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  1. Article ; Online: Association of microbiota with cancer treatment.

    Yoshimura, Kiyoshi

    International journal of clinical oncology

    2023  Volume 28, Issue 3, Page(s) 341–346

    Abstract: The impact of immune checkpoint molecule inhibitors on cancer treatment is significant. At the same time, further improvement in their efficacy has become essential. For this reason, there has been increasing interest in investigating the state of the ... ...

    Abstract The impact of immune checkpoint molecule inhibitors on cancer treatment is significant. At the same time, further improvement in their efficacy has become essential. For this reason, there has been increasing interest in investigating the state of the cancer microenvironment in which efficacy can be demonstrated. The gut microbiota plays an important role in the cancer microenvironment. Recent developments in the study of gut microbiota have been explosive, benefiting from technological innovations in next-generation sequencing. Gut microbiota are specific enough to identify an individual and change gently with age. Disruptions in the gut microbiota have been extensively studied in relation to a variety of diseases. In addition to monotherapy with anti-PD-1/PD-L1 antibodies, combination therapy with chemotherapy and molecular target therapy, as well as combination therapy with anti-PD-1 and anti-CTLA-4 antibodies, is now widely used in cancer treatment with immune checkpoint inhibitors. Therefore, the development of biomarkers that can predict anti-tumor and adverse events is urgently required due to the complexity of the treatment, and research on gut microbiota is expected in this respect.
    MeSH term(s) Humans ; Antibodies, Monoclonal ; Combined Modality Therapy ; Immunotherapy/methods ; Microbiota ; Neoplasms/therapy ; Tumor Microenvironment
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-02-27
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-023-02302-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4828: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Editorial Comment to GRade, Age, Nodes, and Tumor (GRANT) compared with Leibovich score to predict survival in localized renal cell carcinoma: A nationwide study.

    Yoshimura, Kazuhiro

    International journal of urology : official journal of the Japanese Urological Association

    2022  Volume 29, Issue 7, Page(s) 646

    MeSH term(s) Carcinoma, Renal Cell/pathology ; Humans ; Kidney Neoplasms/pathology ; Nephrectomy ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-04-01
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.14881
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4460: Show issues Location:
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    Zs.MO 278: Show issues

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  3. Article: Factors associated with foreign-educated nurses' willingness to continue working in Japan: a qualitative study.

    Tanaka, Kazuko / Yoshimura, Koichi

    BMC nursing

    2024  Volume 23, Issue 1, Page(s) 228

    Abstract: Background: Japan has been accepting foreign nurse candidates since 2008 under Economic Partnership Agreements (EPAs). As globalisation progresses, nurses from diverse backgrounds are expected to play an active role in the medical field. Using an ... ...

    Abstract Background: Japan has been accepting foreign nurse candidates since 2008 under Economic Partnership Agreements (EPAs). As globalisation progresses, nurses from diverse backgrounds are expected to play an active role in the medical field. Using an interview survey, this study examined the factors associated with EPA nurses' willingness to continue working in Japan.
    Methods: We conducted semi-structured interviews from January 2022 to July 2023 with eight EPA nurses and one EPA nurse candidate working in Japan to investigate the factors associated with foreign-educated nurses' willingness to continue working in Japan. The interview guide included items on the status of the daily performance of their duties, what they found pleasurable in their nursing experience in Japan, difficulties they encountered in carrying out their nursing duties, and their expectations of the Japanese staff around them. Data were analysed using thematic analysis.
    Results: From the interview data, seven themes were extracted. To continue working in Japan, it was important for EPA nurses to be able to communicate with patients and colleagues, maintain self-esteem and motivation, be resilient, have support from EPA peers and family members, be accepted by others such as patients and colleagues, and be satisfied with the support they received.
    Conclusion: The EPA nurses experienced many difficulties after becoming nurses and tended to be isolated because of their non-Japanese status. The results suggest that not only support from colleagues and supervisors but also a general understanding of EPA nurses from Japanese society is necessary. As globalisation accelerates, the Japanese nursing field needs to understand the diversity of the nursing profession and build a support system that will enable them to continue to take pride and feel motivated in their work.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-024-01890-4
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  4. Article ; Online: Physiological function and regulation of ascorbate peroxidase isoforms.

    Yoshimura, Kazuya / Ishikawa, Takahiro

    Journal of experimental botany

    2024  Volume 75, Issue 9, Page(s) 2700–2715

    Abstract: Ascorbate peroxidase (APX) reduces H2O2 to H2O by utilizing ascorbate as a specific electron donor and constitutes the ascorbate-glutathione cycle in organelles of plants including chloroplasts, cytosol, mitochondria, and peroxisomes. It has been almost ... ...

    Abstract Ascorbate peroxidase (APX) reduces H2O2 to H2O by utilizing ascorbate as a specific electron donor and constitutes the ascorbate-glutathione cycle in organelles of plants including chloroplasts, cytosol, mitochondria, and peroxisomes. It has been almost 40 years since APX was discovered as an important plant-specific H2O2-scavenging enzyme, during which time many research groups have conducted molecular physiological analyses. It is now clear that APX isoforms function not only just as antioxidant enzymes but also as important factors in intracellular redox regulation through the metabolism of reactive oxygen species. The function of APX isoforms is regulated at multiple steps, from the transcriptional level to post-translational modifications of enzymes, thereby allowing them to respond flexibly to ever-changing environmental factors and physiological phenomena such as cell growth and signal transduction. In this review, we summarize the physiological functions and regulation mechanisms of expression of each APX isoform.
    MeSH term(s) Ascorbate Peroxidases/metabolism ; Ascorbate Peroxidases/genetics ; Isoenzymes/metabolism ; Isoenzymes/genetics ; Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Plants/enzymology ; Plants/metabolism ; Protein Isoforms/metabolism
    Chemical Substances Ascorbate Peroxidases (EC 1.11.1.11) ; Isoenzymes ; Plant Proteins ; Protein Isoforms
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 55/29: Show issues

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  5. Article ; Online: Cell-Assisted Lipotransfer and Therapeutic Use of Adipose Stem Cells Thereafter.

    Yoshimura, Kotaro

    Aesthetic plastic surgery

    2020  Volume 44, Issue 4, Page(s) 1266–1267

    MeSH term(s) Adipocytes ; Adipose Tissue ; Humans ; Stem Cells
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-020-01781-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1296: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A downscaling and bias correction method for climate model ensemble simulations of local-scale hourly precipitation.

    Yoshikane, Takao / Yoshimura, Kei

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9412

    Abstract: Ensemble simulations of climate models are used to assess the impact of climate change on precipitation, and require downscaling at the local scale. Statistical downscaling methods have been used to estimate daily and monthly precipitation from observed ... ...

    Abstract Ensemble simulations of climate models are used to assess the impact of climate change on precipitation, and require downscaling at the local scale. Statistical downscaling methods have been used to estimate daily and monthly precipitation from observed and simulated data. Downscaling of short-term precipitation data is necessary for more accurate prediction of extreme precipitation events and related disasters at the regional level. In this study, we developed and investigated the performance of a downscaling method for climate model simulations of hourly precipitation. Our method was designed to recognize time-varying precipitation systems that can be represented at the same resolution as the numerical model. Downscaling improved the estimation of the spatial distribution of hourly precipitation frequency, monthly average, and 99th percentile values. The climate change in precipitation amount and frequency were shown in almost all areas by using the 50 ensemble averages of estimated precipitation, although the natural variability was too large to compare with observations. The changes in precipitation were consistent with simulations. Therefore, our downscaling method improved the evaluation of the climatic characteristics of extreme precipitation events and more comprehensively represented the influence of local factors, such as topography, which have been difficult to evaluate using previous methods.
    MeSH term(s) Climate Models ; Bias ; Climate Change ; Disasters
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36489-3
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  7. Article: Association between pH regulation of the tumor microenvironment and immunological state.

    Hosonuma, Masahiro / Yoshimura, Kiyoshi

    Frontiers in oncology

    2023  Volume 13, Page(s) 1175563

    Abstract: The tumor microenvironment (TME) is characterized by interactions among various cells, including tumor cells, immune cells, stromal cells, and blood vessels mediated by factors such as cytokines and metabolites. The development of cancer immunotherapy in ...

    Abstract The tumor microenvironment (TME) is characterized by interactions among various cells, including tumor cells, immune cells, stromal cells, and blood vessels mediated by factors such as cytokines and metabolites. The development of cancer immunotherapy in recent years has facilitated a more comprehensive understanding of the TME. The TME changes with cancer type and host immune status, as well as with therapeutic intervention. However, studies on pH regulation of the TME have been mostly based on lactate, a metabolite of tumor cells. Notably, the Warburg effect results in the increased production of secreted lactate, thereby acidifying the extracellular microenvironment and affecting the surrounding cells. Lactate inhibits the activation and proliferation of CD8+ T cells, M1 macrophages, natural killer (NK) cells, and dendritic cells, contributing to tumor cell immune escape. It is also involved in angiogenesis and tissue remodeling, as well as promotes tumor growth and invasion. In this review, we have discussed the lactate-based pH regulation in tumor cells in the TME and its effects on the other constituent cells.
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1175563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Magnetic properties induced by the Yb-valence inhomogeneity in the layered Kondo-lattice compound Yb

    Yamanaka, S / Hikiji, M / Michioka, C / Ueda, H / Yoshimura, K

    Journal of physics. Condensed matter : an Institute of Physics journal

    2023  Volume 35, Issue 36

    Abstract: We have successfully grown single crystals of a novel ytterbium-based layered compoundYb4RuGe8and studied its structural, magnetic, thermal, and transport properties. The magnetic susceptibility has a broad peak caused by the Kondo effect at ... ...

    Abstract We have successfully grown single crystals of a novel ytterbium-based layered compoundYb4RuGe8and studied its structural, magnetic, thermal, and transport properties. The magnetic susceptibility has a broad peak caused by the Kondo effect at approximately40 Kand is enhanced below15 Kowing to the development of additional magnetic correlations. An analysis with the grand-Kadowaki-Woods relation reveals that the low-temperature state except for the effect of the additional magnetic correlations is a heavy-mass Fermi liquid.
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/acda07
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  9. Article ; Online: Discussion: Promotion of Primary Murine Breast Cancer Growth and Metastasis by Adipose-Derived Stem Cells Is Reduced in the Presence of Autologous Fat Graft.

    Yoshimura, Kotaro

    Plastic and reconstructive surgery

    2019  Volume 143, Issue 1, Page(s) 148–149

    MeSH term(s) Adipocytes ; Animals ; Breast Neoplasms ; Humans ; Mice ; Stem Cells
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000005143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
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    Zs.MO 293: Show issues

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  10. Article: [Repair of Iatrogenic Recto-Urethral Fistulas : Experience of 6 Cases].

    Yoshimura, Koji

    Hinyokika kiyo. Acta urologica Japonica

    2019  Volume 65, Issue 9, Page(s) 355–361

    Abstract: I repaired iatrogenic recto-urethral fistulas (RUF) in 6 patients. All the fistulas had developed after surgery, 5 for prostate cancer (prostatectomy) and the remaining one for pelvic solitary fibrous tumor. All of them were"simple"fistulas. I performed ... ...

    Abstract I repaired iatrogenic recto-urethral fistulas (RUF) in 6 patients. All the fistulas had developed after surgery, 5 for prostate cancer (prostatectomy) and the remaining one for pelvic solitary fibrous tumor. All of them were"simple"fistulas. I performed repair using the transperineal approach with gracilis muscle flap interposition in 4 cases, and using the transsphincteric approach (modified York-Mason method) in 2, with the cooperation of general surgeons and/or plastic surgeons. All fistulas were successfully repaired. The operation time ranged from 414 to 464 minutes for transperineal repair and 246 and 253 minutes for transsphincteric repair. The blood loss ranged from 100 to 533 ml for transperineal repair and 30 and 60 ml for transsphincteric repair. Transsphincteric approach was less invasive and may be the first choice for simple RUF repair.
    MeSH term(s) Humans ; Iatrogenic Disease ; Male ; Prostatectomy ; Rectal Fistula ; Urinary Fistula
    Language Japanese
    Publishing date 2019-11-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    DOI 10.14989/ActaUrolJap_65_9_355
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 411: Show issues Location:
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