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Article: Optimization method for human-robot command combinations of hexapod robot based on multi-objective constraints.

Chen, Xiaolei / You, Bo / Dong, Zheng

2024 Volume 18, Page(s) 1393738

Abstract: Due to the heavy burden on human drivers when remotely controlling hexapod robots in complex terrain environments, there is a critical need for robot intelligence to assist in generating control commands. Therefore, this study proposes a mapping process ... ...

Abstract	Due to the heavy burden on human drivers when remotely controlling hexapod robots in complex terrain environments, there is a critical need for robot intelligence to assist in generating control commands. Therefore, this study proposes a mapping process framework that generates a combination of human-robot commands based on decision target values, focusing on the task of robot intelligence assisting drivers in generating human-robot command combinations. Furthermore, human-robot state constraints are quantified as geometric constraints on robot motion and driver fatigue constraints. By optimizing and filtering the feasible set of human-robot commands based on human-robot state constraints, instruction combinations are formed and recommended to the driver in real-time, thereby enhancing the efficiency and safety of human-machine coordination. To validate the effectiveness of the proposed method, a remote human-robot collaborative driving control system based on wearable devices is designed and implemented. Experimental results demonstrate that drivers utilizing the human-robot command recommendation system exhibit significantly improved robot walking stability and reduced collision rates compared to individual driving.
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2453002-5
ISSN	1662-5218
ISSN	1662-5218
DOI	10.3389/fnbot.2024.1393738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bifunctional Electrocatalysts for Overall and Hybrid Water Splitting.

Quan, Li / Jiang, Hui / Mei, Guoliang / Sun, Yujie / You, Bo

Chemical reviews

2024 Volume 124, Issue 7, Page(s) 3694–3812

Abstract: Electrocatalytic water splitting driven by renewable electricity has been recognized as a promising approach for green hydrogen production. Different from conventional strategies in developing electrocatalysts for the two half-reactions of water ... ...

Abstract	Electrocatalytic water splitting driven by renewable electricity has been recognized as a promising approach for green hydrogen production. Different from conventional strategies in developing electrocatalysts for the two half-reactions of water splitting (e.g., the hydrogen and oxygen evolution reactions, HER and OER) separately, there has been a growing interest in designing and developing bifunctional electrocatalysts, which are able to catalyze both the HER and OER. In addition, considering the high overpotentials required for OER while limited value of the produced oxygen, there is another rapidly growing interest in exploring alternative oxidation reactions to replace OER for hybrid water splitting toward energy-efficient hydrogen generation. This Review begins with an introduction on the fundamental aspects of water splitting, followed by a thorough discussion on various physicochemical characterization techniques that are frequently employed in probing the active sites, with an emphasis on the reconstruction of bifunctional electrocatalysts during redox electrolysis. The design, synthesis, and performance of diverse bifunctional electrocatalysts based on noble metals, nonprecious metals, and metal-free nanocarbons, for overall water splitting in acidic and alkaline electrolytes, are thoroughly summarized and compared. Next, their application toward hybrid water splitting is also presented, wherein the alternative anodic reactions include sacrificing agents oxidation, pollutants oxidative degradation, and organics oxidative upgrading. Finally, a concise statement on the current challenges and future opportunities of bifunctional electrocatalysts for both overall and hybrid water splitting is presented in the hope of guiding future endeavors in the quest for energy-efficient and sustainable green hydrogen production.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00332
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Article ; Online: CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.

Pan, Yipeng / You, Bo / Zhao, Xue / Zhang, Shanxin / Li, Wei

BMC cancer

2024 Volume 24, Issue 1, Page(s) 525

Abstract: Background: Regorafenib, a multi-targeted kinase inhibitor, has been used in the treatment of Hepatocellular carcinoma (HCC). The purpose of this study is to investigate the mechanism of Regorafenib in HCC.: Methods: Regorafenib's impact on the ... ...

Abstract	Background: Regorafenib, a multi-targeted kinase inhibitor, has been used in the treatment of Hepatocellular carcinoma (HCC). The purpose of this study is to investigate the mechanism of Regorafenib in HCC. Methods: Regorafenib's impact on the sensitivity of HCC cells was assessed using CCK8. Differential gene expression analysis was performed by conducting mRNA sequencing after treatment with Regorafenib. The m6A methylation status of CHOP and differential expression of m6A methylation-related proteins were assessed by RIP and Western Blot. To explore the molecular mechanisms involved in the therapeutic effects of Regorafenib in HCC and the impact of METTL14 and CHOP on Regorafenib treatment, we employed shRNA/overexpression approaches to transfect METTL14 and CHOP genes, as well as conducted in vivo experiments. Results: Treatment with Regorafenib led to a notable decrease in viability and proliferation of SK-Hep-1 and HCC-LM3 cells. The expression level of CHOP was upregulated after Regorafenib intervention, and CHOP underwent m6A methylation. Among the m6A methylation-related proteins, METTL14 exhibited the most significant downregulation. Mechanistic studies revealed that Regorafenib regulated the cell cycle arrest in HCC through METTL14-mediated modulation of CHOP, and the METTL14/CHOP axis affected the sensitivity of HCC to Regorafenib. In vivo, CHOP enhanced the anticancer effect of Regorafenib. Conclusion: The inhibition of HCC development by Regorafenib is attributed to its modulation of m6A expression of CHOP, mediated by METTL14, and the METTL14/CHOP axis enhances the sensitivity of HCC to Regorafenib. These findings provide insights into the treatment of HCC and the issue of drug resistance to Regorafenib.
MeSH term(s)	Humans ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/metabolism ; Phenylurea Compounds/pharmacology ; Phenylurea Compounds/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/metabolism ; Mice ; Animals ; Cell Line, Tumor ; Cell Cycle Checkpoints/drug effects ; Methyltransferases/metabolism ; Methyltransferases/genetics ; Transcription Factor CHOP/metabolism ; Transcription Factor CHOP/genetics ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Drug Resistance, Neoplasm/genetics ; Xenograft Model Antitumor Assays ; Mice, Nude ; Adenosine/analogs & derivatives
Chemical Substances	regorafenib (24T2A1DOYB) ; Pyridines ; Phenylurea Compounds ; METTL14 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; Transcription Factor CHOP (147336-12-7) ; DDIT3 protein, human ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12275-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficient Noble-Metal-Free Integration Electrolysis for Solar H

Zhu, Zhiwei / Zhao, Xin / Xia, Bao Yu / You, Bo

ChemSusChem

2024 Volume 17, Issue 7, Page(s) e202301213

Abstract: Solar driven proton exchange membrane water electrolysis (PEMWE) is of great promise for stable and high-purity ... ...

Abstract	Solar driven proton exchange membrane water electrolysis (PEMWE) is of great promise for stable and high-purity H
Language	English
Publishing date	2024-01-09
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202301213
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Article ; Online: The characteristics of stepwise ultrasonic hydrolysates of sludge for enhancing denitrification

You, Bo-Cheng / Huang, Zhengzhong / Chuang, Shun-Hsing

Bioresource Technology. 2023 Feb., v. 370 p.128566-

2023

Abstract: The disposal of waste activated sludge (WAS) accounts for approximately 60 % of wastewater treatment plant operating costs. In this study, according to the reaction time and water quality parameters, ultrasonic hydrolysis of WAS is divided into three ... ...

Abstract	The disposal of waste activated sludge (WAS) accounts for approximately 60 % of wastewater treatment plant operating costs. In this study, according to the reaction time and water quality parameters, ultrasonic hydrolysis of WAS is divided into three stages, including floc-disintegration (0–25.2 kJ/g TS), cell-disruption (25.2–36 kJ/g TS), and cell-degradation (over 36 kJ/g TS). The results show that more than 70 % carbon distributes inside the cell, which also contains 63.8 % protein enhancing denitrification capacity. Moreover, cell-degradation hydrolysate has a higher proportion of readily biodegradable COD, indicating that intracellular organic matter is more capable of denitrification than extracellular. Therefore, the optimal ultrasonic operating range is Eₛ = 36–72 kJ/g TS as carbon source, and obtain the hydrolysate with high ratio of soluble chemical oxygen demand to total nitrogen for denitrification. Furthermore, this study supports the comprehensive interpretation of ultrasonic hydrolyzed WAS and the characteristics of hydrolysate as carbon source for enhancing denitrification.
Keywords	activated sludge ; biodegradability ; carbon ; chemical oxygen demand ; denitrification ; hydrolysates ; hydrolysis ; organic matter ; total nitrogen ; ultrasonics ; wastewater treatment ; water quality ; Carbon source ; Circular economy ; Hydrolysis stage ; Waste activated sludge
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.128566
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dynamic Electrodeposition on Bubbles: An Effective Strategy toward Porous Electrocatalysts for Green Hydrogen Cycling.

Jiang, Hui / Sun, Yujie / You, Bo

Accounts of chemical research

2023 Volume 56, Issue 12, Page(s) 1421–1432

Abstract: ConspectusClosed-loop cycling of green hydrogen is a promising alternative to the current hydrocarbon economy for mitigating the energy crisis and environmental pollution. It stores energy from renewable energy sources like solar, wind, and hydropower ... ...

Abstract	ConspectusClosed-loop cycling of green hydrogen is a promising alternative to the current hydrocarbon economy for mitigating the energy crisis and environmental pollution. It stores energy from renewable energy sources like solar, wind, and hydropower into the chemical bond of dihydrogen (H
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.3c00059
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Article ; Online: MicroRNA-30a depresses hepatic stellate cell activation against liver fibrosis through blockade of the TGF-β1/Smad2/3 pathway.

Pan, Yipeng / You, Bo / Zhao, Xue / Li, Wei

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–15

Abstract: This study explored the mechanism of microRNA (miR)-30a in the activation of hepatic stellate cells (HSCs) to deepen the understanding of the pathogenesis of liver fibrosis. Subsequent to knockdown and ectopic experiments, HSCs were induced with 10 ng/mL ...

Abstract	This study explored the mechanism of microRNA (miR)-30a in the activation of hepatic stellate cells (HSCs) to deepen the understanding of the pathogenesis of liver fibrosis. Subsequent to knockdown and ectopic experiments, HSCs were induced with 10 ng/mL transforming growth factor (TGF)-β1 to inspect the role of the miR-30a/TGF-β receptor 1 (TGFBR1) axis in HSC proliferation and activation. qRT-PCR was utilized to examine TGFBR1 mRNA and miR-30a expression and western blot to test TGFBR1, alpha smooth muscle actin (α-SMA), Collagen I and mothers against DPP homolog 2/3 (Smad2/3) protein expression. The fluorescence intensity of α-SMA was measured with immunofluorescence staining. The interaction of TGFBR1 with miR-30a was tested with a dual-luciferase reporter assay. TGF-β1 treated HSCs had upregulated expressions of α-SMA and Collagen I. In addition, downregulated miR-30a, upregulated TGFBR1 and activated TGF-β1/Smad2/3 pathway were found in activated HSCs. Upregulation of miR-30a or downregulation of TGFBR1 suppressed the activation and growth of HSCs. miR-30a repression activated the TGF-β1/Smad2/3 pathway and promoted HSC proliferation and activation, while suppression of TGFBR1 revered these effects. miR-30a was an upstream regulatory factor of TGFBR1. miR-30a blocks the TGF-β1/Smad2/3 pathway to inhibit HSC activation against liver fibrosis by targeting TGFBR1.
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2197714
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Article ; Online: Atomically Dispersed Co-N/C Catalyst for Divergent Synthesis of Nitrogen-Containing Compounds from Alkenes.

Xue, Wenxuan / Zhu, Zhiwei / Chen, Sanxia / You, Bo / Tang, Conghui

Journal of the American Chemical Society

2023

Abstract: Alkene functionalization with a single-atom catalyst (SAC) which merges homogeneous and heterogeneous catalysis is a fascinating route to obtain high-value-added molecules. However, C-N bond formation of alkene with SAC is still unexplored. Herein, a ... ...

Abstract	Alkene functionalization with a single-atom catalyst (SAC) which merges homogeneous and heterogeneous catalysis is a fascinating route to obtain high-value-added molecules. However, C-N bond formation of alkene with SAC is still unexplored. Herein, a bimetal-organic framework-derived Co-N/C catalyst with an atomically dispersed cobalt center is reported to show good activity of chemoselective aziridination/oxyamination reactions from alkene and hydroxylamine, and late-stage functionalization of complex alkenes and diversified synthetic transformations of the aziridine product further expand the utility of this method. Moreover, this system proceeds without external oxidants and exhibits mild, atom-economic, and recyclable characters. Detailed spectroscopic characterizations and mechanistic studies revealed the structure of the catalytic center and possible intermediates involved in the mechanism cycle.
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c12344
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Article ; Online: A Simultaneous Localization and Mapping System Using the Iterative Error State Kalman Filter Judgment Algorithm for Global Navigation Satellite System.

You, Bo / Zhong, Guangjin / Chen, Chen / Li, Jiayu / Ma, Ersi

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 13

Abstract: Outdoor autonomous mobile robots heavily rely on GPS data for localization. However, GPS data can be erroneous and signals can be interrupted in highly urbanized areas or areas with incomplete satellite coverage, leading to localization deviations. In ... ...

Abstract	Outdoor autonomous mobile robots heavily rely on GPS data for localization. However, GPS data can be erroneous and signals can be interrupted in highly urbanized areas or areas with incomplete satellite coverage, leading to localization deviations. In this paper, we propose a SLAM (Simultaneous Localization and Mapping) system that combines the IESKF (Iterated Extended Kalman Filter) and a factor graph to address these issues. We perform IESKF filtering on LiDAR and inertial measurement unit (IMU) data at the front-end to achieve a more accurate estimation of local pose and incorporate the resulting laser inertial odometry into the back-end factor graph. Furthermore, we introduce a GPS signal filtering method based on GPS state and confidence to ensure that abnormal GPS data is not used in the back-end processing. In the back-end factor graph, we incorporate loop closure factors, IMU preintegration factors, and processed GPS factors. We conducted comparative experiments using the publicly available KITTI dataset and our own experimental platform to compare the proposed SLAM system with two commonly used SLAM systems: the filter-based SLAM system (FAST-LIO) and the graph optimization-based SLAM system (LIO-SAM). The experimental results demonstrate that the proposed SLAM system outperforms the other systems in terms of localization accuracy, especially in cases of GPS signal interruption.
MeSH term(s)	Judgment ; Algorithms
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23136000
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Article ; Online: Design and Motion Simulation of a Soft Robot for Crawling in Pipes

Zhang Yu / Huang Peiyu / You Bo / Yu Zhibin / Li Dongjie / Dong Guoqi

Applied Bionics and Biomechanics, Vol

2023 Volume 2023

Abstract: In recent years, soft pipeline robot, as a new concept, is proposed to adapt to tunnel. The soft pipeline robots are made of soft materials such as rubber or silicone. These materials have good elasticity, which enhance the adaptability of the soft ... ...

Abstract	In recent years, soft pipeline robot, as a new concept, is proposed to adapt to tunnel. The soft pipeline robots are made of soft materials such as rubber or silicone. These materials have good elasticity, which enhance the adaptability of the soft pipeline robot. Therefore, the soft pipeline robot has better performance on deformability than rigid robot. However, the structure of tunnel is complex and varied that brought challenges on design structure of soft pipeline robot. In this paper, we propose soft pipeline robot with simple structure and easy fabrication, which can be realized straight, turning motion in a variety of tunnels with different diameters. The soft pipeline robot composed of two types of structure, which are expansion part and deformation part. Front and rear deformation part for bending and position fixation, and middle expansion part for elongation, so the pipeline soft robot can be moved in various structures of tunnels. Moreover, the locomotion ability and adaptability in tunnel are verified by simulating on software. The structure of chamber proposed in this paper can guide the design method of soft pipeline robot.
Keywords	Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
Subject code	629
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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