, Kohkichi / Yoshida, Tadashi

    Iranian journal of kidney diseases

    2021  Volume 15, Issue 3, Page(s) 168

    Abstract: No Abstract. ...

    Abstract No Abstract.
    MeSH term(s) Kidney/diagnostic imaging ; Kidney Transplantation/adverse effects
    Language English
    Publishing date 2021-05-14
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2388271-2
    ISSN 1735-8604 ; 1735-8582
    ISSN (online) 1735-8604
    ISSN 1735-8582
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  4. Article ; Online: Transient hypercalcemia in a patient with SAPHO syndrome.

    Yoshida, Tadashi / Oya, Mototsugu

    Journal of general and family medicine

    2021  Volume 23, Issue 1, Page(s) 44–46

    Abstract: We here report a case of SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome with hypercalcemia. The patient was diagnosed with SAPHO syndrome at the age of 54, because he exhibited osteitis and hyperostosis around the sternoclavicular ... ...

    Abstract We here report a case of SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome with hypercalcemia. The patient was diagnosed with SAPHO syndrome at the age of 54, because he exhibited osteitis and hyperostosis around the sternoclavicular joints and the temporomandibular joints bilaterally and had past medical history of palmoplantar pustulosis. At the age of 67, he exhibited appetite loss and nausea. Corrected serum calcium was 13.0 mg/dl. Adequate hydration was recommended, and his calcium levels returned to the normal range without any medical treatment. Although speculative, his hypercalcemia was considered to be caused by an increased bone activity in SAPHO syndrome. This is the first report describing transient hypercalcemia in a patient with SAPHO syndrome.
    Language English
    Publishing date 2021-07-07
    Publishing country Japan
    Document type Case Reports
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.480
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  5. Article: Functional improvements in β-conglycinin by preparing edible bioconjugates with

    Yoshida, Tadashi / Hamaji, Ikumi / Hashimoto, Takeshi / Matsumoto, Takuya / Hattori, Makoto

    Cytotechnology

    2023  Volume 75, Issue 2, Page(s) 143–151

    Abstract: β-Conglycinin was conjugated with ε-polylysine (PL) by means of microbial transglutaminase (MTGase) to improve its function. The β-conglycinin-PL conjugate was purified by dialysis. Composition of the β-conglycinin-PL was β-conglycinin:PL = 1:18 (molar ... ...

    Abstract β-Conglycinin was conjugated with ε-polylysine (PL) by means of microbial transglutaminase (MTGase) to improve its function. The β-conglycinin-PL conjugate was purified by dialysis. Composition of the β-conglycinin-PL was β-conglycinin:PL = 1:18 (molar ratio) which was confirmed by amino acid analysis. The β-conglycinin-PL was further conjugated with dextran (Dex) by the Maillard reaction. The β-conglycinin-PL-Dex conjugate was purified by dialysis. Conjugation was confirmed by SDS-PAGE and PAS staining. Composition of the β-conglycinin-PL-Dex was β-conglycinin-PL:Dex = 1:41 (molar ratio) which was confirmed by UV spectra measurement and phenol sulfuric acid method. Solubility of β-conglycinin in the acidic range was much improved by conjugation with PL and further improved by further conjugation with Dex. Emulsifying property of β-conglycinin in acidic pH range was much improved by conjugation with PL and Dex. Immunogenicity of β-conglycinin was decreased by conjugation with PL and Dex.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-022-00568-6
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  6. Article: Functional improvements in β-conglycinin by edible bioconjugation with carboxymethyl dextran.

    Yoshida, Tadashi / Tomono, Misato / Takahashi, Ryohei / Hattori, Makoto

    Cytotechnology

    2022  Volume 75, Issue 2, Page(s) 115–121

    Abstract: β-Conglycinin was conjugated with carboxymethyl dextran (CMD) by the Maillard reaction to improve its function. The β-conglycinin-CMD conjugate was purified by dialysis. Conjugation was confirmed by SDS-PAGE with CBB and PAS staining. Composition of the ... ...

    Abstract β-Conglycinin was conjugated with carboxymethyl dextran (CMD) by the Maillard reaction to improve its function. The β-conglycinin-CMD conjugate was purified by dialysis. Conjugation was confirmed by SDS-PAGE with CBB and PAS staining. Composition of the β-conglycinin-CMD was β-conglycinin:CMD = 1:2.7 (molar ratio) which was confirmed by BCA method and phenol sulfuric acid method. Solubility of β-conglycinin in the range of pH 2.0-7.0 was much improved by conjugation with CMD. Emulsifying property of β-conglycinin at pH 7 and in presence of salt was improved by conjugation with CMD. Immunogenicity of β-conglycinin was reduced by conjugation with CMD. Conjugation method performed in this study was considered to be valuable in that it can be used in food processing.
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-022-00565-9
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  7. Article ; Online: Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy.

    Yoshida, Tadashi / Delafontaine, Patrice

    Cells

    2020  Volume 9, Issue 9

    Abstract: Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit ...

    Abstract Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit FoxOs and suppress transcription of E3 ubiquitin ligases that regulate ubiquitin proteasome system (UPS)-mediated protein degradation. Autophagy is likely inhibited by IGF-1 via mTOR and FoxO signaling, although the contribution of autophagy regulation in IGF-1-mediated inhibition of skeletal muscle atrophy remains to be determined. Evidence has suggested that IGF-1/Akt can inhibit muscle atrophy-inducing cytokine and myostatin signaling via inhibition of the NF-κΒ and Smad pathways, respectively. Several miRNAs have been found to regulate IGF-1 signaling in skeletal muscle, and these miRs are likely regulated in different pathological conditions and contribute to the development of muscle atrophy. IGF-1 also potentiates skeletal muscle regeneration via activation of skeletal muscle stem (satellite) cells, which may contribute to muscle hypertrophy and/or inhibit atrophy. Importantly, IGF-1 levels and IGF-1R downstream signaling are suppressed in many chronic disease conditions and likely result in muscle atrophy via the combined effects of altered protein synthesis, UPS activity, autophagy, and muscle regeneration.
    MeSH term(s) Humans ; Hypertrophy/physiopathology ; Insulin-Like Growth Factor I/metabolism ; Muscle, Skeletal/metabolism ; Muscular Atrophy/physiopathology ; Signal Transduction
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091970
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  8. Article ; Online: A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose.

    Nakajima-Kato, Yuko / Komai, Masato / Yoshida, Tadashi / Kanai, Akiko

    Clinical and experimental immunology

    2022  Volume 211, Issue 1, Page(s) 23–30

    Abstract: Intravenous immunoglobulin (IVIG) is a well-established treatment for various autoimmune and inflammatory diseases. However, the standard dose prescribed for autoimmune diseases, including immune thrombocytopenic purpura (ITP), is 2 g/kg, which is ... ...

    Abstract Intravenous immunoglobulin (IVIG) is a well-established treatment for various autoimmune and inflammatory diseases. However, the standard dose prescribed for autoimmune diseases, including immune thrombocytopenic purpura (ITP), is 2 g/kg, which is markedly high and leads to a high treatment burden. In this study, we generated fragment crystallizable (Fc)-modified anti-haptoglobin (Hp) monoclonal antibodies with non-inferior efficacy compared to IVIG at considerably lower doses than IVIG, as shown by in vitro experiments. We evaluated binding activity of anti-Hp antibodies to Fc gamma receptors (FcγRs) with ELISA and inhibitory activity against the ADCC reaction. Furthermore, we successfully established a novel cynomolgus monkey ITP model and demonstrated that the anti-Hp antibody exerted its effect in this model with only a single dose. This Fc-modified anti-Hp monoclonal antibody could be a valuable therapeutic replacement for IVIG for the treatment of ITP.
    MeSH term(s) Animals ; Purpura, Thrombocytopenic, Idiopathic ; Immunoglobulins, Intravenous ; Macaca fascicularis ; Antibodies, Monoclonal ; Receptors, IgG
    Chemical Substances Immunoglobulins, Intravenous ; Antibodies, Monoclonal ; Receptors, IgG
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac112
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    Zs.B 337: Show issues Location:
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  9. Article ; Online: Feasibility of Laparoscopic and Robotic Total Proctocolectomy for Ulcerative Colitis-related Colorectal Cancer.

    Yoshida, Tadashi / Homma, Shigenori / Ichikawa, Nobuki / Fujiyoshi, Sunao / Shibata, Kengo / Imaizumi, Ken / Taketomi, Akinobu

    Anticancer research

    2023  Volume 43, Issue 11, Page(s) 5245–5252

    Abstract: Background/aim: To evaluate the feasibility of laparoscopic and robotic total proctocolectomy (TPC) for ulcerative colitis-associated colorectal cancer (UC-CRC).: Patients and methods: We retrospectively analyzed the postoperative outcomes of TPC in ... ...

    Abstract Background/aim: To evaluate the feasibility of laparoscopic and robotic total proctocolectomy (TPC) for ulcerative colitis-associated colorectal cancer (UC-CRC).
    Patients and methods: We retrospectively analyzed the postoperative outcomes of TPC in 13 patients with UC-CRC between January 2011 and December 2021. Laparoscopic TPC was performed in 10 patients. TPC consisted of two procedures: ileal pouch-anal anastomosis (IAA) and TPC with end ileostomy. Using the da Vinci Xi platform with six ports, robotic TPC and abdominal perineal resection (APR) were performed in two and one patients, respectively. Transanal total mesorectal excision (TaTME) was performed using the perineal approach in five patients.
    Results: UC-CRC was located in the transverse colon, sigmoid colon, rectum, and anal canal in 1, 1, 10, and 1 patients, respectively. IAA, TPC with end ileostomy, and APR were performed in nine, three, and one patients, respectively. Postoperative complications included colitis, portal vein thrombosis, and liver dysfunction, without mortality. The pathological stages were 0, I, IIa, IIIb, and IIIc in five, four, one, two, and one patients, respectively. The tumors were completely resected in all cases. Eleven patients with pStages 0, I, and II survived without recurrence; however, two patients with pStage III died of cancer recurrence.
    Conclusion: This study demonstrated the feasibility of laparoscopic and robotic TPC in patients with UC-CRC. However, long-term outcomes in terms of oncology and patient quality of life must be investigated in future large-scale studies.
    MeSH term(s) Humans ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/surgery ; Proctocolectomy, Restorative/adverse effects ; Feasibility Studies ; Quality of Life ; Retrospective Studies ; Robotic Surgical Procedures/adverse effects ; Laparoscopy/adverse effects ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2023-11-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16726
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    Zs.A 1642: Show issues Location:
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  10. Article ; Online: A Study of risk factors of postoperative ileus after laparoscopic colorectal resection.

    Fujiyoshi, Sunao / Homma, Shigenori / Yoshida, Tadashi / Ichikawa, Nobuki / Shibata, Kengo / Matsui, Hiroki / Taketomi, Akinobu

    Annals of gastroenterological surgery

    2023  Volume 7, Issue 6, Page(s) 949–954

    Abstract: Aim: Postoperative ileus (POI) is a common complication after abdominal surgery. However, the risk factors for POI after laparoscopic colorectal resection are unclear. We therefore investigated the risk factors for POI after laparoscopic colorectal ... ...

    Abstract Aim: Postoperative ileus (POI) is a common complication after abdominal surgery. However, the risk factors for POI after laparoscopic colorectal resection are unclear. We therefore investigated the risk factors for POI after laparoscopic colorectal surgery.
    Methods: This retrospective study involved 484 patients who underwent laparoscopic surgery for primary colorectal cancer at Hokkaido University Hospital. We categorized the patients into a POI group (
    Results: The univariate analysis results showed that the POI group had a higher incidence of male sex (
    Conclusion: Our findings suggest that male sex, COPD, and a BMI of <20 kg/m
    Language English
    Publishing date 2023-06-03
    Publishing country Japan
    Document type Journal Article
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12705
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