LIVIVO - Search results -

Search results

Result 1 - 10 of total 28

Search options

Article ; Online: KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model.

Yoshioka, Toshinori / Yamada, Daisuke / Segi-Nishida, Eri / Nagase, Hiroshi / Saitoh, Akiyoshi

2023 Volume 232, Page(s) 109511

Abstract: Delta opioid receptors (DOPs) play an important role in depression and other mood disorders. However, little is known about the underlying physiological mechanisms. The hypothalamic-pituitary-adrenal axis, adult hippocampal neurogenesis, and ... ...

Abstract	Delta opioid receptors (DOPs) play an important role in depression and other mood disorders. However, little is known about the underlying physiological mechanisms. The hypothalamic-pituitary-adrenal axis, adult hippocampal neurogenesis, and neuroinflammation are regarded as key pathophysiological factors in depression. In this study, we investigated the influence of DOP activation on those factors in a valid animal model of depression, chronic vicarious social defeat stress (cVSDS) mice. cVSDS mice (male C57BL/6J mice) were produced following a 10-day exposure to witness of social defeat stress, and each evaluation was performed more than 28 days after the stress period. Repeated administrations to cVSDS mice with a selective DOP agonist, KNT-127, both during (10 days) and after (28 days) the stress period respectively improved their decreased social interaction behaviors and increased serum corticosterone levels. When administered during the stress period, KNT-127 suppressed decreases in the hippocampal newborn neuron survival rate in cVSDS mice. Moreover, in both administration paradigms, KNT-127 reduced the number of Iba-1- and CD11b-positive cells in the subgranular zone and the granule cell layer of the hippocampal dentate gyrus, indicating a suppression of cVSDS-induced microglial overactivation. These results suggest that KNT-127 acts over the hypothalamic-pituitary-adrenal axis and regulates neurogenesis and neuroinflammation resulting in anti-stress effects, and the antidepressant-like effects of the DOP agonist are implicated in the suppression of the neuroinflammation. This study presents a new finding on the effects of repeated DOP activations on the pathophysiological states of depression.
MeSH term(s)	Male ; Mice ; Animals ; Receptors, Opioid, delta/agonists ; Social Defeat ; Hypothalamo-Hypophyseal System/metabolism ; Neuroinflammatory Diseases ; Mice, Inbred C57BL ; Pituitary-Adrenal System/metabolism ; Analgesics, Opioid/pharmacology ; Hippocampus ; Dentate Gyrus/metabolism ; Stress, Psychological/drug therapy ; Neurogenesis ; Depression/drug therapy
Chemical Substances	KNT 127 ; Receptors, Opioid, delta ; Analgesics, Opioid
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2023.109511
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.242: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Learning acquisition of consistent leader-follower relationships depends on implicit haptic interactions.

Takai, Asuka / Fu, Qiushi / Doibata, Yuzuru / Lisi, Giuseppe / Tsuchiya, Toshiki / Mojtahedi, Keivan / Yoshioka, Toshinori / Kawato, Mitsuo / Morimoto, Jun / Santello, Marco

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3476

Abstract: Are leaders made or born? Leader-follower roles have been well characterized in social science, but they remain somewhat obscure in sensory-motor coordination. Furthermore, it is unknown how and why leader-follower relationships are acquired, including ... ...

Abstract	Are leaders made or born? Leader-follower roles have been well characterized in social science, but they remain somewhat obscure in sensory-motor coordination. Furthermore, it is unknown how and why leader-follower relationships are acquired, including innate versus acquired controversies. We developed a novel asymmetrical coordination task in which two participants (dyad) need to collaborate in transporting a simulated beam while maintaining its horizontal attitude. This experimental paradigm was implemented by twin robotic manipulanda, simulated beam dynamics, haptic interactions, and a projection screen. Clear leader-follower relationships were learned only when strong haptic feedback was introduced. This phenomenon occurred despite participants not being informed that they were interacting with each other and the large number of equally-valid alternative dyadic coordination strategies. We demonstrate the emergence of consistent leader-follower relationships in sensory-motor coordination, and further show that haptic interaction is essential for dyadic co-adaptation. These results provide insights into neural mechanisms responsible for the formation of leader-follower relationships in our society.
MeSH term(s)	Humans ; Haptic Technology ; Learning ; Acclimatization ; Biological Transport
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29722-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala.

Kawaminami, Ayako / Yamada, Daisuke / Yoshioka, Toshinori / Hatakeyama, Azumi / Nishida, Moeno / Kajino, Keita / Saitoh, Tsuyoshi / Nagase, Hiroshi / Saitoh, Akiyoshi

Neuropsychopharmacology reports

2023 Volume 44, Issue 1, Page(s) 256–261

Abstract: Aim: Excitatory projections from the prelimbic cortex (PL) to the basolateral nucleus of the amygdala (BLA) are implicated in the regulation of anxiety-like behaviors, and we previously demonstrated that anxiolytic-like effects of the selective delta- ... ...

Abstract	Aim: Excitatory projections from the prelimbic cortex (PL) to the basolateral nucleus of the amygdala (BLA) are implicated in the regulation of anxiety-like behaviors, and we previously demonstrated that anxiolytic-like effects of the selective delta-opioid receptor (DOP) agonist KNT-127 is involved in suppressing glutamate neurotransmission in the PL. Here, we investigated the mechanisms underlying the anxiolytic-like effect of KNT-127 in mice by combining optogenetic stimulation of the PL-BLA pathway with behavioral analyses. Methods: Four-week-old male C57BL/6J mice received bilateral administration of adeno-associated virus (AAV)2-CaMKIIa-hChR2(H134R)-enhanced yellow fluorescent protein (EYFP) into the PL to induce expression of the light-activated excitatory ionic channel ChR2. Subsequently, an optic fiber cannula connected to a wireless photo-stimulator was implanted into the BLA for optogenetic PL-BLA pathway stimulation. We evaluated innate anxiety using the elevated plus maze (EPM) and open field (OF) tests as well as learned anxiety using the contextual fear conditioning (CFC) test. Results: Optogenetic activation of the PL-BLA pathway enhanced anxiety-like behaviors in the EPM and OF, while prior subcutaneous administration of KNT-127 (10 mg/kg) reduced this anxiogenic effect. In contrast, optogenetic activation of the PL-BLA pathway had no significant effect on conditioned fear. Conclusion: Our findings indicate that the PL-BLA circuit contributes to innate anxiety and that the anxiolytic-like effects of KNT-127 are mediated at least in part by suppression of PL-BLA transmission. The PL delta-opioid receptor may thus be an effective therapeutic target for anxiety disorders.
MeSH term(s)	Mice ; Animals ; Male ; Basolateral Nuclear Complex/metabolism ; Anti-Anxiety Agents ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, delta/metabolism ; Mice, Inbred C57BL ; Anxiety ; Analgesics, Opioid ; Morphinans
Chemical Substances	KNT 127 ; Anti-Anxiety Agents ; Receptors, Opioid, delta ; Analgesics, Opioid ; Morphinans
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ISSN	2574-173X
ISSN (online)	2574-173X
DOI	10.1002/npr2.12406
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Hierarchical motor adaptations negotiate failures during force field learning.

Ikegami, Tsuyoshi / Ganesh, Gowrishankar / Gibo, Tricia L / Yoshioka, Toshinori / Osu, Rieko / Kawato, Mitsuo

PLoS computational biology

2021 Volume 17, Issue 4, Page(s) e1008481

Abstract: Humans have the amazing ability to learn the dynamics of the body and environment to develop motor skills. Traditional motor studies using arm reaching paradigms have viewed this ability as the process of 'internal model adaptation'. However, the ... ...

Abstract	Humans have the amazing ability to learn the dynamics of the body and environment to develop motor skills. Traditional motor studies using arm reaching paradigms have viewed this ability as the process of 'internal model adaptation'. However, the behaviors have not been fully explored in the case when reaches fail to attain the intended target. Here we examined human reaching under two force fields types; one that induces failures (i.e., target errors), and the other that does not. Our results show the presence of a distinct failure-driven adaptation process that enables quick task success after failures, and before completion of internal model adaptation, but that can result in persistent changes to the undisturbed trajectory. These behaviors can be explained by considering a hierarchical interaction between internal model adaptation and the failure-driven adaptation of reach direction. Our findings suggest that movement failure is negotiated using hierarchical motor adaptations by humans.
MeSH term(s)	Adaptation, Physiological ; Arm/physiology ; Humans ; Movement ; Psychomotor Performance
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1008481
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Chronic vicarious social defeat stress attenuates new-born neuronal cell survival in mouse hippocampus.

Yoshioka, Toshinori / Yamada, Daisuke / Kobayashi, Riho / Segi-Nishida, Eri / Saitoh, Akiyoshi

Behavioural brain research

2021 Volume 416, Page(s) 113536

Abstract: Increasing evidence has shown that adult hippocampal neurogenesis is closely related to the pathophysiological condition of depressive disorders. Recently, chronic social defeat stress paradigms have been regarded as important animal models of depression, ...

Abstract	Increasing evidence has shown that adult hippocampal neurogenesis is closely related to the pathophysiological condition of depressive disorders. Recently, chronic social defeat stress paradigms have been regarded as important animal models of depression, accompanied with neural plastic changes in the hippocampus. However, little is known about influences of non-physical stress on neurogenesis. In the present study, we focused on the chronic vicarious social defeat stress paradigm and examined the effect of psychological stress on mouse hippocampal neurogenesis. Immediately after the chronic psychological stress, the cell survival rate in the dentate gyrus of the hippocampus was significantly diminished without modifying the cell proliferation rate. The decreased ratio in cell survival persisted for 4 weeks after the stress-loading period, while the differentiation and maturity of new-born neurons were identical to control groups. Furthermore, treatment with the chronic antidepressant fluoxetine reversed the social behavioral deficits and promoted new-born neurons survival. These results demonstrate that emotional stress in the vicarious social defeat stress paradigm influences neuronal cell survival in the hippocampus, which reinforces its validity as an animal model of depression.
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Cell Survival/drug effects ; Disease Models, Animal ; Fluoxetine/antagonists & inhibitors ; Fluoxetine/pharmacology ; Hippocampus/drug effects ; Male ; Mice ; Neurogenesis/drug effects ; Neurogenesis/physiology ; Neurons/physiology ; Social Defeat
Chemical Substances	Antidepressive Agents ; Fluoxetine (01K63SUP8D)
Language	English
Publishing date	2021-08-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2021.113536
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Examining the usefulness of the brain network marker program using fMRI for the diagnosis and stratification of major depressive disorder: a non-randomized study protocol.

Okada, Go / Sakai, Yuki / Shibakawa, Maki / Yoshioka, Toshinori / Itai, Eri / Shinzato, Hotaka / Yamamoto, Osamu / Kurata, Kenichi / Tamura, Tatsuji / Jitsuiki, Hiroaki / Yamashita, Hidehisa / Mantani, Akio / Yokota, Norio / Kawato, Mitsuo / Okamoto, Yasumasa

BMC psychiatry

2023 Volume 23, Issue 1, Page(s) 63

Abstract: Background: Although many studies have reported the biological basis of major depressive disorder (MDD), none have been put into practical use. Recently, we developed a generalizable brain network marker for MDD diagnoses (diagnostic marker) across ... ...

Abstract	Background: Although many studies have reported the biological basis of major depressive disorder (MDD), none have been put into practical use. Recently, we developed a generalizable brain network marker for MDD diagnoses (diagnostic marker) across multiple imaging sites using resting-state functional magnetic resonance imaging (rs-fMRI). We have planned this clinical trial to establish evidence for the practical applicability of this diagnostic marker as a medical device. In addition, we have developed generalizable brain network markers for MDD stratification (stratification markers), and the verification of these brain network markers is a secondary endpoint of this study. Methods: This is a non-randomized, open-label study involving patients with MDD and healthy controls (HCs). We will prospectively acquire rs-fMRI data from 50 patients with MDD and 50 HCs and anterogradely verify whether our diagnostic marker can distinguish between patients with MDD and HCs. Furthermore, we will longitudinally obtain rs-fMRI and clinical data at baseline and 6 weeks later in 80 patients with MDD treated with escitalopram and verify whether it is possible to prospectively distinguish MDD subtypes that are expected to be effectively responsive to escitalopram using our stratification markers. Discussion: In this study, we will confirm that sufficient accuracy of the diagnostic marker could be reproduced for data from a prospective clinical study. Using longitudinally obtained data, we will also examine whether the "brain network marker for MDD diagnosis" reflects treatment effects in patients with MDD and whether treatment effects can be predicted by "brain network markers for MDD stratification". Data collected in this study will be extremely important for the clinical application of the brain network markers for MDD diagnosis and stratification. Trial registration: Japan Registry of Clinical Trials ( jRCTs062220063 ). Registered 12/10/2022.
MeSH term(s)	Humans ; Brain ; Brain Mapping/methods ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/pathology ; Escitalopram ; Magnetic Resonance Imaging/methods ; Prospective Studies ; Controlled Clinical Trials as Topic
Chemical Substances	Escitalopram (4O4S742ANY)
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-023-04560-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Control strategy of hand movement depends on target redundancy.

Togo, Shunta / Yoshioka, Toshinori / Imamizu, Hiroshi

Scientific reports

2017 Volume 7, Page(s) 45722

Abstract: Reaching toward a point target has been intensively studied in human motor control. However, little is known about reaching toward a redundant target, such as grasping a bar, in which the grasping point is irrelevant to the achievement of a task. We ... ...

Abstract	Reaching toward a point target has been intensively studied in human motor control. However, little is known about reaching toward a redundant target, such as grasping a bar, in which the grasping point is irrelevant to the achievement of a task. We examined whether humans could solve the target-redundancy and control problems in a serial fashion or control their body without solving the target-redundancy problem. We equalized the target ranges between two reaching tasks: a point-to-point reaching task without target-redundancy and a point-to-bar reaching task with target-redundancy. In the both tasks, we measured hand viscoelasticity at movement end as parameters that reflect the adopted control strategy. As a result, the hand viscoelasticity in the point-to-bar reaching task was smaller than that in the point-to-point reaching task, even under the same kinematics. These results indicate that the hand viscoelasticity was modulated depending on the target-redundancy. Moreover, it is suggested that a human reaches toward a redundant target by effectively utilizing information of target redundancy rather than explicitly solving the target-redundancy problem.
MeSH term(s)	Adult ; Biomechanical Phenomena ; Hand ; Humans ; Male ; Motor Activity ; Psychomotor Performance ; Young Adult
Language	English
Publishing date	2017-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep45722
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: Two are not always better than one

Takai, Asuka / Fu, Qiushi / Doibata, Yuzuru / Lisi, Giuseppe / Tsuchiya, Toshiki / Mojtahedi, Keivan / Yoshioka, Toshinori / Kawato, Mitsuo / Morimoto, Jun / Santello, Marco

Role specialization is an important determinant of collaborative task performance

2022

Abstract: Collaboration frequently yields better results in decision making, learning, and haptic interactions than when these actions are performed individually. However, is collaboration always superior to solo actions, or do its benefits depend on whether ... ...

Abstract	Collaboration frequently yields better results in decision making, learning, and haptic interactions than when these actions are performed individually. However, is collaboration always superior to solo actions, or do its benefits depend on whether collaborating individuals have different or the same roles? To answer this question, we asked human subjects to perform virtual-reality collaborative and individual beam transportation tasks. These tasks were simulated in real-time by coupling the motion of a pair of hand-held robotic manipulanda to the virtual beam using virtual spring-dampers. For the task to be considered successful, participants had to complete it within temporal and spatial constraints. While the visual feedback remained the same, the underlying dynamics of the beam were altered to create two distinctive task contexts which were determined by a moving pivot constraint. When the pivot was placed at the center of the beam, two hands contribute to the task with symmetric mechanical leverage (symmetric context). When the pivot was placed at the left side of the beam, two hands contribute to the task with asymmetric mechanical leverage (asymmetric context). Participants performed these task contexts either individually with both hands (solo), or collaboratively by pairing one hand with another one (dyads). We found that dyads in the asymmetric context performed better than solos. In contrast, solos performed the symmetric context better than dyads. Importantly, we found that two hands took different roles in the asymmetric context for both solos and dyads. In contrast, the contribution from each hand was statistically indistinguishable in the symmetric context. Our findings suggest that better performance in dyads than solos is not a general phenomenon, but rather that collaboration yields better performance only when role specialization emerges in dyadic interactions.
Keywords	Quantitative Biology - Neurons and Cognition
Subject code	150
Publishing date	2022-05-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice.

Yoshioka, Toshinori / Ohashi, Misaki / Matsumoto, Kenjiro / Omata, Tomoki / Hamano, Takumi / Yamazaki, Mayuna / Kimiki, Sayaka / Okano, Kotaro / Kobayashi, Riho / Yamada, Daisuke / Hada, Noriyasu / Kato, Shinichi / Saitoh, Akiyoshi

Frontiers in neuroscience

2022 Volume 16, Page(s) 993132

Abstract: Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called "brain-gut interactions." Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel ... ...

Abstract	Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called "brain-gut interactions." Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto-a kampo medicine clinically used for the treatment of IBS-normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities.
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.993132
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: High-frequency ultrasound exposure improves depressive-like behavior in an olfactory bulbectomized rat model of depression.

Yamauchi, Tsugumi / Yoshioka, Toshinori / Yamada, Daisuke / Hamano, Takumi / Ikeda, Maika / Kamei, Masato / Otsuki, Takaya / Sato, Yasuo / Nii, Kyoko / Suzuki, Masashi / Iriyama, Satoshi / Yoshizawa, Kazumi / Nishino, Shoichi / Ichikawa, Hiroko / Miyazaki, Satoru / Saitoh, Akiyoshi

Neuroreport

2022 Volume 33, Issue 10, Page(s) 445–449

Abstract: Objectives: According to previous studies, ultrasound exposure appears to be a noninvasive method for modulating brain activity related to cognition and consciousness; however, its effects on emotional states remain unclear. Therefore, an animal model ... ...

Abstract	Objectives: According to previous studies, ultrasound exposure appears to be a noninvasive method for modulating brain activity related to cognition and consciousness; however, its effects on emotional states remain unclear. Therefore, an animal model is required in which the effects and effect mechanisms of ultrasound exposure can be investigated. Thus, we used olfactory bulbectomized rats as an animal model of depression and investigated their emotional state following ultrasound exposure. Methods: In male Wistar/ST olfactory bulbectomized rats, hyperemotionality was evaluated according to hyperemotionality scoring and the scores before and after 24-h ultrasound exposure were compared. Elevated plus maze (EPM) tests were also conducted after 24-h ultrasound exposure, and blood samples were collected in which plasma corticosterone concentrations were measured. Results: Following exposure to high-frequency (~50 kHz) ultrasound vocalizations (USVs) associated with the pleasant emotions of rats, the hyperemotionality scores of olfactory bulbectomized rats were significantly reduced. Additionally, the latency of the first entry into the open arm of the EPM was significantly decreased in USV-exposed olfactory bulbectomized rats, as were their plasma corticosterone levels. Furthermore, artificial ultrasound (50 kHz) at a similar frequency to that of USV also significantly decreased the hyperemotionality score of olfactory bulbectomized rats. Conclusions: Ultrasound exposure improved depressive-like behavior in olfactory bulbectomized rats and reduced their plasma corticosterone levels. Thus, we recommend the use of olfactory bulbectomized rats as an animal model for investigating the effects and effect mechanisms of ultrasound exposure.
MeSH term(s)	Animals ; Behavior, Animal ; Corticosterone ; Depression ; Disease Models, Animal ; Male ; Olfactory Bulb/surgery ; Rats ; Rats, Wistar ; Smell
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000001804
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3118: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito