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  1. Article ; Online: Optimal left ventricular diameter measurement in subjects with sigmoid septum: comparison with three-dimensional left ventricular volume.

    Okada, Kazunori / Nakabachi, Masahiro / Hayashi, Yasuhiro / Shinagawa, Masaaki / Yoshikawa, Ayaka / Tsujita, Kosuke / Sakamoto, Yoichi

    Journal of echocardiography

    2023  Volume 22, Issue 1, Page(s) 41–47

    Abstract: Background: The purpose of this study was to determine the most appropriate measurement of left ventricular (LV) end-diastolic diameter for subjects with the sigmoid septum (SS) by measuring the LV end-diastolic diameter at the base and mid-ventricle ... ...

    Abstract Background: The purpose of this study was to determine the most appropriate measurement of left ventricular (LV) end-diastolic diameter for subjects with the sigmoid septum (SS) by measuring the LV end-diastolic diameter at the base and mid-ventricle and by examining the relationship between these measurements and the three-dimensional (3D) echocardiographic LV end-diastolic volume.
    Methods: In 91 patients who underwent echocardiography for screening cardiovascular abnormalities, the aorto-septal angle (ASA) was measured as an index of the sigmoid septum. LV end-diastolic diameter was measured at the base and mid-ventricular level (DD
    Results: Among 91 patients, 48 patients had narrow ASA (< 120 degrees) and were divided into the sigmoid septum (SS) group, and the remaining 43 patients were divided into the non-SS group. In the SS group, all DD
    Conclusions: In patients with SS, DD
    MeSH term(s) Humans ; Diastole ; Echocardiography ; Echocardiography, Three-Dimensional ; Heart Ventricles/diagnostic imaging
    Language English
    Publishing date 2023-09-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-023-00626-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137.

    Unuma, Kana / Yoshikawa, Ayaka / Aki, Toshihiko / Uemura, Koichi

    Journal of toxicologic pathology

    2019  Volume 32, Issue 4, Page(s) 305–310

    Abstract: Circulating peroxiredoxin-4 (Prx4) is suggested as a prognosis marker as well as a regulator of many diseases. We aimed to examine 1) whether Prx4 is secreted from the liver in an animal model of sepsis and 2) effects of GYY4137, a hydrogen sulfide donor ...

    Abstract Circulating peroxiredoxin-4 (Prx4) is suggested as a prognosis marker as well as a regulator of many diseases. We aimed to examine 1) whether Prx4 is secreted from the liver in an animal model of sepsis and 2) effects of GYY4137, a hydrogen sulfide donor molecule, on septic liver injury as well as the hepatic secretion of Prx4. Rats (Wistar, male, 6 weeks old) were administered lipopolysaccharide (LPS, 15 mg/kg body weight, i.p.) with or without pre-administration of GYY4137 (50 mg/kg body weight, i.p.) and sacrificed 24 h after LPS administration. Hematoxylin-eosin and Elastica Masson-Goldner stains were used to evaluate hepatic injuries. Cytokine expression levels were determined by qPCR, and the levels of Prx4 in the serum and liver were determined by immunoblotting. Hepatocytes were isolated from rat liver, and the levels of Prx4 in the medium as well as the cells were determined 24 h after the administrations of LPS (1 µg/ml), tumor necrosis factor-α (TNFα, 50 ng/ml), or interleukin-1β (IL-1β, 10 ng/ml), with or without GYY4137 (300 µM). Hepatic inflammation and damage in LPS-administered rats were suppressed by GYY4137. An increase in plasma Prx4 level caused by LPS was observed, but the increase was attenuated by pre-administration of GYY4137. Prx4 was secreted from isolated hepatocytes after stimulation with LPS, TNFα, or IL-1β. GYY4137 attenuated the IL-1β-induced Prx4 secretion from hepatocytes. Secretion from hepatocytes is likely involved in the increase in circulating Prx4 during sepsis. GYY4137 attenuates not only hepatic injury but also Prx4 secretion.
    Language English
    Publishing date 2019-09-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2128461-1
    ISSN 1881-915X ; 0914-9198
    ISSN (online) 1881-915X
    ISSN 0914-9198
    DOI 10.1293/tox.2019-0030
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  3. Article ; Online: Multireference Perturbation Theory Combined with PCM and RISM Solvation Models: A Benchmark Study for Chemical Energetics.

    Saitow, Masaaki / Hori, Keisuke / Yoshikawa, Ayaka / Shimizu, Ryosuke Y / Yokogawa, Daisuke / Yanai, Takeshi

    The journal of physical chemistry. A

    2021  Volume 125, Issue 37, Page(s) 8324–8336

    Abstract: The polarizable continuum model (PCM) has been one of the most widely used approaches to take into account the solvation effect in quantum chemical calculations. In this paper, we performed a series of benchmark calculations to assess the accuracy of the ...

    Abstract The polarizable continuum model (PCM) has been one of the most widely used approaches to take into account the solvation effect in quantum chemical calculations. In this paper, we performed a series of benchmark calculations to assess the accuracy of the PCM scheme combined with the second-order complete-active-space perturbation theory (CASPT2) for molecular systems in polar solvents. For solute molecules with extensive conjugated π orbitals, exemplified by elongated conjugated arylcarbenes, we have incorporated the
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.1c05944
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  4. Article ; Online: The addition of iguratimod can reduce methotrexate dose in rheumatoid arthritis with clinical remission.

    Yoshikawa, Ayaka / Kotani, Takuya / Matsuda, Shogo / Hata, Kenichiro / Matsumura, Yoko / Takeuchi, Tohru

    Modern rheumatology

    2021  Volume 32, Issue 1, Page(s) 68–73

    Abstract: Objectives: We prospectively evaluated whether the addition of iguratimod (IGU) could sustain clinical remission in rheumatoid arthritis (RA) patients after tapering of methotrexate (MTX).: Methods: The study included 47 patients; 25 patients in the ... ...

    Abstract Objectives: We prospectively evaluated whether the addition of iguratimod (IGU) could sustain clinical remission in rheumatoid arthritis (RA) patients after tapering of methotrexate (MTX).
    Methods: The study included 47 patients; 25 patients in the MTX maintenance group, and 22 patients in the IGU addition group who were treated with additional IGU and tapering of MTX dose. Clinical efficacy and safety were evaluated at 12, 24, and 36 weeks.
    Results: In the IGU addition group, the dose of MTX could be reduced from 8.6 ± 2.4 mg/week at baseline to 4.7 ± 2.2 mg/week at 36 weeks (p < .001). Clinical remission was maintained (disease activity score [DAS]28-ESR 1.48 ± 0.63 at baseline and 1.69 ± 0.76 at 36 weeks, p = .911), and disease activity remained low (clinical disease activity index [CDAI] 2.4 ± 1.5 at baseline and 3.1 ± 3.4 at 36 weeks, p = .825). The US-GLOSS score significantly decreased from 9.2 ± 5.3 at baseline to 6.4 ± 4.3 at 36 weeks (p = .034). In the IGU addition group, two patients discontinued IGU because of stomatitis and three patients relapsed during the follow-up period (flare rate: 15.0%). There was no significant difference in RA disease activity at 36 weeks between the two groups.
    Conclusion: Additional use of IGU can effectively reduce the MTX dose required by patients during clinical remission without inducing a flare.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Chromones ; Drug Therapy, Combination ; Humans ; Methotrexate/therapeutic use ; Remission Induction ; Sulfonamides ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Chromones ; Sulfonamides ; iguratimod (4IHY34Y2NV) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1080/14397595.2021.1892945
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  5. Article ; Online: Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats.

    Unuma, Kana / Aki, Toshihiko / Yamashita, Ayaka / Yoshikawa, Ayaka / Uemura, Koichi

    The Journal of toxicological sciences

    2019  Volume 44, Issue 2, Page(s) 107–112

    Abstract: Inhalation of toxic gases is dangerous to humans; experiments using toxic gases themselves are also hazardous to researchers. Gas-releasing molecules are widely used as alternatives to toxic gases, but their impacts on the whole body remain to be ... ...

    Abstract Inhalation of toxic gases is dangerous to humans; experiments using toxic gases themselves are also hazardous to researchers. Gas-releasing molecules are widely used as alternatives to toxic gases, but their impacts on the whole body remain to be examined. To investigate responses during hydrogen sulfide (H
    MeSH term(s) A549 Cells ; Animals ; Brain/drug effects ; Brain/pathology ; Bronchitis/chemically induced ; Bronchitis/metabolism ; Bronchitis/pathology ; Humans ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Liver/drug effects ; Liver/pathology ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Mucin-1/genetics ; Mucin-1/metabolism ; Mucin-5B/genetics ; Mucin-5B/metabolism ; Myocardium/pathology ; Rats, Sprague-Dawley ; Sulfides/toxicity ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Interleukin-1beta ; Mucin-1 ; Mucin-5B ; Sulfides ; Tumor Necrosis Factor-alpha ; sodium bisulfide (FWU2KQ177W)
    Language English
    Publishing date 2019-02-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 770623-6
    ISSN 1880-3989 ; 0388-1350
    ISSN (online) 1880-3989
    ISSN 0388-1350
    DOI 10.2131/jts.44.107
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  6. Article ; Online: Comparative effectiveness of biological disease-modifying antirheumatic drugs and Janus kinase inhibitor monotherapy in rheumatoid arthritis.

    Onishi, Akira / Yamada, Hirotaka / Yamamoto, Wataru / Watanabe, Ryu / Hara, Ryota / Katayama, Masaki / Okita, Yasutaka / Maeda, Yuichi / Amuro, Hideki / Son, Yonsu / Yoshikawa, Ayaka / Hata, Kenichiro / Hashimoto, Motomu / Saegusa, Jun / Morinobu, Akio

    Rheumatology (Oxford, England)

    2023  

    Abstract: Objectives: To examine the effectiveness and drug tolerability of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitor (JAKi) monotherapy in patients with rheumatoid arthritis (RA) in a multicentre cohort study.: ... ...

    Abstract Objectives: To examine the effectiveness and drug tolerability of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitor (JAKi) monotherapy in patients with rheumatoid arthritis (RA) in a multicentre cohort study.
    Methods: Patients with RA initiated with bDMARD/JAKi monotherapy without conventional synthetic DMARDs were included. Monotherapy regimens were categorised as interleukin-6 receptor inhibitors (IL-6Ri), cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig), JAKi, or tumour necrosis factor inhibitors (TNFi). Multiple propensity score-based inverse probability weighting (IPW) was used to reduce selection bias. Linear mixed-effect models with IPW were used to examine changes in the disease activity score in 28 joints (DAS28)-erythrocyte sedimentation rate (ESR) at 24 weeks, and drug retention was compared among monotherapy using IPW Cox proportional hazards models.
    Results: A total of 849 treatment courses from 635 patients were included (IL-6Ri, 218; CTLA4Ig, 183; JAKi, 92; TNFi, 356). The difference in change in DAS28-ESR at week 24 as the primary outcome was -0.93 (95% CI: -1.20 to -0.66) lower in the IL-6Ri group than TNFi, while that of CTLA4Ig and JAKi was similar with that of TNFi (-0.20 [-0.48 to 0.08], -0.25 [-0.67 to 0.16], respectively). IL-6Ri use was associated with significantly lower overall drug discontinuation than TNFi use (hazard ratio = 0.55 [0.39-0.78], P = 0.001). Similar retention rates were identified among CTLA4Ig and JAKi compared to TNFi.
    Conclusion: In the analysis with IPW to reduce selection bias, IL-6Ri monotherapy was superior to TNFi monotherapy in terms of effectiveness and drug retention. No significant differences were identified between CTLA4Ig, JAKi, and TNFi monotherapy.
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead620
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  7. Article ; Online: Predictive factors and treatment outcomes associated with difficult-to-treat rheumatoid arthritis conditions: the ANSWER cohort study.

    Watanabe, Ryu / Ebina, Kosuke / Gon, Takaho / Okano, Tadashi / Murata, Koichi / Murakami, Kosaku / Maeda, Yuichi / Jinno, Sadao / Shirasugi, Iku / Son, Yonsu / Amuro, Hideki / Katayama, Masaki / Hara, Ryota / Hata, Kenichiro / Yoshikawa, Ayaka / Yamamoto, Wataru / Tachibana, Shotaro / Hayashi, Shinya / Etani, Yuki /
    Katsushima, Masao / Fukumoto, Kazuo / Yamada, Shinsuke / Hashimoto, Motomu

    Rheumatology (Oxford, England)

    2024  

    Abstract: Objectives: To investigate the predictive factors for difficult-to-treat rheumatoid arthritis (D2T RA) and assess the efficacy of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi).: Methods: Retrospective ... ...

    Abstract Objectives: To investigate the predictive factors for difficult-to-treat rheumatoid arthritis (D2T RA) and assess the efficacy of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi).
    Methods: Retrospective analysis was conducted on data from the ANSWER cohort comprising 3,623 RA patients treated with bDMARDs or JAKi in Japan. Multivariate Cox proportional hazards modelling was used to analyse the hazard ratios (HRs) for treatment retention.
    Results: Of these, 450 (12.4%) met the first two criteria of EULAR D2T RA definition (defined as D2T RA in this study). Factors contributing to D2T RA included age over 75 (compared to those under 65, HR = 0.46, 95% CI: 0.31 to 0.69), higher rheumatoid factor (RF) titres (HR = 1.005, 95% CI: 1.00 to 1.01), higher clinical disease activity index (HR = 1.02, 95% CI: 1.01 to 1.03), lower methotrexate dosage (HR = 0.97, 95% CI: 0.95 to 0.99), and comorbidities like hypertension (HR = 1.53, 95% CI: 1.2 to 1.95) and diabetes (HR = 1.37, 95% CI: 1.09 to 1.73). Anti-interleukin 6 receptor antibodies (aIL-6R, HR = 0.53, 95% CI: 0.37 to 0.75) and JAKi (HR = 0.64, 95% CI: 0.46 to 0.90) were associated with fewer discontinuations due to ineffectiveness compared to tumour necrosis factor inhibitors. Oral glucocorticoids usage (HR = 1.65, 95% CI: 1.11 to 2.47) was linked to increased discontinuation due to toxic adverse events.
    Conclusion: Younger onset, higher RF titres, and comorbidities predicted D2T RA development. For managing D2T RA, aIL-6R and JAKi exhibited superior drug retention.
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae265
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  8. Article ; Online: Safety of Janus kinase inhibitors compared to biological DMARDs in patients with rheumatoid arthritis and renal impairment: the ANSWER cohort study.

    Nakayama, Yoichi / Onishi, Akira / Yamamoto, Wataru / Yoshikawa, Ayaka / Shiba, Hideyuki / Yoshida, Naofumi / Son, Yonsu / Shirasugi, Iku / Maeda, Toshihisa / Katsushima, Masao / Hashimoto, Motomu / Etani, Yuki / Itami, Tetsu / Nozaki, Yuji / Onizawa, Hideo / Fujii, Takayuki / Murakami, Kosaku / Murata, Koichi / Tanaka, Masao /
    Matsuda, Shuichi / Morinobu, Akio

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 97

    Abstract: Data on the safety of Janus kinase inhibitors (JAKis) in patients with renal impairment are lacking. This study aimed to investigate the safety of JAKis compared to biological (b) DMARDs in patients with rheumatoid arthritis (RA) and renal impairment. We ...

    Abstract Data on the safety of Janus kinase inhibitors (JAKis) in patients with renal impairment are lacking. This study aimed to investigate the safety of JAKis compared to biological (b) DMARDs in patients with rheumatoid arthritis (RA) and renal impairment. We used a multi-centre observational registry of patients with RA in Japan (the ANSWER cohort). We assessed the drug retention rates of b/targeted synthetic DMARDs with different modes of action (tumour necrosis factor inhibitors (TNFis), immunoglobulins fused with cytotoxic T-lymphocyte antigen (CTLA-4-Ig), interleukin-6 receptor inhibitors (IL-6Ris), and JAKis) in patients with RA stratified by pre-treatment estimated glomerular filtration rate (eGFR) levels. The time to discontinuation of bDMARDs or JAKis was analysed using a multivariate Cox proportional hazards model This study included 3775 patients, who were classified into three groups (the normal group (eGFR ≥ 60 mL/min/1.73 m
    MeSH term(s) Humans ; Arthritis, Rheumatoid/drug therapy ; Female ; Male ; Middle Aged ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinase Inhibitors/adverse effects ; Aged ; Antirheumatic Agents/therapeutic use ; Antirheumatic Agents/adverse effects ; Japan ; Glomerular Filtration Rate ; Renal Insufficiency/chemically induced ; Adult ; Cohort Studies ; Biological Products/therapeutic use ; Biological Products/adverse effects
    Chemical Substances Janus Kinase Inhibitors ; Antirheumatic Agents ; Biological Products
    Language English
    Publishing date 2024-05-10
    Publishing country Italy
    Document type Journal Article ; Multicenter Study ; Observational Study ; Comparative Study
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-024-01360-w
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  9. Article ; Online: Prognostic Factors Affecting Death in Patients with Rheumatoid Arthritis Complicated by

    Shiba, Hideyuki / Kotani, Takuya / Nagai, Koji / Hata, Kenichiro / Yamamoto, Wataru / Yoshikawa, Ayaka / Wada, Yumiko / Hiramatsu, Yuri / Makino, Hidehiko / Ueda, Yo / Onishi, Akira / Murata, Koichi / Amuro, Hideki / Son, Yonsu / Hara, Ryota / Hirano, Toru / Ebina, Kosuke / Katayama, Masaki / Hashimoto, Motomu /
    Takeuchi, Tohru

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: This multicenter retrospective study aimed to clarify the prognostic factors for mortality and changes in treatment modalities and disease activities after the onset ... ...

    Abstract This multicenter retrospective study aimed to clarify the prognostic factors for mortality and changes in treatment modalities and disease activities after the onset of
    MeSH term(s) Humans ; Female ; Aged ; Male ; Pneumonia, Pneumocystis/complications ; Pneumonia, Pneumocystis/drug therapy ; Retrospective Studies ; Cohort Studies ; Pneumocystis carinii ; Prognosis ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Prednisolone/therapeutic use
    Chemical Substances Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087399
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  10. Article ; Online: Simplified disease activity index and clinical disease activity index before and during pregnancy correlate with those at postpartum in patients with rheumatoid arthritis.

    Nakamura, Eri / Kotani, Takuya / Hiramatsu, Yuri / Hata, Kenichiro / Yoshikawa, Ayaka / Matsumura, Yoko / Tokai, Nao / Wada, Yumiko / Fujita, Daisuke / Takeuchi, Tohru

    Modern rheumatology

    2020  Volume 31, Issue 4, Page(s) 809–816

    Abstract: Objectives: We explored rheumatoid arthritis (RA) disease activity before, during, and after pregnancy in patients treated with tight control and investigated the association between disease activity in the postpartum period and those before and during ... ...

    Abstract Objectives: We explored rheumatoid arthritis (RA) disease activity before, during, and after pregnancy in patients treated with tight control and investigated the association between disease activity in the postpartum period and those before and during pregnancy.
    Methods: We retrospectively reviewed disease activity and medications of 27 patients before pregnancy, at every trimester, and in the postpartum period.
    Results: Prednisolone was administered to 33% of patients with a median dose of 0 (0-2.5) mg/day and biologic agents was 78% in the third trimester. The median remission rates during all periods were the Disease Activity Score-28-C-reactive Protein assessed with three variables (DAS28-CRP-3) 85%, Simplified Disease Activity Index (SDAI) 55%, and Clinical Disease Activity Index (CDAI) 54%. Although SDAI and CDAI decreased significantly from before pregnancy to the first trimester and increased from the third trimester to the postpartum period, DAS28-CRP-3 did not change during all periods. Although SDAI and CDAI before and during pregnancy were significantly correlated with those in the postpartum period, DAS28-CRP-3 was not.
    Conclusions: Tight control before pregnancy suppressed RA disease activity during pregnancy and in the postpartum period. SDAI/CDAI before and during pregnancy were predictive for disease activity in the postpartum period.
    MeSH term(s) Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Biological Factors/therapeutic use ; C-Reactive Protein/analysis ; Female ; Humans ; Male ; Postpartum Period/physiology ; Prednisolone/therapeutic use ; Pregnancy ; Remission Induction ; Research Design ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Antirheumatic Agents ; Biological Factors ; C-Reactive Protein (9007-41-4) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1080/14397595.2020.1829342
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