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  1. Article: The COLOMATE Platform: An Indispensable Initiative Promoting True Precision Oncology Prioritized for Patients With Cancer-From "MAYBE" to "MUST BE".

    Yoshino, Takayuki

    Oncology (Williston Park, N.Y.)

    2021  Volume 35, Issue 9, Page(s) 554

    MeSH term(s) Circulating Tumor DNA/analysis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Humans ; Liquid Biopsy ; Precision Medicine
    Chemical Substances Circulating Tumor DNA
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    DOI 10.46883/ONC.2021.3509.0554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 372: Show issues

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  2. Article: COLOMATE challenge to overcome resistance in metastatic colorectal cancer.

    Yoshino, Takayuki

    Oncology (Williston Park, N.Y.)

    2021  Volume 35, Issue 10, Page(s) 656

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Cell-Free Nucleic Acids ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/physiology ; ErbB Receptors/antagonists & inhibitors ; Humans ; Neoplasm Metastasis ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors
    Chemical Substances Antineoplastic Agents ; Cell-Free Nucleic Acids ; ErbB Receptors (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    DOI 10.46883/ONC.2021.3510.0656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  3. Article: Use of regorafenib before re-challenging with chemotherapy-based regimens in patients with metastatic colorectal cancer: mechanistic rationale.

    Yoshino, Takayuki

    Clinical advances in hematology & oncology : H&O

    2021  Volume 18 Suppl 2, Issue 1, Page(s) 14–18

    MeSH term(s) Colorectal Neoplasms/drug therapy ; Humans ; Neoplasm Metastasis ; Phenylurea Compounds/therapeutic use ; Pyridines/therapeutic use
    Chemical Substances Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6505: Show issues Location:
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  4. Book: The mechanism of action of Regorafenib in colorectal cancer: a guide for the community physician

    Grothey, Axel / Prager, Gerald / Yoshino, Takayuki

    (Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 17, issue 8, supplement 12 (August 2019))

    2019  

    Author's details moderator Axel Grothey, MD ; discussants Gerald Prager, MD, Takayuki Yoshino,MD
    Series title Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 17, issue 8, supplement 12 (August 2019)
    Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Collection Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Language English
    Size 19 Seiten, Diagramme
    Publisher Millennium Medical Publishing
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020198485
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 6505 -17,8,Suppl.12- verfügbar in Königswinter Königswinter

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  5. Book: Optimizing the treatment sequence from second-line to third-line therapy in patients with metastatic colorectal cancer

    Grothey, Axel / Bekaii-Saab, Tanios / Yoshino, Takayuki / Prager, Gerald

    (Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 18, issue 1, supplement 2 (January 2020))

    2020  

    Author's details moderator Axel Grothey, MD; discussants Tanios S. Bekaii-Saab, MD, Takayuki Yoshino, MD, Gerald W. Prager, MD
    Series title Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 18, issue 1, supplement 2 (January 2020)
    Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Collection Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Language English
    Size 23 Seiten, Diagramme
    Publisher Millennium Medical Publishing
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020952769
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -18,Suppl.2- verfügbar in Königswinter Königswinter

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  6. Article: Current and Future Research Into the Mechanism of Action of Regorafenib.

    Yoshino, Takayuki

    Clinical advances in hematology & oncology : H&O

    2020  Volume 17 Suppl 12, Issue 8, Page(s) 14–16

    MeSH term(s) Clinical Trials as Topic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Phenylurea Compounds/pharmacokinetics ; Phenylurea Compounds/therapeutic use ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use
    Chemical Substances Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6505: Show issues Location:
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  7. Article: [Chemotherapy for Unresectable Advanced, Metastatic or Recurrent Colorectal Cancer].

    Miyashita, Yu / Kawazoe, Akihito / Yoshino, Takayuki

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 51, Issue 3, Page(s) 245–249

    Abstract: Colorectal cancer(CRC)is one of the most commonly diagnosed cancers worldwide. Unresectable advanced, metastatic or recurrent CRC(mCRC)remains incurable for most patients. Systemic chemotherapy is standard treatment for patients with mCRC. The goals of ... ...

    Abstract Colorectal cancer(CRC)is one of the most commonly diagnosed cancers worldwide. Unresectable advanced, metastatic or recurrent CRC(mCRC)remains incurable for most patients. Systemic chemotherapy is standard treatment for patients with mCRC. The goals of systemic chemotherapy include prolonging survival by stopping cancer progression and palliation. In recent years, advances in the treatment of mCRC have enabled personalized care based on the tumor's molecular profile with improved outcomes for some subtypes. Targeted biologic therapies and immune checkpoint inhibitors have changed the approach to management of uncommon molecularly defined subsets of mCRC. The development of chemotherapy using cytotoxic drugs, biologic monoclonal antibodies, and immune checkpoint inhibitors has prolonged median overall survival up to approximately 30 months. In this report, we describe the evolution of systemic chemotherapy for mCRC, recent advances in standard treatment, and future prospects for the treatment of mCRC.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/pathology
    Chemical Substances Immune Checkpoint Inhibitors ; Antineoplastic Agents
    Language Japanese
    Publishing date 2024-03-15
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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  8. Article ; Online: Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience.

    Ohtsu, Atsushi / Goto, Koichi / Yoshino, Takayuki

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2023  Volume 99, Issue 8, Page(s) 241–253

    Abstract: We launched SCRUM-Japan platform for the cancer genome profiling (CGP) test screening followed by the enrollment to genomically-matched clinical trials in 2015. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed ... ...

    Abstract We launched SCRUM-Japan platform for the cancer genome profiling (CGP) test screening followed by the enrollment to genomically-matched clinical trials in 2015. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrolling to a total of 127 industry-/investigator-initiated registration trials, which resulted in regulatory approvals of 12 new agents with 14 indications in Japan. Using the clinical-genomic database, a new driver gene was recently discovered with dramatic response by genomically-matched agent. Our comparative study with tissue-based CGPs revealed more usefulness of liquid biopsy in terms of less invasive manner, shorter turn-round time, and higher enrollment rate for matched treatments than tissue-based in gastrointestinal cancers. For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assay in association with two randomized control trials have also started in 2020 (CIRCULATE-Japan). The observational cohort study showed obvious efficacy of the MRD monitoring for predicting recurrence, leading to change clinical practice in patient selection who should receive adjuvant therapy in the near future.
    MeSH term(s) Humans ; Japan ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Patient Care ; Genomics
    Language English
    Publishing date 2023-08-09
    Publishing country Japan
    Document type Observational Study ; Journal Article
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.99.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Therapeutic landscape and future direction of metastatic colorectal cancer.

    Bando, Hideaki / Ohtsu, Atsushi / Yoshino, Takayuki

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 20, Issue 5, Page(s) 306–322

    Abstract: In the era of targeted therapy based on genomic alterations, the treatment strategy for metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment initiation, determination of tumour genomic status for KRAS and NRAS, ... ...

    Abstract In the era of targeted therapy based on genomic alterations, the treatment strategy for metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment initiation, determination of tumour genomic status for KRAS and NRAS, BRAF
    MeSH term(s) Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/therapeutic use ; Proto-Oncogene Proteins p21(ras)/genetics ; Cetuximab/genetics ; Cetuximab/therapeutic use ; Rectal Neoplasms ; Mutation
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-022-00736-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6020: Show issues Location:
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    Zs.MG 97: Show issues

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  10. Article ; Online: Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation.

    Narai-Kanayama, Asako / Hayakawa, Sumio / Yoshino, Takayuki / Honda, Futa / Matsuda, Hiroko / Oishi, Yumiko

    Biochimica et biophysica acta. Biomembranes

    2024  Volume 1866, Issue 5, Page(s) 184312

    Abstract: Epigallocatechin-3-O-gallate (EGCg), the major catechin responsible for the health-enhancing and disease-preventive effects of green tea, is susceptible to auto-oxidation at physiological pH levels. However, whether the oxidized EGCg resulting from ... ...

    Abstract (-)-Epigallocatechin-3-O-gallate (EGCg), the major catechin responsible for the health-enhancing and disease-preventive effects of green tea, is susceptible to auto-oxidation at physiological pH levels. However, whether the oxidized EGCg resulting from its oral consumption possesses any bioactive functions remains unclear. This study presents a differential analysis of intact and oxidized EGCg regarding their interactions with phosphatidylcholine liposomes, serving as a simple biomembrane model. In the presence of ascorbic acid, pre-oxidized EGCg induced liposomal aggregation in a dose-dependent manner, whereas intact EGCg did not. Toxicity evaluation using calcein-loaded liposomes revealed that liposomal aggregation is associated with minimal membrane damage. Through fractionation of the oxidized EGCg sample, the fraction containing theasinensins showed high liposomal aggregation activity. Overall, these results suggest that oxidatively condensed EGCg dimers may stimulate various cells by altering the plasma membrane in a manner different from that of EGCg monomers.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2024.184312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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