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  1. Article ; Online: Outcomes of allogeneic stem cell transplantation for patients with hematologic diseases ≥60 years old.

    Shima, Takahiro / Takigawa, Ken / Utsumi, Sae / Yoshino, Teruhiko / Naganuma, Megumi / Minami, Mariko / Hayashi, Masayasu / Matsuo, Yayoi / Kuriyama, Takuro / Eto, Tetsuya

    Blood cell therapy

    2023  Volume 6, Issue 2, Page(s) 30–41

    Abstract: Hematologic diseases frequently affect people >60 years old, and allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for these patients. Although several multicenter studies proposed the risk assessment of allo-SCT for the ...

    Abstract Hematologic diseases frequently affect people >60 years old, and allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for these patients. Although several multicenter studies proposed the risk assessment of allo-SCT for the elderly, they receive different treatments and management at each facility. Therefore, accumulating data from institutions that exhibit relatively the same treatment policy and patient care is important. This retrospective study aimed to clarify the prognostic factors of allo-SCT for the elderly in our institution. Of the 104 patients, 51.0% were 60-64 years old, and 49.0% were ≥65 years old. The 3-year overall survival (OS) was 40.9% and 35.7% for patients 60-64 and ≥65 years old, respectively, which is not significant. While the disease status prior to allo-SCT demonstrated strong effects on the 3-year OS for patients that are 60-64 years old (in remission, 76.9%; non-remission, 15.7%,
    Language English
    Publishing date 2023-04-21
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-7026
    ISSN (online) 2432-7026
    DOI 10.31547/bct-2022-018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Acute myeloid leukemia with type I CBFB::MYH11 fusion gene not detected by screening test for leukemia-related chimeric genes].

    Utsumi, Sae / Shima, Takahiro / Kubara, Chiaki / Semba, Yuichiro / Hayashi, Masayasu / Takigawa, Ken / Yoshino, Teruhiko / Minami, Mariko / Matsuo, Yayoi / Kuriyama, Takuro / Akashi, Koichi / Maeda, Takahiro / Taniguchi, Shuichi / Eto, Tetsuya

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2024  Volume 64, Issue 12, Page(s) 1503–1507

    Abstract: A 27-year-old woman with pancytopenia was admitted to our hospital. Bone marrow aspiration revealed 52.2% myeloperoxidase-positive myeloblasts, leading to a diagnosis of acute myeloid leukemia. While a screening test for chimeric genes related to ... ...

    Abstract A 27-year-old woman with pancytopenia was admitted to our hospital. Bone marrow aspiration revealed 52.2% myeloperoxidase-positive myeloblasts, leading to a diagnosis of acute myeloid leukemia. While a screening test for chimeric genes related to leukemia initially yielded negative results, including for the CBFB::MYH11 fusion gene, G-banded karyotyping uncovered the presence of inv (16)(p13.1q22). Further investigation by fluorescence in situ hybridization (FISH) confirmed the split signals for CBFB. A second screening test for leukemia-related chimeric genes with different PCR primers revealed the elusive CBFB::MYH11 fusion gene. Subsequently, the type I CBFB::MYH11 fusion gene was identified through exhaustive exploration using RNA sequencing for fusion gene discovery. This exceptional case highlights the existence of a distinctive subtype of CBFB::MYH11 that may yield false-negative results in conventional chimeric fusion screening, thus emphasizing the indispensable utility of PCR primer modification, FISH, and RNA sequencing in the investigative process.
    MeSH term(s) Female ; Humans ; Adult ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Karyotyping ; Oncogene Proteins, Fusion/genetics ; Core Binding Factor beta Subunit/genetics ; Myosin Heavy Chains/genetics
    Chemical Substances Oncogene Proteins, Fusion ; CBFB protein, human ; Core Binding Factor beta Subunit ; MYH11 protein, human ; Myosin Heavy Chains (EC 3.6.4.1)
    Language Japanese
    Publishing date 2024-01-12
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.64.1503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1175: Show issues Location:
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    Zs.MO 535: Show issues

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  3. Article: [Congenital thrombotic thrombocytopenic purpura diagnosed in adulthood after repeated thrombocytopenia since neonatal period].

    Yoshino, Teruhiko / Kuriyama, Takuro / Utsumi, Sae / Shimakawa, Takashi / Minami, Mariko / Hayashi, Masayasu / Matsuo, Yayoi / Kokame, Koichi / Nakamura, Eriko / Matsumoto, Masanori / Eto, Tetsuya / Taniguchi, Shuichi

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2024  Volume 65, Issue 3, Page(s) 142–146

    Abstract: A 27-year-old woman was diagnosed with idiopathic thrombocytopenic purpura in the neonatal period, and was admitted to our hospital after presenting with impaired consciousness, purpura, nausea and vomiting, with a platelet count of 10× ... ...

    Abstract A 27-year-old woman was diagnosed with idiopathic thrombocytopenic purpura in the neonatal period, and was admitted to our hospital after presenting with impaired consciousness, purpura, nausea and vomiting, with a platelet count of 10×10
    MeSH term(s) Adult ; Infant, Newborn ; Female ; Humans ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Platelet Count ; Plasma ; Blood Transfusion ; Purpura, Thrombocytopenic, Idiopathic ; ADAMTS13 Protein/genetics
    Chemical Substances ADAMTS13 Protein (EC 3.4.24.87)
    Language Japanese
    Publishing date 2024-04-02
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.65.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 535: Show issues

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  4. Article: [CD20-negative diffuse large B-cell lymphoma complicated by rheumatoid arthritis].

    Yoshino, Teruhiko / Makiyama, Junya / Imaizumi, Yoshitaka / Matsuo, Emi / Kitanosono, Hideaki / Nakashima, Jun / Kato, Takeharu / Miyoshi, Hiroaki / Ohshima, Koichi / Yoshida, Shinichiro / Miyazaki, Yasushi

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2020  Volume 61, Issue 1, Page(s) 33–38

    Abstract: CD20 antigen is an important marker for diagnosis of B-cell neoplasms that is highly expressed on the surface of neoplastic B lymphocytes. Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphoma, of which diffuse ... ...

    Abstract CD20 antigen is an important marker for diagnosis of B-cell neoplasms that is highly expressed on the surface of neoplastic B lymphocytes. Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common type. We report an unusual case of CD20-negative DLBCL complicated by rheumatoid arthritis. An 81-year old female presented with a left-sided cervical tumor, enlarged tonsil, and polyarticular pain. Pathological findings of the left tonsil showed proliferation of large atypical cells with irregular shaped nuclei. Most large cells were negative for CD3 and CD20. Additionally, these cells were positive for CD79a, BCL2, and MUM1, and negative for CD10, CD138, BCL6, PAX5, EBV-ISH, HHV8, and ALK.. Therefore, she was diagnosed with CD20-negative DLBCL complicated with RA and received dose-modified CHOP that achieved partial remission. Because CD20-negative DLBCL is rare, the identification of the clinicopathological features of this disease is urgently required.
    MeSH term(s) Aged, 80 and over ; Antigens, CD20 ; Arthritis, Rheumatoid/complications ; Biomarkers ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/complications ; Neprilysin
    Chemical Substances Antigens, CD20 ; Biomarkers ; Neprilysin (EC 3.4.24.11)
    Language Japanese
    Publishing date 2020-01-21
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.61.33
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  5. Article: Lipid peroxides induce early onset of catagen phase in murine hair cycles.

    Naito, Atsushi / Midorikawa, Tatsuyuki / Yoshino, Teruhiko / Ohdera, Motoyasu

    International journal of molecular medicine

    2008  Volume 22, Issue 6, Page(s) 725–729

    Abstract: The precise mechanisms of alopecia, a pathophysiological disorder with negative psychological implications, are unknown. Androgen and hereditary predisposition are major causes, but the condition is also affected by stress, an irregular diet and high ... ...

    Abstract The precise mechanisms of alopecia, a pathophysiological disorder with negative psychological implications, are unknown. Androgen and hereditary predisposition are major causes, but the condition is also affected by stress, an irregular diet and high levels of sebum secretion. We focused on oxidative stress and analyzed the effect of the lipid peroxides on hair follicles. Our first observation was that the topical application of linolein hydroperoxides, one of the lipid peroxides, lead to the early onset of the catagen phase in murine hair cycles. Furthermore, by using TUNEL staining we found that lipid peroxides induced apoptosis of hair follicle cells. They also induced apoptosis in human epidermal keratinocytes by up-regulating apoptosis-related genes. These results indicated that lipid peroxides, which can cause free radicals, induce the apoptosis of hair follicle cells, and this is followed by early onset of the catagen phase. These observations may provide insight into the mechanisms underlying the development of alopecia in humans.
    MeSH term(s) Alopecia ; Animals ; Apoptosis/genetics ; Hair/growth & development ; Hair Follicle/cytology ; Hair Follicle/drug effects ; Hair Follicle/pathology ; Humans ; In Situ Nick-End Labeling ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/pathology ; Lipid Peroxides/metabolism ; Lipid Peroxides/pharmacology ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Oxidative Stress/genetics ; Reactive Oxygen Species/metabolism ; Up-Regulation/drug effects
    Chemical Substances Lipid Peroxides ; Reactive Oxygen Species
    Language English
    Publishing date 2008-12
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1444428-8
    ISSN 1107-3756
    ISSN 1107-3756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4942: Show issues Location:
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  6. Article: Ephrin-A3 not only increases the density of hair follicles but also accelerates anagen development in neonatal mice.

    Yamada, Yuko / Midorikawa, Tatsuyuki / Oura, Hajimu / Yoshino, Teruhiko / Ohdera, Motoyasu / Kubo, Yoshiaki / Arase, Seiji

    Journal of dermatological science

    2008  Volume 52, Issue 3, Page(s) 178–185

    Abstract: Background: Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases (Eph). Although ephrins are known to regulate a variety of developmental processes, little is known of their role in hair development. Previously, we studied the gene ... ...

    Abstract Background: Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases (Eph). Although ephrins are known to regulate a variety of developmental processes, little is known of their role in hair development. Previously, we studied the gene expression of dermal papilla cells from androgenetic alopecia and found that ephrin-A3 was significantly down-regulated.
    Objective: To characterize the expression of ephrin-A3 in the hair cycle and evaluate the effect of ephrin-A3 on hair growth.
    Methods: We investigated gene expression and protein expression of each ephrin-As and EphAs in the skin of neonatal mice through the first and second hair cycle using quantitative PCR and immunohistochemical analysis, respectively. We also injected ephrin-A3 protein into the skin of neonatal mice and demonstrated the effect of ephrin-A3 on hair follicle development.
    Results: Expression of ephrin-A3 revealed a rapid increase at the beginning of the anagen phase, a peak during the mid-anagen, and a rapid fading during the telogen phase. In addition, we found ephrin-A3 protein was expressed in the developing hair follicles with a characteristic spatiotemporal localization. Furthermore, injection of ephrin-A3 into the skin of neonatal mice markedly accelerated the differentiation process of hair follicles. In addition, injection of ephrin-A3 unexpectedly increased the number of hair follicles.
    Conclusion: These findings demonstrated that ephrin-A3 not only accelerates anagen development but also increases the density of hair follicles, and also suggested that an ephrin-A-EphA signal pathway is closely involved in hair follicle development.
    MeSH term(s) Animals ; Animals, Newborn ; Endothelial Cells/chemistry ; Ephrin-A3/analysis ; Ephrin-A3/genetics ; Ephrin-A3/physiology ; Female ; Hair Follicle/growth & development ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL
    Chemical Substances Ephrin-A3
    Language English
    Publishing date 2008-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1024446-3
    ISSN 0923-1811
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2008.05.007
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    Zs.A 2870: Show issues Location:
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  7. Article: Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis.

    Midorikawa, Tatsuyuki / Chikazawa, Takashi / Yoshino, Teruhiko / Takada, Koji / Arase, Seiji

    Journal of dermatological science

    2004  Volume 36, Issue 1, Page(s) 25–32

    Abstract: Background: Androgenic alopecia (AGA) is the most common type of baldness in men. Although etiological studies have proved that androgen is one of the causes of this symptom, the defined molecular mechanism underlying androgen-related actions remains ... ...

    Abstract Background: Androgenic alopecia (AGA) is the most common type of baldness in men. Although etiological studies have proved that androgen is one of the causes of this symptom, the defined molecular mechanism underlying androgen-related actions remains largely unknown.
    Objectives: To clarify the difference in the gene expression profile of dermal papilla cells (DPCs) in skin affected by baldness.
    Methods: DNA macroarray study was carried out on cultured DPCs from AGA skin comparing with DPCs from skin that is not affected by baldness.
    Results: From DNA macroarray analysis, we observed that 107 of the 1185 analyzed genes had differing expression levels. A marked difference was observed in the decreased gene expression of BMP2 and ephrin A3 and up-regulated in NT-4 gene. In order to clarify the roles of BMP2 and ephrin A3 in the hair follicles, we examined the proliferation of hair follicle keratinocyte and expression of a hair acidic keratin gene. Both BMP2 and ephrin A3 raised the proliferation rate of the outer root sheath cells (ORSCs) and induced gene expression in acidic hair keratin 3-II.
    Conclusion: These results lead us to the hypothesis that both BMP2 and ephrin A3 function as hair growth promoting factors in the hair cycle.
    MeSH term(s) Alopecia/genetics ; Alopecia/metabolism ; Androgens/metabolism ; Animals ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins/biosynthesis ; Cell Proliferation ; Dermis/cytology ; Dose-Response Relationship, Drug ; Down-Regulation ; Ephrin-A3/biosynthesis ; Gene Expression Regulation ; Hair Follicle/metabolism ; Humans ; Keratins/biosynthesis ; Male ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Skin/metabolism ; Skin/pathology ; Transforming Growth Factor beta/biosynthesis ; Up-Regulation
    Chemical Substances Androgens ; BMP2 protein, human ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins ; Ephrin-A3 ; Transforming Growth Factor beta ; Keratins (68238-35-7)
    Language English
    Publishing date 2004-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1024446-3
    ISSN 0923-1811
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2004.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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