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Artikel ; Online: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour: facts and controversies.

Yoshida, Akihiko

2023 Band 84, Heft 1, Seite(n) 86–101

Abstract: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour are unique entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic Tumours, whose definitions include molecular genetic abnormalities. These ... ...

Abstract	NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour are unique entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic Tumours, whose definitions include molecular genetic abnormalities. These aggressive tumours require rapid work-ups on biopsies, but a broad list of differential diagnoses poses challenges for practising pathologists. This review provides an update on their key clinicopathological and molecular characteristics, as well as controversies regarding tumour classification and diagnostic strategy. Phenotypical assessment plays a substantial role in diagnosis because recurrent and predictable clinicopathological findings exist, including robust immunohistochemical phenotypes. Accurate diagnosis is crucial for appropriate management and a clearer understanding of the disease.
Mesh-Begriff(e)	Humans ; Transcription Factors/genetics ; Nuclear Proteins/genetics ; DNA Helicases/genetics ; Biomarkers, Tumor ; Carcinoma/diagnosis ; Carcinoma/pathology ; Thoracic Neoplasms/diagnosis ; Thoracic Neoplasms/genetics ; Thoracic Neoplasms/pathology
Chemische Substanzen	Transcription Factors ; Nuclear Proteins ; DNA Helicases (EC 3.6.4.-) ; Biomarkers, Tumor ; SMARCA4 protein, human (EC 3.6.1.-)
Sprache	Englisch
Erscheinungsdatum	2023-10-24
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.15063
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ewing and Ewing-like sarcomas: A morphological guide through genetically-defined entities.

Yoshida, Akihiko

Pathology international

2022 Band 73, Heft 1, Seite(n) 12–26

Abstract: The fifth edition of the World Health Organization classification of soft tissue and bone tumors redefined Ewing sarcoma by fusions between EWSR1/FUS and ETS family of transcription factors, and recognized three tumor groups among Ewing-like sarcoma: CIC- ...

Abstract	The fifth edition of the World Health Organization classification of soft tissue and bone tumors redefined Ewing sarcoma by fusions between EWSR1/FUS and ETS family of transcription factors, and recognized three tumor groups among Ewing-like sarcoma: CIC-rearranged sarcoma, sarcoma with BCOR genetic alterations, and round cell sarcoma with EWSR1::non-ETS fusions. Although this classification underscores the critical role of molecular genetics in the diagnosis of small round cell sarcoma, each entry is recognized as a specific entity not only because they have different genetics but because their phenotypes are distinct and reasonably robust to support the diagnosis. This review focuses on the morphological aspects of Ewing sarcoma and a subset of Ewing-like sarcomas (CIC-rearranged sarcoma, BCOR-associated sarcoma, and EWSR1::NFATC2 sarcoma) for which phenotypic characteristics have been well established. Classic histological findings, uncommon variations, and recurrent diagnostic pitfalls are addressed, along with the utility of recently developed immunohistochemical markers (NKX2.2, PAX7, ETV4, BCOR, CCNB3, and NKX3.1). Phenotypic expertise would significantly expedite the diagnostic process and complement (or sometimes outperform) genetic testing, even in well-resourced settings. Morphological knowledge plays an even more substantial role in facilities that do not have easy access to molecular testing.
Mesh-Begriff(e)	Humans ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology ; Sarcoma/diagnosis ; Sarcoma, Small Cell/diagnosis ; Sarcoma, Small Cell/genetics ; Sarcoma, Small Cell/pathology ; Transcription Factors/genetics ; Bone Neoplasms/diagnosis ; Bone Neoplasms/genetics ; Biomarkers, Tumor/genetics ; Oncogene Proteins, Fusion/genetics
Chemische Substanzen	Transcription Factors ; Biomarkers, Tumor ; Oncogene Proteins, Fusion
Sprache	Englisch
Erscheinungsdatum	2022-12-09
Erscheinungsland	Australia
Dokumenttyp	Journal Article ; Review
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13293
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Osteosarcoma: Old and New Challenges.

Yoshida, Akihiko

Surgical pathology clinics

2021 Band 14, Heft 4, Seite(n) 567–583

Abstract: Diagnosis of osteosarcoma can be challenging because of its diverse histological patterns and the lack of diagnostic biomarkers for most examples. This review summarizes the key pathologic findings of osteosarcoma subtypes (high-grade central, parosteal, ...

Abstract	Diagnosis of osteosarcoma can be challenging because of its diverse histological patterns and the lack of diagnostic biomarkers for most examples. This review summarizes the key pathologic findings of osteosarcoma subtypes (high-grade central, parosteal, low-grade central, periosteal, high-grade surface, and secondary) with an emphasis on describing and illustrating histological heterogeneity to help general pathologists. Differential diagnoses are listed for each entity, and histological subtype and distinguishing features, including molecular genetic findings (eg, MDM2, IDH, H3F3A, FOS, and USP6), are discussed. The review also covers recently established and emerging concepts and controversies regarding osteosarcoma.
Mesh-Begriff(e)	Bone Neoplasms/diagnosis ; Bone Neoplasms/genetics ; Diagnosis, Differential ; Humans ; Osteosarcoma/diagnosis ; Osteosarcoma/genetics
Sprache	Englisch
Erscheinungsdatum	2021-10-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2021.06.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Involvement of neurons in the non-human primate anterior striatum in proactive inhibition.

Yoshida, Atsushi / Hikosaka, Okihide

bioRxiv : the preprint server for biology

2024

Abstract: Behaving as desired requires selecting the appropriate behavior and inhibiting the selection of inappropriate behavior. This inhibitory function involves multiple processes, such as reactive and proactive inhibition, instead of a single process. In this ... ...

Abstract	Behaving as desired requires selecting the appropriate behavior and inhibiting the selection of inappropriate behavior. This inhibitory function involves multiple processes, such as reactive and proactive inhibition, instead of a single process. In this study, macaque monkeys were required to perform a task in which they had to sequentially select (accept) or refuse (reject) a choice. Neural activity was recorded from the anterior striatum, which is considered to be involved in behavioral inhibition, focusing on the distinction between proactive and reactive inhibitions. We identified neurons with significant activity changes during the rejection of bad objects. Cluster analysis revealed three distinct groups, of which one showed obviously increased activity during object rejection, suggesting its involvement in proactive inhibition. This activity pattern was consistent irrespective of the rejection method, indicating a role beyond mere saccadic suppression. Furthermore, minimal activity changes during the fixation task indicated that these neurons were not primarily involved in reactive inhibition. In conclusion, these findings suggest that the anterior striatum plays a crucial role in cognitive control and orchestrates goal-directed behavior through proactive inhibition, which may be critical in understanding the mechanisms of behavioral inhibition dysfunction that occur in patients with basal ganglia disease.
Sprache	Englisch
Erscheinungsdatum	2024-04-28
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2024.04.24.591009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Performance of a handheld point of care ultrasonography to assess IUD position compared to conventional transvaginal ultrasonography.

Araujo, K G / Yoshida, A / Juliato, C R T / Sarian, L O / Derchain, S

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

2024 Band 29, Heft 2, Seite(n) 69–75

Abstract: Objective: To compare the performance of the abdominal handheld point-of-care ultrasonography (POCUS) Butterfly-iQ to gold standard transvaginal ultrasonography (US) in identifying the position of intrauterine devices (IUDs) in the hands of a medical ... ...

Abstract	Objective: To compare the performance of the abdominal handheld point-of-care ultrasonography (POCUS) Butterfly-iQ to gold standard transvaginal ultrasonography (US) in identifying the position of intrauterine devices (IUDs) in the hands of a medical doctor specialised in ultrasonography. Methods: In this diagnostic accuracy study, a single operator conducted abdominal POCUS followed by conventional transvaginal US. Seventy patients utilising copper or hormonal IUDs were assessed between June 2021 and October 2022. IUDs were categorised as entirely within the uterine cavity or malpositioned. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for detecting malpositioned IUDs, with conventional US results serving as the reference standard. Concordance rate and Kappa coefficient were computed to assess the agreement between the two ultrasound modalities. Results: Among the 70 patients, 46 (65.7%) used copper IUDs, and 24 (34.3%) used hormonal IUDs. Conventional transvaginal US showed IUDs entirely within the uterine cavity in 56 (80%) patients and 14 (20%) IUDs were malpositioned. Of the 14 malpositioned IUDs seen by conventional US, POCUS identified 13 demonstrating a sensitivity of 92.9% (66.1-99.8). Of the 56 IUDs entirely within the uterine cavity shown by conventional US, only two cases were considered malpositioned by POCUS demonstrating a specificity of 96.4% (87.7-99.6). The concordance rate was 95.7%, and the Kappa value was 0.87 in differentiating between IUDs entirely within the uterine cavity and those that were malpositioned. Conclusion: Abdominal POCUS using Butterfly-iQ, when administered by an imaging specialist, exhibited excellent performance in confirming IUDs entirely within the uterine cavity.
Mesh-Begriff(e)	Humans ; Female ; Ultrasonography/methods ; Adult ; Point-of-Care Systems ; Sensitivity and Specificity ; Intrauterine Devices/adverse effects ; Middle Aged ; Uterus/diagnostic imaging ; Young Adult ; Intrauterine Devices, Copper
Sprache	Englisch
Erscheinungsdatum	2024-03-05
Erscheinungsland	England
Dokumenttyp	Journal Article ; Comparative Study
ZDB-ID	1397560-2
ISSN	1473-0782 ; 1362-5187
ISSN (online)	1473-0782
ISSN	1362-5187
DOI	10.1080/13625187.2024.2315231
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prenatal diagnosis of uterus didelphys without hydrocolpos.

Kaji, T / Maeda, K / Imaizumi, J / Shirakawa, A / Mineda, A / Yoshida, A / Iwasa, T

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2024

Sprache	Englisch
Erscheinungsdatum	2024-01-05
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.27572
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Physical meaning of the equinoctial effect for semi-annual variation in geomagnetic activity

Yoshida, A.

eISSN: 1432-0576

2018

Abstract: Physical meaning of the equinoctial effect for semi-annual variation in geomagnetic activity is investigated based on the three-hourly am index and solar wind parameters. When the z component of the interplanetary magnetic field (IMF) in geocentric solar ...

Abstract	Physical meaning of the equinoctial effect for semi-annual variation in geomagnetic activity is investigated based on the three-hourly am index and solar wind parameters. When the z component of the interplanetary magnetic field (IMF) in geocentric solar magnetospheric (GSM) coordinates is southward, am indices are well correlated with B s V x 2 , where B s is the southward component of the IMF and V x is the solar wind velocity in the sun-earth direction. The am - B s V x 2 relationship, however, depends on the range of V x 2 : the am in higher ranges of V x 2 tends to be larger than am in lower ranges of V x 2 for the same value of B s V x 2 for both equinoctial and solstitial epochs. Using the data sets of the same V x 2 range, it is shown that distribution of points in the am - B s V x 2 diagram at the solstitial epochs overlaps with that at the equinoctial epochs and the average am values in each B s V x 2 bin in solstitial epochs are closely consistent with those in equinoctial epochs, if V x 2 for each point at solstices are reduced to V x 2 sin 2 (Ψ) where Ψ is the geomagnetic colatitude of the sub-solar point. Further, it is shown that monthly averages of the am index in the long period is well correlated with the values of sin 2 (ψ) for the middle day of each month. These findings indicate that the factor that contributes to the generation of geomagnetic disturbance is not the velocity of the solar wind, but the component of the solar wind velocity perpendicular to the dipole axis of the geomagnetic field. The magnitude of the perpendicular velocity component varies semi-annually even if the solar wind velocity remains constant, which is considered to be the long-missed key factor causing the equinoctial effect.
Thema/Rubrik (Code)	333 ; 290
Sprache	Englisch
Erscheinungsdatum	2018-09-27
Erscheinungsland	de
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: CIC-Rearranged Sarcoma.

Makise, Naohiro / Yoshida, Akihiko

Surgical pathology clinics

2023 Band 17, Heft 1, Seite(n) 141–151

Abstract: CIC-rearranged sarcoma is a rare type of small round cell sarcoma. The tumors often affect the deep soft tissues of patients in a wide age range. They are highly aggressive, respond poorly to chemotherapy, and have a worse outcome than Ewing sarcoma. CIC- ...

Abstract	CIC-rearranged sarcoma is a rare type of small round cell sarcoma. The tumors often affect the deep soft tissues of patients in a wide age range. They are highly aggressive, respond poorly to chemotherapy, and have a worse outcome than Ewing sarcoma. CIC-rearranged sarcoma has characteristic and recognizable histology, including lobulated growth, focal myxoid changes, round to epithelioid cells, and minimal variation of nuclear size and shape. Nuclear ETV4 and WT1 expression are useful immunohistochemical findings. CIC fusion can be demonstrated using various methods; however, even next-generation sequencing suffers from imperfect sensitivity, especially for CIC::DUX4.
Mesh-Begriff(e)	Humans ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Sarcoma, Small Cell/diagnosis ; Sarcoma, Small Cell/genetics ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/genetics ; Sarcoma/diagnosis ; Sarcoma/genetics ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/genetics
Chemische Substanzen	Biomarkers, Tumor
Sprache	Englisch
Erscheinungsdatum	2023-08-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2023.06.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Editorial: Altered epigenetic modification mediated dysregulated transcriptional networks in drug resistance.

Brunetti, Bryce / Yoshida, Akihiro

Frontiers in oncology

2023 Band 13, Seite(n) 1196448

Sprache	Englisch
Erscheinungsdatum	2023-04-21
Erscheinungsland	Switzerland
Dokumenttyp	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1196448
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Opposing functions of glutamatergic inputs between the globus pallidus external segment and substantia nigra pars reticulata.

Yoshida, Atsushi / Hikosaka, Okihide

bioRxiv : the preprint server for biology

2023

Abstract: The indirect pathway of the basal ganglia, including the subthalamic nucleus (STN) and globus pallidus external segment (GPe), is believed to play a crucial role in suppressing involuntary movements. However, recent evidence suggests the STN and GPe also ...

Abstract	The indirect pathway of the basal ganglia, including the subthalamic nucleus (STN) and globus pallidus external segment (GPe), is believed to play a crucial role in suppressing involuntary movements. However, recent evidence suggests the STN and GPe also facilitate voluntary movements. This study hypothesized that excitatory inputs from the STN to the GPe contribute to this facilitation, and that excitatory projections to the substantia nigra pars reticulata (SNr) are involved in the inhibition. To disrupt the STN-GPe or STN-SNr projections in monkeys during choice and fixation tasks, glutamate receptor inhibitors were injected into the GPe or SNr, which induced delayed saccade latencies toward good choices in the choice task (GPe) and caused frequent reflexive saccades to objects in the fixation task (SNr). Our findings suggest excitatory inputs to the GPe and SNr work in opposing manners, providing new insights that redefine our understanding of the functions of basal ganglia pathways.
Sprache	Englisch
Erscheinungsdatum	2023-07-28
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2023.07.25.550377
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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