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  1. Article ; Online: Ventricular phase analysis moves on to the next phase: What technologists should keep in mind.

    Yoshinaga, Keiichiro

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2020  Volume 28, Issue 3, Page(s) 1172–1174

    MeSH term(s) Cardiac Resynchronization Therapy ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography ; Electrocardiography ; Heart Failure/complications ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Humans ; Patient Selection ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-020-02216-y
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  2. Article ; Online: Role of Metabolic Imaging in Detecting Cardiac Involvement in Sarcoidosis.

    Yoshinaga, Keiichiro

    Circulation journal : official journal of the Japanese Circulation Society

    2015  Volume 79, Issue 12, Page(s) 2551–2552

    MeSH term(s) Cardiomyopathies/diagnosis ; Heart ; Humans ; Magnetic Resonance Imaging ; Sarcoidosis
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Comment ; Editorial
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-15-1099
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  3. Article ; Online: Predicting cardiac events using ventricular dyssynchrony in patients who received implantable cardioverter defibrillators: Are more treatment options required?

    Yoshinaga, Keiichiro

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2015  Volume 24, Issue 1, Page(s) 130–133

    MeSH term(s) Death, Sudden, Cardiac ; Defibrillators, Implantable ; Heart Ventricles ; Humans ; Tachycardia, Ventricular
    Language English
    Publishing date 2015-11-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-015-0326-x
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  4. Article ; Online: Cardiovascular event risk assessment using myocardial perfusion imaging with a view to wide clinical application.

    Yoshinaga, Keiichiro

    Circulation journal : official journal of the Japanese Circulation Society

    2011  Volume 75, Issue 10, Page(s) 2318–2319

    MeSH term(s) Coronary Artery Disease/diagnosis ; Humans ; Myocardial Perfusion Imaging/methods ; Research Design/standards
    Language English
    Publishing date 2011-08-26
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.cj-11-0841
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  5. Article ; Online: Improving the worldwide quality of nuclear cardiology practice and research: The role of the official journal.

    Yoshinaga, Keiichiro / Tamaki, Nagara

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2016  Volume 24, Issue 2, Page(s) 335–337

    MeSH term(s) Biomedical Research/standards ; Cardiology/standards ; Humans ; Nuclear Medicine/standards ; Periodicals as Topic ; Quality of Health Care ; Societies, Medical
    Language English
    Publishing date 2016-09-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-016-0655-4
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  6. Article: [Myocardial viability assessment and perioperative cardiovascular evaluation using single photon emission tomography and positron emission tomography].

    Yoshinaga, Keiichiro

    Kyobu geka. The Japanese journal of thoracic surgery

    2007  Volume 60, Issue 8 Suppl, Page(s) 627–634

    Abstract: Nuclear cardiology including single photon emission computed tomography (SPECT) and positron emission tomography (PET) can play important roles as myocardial viability assessment and perioperative cardiovascular evaluation for noncardiac surgery. ... ...

    Abstract Nuclear cardiology including single photon emission computed tomography (SPECT) and positron emission tomography (PET) can play important roles as myocardial viability assessment and perioperative cardiovascular evaluation for noncardiac surgery. Increasing prevalance of coronary artery disease (CAD) is associated with an increasing number of patients with heart failure secondary to CAD. Three main therapies, medical, revascularizations, and heart transplantation, are currently available. Appropriate revascularization can improve left ventricular function, and hence could also improve an outcome. However, patients with reduced left ventricle (LV) function have higher perioperative cardiac risks. Therefore, it is important to evaluate the extent of myocardial viability to assist in deciding patient managements. In nuclear imaging, thallium-201 (201T1) SPECT, technetium-99m (99mTc) sestamibi SPECT, and 18F fluorodeoxyglucose (FDG) are applied for viability assessment. FDG is a glucose analogue and is used to measure myocardial glucose utilization. Among noninvasive imaging, FDG-PET is considered to be a standard measurement. Perioperative cardiovascular complications significantly deteriorate the outcome not only of the postoperative period but also over the subsequent 1 to 2 years. Intrathoracic noncardiac surgeries themselves are at intermediate or high perioperative risk. Thus, careful preoperative cardiac risk assessment is necessary for predicting cardiac complications. In the present review, we overview the present status of viability assessment and perioperative cardiovascular evaluation, and discuss some new approaches.
    MeSH term(s) Coronary Circulation ; Fluorodeoxyglucose F18 ; Heart/diagnostic imaging ; Humans ; Myocardial Ischemia/diagnostic imaging ; Myocardium/pathology ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tissue Survival ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language Japanese
    Publishing date 2007-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Current status of nuclear cardiology in Japan: Ongoing efforts to improve clinical standards and to establish evidence.

    Yoshinaga, Keiichiro / Tamaki, Nagara

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2015  Volume 22, Issue 4, Page(s) 690–699

    Abstract: Nuclear cardiology imaging tests are widely performed in Japan as clinical practice. The Japanese nuclear cardiology community has developed new diagnostic imaging tests using (123)I-beta-methyl-p-iodophenyl-pentadecanoic acid, (123)I- ... ...

    Abstract Nuclear cardiology imaging tests are widely performed in Japan as clinical practice. The Japanese nuclear cardiology community has developed new diagnostic imaging tests using (123)I-beta-methyl-p-iodophenyl-pentadecanoic acid, (123)I-metaiodobenzylguanidine, and (18)F-fluorodeoxyglucose PET for detecting cardiac involvement in sarcoidosis. These tests have become popular worldwide. The Japanese Circulation Society and the Japanese Society of Nuclear Cardiology have published clinical imaging guidelines showing indications and standards for the new imaging tests. JSNC is currently striving to improve the standard of clinical practice and is promoting research activities.
    MeSH term(s) Cardiology/standards ; Cardiology/trends ; Evidence-Based Medicine/standards ; Evidence-Based Medicine/trends ; Image Enhancement/standards ; Japan ; Nuclear Medicine/standards ; Nuclear Medicine/trends ; Practice Guidelines as Topic ; Radiopharmaceuticals/standards ; Tomography, Emission-Computed/standards ; Tomography, Emission-Computed/trends
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2015-04-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-015-0136-1
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  8. Article ; Online: Absolute quantification of myocardial blood flow.

    Yoshinaga, Keiichiro / Manabe, Osamu / Tamaki, Nagara

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2016  Volume 25, Issue 2, Page(s) 635–651

    Abstract: With the increasing availability of positron emission tomography (PET) myocardial perfusion imaging, the absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings. Quantitative MBF provides an important additional ... ...

    Abstract With the increasing availability of positron emission tomography (PET) myocardial perfusion imaging, the absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings. Quantitative MBF provides an important additional diagnostic or prognostic information over conventional visual assessment. The success of MBF quantification using PET/computed tomography (CT) has increased the demand for this quantitative diagnostic approach to be more accessible. In this regard, MBF quantification approaches have been developed using several other diagnostic imaging modalities including single-photon emission computed tomography, CT, and cardiac magnetic resonance. This review will address the clinical aspects of PET MBF quantification and the new approaches to MBF quantification.
    MeSH term(s) Blood Flow Velocity ; Cardiology/methods ; Coronary Circulation ; Heart/diagnostic imaging ; Humans ; Kinetics ; Magnetic Resonance Imaging ; Multimodal Imaging ; Myocardial Perfusion Imaging ; Myocardium/pathology ; Positron-Emission Tomography ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-016-0591-3
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  9. Article ; Online: Recommendations for

    Kumita, Shinichiro / Yoshinaga, Keiichiro / Miyagawa, Masao / Momose, Mitsuru / Kiso, Keisuke / Kasai, Tokuo / Naya, Masanao

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2019  Volume 26, Issue 4, Page(s) 1414–1433

    MeSH term(s) Cardiomyopathies/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Japan ; Positron-Emission Tomography ; Practice Guidelines as Topic ; Radiopharmaceuticals ; Sarcoidosis/diagnostic imaging
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-019-01755-3
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  10. Article ; Online: Validation of regional myocardial blood flow quantification using three-dimensional PET with rubidium-82: repeatability and comparison with two-dimensional PET data acquisition.

    Manabe, Osamu / Klein, Ran / Katoh, Chietsugu / Magota, Keiichi / deKemp, Robert A / Naya, Masanao / Tamaki, Nagara / Yoshinaga, Keiichiro

    Nuclear medicine communications

    2020  Volume 41, Issue 8, Page(s) 768–775

    Abstract: Introduction: Three-dimensional (3D) data acquisition is now standard on PET/computed tomography scanners. The aim of this study was to evaluate the repeatability of myocardial blood flow (MBF) estimation with rubidium-82 (Rb) 3D PET and to validate ... ...

    Abstract Introduction: Three-dimensional (3D) data acquisition is now standard on PET/computed tomography scanners. The aim of this study was to evaluate the repeatability of myocardial blood flow (MBF) estimation with rubidium-82 (Rb) 3D PET and to validate regional MBF measurements by comparison with two-dimensional (2D) PET.
    Patients and methods: Fifteen healthy individuals (31.6 ± 11.4 years old) were enrolled for the evaluation of the short-term repeatability of rest 3D MBF quantification. Another 19 healthy individuals (35.3 ± 12.6 years old) underwent rest and pharmacological stress PET using 2D and 3D data acquisition within a 1-month interval. The injected dose was 1500 MBq for 2D and 555 MBq for 3D PET acquisition.
    Results: MBF at rest showed good repeatability [whole left ventricular MBF; 0.54 ± 0.13 vs. 0.52 ± 0.13 mL/min/g, P = 0.98]. Rest MBF, stress MBF, and myocardial flow reserve (MFR) were not significantly different between 3D and 2D data acquisition. 3D MBF correlated well with 2D MBF over a wide flow range for both whole left ventricular (r = 0.97, P < 0.0001) and regional values (r = 0.61, P < 0.0001).
    Conclusion: MBF measured with 3D PET showed very good test-retest repeatability. Whole left ventricular and regional MBF measurements obtained using lower Rb-dose 3D PET were highly correlated over a wide range with those from 2D PET. Therefore, MBF with 3D PET can be applied using a lower Rb dosage in clinical settings with reduced radiation exposure.
    MeSH term(s) Adult ; Coronary Circulation ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Positron-Emission Tomography ; Rubidium Radioisotopes
    Chemical Substances Rubidium Radioisotopes ; Rubidium-82 (9K730EL8KU)
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Comparative Study ; Journal Article ; Validation Study
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001218
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