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Article ; Online: Assessment of the Physicochemical Quality of Groundwater in the Errachidia Region (SE, Morocco)

Maryam Azirar / Said Benyoussef / Mourad Arabi / Abdellali Abdaoui / Younes Filali Zegzouti / Ali Ait Boughrous

Ecological Engineering & Environmental Technology, Vol 24, Iss 9, Pp 64-

2023 Volume 70

Abstract: This study aimed to assess groundwater quality in the Errachidia region, southeast Morocco, where a total of one hundred wells were periodically surveyed, and ten wells were selected for monthly monitoring based on their proximity to known surface ... ...

Abstract	This study aimed to assess groundwater quality in the Errachidia region, southeast Morocco, where a total of one hundred wells were periodically surveyed, and ten wells were selected for monthly monitoring based on their proximity to known surface pollution sources. Various physicochemical parameters were measured. Results outcomes encompass temperature fluctuations ranging from 21°C to 30°C, generally neutral pH levels, heightened electrical conductivity (900 to 2220 µS/cm), diminished dissolved oxygen levels (1.91 mg/L), and the presence of nitrates within prescribed thresholds for potable water. Nevertheless, one station exceeded the nitrate threshold (30 mg/L). Elevated sulfate ion concentrations were detected (764.6 mg/L), potentially originating from urban wastewater. Chloride levels fell within acceptable limits (67.45 to 245 mg/L), and calcium content displayed variability (89.6 to 208.6 mg/L), but remained below authorized values. Hierarchical clustering identified four distinctive well groups predicated on their physicochemical attributes, thereby underscoring the impact of pollution sources on water quality. The study indicated an improvement in the region's water quality, transitioning from poor to moderate, and in some instances, to good quality.
Keywords	physicochemical quality ; groundwater ; climate change ; pollution ; errachidia ; morocco ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Polish Society of Ecological Engineering (PTIE)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors Associated with COVID-19 Vaccine Acceptance in Morocco

Imane Berni / Aziza Menouni / Younes Filali Zegzouti / Marie-Paule Kestemont / Lode Godderis / Samir El Jaafari

Vaccines, Vol 10, Iss 784, p

Applying the Health Belief Model

2022 Volume 784

Abstract: To identify factors that influenced Moroccans’ intention to get a COVID-19 vaccine, a cross-sectional survey among a Moroccan sample was conducted based on Health Belief Model constructs. Participants’ sociodemographic characteristics, perceived ... ...

Abstract	To identify factors that influenced Moroccans’ intention to get a COVID-19 vaccine, a cross-sectional survey among a Moroccan sample was conducted based on Health Belief Model constructs. Participants’ sociodemographic characteristics, perceived susceptibility, perceived severity, perceived barriers, perceived benefits, self-efficacy, cues to action, and intention to receive vaccine data were collected and analyzed using a structural equation model (SEM). The survey was completed by 3800 individuals; 57.2% were men, 44.5% were aged 30 to 44, and 44.6% were married. After controlling for confounders, being a woman and having a chronic disease were associated with higher acceptance of the COVID-19 vaccine. The strongest predictor for the intention of receiving a vaccine was participants who were married. Most of the HBM constructs were shown to be significantly associated with vaccine acceptance. Susceptibility and Benefits were the strongest predictors of acceptance of the COVID-19 vaccine (standardized path coefficient, SPC = 0.23), followed by Severity (SPC = 0.22). Conversely, given the negative correlation between barriers and intention (SPC = −0.08), it is necessary to maintain a high level of transparency regarding the vaccines’ safety. Our study provides guidance for an implementation of vaccination strategies, intending to bolster the overall COVID-19 immunization program.
Keywords	COVID-19 ; Health Belief Model ; vaccine acceptance ; Morocco ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein.

Moujane, Soumia / Bouadid, Ismail / Bouymajane, Aziz / Younes, Filali Zegzouti / Benlyas, Mohamed / Mohammed, Bouachrine / Cacciola, Francesco / Vinci, Roberto Laganà / Tropea, Alessia / Mondello, Luigi / Altemimi, Ammar B / Eddouks, Mohamed / Moualij, Benaissa

Fitoterapia

2024 Volume 175, Page(s) 105923

Abstract: Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. ... ...

Abstract	Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. Therefore, the therapeutic strategies based on biologically active substances from plants are needed to develop for the treatment of cervical cancer. The aim of the present study was to assess in vivo toxicity, hematological and biochemical blood parameters in Wistar rats fed Retama sphaerocarpa aqueous leaf extract (RS-AE), as well as to perform in silico molecular docking studies and dynamic simulation of phenolic compounds against HPV16 oncoprotein E6 in order to identify potential inhibitors. RS-AE was found not to induce acute or sub-acute oral toxicity or significant alterations in hematological and biochemical blood parameters in Wistar rats. A total of 11 phenolic compounds were identified in RS-AE, including dihydrodaidzein glucuronide, chrysoperiol pentoside, genistin and vitexin, which turned out to have the highest binding affinity to HPV16 oncoprotein E6. Based on these results, these RS-AE phenolic compounds could be used as natural drugs against the HPV16 E6 oncoprotein.
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2024.105923
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Article ; Online: Benefits of Argan Oil on Human Health—May 4–6 2017, Errachidia, Morocco

Gérard Lizard / Younes Filali-Zegzouti / Adil El Midaoui

International Journal of Molecular Sciences, Vol 18, Iss 7, p

2017 Volume 1383

Abstract: ... n/ ... ...

Abstract	n/a
Keywords	n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats

Eimad Dine Tariq Bouhlali / Mgal Derouich / Abdelbassat Hmidani / Bouchra Bourkhis / Tarik Khouya / Younes Filali-Zegzouti / Chakib Alem

The Scientific World Journal, Vol

A Comparison with Vitamin C

2021 Volume 2021

Abstract: Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to ...

Abstract	Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as Jihl and Majhoul, aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. The polyphenol profile was built by means of an HPLC analysis. Hepatic damage was provoked by exposing rats to PCM at a dose of 1.5 g/kg once a week. Besides PCM, Jihl and Majhoul date seed extracts (200 and 400 mg/kg) were administered orally in a day-to-day routine. Our findings showed that among the examined polyphenol compounds, p-coumaric acid, quercetin, caffeic acid, and rutin were the most abundant phytochemicals. Date pits significantly (p<0.001) stabilized the PCM-driven alterations in liver function parameters (AST, ALT, ALP, LDH, total protein, direct bilirubin, and total bilirubin). Moreover, Phoenix dactylifera pits enhanced considerably (p<0.001) the activities of antioxidant enzymes (SOD, CAT, and GPx) as well as the level of reduced glutathione (GSH). The established hepatoprotective effect may be due to the date seeds antioxidant effect and their ability to trap free radicals. The main outcomes of the present study could validate the traditional use of these date seeds to manage various health conditions.
Keywords	Technology ; T ; Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MAROCOVID

Imane Berni / Aziza Menouni / Younes Filali Zegzouti / Marie-Paule Kestemont / Lode Godderis / Samir El Jaafari

International Journal of Environmental Research and Public Health, Vol 18, Iss 5745, p

Snapshot Monitoring of Knowledge and Perceptions of Safety Behaviors during the COVID-19 Outbreak in Morocco

2021 Volume 5745

Abstract: To assess whether knowledge, attitude, and perceptions of the COVID-19 pandemic predicted changes in behaviors among the general Moroccan population, a cross-sectional online survey was conducted between 30 March and 20 April involving a total of 14,157 ... ...

Abstract	To assess whether knowledge, attitude, and perceptions of the COVID-19 pandemic predicted changes in behaviors among the general Moroccan population, a cross-sectional online survey was conducted between 30 March and 20 April involving a total of 14,157 participants. The statistical analysis of the data included univariate and multivariate logistic regression analysis. Our results suggest that less than ten days after the Moroccan government announced “Health state of Emergency” response to the COVID-19 outbreak, public knowledge, attitude and responses to the pandemic were relatively high. More than half the respondents (63.2%) reported that they complied with more than five of nine recommended safety measures, including avoiding going out (93.2%), and frequent handwashing with soap and water (78.2%). Factors associated with an increased likelihood to adopt safety measures included perceptions that COVID-19 was a human health risk, the pandemic will continue for a long time, availability of clear information, and a lack of medicine. The largest predictor of safety behavior change was age; participants older than 55 were more likely to adopt recommended safety behaviors. Although knowledge and perception among the general public was reasonable, more encouragement from government via health education programs is needed to maintain appropriate behaviors.
Keywords	COVID-19 ; knowledge ; attitude ; perceptions ; safety behavior ; Medicine ; R
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: In-Silico Molecular Modeling Studies to Identify Novel Potential Inhibitors of HPV E6 Protein.

Soumia, Moujane / Hajji, Halima / El Mzibri, Mohamed / Younes, Filali Zegzouti / Mohammed, Bouachrine / Mohamed, Benlyas / Benaissa, Moualij

Vaccines

2022 Volume 10, Issue 9

Abstract: The etiological agent of some anogenital tract cancers is infection with the high-risk human papillomavirus (HPV). Currently, prophylactic vaccines against HPV have been validated, but the presence of drug treatment directed against the infection and its ...

Abstract	The etiological agent of some anogenital tract cancers is infection with the high-risk human papillomavirus (HPV). Currently, prophylactic vaccines against HPV have been validated, but the presence of drug treatment directed against the infection and its oncogenic effects remain essential. Among the best drug targets, viral oncoprotein E6 has been identified as a key factor in cell immortalization and tumor progression in HPV-positive cells. E6, through interaction with the cellular ubiquitin ligase E6AP, can promote the degradation of p53, a tumor suppressor protein. Therefore, suppression of the creation of the E6-E6AP complex is one of the essential strategies to inhibit the survival and proliferation of infected cells. In the present study, we proposed an in-silico approach for the discovery of small molecules with inhibitory activity on the E6-E6AP interaction. The first three compounds (F0679-0355, F33774-0275, and F3345-0326) were selected on the basis of virtual screening and prediction of the molecules' ADMET properties and docking with E6 protein, these molecules were selected for further study by investigating their stability in the E6 complex and their inhibitory effect on the E6-E6AP interaction by molecular dynamics (MD) simulation. The identified molecules thus represent a good starting point for the development of anti-HPV drugs.
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10091452
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome

Adil El Midaoui / Youssef Haddad / Younes Filali-Zegzouti / Réjean Couture

International Journal of Molecular Sciences, Vol 18, Iss 11, p

A Preclinical Study

2017 Volume 2492

Abstract: The present study aims at examining the effects of argan oil on the three main cardiovascular risk factors associated with metabolic syndrome (hypertension, insulin resistance and obesity) and on one of its main complications, neuropathic pain. Male ... ...

Abstract	The present study aims at examining the effects of argan oil on the three main cardiovascular risk factors associated with metabolic syndrome (hypertension, insulin resistance and obesity) and on one of its main complications, neuropathic pain. Male Sprague-Dawley rats had free access to a drinking solution containing 10% d-glucose or tap water for 12 weeks. The effect of argan oil was compared to that of corn oil given daily by gavage during 12 weeks in glucose-fed rats. Glucose-fed rats showed increases in systolic blood pressure, epididymal fat, plasma levels of triglycerides, leptin, glucose and insulin, insulin resistance, tactile and cold allodynia in association with a rise in superoxide anion production and NADPH oxidase activity in the thoracic aorta, epididymal fat and gastrocnemius muscle. Glucose-fed rats also showed rises in B1 receptor protein expression in aorta and gastrocnemius muscle. Argan oil prevented or significantly reduced all those anomalies with an induction in plasma adiponectin levels. In contrast, the same treatment with corn oil had a positive impact only on triglycerides, leptin, adiponectin and insulin resistance. These data are the first to suggest that argan oil is an effective nutri-therapeutic agent to prevent the cardiovascular risk factors and complications associated with metabolic syndrome.
Keywords	metabolic syndrome ; oxidative stress ; kinin receptors ; argan oil ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exposition au mercure et état de santé des médecins dentistes de deux régions du centre du Maroc

Nourdine Attiya / Rkia Fattahi / Ahmed El-Haidani / Nadia Lahrach / Mohamed-Yassine Amarouch / Younes Filali-Zegzouti

The Pan African Medical Journal, Vol 36, Iss

enquête transversale descriptive

2020 Volume 110

Abstract: INTRODUCTION: l´exposition au mercure est un problème de santé publique mondialement reconnu. Si les intoxications aiguës ou subaiguës par ce métal font l´objet d´un consensus diagnostique, l´impact d´une exposition chronique à de faibles doses est ... ...

Abstract	INTRODUCTION: l´exposition au mercure est un problème de santé publique mondialement reconnu. Si les intoxications aiguës ou subaiguës par ce métal font l´objet d´un consensus diagnostique, l´impact d´une exposition chronique à de faibles doses est encore sujet à débat. En dentisterie, le mercure est utilisé pour la réalisation des amalgames dentaires. De ce fait, les professionnels de la médecine dentaire et spécialement des médecins dentistes représentent une population exposée à ce facteur de risque. Dans ce contexte, une enquête épidémiologique descriptive, transversale et exhaustive a été réalisée afin d´évaluer cette exposition chez les médecins dentistes dans deux régions du centre du Maroc. Parallèlement, leur état de santé globale a été relevé afin de juger de la pertinence d´une enquête étiologique ultérieure pour étudier l´impact probable de l´exposition à ce facteur de risque. METHODES: la présente étude a été réalisée par le biais d´un questionnaire auto-renseigné par les participants. L´exposition professionnelle des médecins dentistes a été évaluée en déterminant la fréquence d´utilisation de l´amalgame dentaire. Les différentes sources de mercure qui modulent la pollution de fond ou qui provoquent des pics d´exposition et qui sont en rapport l´environnement ou les habitudes du travail ont aussi été étudiés. Les sources d´exposition non professionnelle prises en compte sont le tabagisme, la vaccination, la consommation de poisson et la présence des amalgames dentaire en bouche. Enfin, l´état de santé des praticiens recrutés dans l´étude a été sondé globalement en se basant sur leurs déclarations. RESULTATS: Cent quatre vingt douze (192) médecins dentistes ont été recrutés dans cette étude. Parmi lesquels, 76,04% déclarent utiliser l´amalgame dans leur pratique avec une fréquence variable. De plus, plusieurs sources de surexposition en rapport avec les conditions ou les habitudes du travail ont été mises en évidence. La principale source d´exposition non professionnelle dans notre population est en rapport avec la présence des amalgames dentaires en bouche (63,45%). Les plaintes sanitaires exprimées par les participants concernaient en chef de file les problèmes neuropsychologiques et ce chez 46,35% de la population. En prenant en compte la neurotoxicité reconnue du mercure, une étude étiologique s´avère parfaitement justifiable dans notre contexte. CONCLUSION: l´exposition au mercure chez les médecins dentistes des régions étudiées est réelle. Des mesures de prévention sont à promouvoir. La réalisation d´une recherche étiologique pour juger l´impact de cette exposition est parfaitement indiquée.
Keywords	mercure ; amalgame dentaire ; exposition professionnelle ; médecins dentistes ; enquête transversale ; maroc ; Medicine ; R
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties

Eimad dine Tariq Bouhlali / Abdelbasset Hmidani / Bouchra Bourkhis / Tarik Khouya / Mhamed Ramchoun / Younes Filali-Zegzouti / Chakib Alem

Heliyon, Vol 6, Iss 2, Pp e03436- (2020)

2020

Abstract: Date (Phoenix dactylifera L.) seeds are seen as good drug to cure rheumatoid arthritis and asthma in Moroccan traditional medicine. The present research aimed to study the anti-inflammatory effect, of methanol extract of different date seed varieties ... ...

Abstract	Date (Phoenix dactylifera L.) seeds are seen as good drug to cure rheumatoid arthritis and asthma in Moroccan traditional medicine. The present research aimed to study the anti-inflammatory effect, of methanol extract of different date seed varieties using membrane stabilizing effect, nitric oxide radical scavenging activity, inhibition of protein denaturation, carrageenan-induced paw edema and croton oil induced ear edema. The polyphenolic profile was examined using HPLC-DAD. Rutin, quercetin, p-coumaric and caffeic acids were the main among the analysed phenolic compounds. Concerning the anti-inflammatory activity, the analysed date seed were significantly effective in scavenging nitric oxide free radical, in stabilisation of erythrocyte membrane and possessed a high anti denaturation effect. In agreement with this finding, date seed exhibited a profound ability to reduce paw and ear swelling induced by carrageenan and croton oil respectively. The biochemical parameters showed that date seed are able to reduce the erythrocyte sedimentation rate (ERS) and C-reactive protein (CRP) concentration in rats used in Carrageenan-induced paw edema model. The predominant phenolic compounds are the potential candidates that drive these activities and the differences observed among varieties are related to their chemical composition. These data suggest that date seeds can be explored as a therapeutic agent for the treatment of inflammatory diseases.
Keywords	Toxicology ; Inflammation ; Natural product ; Polyphenol ; Oxidative stress ; Antioxidant ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	571
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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