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Article: A Case of Painful Diplopia after COVID-19 Vaccination: Could It Be Tolosa-Hunt Syndrome?

Ammari, Wafa / Kammoun, Alyssa / Zaghdoudi, Asma / Berriche, Olfa / Younes, Samia / Messaoud, Riadh

2023 Volume 44, Issue 4, Page(s) 240–243

Abstract: Herein, we report a rare case of Tolosa-Hunt syndrome (THS) following coronavirus disease 2019 (COVID-19) vaccine administration. A 64-year-old patient presented with recurrent horizontal diplopia and ipsilateral orbital pain, 2 weeks after being ... ...

Abstract	Herein, we report a rare case of Tolosa-Hunt syndrome (THS) following coronavirus disease 2019 (COVID-19) vaccine administration. A 64-year-old patient presented with recurrent horizontal diplopia and ipsilateral orbital pain, 2 weeks after being administered the COVID-19 vaccination. A diagnosis of THS was based on the relevant criteria after ruling out the differential diagnoses. The clinical presentation improved with corticosteroid administration. THS must be recognized as a complication of COVID-19 vaccination. This association can be explained by an autoimmune response.
Language	English
Publishing date	2023-07-18
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2674300-0
ISSN	2092-6715 ; 2005-6443
ISSN (online)	2092-6715
ISSN	2005-6443
DOI	10.4082/kjfm.22.0201
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Article ; Online: Catatonia in patients with dementia: a case report.

Younes, Samira / Khouadja, Sabria / Younes, Samia / Zarrouk, Lazhar

The Pan African medical journal

2019 Volume 33, Page(s) 117

Abstract: Catatonia occurring as part of a clinical picture of dementia has been reported with almost all types of dementia. It remains under-diagnosed in older adults and those with dementia. We review a case of a young patient admitted in our psychiatric ... ...

Abstract	Catatonia occurring as part of a clinical picture of dementia has been reported with almost all types of dementia. It remains under-diagnosed in older adults and those with dementia. We review a case of a young patient admitted in our psychiatric department for catatonia and after efficient treatment with Lorazepam, assessment revealed a dementia. Catatonia is a severe neuropsychiatric syndrome with an excellent prognosis if recognized and treated without delay.
MeSH term(s)	Anti-Anxiety Agents/administration & dosage ; Catatonia/drug therapy ; Catatonia/etiology ; Dementia/complications ; Dementia/diagnosis ; Humans ; Lorazepam/administration & dosage ; Male ; Middle Aged ; Prognosis ; Treatment Outcome
Chemical Substances	Anti-Anxiety Agents ; Lorazepam (O26FZP769L)
Language	English
Publishing date	2019-06-14
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2019.33.117.18629
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Article ; Online: External validations of the ABCD2 score in prediction of stroke risk after transient ischemic attack. A Tunisian hospital-based cohort study.

Nizar, Daoussi / Amine, MSolli M / Aissi, Mouna / Machraoui, Rafik / Adel, Sekma / Khaoula, Bel Haj Ali / Blel, Semir / Younes, Samia / Boukef, Riadh / Henteti, Fayçal / Nouira, Semir / Hamdi, Boubaker / Frih, Mahbouba

The International journal of neuroscience

2023 Volume 133, Issue 11, Page(s) 1218–1223

Abstract: Background and purpose: Identification of patients with high risk of stroke after transient ischemic attack (TIA) could be helpful to optimize stroke prevention. We aimed to externally validate the ABCD2 score for the prediction of stroke after TIA in a ...

Abstract	Background and purpose: Identification of patients with high risk of stroke after transient ischemic attack (TIA) could be helpful to optimize stroke prevention. We aimed to externally validate the ABCD2 score for the prediction of stroke after TIA in a Tunisian population. Methods: We conducted a retrospective observational study of consecutive patients admitted for TIA in four university hospitals in Tunisia. Patients were screened for onset of stroke. Sensitivity, specificity, positive and negative predictive values with areas under the receiver operating characteristic (ROC) curves were calculated for risk of stroke at 2, 7, 30 and 90 days after the index event. Results: Of 415 patients screened in this study, the total cumulative subsequent stroke rates after TIA at 2, 7, 30 and 90 days were respectively, 4.8%, 10.6%, 13.5% and 20.2%. Using a cut-off value of 4, the ABCD2 showed an overall good sensitivity (95%, 97.7%, 96.4% and 97.6% respectively at 2, 7, 30 and 90 days). Areas under ROC cure of the ABCD2 score in patients with TIA for stroke onset at 2, 7, 30 and 90 days were respectively 0.67 (95% CI, 0.55-0.79), 0.79 (95% CI, 0.71-0.85), 0.79 (95% CI, 0.72-0.85), and 0.76 (95% CI, 0.70-0.81). Conclusion: Our findings suggest that the ABCD2 score could be used in our population to discriminate patient with TIA at low and high risk of developing recurrent stroke.
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2020.1835897
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Article ; Online: Seronegative acute encephalitis following COVID-19 vaccines: a case series of an overlooked diagnosis with literature review.

Mansour, Khadija / Chadli, Zohra / Ghachem, Ichrak / Fredj, Nadia Ben / Romdhane, Haifa Ben / Fadhel, Najah Ben / Boughatas, Naceurs / Aouam, Karim / Chaabane, Amel / Younes, Samia

European journal of clinical pharmacology

2023 Volume 79, Issue 7, Page(s) 975–987

Abstract: Purpose: Autoimmune encephalitis is a neurological emergency of new-onset altered mental status, caused by an exaggerated immune-mediated response that targets the central nervous system. Autoimmune encephalitis has become an emerging differential ... ...

Abstract	Purpose: Autoimmune encephalitis is a neurological emergency of new-onset altered mental status, caused by an exaggerated immune-mediated response that targets the central nervous system. Autoimmune encephalitis has become an emerging differential diagnosis, when a classical infection cannot explain neurological symptoms. Displaying overlapping clinical presentations, ranging from the insidious onset of cognitive deficiency to more severe forms of encephalopathy with refractory seizures, autoimmune encephalitis can be challenging for clinicians. When evidence of malignancy is absent and pathogenic autoantibodies are undetected, with typical clinical and imaging features of autoimmune encephalitis, seronegative autoimmune encephalitis may be considered. Recently, vaccination-related autoimmune encephalitis and acute encephalitis after COVID-19 vaccination have attracted attention. Methods and results: We report a case series consisting of three patients with autoimmune encephalitis occurring shortly after COVID-19 vaccination and a current review of all previous reported autoimmune encephalitis related to COVID-19 vaccines. Conclusion: We emphasise on the prompt diagnosis of autoimmune encephalitis induced by Covid-19 vaccines and its timely treatment to improve the clinical outcome of this severe neurological condition. Post-licencing vaccine safety surveillance for potential adverse events is essential for vaccine safety and public confidence.
MeSH term(s)	Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Encephalitis/diagnosis ; Encephalitis/etiology ; Autoimmune Diseases of the Nervous System ; COVID-19 Testing
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-05-26
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-023-03510-7
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Article: Mitochondrial DNA and Alzheimer’s disease: a first case–control study of the Tunisian population

Ben Salem, Nesrine / Boussetta, Sami / de Rojas, Itziar / Moreno-Grau, Sonia / Montrreal, Laura / Mokni, Narjes / Mahmoud, Imene / Younes, Samia / Daouassi, Nizar / Frih-Ayed, Mahbouba / Hammami, Afef / Ben Ammar Elgaaied, Amel / Ruiz, Agustín / Cherni, Lotfi

Molecular biology reports. 2022 Mar., v. 49, no. 3

2022

Abstract: BACKGROUND: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial ... ...

Abstract	BACKGROUND: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial alteration has been proposed as a possible cause of AD. Therefore, several studies have focused on finding an association between inherited mitochondrial DNA variants and AD onset. METHODS: In this study, we looked, for the first time, for a potential association between mitochondrial haplogroups or polymorphisms and AD in the Tunisian population. We also evaluated the distribution of the major genetic risk factor for AD, the apolipoprotein E epsilon 4 (APOE ε4), in this population. In total, 159 single-nucleotide polymorphisms (SNPs) of mitochondrial DNA haplogroups were genotyped in 254 individuals (58 patients and 196 controls). An additional genotyping of APOE ε4 was performed. RESULTS: No significant association between mitochondrial haplogroups and AD was found. However, two individual SNPs, A5656G (p = 0.03821, OR = 10.46) and A13759G (p = 0.03719, OR = 10.78), showed a significant association with AD. APOE 4 was confirmed as a risk factor for AD (p = 0.000014). CONCLUSION: Our findings may confirm the absence of a relation between mitochondrial haplogroups and AD and support the possible involvement of some inherited variants in the pathogenicity of AD.
Keywords	apolipoprotein E ; case-control studies ; etiology ; genotyping ; mitochondria ; mitochondrial DNA ; molecular biology ; neurodegenerative diseases ; pathogenicity ; risk factors
Language	English
Dates of publication	2022-03
Size	p. 1687-1700.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06978-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Psychiatric disorders in the acoustic neuroma: about a case.

Younes, Samira / Khouadja, Sabria / Younes, Samia / Soussia, Rim Ben / Bouali, Walid / Mohamed, Ahmed Haj / Zarrouk, Lazhar

The Pan African medical journal

2019 Volume 33, Page(s) 80

Abstract: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder characterized by formation of central nervous system tumors. They are associated to significant morbidity due to multiple problems such as hearing loss that can lead to many psychiatric ...

Abstract	Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder characterized by formation of central nervous system tumors. They are associated to significant morbidity due to multiple problems such as hearing loss that can lead to many psychiatric disorders.
MeSH term(s)	Hearing Loss/etiology ; Humans ; Male ; Mental Disorders/diagnosis ; Mental Disorders/etiology ; Neurofibromatosis 2/complications ; Neurofibromatosis 2/diagnosis ; Neuroma, Acoustic/diagnosis ; Neuroma, Acoustic/etiology ; Young Adult
Language	English
Publishing date	2019-06-04
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2019.33.80.18398
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Article ; Online: Mitochondrial DNA and Alzheimer's disease: a first case-control study of the Tunisian population.

Molecular biology reports

2021 Volume 49, Issue 3, Page(s) 1687–1700

Abstract: Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial ... ...

Abstract	Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial alteration has been proposed as a possible cause of AD. Therefore, several studies have focused on finding an association between inherited mitochondrial DNA variants and AD onset. Methods: In this study, we looked, for the first time, for a potential association between mitochondrial haplogroups or polymorphisms and AD in the Tunisian population. We also evaluated the distribution of the major genetic risk factor for AD, the apolipoprotein E epsilon 4 (APOE ε4), in this population. In total, 159 single-nucleotide polymorphisms (SNPs) of mitochondrial DNA haplogroups were genotyped in 254 individuals (58 patients and 196 controls). An additional genotyping of APOE ε4 was performed. Results: No significant association between mitochondrial haplogroups and AD was found. However, two individual SNPs, A5656G (p = 0.03821, OR = 10.46) and A13759G (p = 0.03719, OR = 10.78), showed a significant association with AD. APOE 4 was confirmed as a risk factor for AD (p = 0.000014). Conclusion: Our findings may confirm the absence of a relation between mitochondrial haplogroups and AD and support the possible involvement of some inherited variants in the pathogenicity of AD.
MeSH term(s)	Alleles ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Case-Control Studies ; DNA, Mitochondrial/genetics ; Genetic Predisposition to Disease ; Genotype ; Humans ; Mitochondria/genetics ; Polymorphism, Single Nucleotide/genetics ; Tunisia/epidemiology
Chemical Substances	Apolipoprotein E4 ; Apolipoproteins E ; DNA, Mitochondrial
Language	English
Publishing date	2021-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06978-7
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Article ; Online: Présentation atypique d'une granulomatose avec polyangeite: à propos d'une observation pédiatrique.

Berriche, Olfa / Younes, Samia / Ammari, Wafa / Alaya, Wafa / Kessomtini, Wassia / Hammami, Sonia

The Pan African medical journal

2015 Volume 21, Page(s) 141

Title translation	Atypical presentation of granulomatosis with polyangiitis: about a pediatric observation.
MeSH term(s)	Child ; Female ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/physiopathology ; Humans ; Inflammation/etiology ; Necrosis ; Vasculitis/etiology
Language	French
Publishing date	2015
Publishing country	Uganda
Document type	Case Reports ; Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2015.21.141.7086
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Article: Primary Hyperparathyroidism and Hyperthyroidism in a Patient with Myotonic Dystrophy: A Case Report and Review of the Literature.

Cherif, Yosra / Zantour, Baha / Alaya, Wafa / Berriche, Olfa / Younes, Samia / Sfar, Mohamed Habib

Case reports in endocrinology

2015 Volume 2015, Page(s) 735868

Abstract: Various endocrine manifestations are commonly described in myotonic dystrophy (MD), including primary hypogonadism, diabetes mellitus, and thyroid and parathyroid dysfunction. We describe a 46-year-old woman with a family history of MD with her son. She ... ...

Abstract	Various endocrine manifestations are commonly described in myotonic dystrophy (MD), including primary hypogonadism, diabetes mellitus, and thyroid and parathyroid dysfunction. We describe a 46-year-old woman with a family history of MD with her son. She was diagnosed with cardiac arrhythmia and required the implantation of a pacemaker. She was noted to have a bilateral cataract. She complained of muscle weakness, diffuse myalgia, and palpitation. The electromyography (EMG) showed myotonic discharges. Laboratory tests showed high serum calcium 2.83 mmol/L, serum phosphate 1.2 mmol/L, parathormone 362.5 pg/mL, thyroid stimulating hormone TSH 0.02 mIU/L (normal range: 0.34-5.6 mIU/L), FT4 21.17 ng/mL, and negative anti-thyroperoxidase antibodies. Cervical ultrasound revealed a multinodular goiter. The 99mTc-MIBI scintigraphy localized a lower right parathyroid adenoma. The clinical data, the family history of MD, EMG data, and endocrine disturbances were strongly suggestive of MD associated with hyperthyroidism and primary hyperparathyroidism.
Language	English
Publishing date	2015-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627633-1
ISSN	2090-651X ; 2090-6501
ISSN (online)	2090-651X
ISSN	2090-6501
DOI	10.1155/2015/735868
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Article: Seizures and movement disorders induced by hyperglycemia without ketosis in elderly.

Younes, Samia / Cherif, Yousra / Aissi, Mouna / Alaya, Wafa / Berriche, Olfa / Boughammoura, Amel / Frih-Ayed, Mahbouba / Zantour, Baha / Habib Sfar, Mohamed

Iranian journal of neurology

2014 Volume 13, Issue 3, Page(s) 172–176

Abstract: Background: Non-ketotic hyperglycemia (NKHG) may increase the probability of seizures and movement disorders.: Methods: We describe a series of 14 elders admitted for seizures and movement disorders linked to NKHG.: Results: Twelve patients ... ...

Abstract	Background: Non-ketotic hyperglycemia (NKHG) may increase the probability of seizures and movement disorders. Methods: We describe a series of 14 elders admitted for seizures and movement disorders linked to NKHG. Results: Twelve patients developed motor seizures and two others movement disorders. Glucose levels varied 9.28 to 32 mmol/l, while osmolarity values varied from 302.28 to 328 mosmol/l. All patients responded well to insulin therapy and four of them needed anti-epileptic drugs. Conclusion: Seizures or movement disorders in elderly with NKHG could be misdiagnosed as neurological diseases. Blood glucose must be audited whenever patients with seizures or movement disorders are encountered, as the condition may quickly resolve when NKHG is controlled.
Language	English
Publishing date	2014-10-16
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2685400-4
ISSN	2252-0058 ; 2008-384X
ISSN (online)	2252-0058
ISSN	2008-384X
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