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  1. Article: Cut-off value of the eHEALS score as a measure of eHealth skills among rural residents in Gansu, China.

    Zhu, Yang / Wang, Xiaohui / You, Xinyi / Zhao, Hongmei / Guo, Yawei / Cao, Wangnan / Xin, Meiqi / Li, Jinghua

    Digital health

    2023  Volume 9, Page(s) 20552076231205269

    Abstract: Background: In this study, our aim was to quantify eHealth literacy and determine a cut-off value for eHEALS scores that signifies adequate eHealth literacy among rural residents in Gansu, China.: Methods: This cross-sectional investigation ... ...

    Abstract Background: In this study, our aim was to quantify eHealth literacy and determine a cut-off value for eHEALS scores that signifies adequate eHealth literacy among rural residents in Gansu, China.
    Methods: This cross-sectional investigation encompassed 18 rural areas across three cities-Lanzhou, Wuwei, and Dingxi-in Gansu. A total of 451 residents were recruited and underwent evaluations for both eHealth literacy and eHealth skills, utilizing the eHEALS and self-constructed tasks, respectively. A receiving operator characteristic curve was plotted with eHealth skills as the dependent variable and eHealth literacy levels as the independent variable, aiming to determine a cut-off value for eHEALS indicating adequate eHealth literacy and evaluate its predictive capacity.
    Results: Among the 451 respondents, 10.9% did not possess a personal electronic device with Internet access, while 6.4% owned but had never used them. Within the remaining 373 residents, the mean eHealth literacy score was 25.85 (SD:10.93), item scores ranged from 3.12 (SD:1.45) to 3.42 (SD:1.60). Completion rates for three eHealth skills varied from 39.1% to 59.8%. The cut-off value was 29.5 determined by the Youden index. The area under the receiver operating curve was 0.829, with a sensitivity of 86.7%, and a specificity of 66.8%.
    Conclusions: Our findings emphasized that eHealth literacy among rural residents remains at a low level. Moreover, we identified a cut-off value of 29.5 for eHEALS scores that signifies adequate eHealth literacy within this demographic.
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819396-9
    ISSN 2055-2076
    ISSN 2055-2076
    DOI 10.1177/20552076231205269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expression and Purification of FGFR1-Fc Fusion Protein and Its Effects on Human Lung Squamous Carcinoma.

    Zheng, Lulu / Liu, Huan / Chen, Lingfeng / You, Xinyi / Lv, Fangyi / Fan, Haibing / Hui, Qi / Liu, Baohua / Wang, Xiaojie

    Applied biochemistry and biotechnology

    2023  Volume 196, Issue 1, Page(s) 573–587

    Abstract: Molecular-targeted therapies for lung squamous cell carcinoma (LSCC) are limited mainly because targetable oncogenic aberrations are absent in LSCC. Recent genomic analyses have revealed that the fibroblast growth factor (FGF) signaling pathway plays a ... ...

    Abstract Molecular-targeted therapies for lung squamous cell carcinoma (LSCC) are limited mainly because targetable oncogenic aberrations are absent in LSCC. Recent genomic analyses have revealed that the fibroblast growth factor (FGF) signaling pathway plays a fundamental role in LSCC progression via cancer cell proliferation and angiogenesis. In the present study, we designed, expressed, and purified a fibroblast growth factor receptor fragment (FGFR1-Fc) fusion protein using NS/0 cells. In FGF2-FGFR1 overexpressed NCI-H1703 cells, the FGFR1-Fc fusion protein effectively inhibited proliferation and invasion and arrested the cell cycle at the G0-G1 phase. In NCI-H1703 cells treated with the FGFR1-Fc fusion protein, the phosphorylation levels of FGFR1, FRS2, ERK, and AKT were significantly reduced. Using an siRNA assay, we demonstrated that FGF2-FGFR1 is the major anti-tumor target of FGFR1-Fc fusion the FGFR1-Fc fusion protein, which also significantly inhibited proliferation and invasion by NCI-H1703 cells via the FGF2-FGFR1 signaling pathway. In addition, the FGFR1-Fc fusion protein significantly inhibited angiogenesis in an embryonic chorioallantoic membrane model. The FGFR1-Fc fusion protein may be an effective therapeutic candidate for LSCC.
    MeSH term(s) Humans ; Fibroblast Growth Factor 2 ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Carcinoma, Non-Small-Cell Lung ; Cell Proliferation ; Carcinoma, Squamous Cell/genetics ; Lung Neoplasms/drug therapy ; Lung/metabolism ; Cell Line, Tumor ; Immunoglobulin G ; Recombinant Fusion Proteins
    Chemical Substances FP-1039 (CTG26PRE5S) ; Fibroblast Growth Factor 2 (103107-01-3) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1) ; FGFR1 protein, human (EC 2.7.10.1) ; Immunoglobulin G ; Recombinant Fusion Proteins
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04542-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Ideology in Open Source Development

    Yue, Yang / Yu, Xiaoran / You, Xinyi / Wang, Yi / Redmiles, David

    2021  

    Abstract: Open source development, to a great extent, is a type of social movement in which shared ideologies play critical roles. For participants of open source development, ideology determines how they make sense of things, shapes their thoughts, actions, and ... ...

    Abstract Open source development, to a great extent, is a type of social movement in which shared ideologies play critical roles. For participants of open source development, ideology determines how they make sense of things, shapes their thoughts, actions, and interactions, enables rich social dynamics in their projects and communities, and hereby realizes profound impacts at both individual and organizational levels. While software engineering researchers have been increasingly recognizing ideology's importance in open source development, the notion of "ideology" has shown significant ambiguity and vagueness, and resulted in theoretical and empirical confusion. In this article, we first examine the historical development of ideology's conceptualization, and its theories in multiple disciplines. Then, we review the extant software engineering literature related to ideology. We further argue the imperatives of developing an empirical theory of ideology in open source development, and propose a research agenda for developing such a theory. How such a theory could be applied is also discussed.

    Comment: To be published in CHASE 2021
    Keywords Computer Science - Software Engineering
    Subject code 020
    Publishing date 2021-04-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: [Metabolomic study on urine of chronic inflammation rats treated with Buyang Huanwu Decoction based on UPLC-Q-TOF-MS].

    You, Xin-Yi / Jiang, Li / Wang, Wen-Feng / Xu, Xia / Zhang, Shou-Wen / Liu, Hong-Ning / Yan, Xiao-Jun / Nie, Peng / Li, Bing-Tao / Xu, Guo-Liang

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 19, Page(s) 5345–5355

    Abstract: The study investigated the effect of Buyang Huanwu Decoction(BYHWD) on endogenous biomarkers in the urine of rats with chronic inflammation induced by lipopolysaccharide(LPS) using ultra-high performance liquid chromatography-quadrupole-time-of-flight- ... ...

    Abstract The study investigated the effect of Buyang Huanwu Decoction(BYHWD) on endogenous biomarkers in the urine of rats with chronic inflammation induced by lipopolysaccharide(LPS) using ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry(UPLC-Q-TOF-MS), aiming to elucidate the molecular mechanism underlying the therapeutic effect of BYHWD on chronic inflammation from a metabolomics perspective. Male SD rats were randomly divided into a normal group, a model group, and low-, medium-, and high-dose BYHWD groups(7.5, 15, and 30 g·kg~(-1)). The model group and BYHWD groups received tail intravenous injection of LPS(200 μg·kg~(-1)) on the first day of each week, followed by oral administration of BYHWD once a day for four consecutive weeks. Urine samples were collected at the end of the administration period, and UPLC-Q-TOF-MS was used to analyze the metabolic profiles of the rat urine in each group. Multivariate statistical analysis methods such as principal component analysis(PCA), partial least squares-discriminant analysis(PLS-DA), and orthogonal partial least squares-discriminant analysis(OPLS-DA) were used to analyze the effect of BYHWD on endogenous metabolites. One-way ANOVA and variable importance for the projection(VIP) were used to screen for potential biomarkers related to chronic inflammation. The identified biomarkers were subjected to pathway and enrichment analysis using MetaboAnalyst 5.0. A total of 25 potential biomarkers were screened and identified in the rat urine in this experiment. Compared with the normal group, the model group showed significant increases in the levels of 14 substances(P<0.05) and significant decreases in the levels of 11 substances(P<0.05). BYHWD was able to effectively reverse the trend of most endogenous biomarkers. Compared with the model group, BYHWD significantly down-regulated 13 biomarkers(P<0.05) and up-regulated 10 biomarkers(P<0.05). The metabolic products were mainly related to the biosynthesis of pantothenic acid and coenzyme A, tryptophan metabolism, retinol metabolism, and propionate metabolism. BYHWD has therapeutic effect on chronic inflammation induced by LPS, which may be related to its ability to improve the levels of endogenous metabolites, enhance the body's anti-inflammatory and antioxidant capabilities, and restore normal metabolic activity.
    MeSH term(s) Rats ; Male ; Animals ; Chromatography, High Pressure Liquid/methods ; Lipopolysaccharides ; Rats, Sprague-Dawley ; Metabolomics/methods ; Inflammation/drug therapy ; Biomarkers/urine
    Chemical Substances buyang huanwu ; Lipopolysaccharides ; Biomarkers
    Language Chinese
    Publishing date 2023-12-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230510.401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months.

    Lu, Chao / Jin, Lei / Bi, Jianing / Jin, Hongyi / You, Xinyi / Peng, Lulu / Fan, Haibing / Wang, Huan / Wang, Liangshun / Fan, Zhengkai / Wang, Xiaojie / Liu, Baohua

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1176136

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1176136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How does biochar influence soil nitrification and nitrification-induced N

    Liu, Qi / Wu, Yaxin / Ma, Jing / Jiang, Jiang / You, Xinyi / Lv, Runjin / Zhou, Sijing / Pan, Chang / Liu, Benjuan / Xu, Qiao / Xie, Zubin

    The Science of the total environment

    2023  Volume 908, Page(s) 168530

    Abstract: Nitrification is a major pathway of ... ...

    Abstract Nitrification is a major pathway of N
    MeSH term(s) Soil/chemistry ; Nitrification ; Ammonia/metabolism ; Soil Microbiology ; Archaea/metabolism ; Nitrous Oxide/analysis
    Chemical Substances Soil ; biochar ; Ammonia (7664-41-7) ; Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2023-11-13
    Publishing country Netherlands
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Moderating effect of self-efficacy on the association of intimate partner violence with risky sexual behaviors among men who have sex with men in China.

    Zhu, Yang / Hou, Fengsu / Chen, Chun / Wei, Dannuo / Peng, Liping / You, Xinyi / Gu, Jing / Hao, Chun / Hao, Yuantao / Li, Jinghua

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 895

    Abstract: Background: In China, men who have sex with men (MSM) face a high risk of HIV infection. Intimate partner violence (IPV) is common in this population and leads to various adverse consequences, including risky sexual behaviors, substance abuse, and poor ... ...

    Abstract Background: In China, men who have sex with men (MSM) face a high risk of HIV infection. Intimate partner violence (IPV) is common in this population and leads to various adverse consequences, including risky sexual behaviors, substance abuse, and poor mental health, which pose huge challenges to HIV prevention and control.
    Methods: An anonymous cross-sectional study was conducted to investigate the lifetime prevalence of IPV and prevalence of risky sexual behaviors during the previous 6 months in a convenience sample of 578 MSM from 15 cities covering seven geographical divisions in mainland China. The associations between IPV and risky sexual behaviors and the moderating effect of self-efficacy on these associations were explored through univariate and multivariate regression analyses.
    Results: The prevalence rates of IPV perpetration and victimization were 32.5% and 32.7%, respectively. The proportions of participants who reported inconsistent condom use with regular or casual partners and multiple regular or casual sexual partners were 25.8%, 8.3%, 22.2%, and 37.4%, respectively. Multiple IPV experiences were positively associated with risky sexual behaviors; for example, any IPV victimization was positively associated with multiple regular partners, adjusted odds ratio (ORa) = 1.54, 95% CI [1.02,2.32], and multiple casual partners, ORa = 1.93, 95% CI [1.33, 2.80]. Any IPV perpetration was positively associated with inconsistent condom use with regular partners, ORa = 1.58, 95% CI [1.04, 2.40], and multiple casual partners, ORa = 2.11, 95% CI [1.45, 3.06]. Self-efficacy was identified as a significant moderator of the association between multiple casual sexual partnership and emotional IPV.
    Conclusions: In conclusion, given the high prevalence of both IPV and risky sexual behaviors among Chinese MSM in this study, the inclusion of self-efficacy in interventions targeting IPV and risky sexual behaviors should be considered.
    MeSH term(s) China/epidemiology ; Cross-Sectional Studies ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Intimate Partner Violence ; Male ; Prevalence ; Risk Factors ; Self Efficacy ; Sexual Partners ; Sexual and Gender Minorities
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06618-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Gross tumor volume of adenocarcinoma of esophagogastric junction corresponding to cT and cN stages measured with computed tomography to quantitatively determine resectabiliy: A case control study.

    Li, Ke-Ying / Ou, Jing / Zhou, Hai-Ying / Yu, Zi-Yi / Gao, Dan / You, Xin-Yi / Zhang, Xiao-Ming / Li, Rui / Chen, Tian-Wu

    Frontiers in oncology

    2022  Volume 12, Page(s) 1038135

    Abstract: Purpose: To determine whether gross tumor volume (GTV) of adenocarcinoma of esophagogastric junction (AEG) corresponding to cT and cN stages measured on CT could help quantitatively determine resectability.: Materials and methods: 343 consecutive ... ...

    Abstract Purpose: To determine whether gross tumor volume (GTV) of adenocarcinoma of esophagogastric junction (AEG) corresponding to cT and cN stages measured on CT could help quantitatively determine resectability.
    Materials and methods: 343 consecutive patients with AEG, including 279 and 64 randomly enrolled in training cohort (TC) and validation cohort (VC), respectively, underwent preoperative contrast-enhanced CT. Univariate and multivariate analyses for TC were performed to determine factors associated with resectability. Receiver operating characteristic (ROC) analyses were to determine if GTV corresponding to cT and cN stages could help determine resectability. For VC, Cohen's Kappa tests were to assess performances of the ROC models.
    Results: cT stage, cN stage and GTV were independently associated with resectability of AEG with odds ratios of 4.715, 4.534 and 1.107, respectively. For differentiating resectable and unresectable AEG, ROC analyses showed that cutoff GTV of 32.77 cm
    Conclusions: GTV, cT and cN stages could be independent determinants of resectability of AEG. And GTV corresponding to cT and cN stages can help quantitatively determine resectability.
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1038135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preliminary validation of the Chinese version of the Shame and Stigma Scale among patients with facial disfigurement from nasopharyngeal carcinoma.

    Cai, Yuqi / Zhang, Yuan / Cao, Wangnan / Hou, Fengsu / Xin, Meiqi / Guo, Vivian Yawei / Deng, Yang / Wang, Shenghao / You, Xinyi / Li, Jinghua

    PloS one

    2022  Volume 17, Issue 12, Page(s) e0279290

    Abstract: Objective: This study examined the reliability and validity of a Shame and Stigma Scale (SSS) and assessed shame and stigma among patients with facial disfigurement from nasopharyngeal carcinoma (NPC).: Methods: Data were collected from 218 patients ... ...

    Abstract Objective: This study examined the reliability and validity of a Shame and Stigma Scale (SSS) and assessed shame and stigma among patients with facial disfigurement from nasopharyngeal carcinoma (NPC).
    Methods: Data were collected from 218 patients with NPC through a cross-sectional survey between January 14, 2020, and December 1, 2020. The original SSS is a 20-item scale with four dimensions (i.e., shame with appearance, sense of stigma, regret, and social/speech concern). We used Cronbach's alpha and McDonald's omega to assess reliability and exploratory factor analysis (EFA) to assess the factor structure. We also used Pearson correlation analysis to examine the relationship between each item and total score of scale items and convergent validity.
    Results: The final 18-item SSS had a Cronbach's alpha coefficient of .89. The EFA revealed that the SSS has a four-factor structure: sense of stigma, social/speech concern, shame with appearance, and regret. These factors showed satisfactory reliability, with McDonald's omega coefficients of .87, .77, .86, and .79, respectively. The scale showed significant relationship between each item and total score of scale items with respect to item-total correlations, item-subscale correlations, and item-other-subscale correlations. Convergent validity was supported by the significant positively correlated with the total scores for depression and anxiety.
    Conclusion: The SSS is valid and reliable in assessing shame and stigma and monitoring treatment compliance among patients with NPC.
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0279290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Same-sex behavior disclosure to health care providers associated with greater awareness of pre-exposure prophylaxis.

    Cao, Wangnan / You, Xinyi / Li, Jinghua / Peng, Liping / Gu, Jing / Hao, Chun / Hou, Fengsu / Wei, Dannuo / Deng, Yang / Hao, Yuantao / Mo, Phoenix Kit-Han

    BMC public health

    2021  Volume 21, Issue 1, Page(s) 2243

    Abstract: Background: This study aimed to determine whether the disclosure of same-sex behavior to health care providers (HCPs) is associated with higher rates of prior human immunodeficiency virus (HIV) testing experience and greater awareness of immediate ... ...

    Abstract Background: This study aimed to determine whether the disclosure of same-sex behavior to health care providers (HCPs) is associated with higher rates of prior human immunodeficiency virus (HIV) testing experience and greater awareness of immediate antiretroviral therapy (ART), Undetectable = Untransmittable (U=U), and pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM).
    Methods: We conducted a cross-sectional survey among 689 adult males in Chengdu, China who self-reported having had anal intercourse with at least one man in the past 6 months. We measured same-sex behavior disclosure to three types of HCPs (hospital clinicians, community-based organization peer educators, and Center for Disease Control and Prevention public health specialists), and the awareness of immediate ART, U=U, and PrEP.
    Results: Of the 689 enrolled participants, 31.4% had disclosed their same-sex behavior to some or all of the clinicians, 83.9% had done so to the peer educators, and 56.8% had done so to the public health specialists. Approximately four in five (82.1%) of the participants had ever been tested for HIV. The awareness rate was 84.8% for immediate ART, 20.2% for U=U, and 50.7% for PrEP. After controlling for significant background variables, same-sex behavior disclosure to clinicians was associated with greater awareness of PrEP (adjusted odds ratio [AOR] = 1.64; 95% confidence interval [CI]: 1.08-2.48), but similar findings were not reported regarding disclosure to peer educators or public health specialist. Same-sex behavior disclosure to any types of HCPs was not associated with HIV testing experience, and awareness of immediate ART or U=U.
    Conclusions: The rates of same-sex behavior disclosure varied with different types of HCPs. Disclosure to clinicians was associated with greater awareness of PrEP, but not awareness of immediate ART or U=U.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Disclosure ; HIV Infections/prevention & control ; Health Knowledge, Attitudes, Practice ; Health Personnel ; Homosexuality, Male ; Humans ; Male ; Pre-Exposure Prophylaxis ; Sexual Behavior ; Sexual and Gender Minorities
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-021-12317-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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