Article ; Online: Olfactory control of blood progenitor maintenance.
2013 Volume 155, Issue 5, Page(s) 1141–1153
Abstract: Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory ... ...
| Abstract | Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP: |
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| MeSH term(s) | Animals ; Drosophila melanogaster/cytology ; Drosophila melanogaster/physiology ; Hemolymph/cytology ; Lymphoid Tissue/cytology ; Neurons/metabolism ; Olfactory Perception ; Olfactory Receptor Neurons/metabolism ; Signal Transduction ; Stem Cells/cytology ; Stem Cells/metabolism ; gamma-Aminobutyric Acid/metabolism |
| Chemical Substances | gamma-Aminobutyric Acid (56-12-2) |
| Language | English |
| Publishing date | 2013-11-22 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 187009-9 |
| ISSN | 1097-4172 ; 0092-8674 |
| ISSN (online) | 1097-4172 |
| ISSN | 0092-8674 |
| DOI | 10.1016/j.cell.2013.10.032 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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