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  1. Article ; Online: NAD

    Itoh, Hiroshi / Yoshino, Jun

    Nature metabolism

    2023  Volume 5, Issue 3, Page(s) 357–359

    MeSH term(s) Humans ; RNA, Mitochondrial ; NAD ; RNA/genetics ; DNA, Mitochondrial/genetics
    Chemical Substances RNA, Mitochondrial ; NAD (0U46U6E8UK) ; RNA (63231-63-0) ; DNA, Mitochondrial
    Language English
    Publishing date 2023-03-13
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00762-6
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  2. Article ; Online: ACMSD: A Novel Target for Modulating NAD

    Yoshino, Jun

    Trends in endocrinology and metabolism: TEM

    2019  Volume 30, Issue 4, Page(s) 229–232

    Abstract: ... ...

    Abstract NAD
    MeSH term(s) Animals ; Carboxy-Lyases ; Homeostasis ; Humans ; Mice ; NAD ; Niacin ; Tryptophan
    Chemical Substances NAD (0U46U6E8UK) ; Niacin (2679MF687A) ; Tryptophan (8DUH1N11BX) ; Carboxy-Lyases (EC 4.1.1.-)
    Language English
    Publishing date 2019-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2019.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2999: Show issues Location:
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  3. Article ; Online: The role of breakfast in adipose tissue biology.

    Yoshino, Jun

    The Journal of physiology

    2018  Volume 596, Issue 4, Page(s) 551–552

    MeSH term(s) Adipose Tissue ; Adult ; Breakfast ; Fasting ; Humans ; Obesity
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP275576
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  4. Article: Comparison of Changes in Chest Wall Mechanics and Respiratory Timing Between Patient-Controlled Epidural Analgesia and Intravenous Patient-Controlled Analgesia After Laparoscopic Gastrectomy: A Randomized Controlled Trial.

    Asada, Masako / Nobukuni, Keiko / Yoshino, Jun / Fujimura, Naoyuki

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37276

    Abstract: Background: Upper abdominal surgery is associated with postoperative diaphragmatic dysfunction. Whether patient-controlled epidural analgesia (PCEA) is superior to intravenous patient-controlled analgesia (IV-PCA) in preventing postoperative ... ...

    Abstract Background: Upper abdominal surgery is associated with postoperative diaphragmatic dysfunction. Whether patient-controlled epidural analgesia (PCEA) is superior to intravenous patient-controlled analgesia (IV-PCA) in preventing postoperative diaphragmatic dysfunction is still unclear in laparoscopic gastric surgery.
    Methods: Sixteen patients undergoing laparoscopic gastrectomy randomly received either PCEA or IV-PCA. The primary outcomes were the change in chest wall mechanics and respiratory timing, measured by respiratory inductive plethysmography (Respitrace; Ambulatory Monitoring Inc., Ardsley, New York, United States) before and after surgery, and analyzed by a data acquisition system (PowerLab; ADInstruments, Dunedin, New Zealand). Inspiratory time (Ti), expiratory time (Te), total respiratory cycle time (Ttot), proportion of inspiratory time over total respiratory cycle time (Ti/Ttot), respiratory rate (RR), and abdominal contribution to tidal volume (AB/V
    Results: Postoperative AB/V
    Conclusions: Continuous ropivacaine infusion with PCEA partially attenuated diaphragmatic dysfunction after laparoscopic gastrectomy, while pain relief by continuous intravenous administration of fentanyl could not attenuate diaphragmatic dysfunction. This suggests that PCEA might ameliorate postoperative diaphragmatic dysfunction after laparoscopic gastrectomy.
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37276
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  5. Article ; Online: Effects of galvanic vestibular stimulation on postural righting reactions in hemiplegia.

    Horikawa, Akari / Amimoto, Kazu / Horikawa, Shota / Hiramoto, Ken / Nishio, Masaki / Yoshino, Jun / Ikeda, Yumi

    Neuroscience letters

    2024  Volume 827, Page(s) 137735

    Abstract: Patients with post-stroke hemiplegia often exhibit reduced ability to maintain sitting balance, a crucial factor for predicting prognosis. Galvanic vestibular stimulation (GVS) influences postural control by stimulating vestibular organ. Although several ...

    Abstract Patients with post-stroke hemiplegia often exhibit reduced ability to maintain sitting balance, a crucial factor for predicting prognosis. Galvanic vestibular stimulation (GVS) influences postural control by stimulating vestibular organ. Although several studies have focused on GVS in static postures, no studies have demonstrated the influence of GVS on righting reactions. Therefore, we aimed to investigate the effects of GVS on postural righting reactions in seated patients with stroke-induced hemiplegia. Using a vertical board (VB), righting reactions were induced by tilting the VB at 10° after patients sat for 1 min. Patients adjusted their bodies until feeling vertical upon prompt. Twenty-two left hemiplegic patients with cerebrovascular disease participated, divided into two groups undergoing right cathode GVS (RC-GVS) followed by left cathode GVS or vice versa, preceded by sham stimulation. Centre of pressure and the joint angle were measured. During the postural righting reactions towards the paralysed side, RC-GVS enhanced the righting reactions and moved the mean position on the x-axis (COPx) to the right and the mean position on the y-axis (COPy) to the front. During the postural righting reaction towards the right side, RC-GVS induced resistance against the righting reaction, COPx was deflected to the right, COPy was deflected backward, and the angle of the neck tilt increased. The findings revealed that GVS with anodal stimulation on the paralysed side could promote righting reactions in patients with post-stroke hemiplegia. SIGNIFICANCE STATEMENT: The study findings suggest that using the contralesional placement of the anode promotes righting reactions, and galvanic vestibular stimulation can induce joint movements in the neck and trunk by polarising it to act as resistance against righting reactions.
    MeSH term(s) Humans ; Hemiplegia/etiology ; Vestibule, Labyrinth/physiology ; Movement ; Postural Balance/physiology ; Stroke/complications ; Electric Stimulation
    Language English
    Publishing date 2024-03-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2024.137735
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
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  6. Article ; Online: Metabolically Healthy Obesity is not a Myth.

    Farabi, Sarah S / Smith, Gordon I / Yoshino, Jun / Klein, Samuel

    JCEM case reports

    2023  Volume 1, Issue 2, Page(s) luad015

    Abstract: People with obesity who do not have the metabolic syndrome or components of the metabolic syndrome have been characterized as having metabolically healthy obesity (MHO). However, the existence of MHO has been questioned because people with MHO are at ... ...

    Abstract People with obesity who do not have the metabolic syndrome or components of the metabolic syndrome have been characterized as having metabolically healthy obesity (MHO). However, the existence of MHO has been questioned because people with MHO are at greater risk of developing diabetes and fatal cardiovascular disease than people who are lean and healthy. Here we report findings from a 25-year-old woman with rigorously defined MHO (normal oral glucose tolerance, insulin sensitivity [assessed using the hyperinsulinemic-euglycemic clamp procedure], plasma triglyceride, and intrahepatic triglyceride content) evaluated at baseline (body mass index, 37.7 kg/m
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad015
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  7. Article ; Online: Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight/obesity.

    Chondronikola, Maria / Yoshino, Jun / Ramaswamy, Raja / Giardina, Joseph Daniel / Laforest, Richard / Wahl, Richard L / Patterson, Bruce W / Mittendorfer, Bettina / Klein, Samuel

    Cell reports. Medicine

    2024  Volume 5, Issue 1, Page(s) 101370

    Abstract: Although a high amount of brown adipose tissue (BAT) is associated with low plasma triglyceride concentration, the mechanism responsible for this relationship in people is not clear. Here, we evaluate the interrelationships among BAT, very-low-density ... ...

    Abstract Although a high amount of brown adipose tissue (BAT) is associated with low plasma triglyceride concentration, the mechanism responsible for this relationship in people is not clear. Here, we evaluate the interrelationships among BAT, very-low-density lipoprotein triglyceride (VLDL-TG), and free fatty acid (FFA) plasma kinetics during thermoneutrality in women with overweight/obesity who had a low (<20 mL) or high (≥20 mL) volume of cold-activated BAT (assessed by using positron emission tomography in conjunction with 2-deoxy-2-[
    MeSH term(s) Humans ; Female ; Overweight ; Fatty Acids, Nonesterified ; Adipose Tissue, Brown/diagnostic imaging ; Obesity ; Triglycerides ; Lipoproteins, VLDL
    Chemical Substances Fatty Acids, Nonesterified ; Triglycerides ; Lipoproteins, VLDL
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101370
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  8. Article ; Online: Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice.

    Franczyk, Michael P / He, Mai / Yoshino, Jun

    Journal of the Endocrine Society

    2021  Volume 5, Issue 5, Page(s) bvab024

    Abstract: Obesity is associated with insulin resistance, an important risk factor of type 2 diabetes, atherogenic dyslipidemia, and nonalcoholic fatty liver disease. The major purpose of this study was to test hypothesize that prophylactic removal of epididymal ... ...

    Abstract Obesity is associated with insulin resistance, an important risk factor of type 2 diabetes, atherogenic dyslipidemia, and nonalcoholic fatty liver disease. The major purpose of this study was to test hypothesize that prophylactic removal of epididymal visceral adipose tissue (VAT) prevents obesity-induced multi-organ (liver, skeletal muscle, adipose tissue) insulin resistance. Accordingly, we surgically removed epididymal VAT pads from adult C57BL/6J mice and evaluated in vivo and cellular metabolic pathways involved in glucose and lipid metabolism following chronic high-fat diet (HFD) feeding. We found that VAT removal decreases HFD-induced body weight gain while increasing subcutaneous adipose tissue (SAT) mass. Strikingly, VAT removal prevents obesity-induced insulin resistance and hyperinsulinemia and markedly enhances insulin-stimulated AKT-phosphorylation at serine-473 (Ser473) and threonine-308 (Thr308) sites in SAT, liver, and skeletal muscle. VAT removal leads to decreases in plasma lipid concentrations and hepatic triglyceride (TG) content. In addition, VAT removal increases circulating adiponectin, a key insulin-sensitizing adipokine, whereas it decreases circulating interleukin 6, a pro-inflammatory adipokine. Consistent with these findings, VAT removal increases adenosine monophosphate-activated protein kinase C phosphorylation, a major downstream target of adiponectin signaling. Data obtained from RNA sequencing suggest that VAT removal prevents obesity-induced oxidative stress and inflammation in liver and SAT, respectively. Taken together, these findings highlight the metabolic benefits and possible action mechanisms of prophylactic VAT removal on obesity-induced insulin resistance and hepatosteatosis. Our results also provide important insight into understanding the extraordinary capability of adipose tissue to influence whole-body glucose and lipid metabolism as an active endocrine organ.
    Language English
    Publishing date 2021-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvab024
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  9. Article ; Online: A case of spinal nerve neurotoxicity with ropivacaine after combined spinal and epidural anesthesia.

    Shimauchi, Tsukasa / Yoshino, Jun / Fujimura, Naoyuki

    JA clinical reports

    2021  Volume 7, Issue 1, Page(s) 72

    Abstract: Background: Neurotoxicity caused by a local anesthetic after regional anesthesia is a rare but serious problem for anesthesiologists. It is difficult to diagnose neurotoxicity from anesthetics because of the large number of possible diagnoses. In this ... ...

    Abstract Background: Neurotoxicity caused by a local anesthetic after regional anesthesia is a rare but serious problem for anesthesiologists. It is difficult to diagnose neurotoxicity from anesthetics because of the large number of possible diagnoses. In this case report, careful monitoring by neurological examinations helped to diagnose local neurotoxicity caused after epidural anesthesia.
    Case description: A 41-year-old pregnant woman who underwent emergency cesarean delivery under combined spinal-epidural anesthesia suffered left leg paralysis after surgery. Multiple neurological examinations (e.g., electromyography, nerve conduction study) revealed that the paralysis was induced by the neurotoxicity of ropivacaine. The neurological examinations were also useful to monitor the recovery process.
    Conclusions: This is the first clinical case report that describes the diagnosis of and recovery from local anesthesia-induced neurotoxicity monitored by electromyography and nerve conduction study. Neurological disorders caused by regional anesthetics should be carefully examined and diagnosed using these neurological examinations.
    Language English
    Publishing date 2021-09-28
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-021-00476-2
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  10. Article: [Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism].

    Yoshino, Jun

    Nihon rinsho. Japanese journal of clinical medicine

    2013  Volume 71, Issue 12, Page(s) 2187–2193

    Abstract: Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops that involve clock genes. A growing body of research suggests that there is biological crosstalk between circadian rhythm and metabolism. We recently found that ... ...

    Abstract Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops that involve clock genes. A growing body of research suggests that there is biological crosstalk between circadian rhythm and metabolism. We recently found that the key NAD biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent deacetylase SIRT1 play a critical role in such crosstalk, by creating a novel feedback loop in which NAD functions as a "metabolic oscillator". This review aims to summarize recent progress in elucidating the pathophysiological importance of clock genes, NAMPT-mediated NAD biosynthesis, and SIRT1, in the crosstalk between circadian rhythm and metabolism.
    MeSH term(s) Animals ; Circadian Rhythm/genetics ; Circadian Rhythm/physiology ; Cytokines/metabolism ; Feedback, Physiological/physiology ; Humans ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; Sirtuin 1/metabolism
    Chemical Substances Cytokines ; NAD (0U46U6E8UK) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
    Language Japanese
    Publishing date 2013-12
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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