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  1. Article ; Online: Lifestyle interventions to delay senescence.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100676

    Abstract: Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by ... ...

    Abstract Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Senescence: No country for old cells.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100697

    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease.

    Martel, Jan / Chang, Shih-Hsin / Chevalier, Gaétan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 46, Issue 1, Page(s) 48–59

    Abstract: Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which ... ...

    Abstract Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and the geomagnetic field. Research suggests that the circadian rhythm, which controls several physiological functions in the human body, can be influenced by light but also by the earth's EMFs. Cyclic solar disturbances, including sunspots and seasonal weakening of the geomagnetic field, can affect human health, possibly by disrupting the circadian rhythm and downstream physiological functions. Severe disruption of the circadian rhythm increases inflammation which can induce fatigue, fever and flu-like symptoms in a fraction of the population and worsen existing symptoms in old and diseased individuals, leading to periodic spikes of infectious and chronic diseases. Possible mechanisms underlying sensing of the earth's EMFs involve entrainment via electrons and electromagnetic waves, light-dependent radical pair formation in retina cryptochromes, and paramagnetic magnetite nanoparticles. Factors such as electromagnetic pollution from wireless devices, base antennas and low orbit internet satellites, shielding by non-conductive materials used in shoes and buildings, and local geomagnetic anomalies may also affect sensing of the earth's EMFs by the human body and contribute to circadian rhythm disruption and disease development.
    MeSH term(s) Humans ; Electromagnetic Fields/adverse effects ; Circadian Rhythm
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects.

    Wu, Cheng-Yeu / Martel, Jan / Young, John D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 8545

    Abstract: Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 ... ...

    Abstract Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction.
    MeSH term(s) Arteries/metabolism ; Arteries/pathology ; Arteriosclerosis/metabolism ; Arteriosclerosis/pathology ; Calcinosis/metabolism ; Calcinosis/pathology ; Calcium Phosphates/metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2/physiopathology ; Humans ; Minerals/chemistry ; Minerals/metabolism ; Organic Chemicals/chemistry ; Organic Chemicals/metabolism
    Chemical Substances Calcium Phosphates ; Minerals ; Organic Chemicals ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-65276-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physical attributes of salivary calcium particles and their interaction with gingival epithelium.

    Peng, Hsin-Hsin / Huang, Pei-Rong / Young, John D / Ojcius, David M

    Biomedical journal

    2020  Volume 44, Issue 6, Page(s) 686–693

    Abstract: Background: The formation of dental plaque and its involvement in the pathogenesis of periodontitis is a topic of intense interest given the high prevalence of periodontitis in humans. Even though calcium-based particles play an active role in both ... ...

    Abstract Background: The formation of dental plaque and its involvement in the pathogenesis of periodontitis is a topic of intense interest given the high prevalence of periodontitis in humans. Even though calcium-based particles play an active role in both dental plaque formation and periodontitis, few publications describe the physical-chemical properties of these particles.
    Methods: Saliva samples were collected from healthy volunteers. From these samples, saliva-derived particles were isolated and stained for calcium using calcein or Fluo-4. The salivary particles were also subjected to characterization by flow cytometry and immunoblotting. Internalization of calcein-labeled salivary particles by gingival epithelial cells was visualized by confocal microscopy.
    Results: We found that calcium-based salivary particles from healthy volunteers varied greatly in size but were enriched in particles of sizes at or greater than 1.5 μm. Immunoblotting analysis of the salivary particles identified several proteins including albumin, fetuin-A, and statherin, which have been found in calcium phosphate particles from other tissues or are known to modulate calcium homeostasis in saliva. In addition, calcium particles were internalized by both gingival epithelial cells and monocyte-derived macrophages.
    Conclusion: Salivary calcium particles were enriched in the micrometer range, internalized by gingival epithelial cells, and contain albumin, fetuin-A and statherin, regulators of particle formation. These characteristics of the calcium-based salivary particles and their biological activities provide a basis for further studies to understand the molecular basis for pathogenesis of periodontitis.
    MeSH term(s) Calcium/analysis ; Calcium/metabolism ; Epithelium/metabolism ; Gingiva/metabolism ; Gingiva/pathology ; Humans ; Periodontitis ; Saliva/chemistry
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Could nasal nitric oxide help to mitigate the severity of COVID-19?

    Martel, Jan / Ko, Yun-Fei / Young, John D / Ojcius, David M

    Microbes and infection

    2020  Volume 22, Issue 4-5, Page(s) 168–171

    Abstract: The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce ...

    Abstract The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce bronchodilatory and vasodilatory effects. Studies indicate that NO may also help to reduce respiratory tract infection by inactivating viruses and inhibiting their replication in epithelial cells. In view of the pandemic caused by the novel coronavirus (SARS-CoV-2), clinical trials have been designed to examine the effects of inhaled nitric oxide in COVID-19 subjects. We discuss here additional lifestyle factors such as mouth breathing which may affect the antiviral response against SARS-CoV-2 by bypassing the filtering effect of the nose and by decreasing NO levels in the airways. Simple devices that promote nasal breathing during sleep may help prevent the common cold, suggesting potential benefits against coronavirus infection. In the absence of effective treatments against COVID-19, the alternative strategies proposed here should be considered and studied in more detail.
    MeSH term(s) Administration, Intranasal ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Humans ; Nitric Oxide/administration & dosage ; Nitric Oxide/therapeutic use ; Pandemics/prevention & control ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Viral Load/drug effects
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country France
    Document type Editorial
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Phytochemicals as Prebiotics and Biological Stress Inducers.

    Martel, Jan / Ojcius, David M / Ko, Yun-Fei / Young, John D

    Trends in biochemical sciences

    2020  Volume 45, Issue 6, Page(s) 462–471

    Abstract: Phytochemicals in fruits and vegetables produce health benefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of action. Here, we address these issues by considering the prebiotic and biological properties of ... ...

    Abstract Phytochemicals in fruits and vegetables produce health benefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of action. Here, we address these issues by considering the prebiotic and biological properties of phytochemicals. A fraction of phytochemicals consumed orally passes through the gut lumen, where it modulates the composition of the gut microbiota and maintains intestinal integrity. Phytochemicals and microbiota-derived metabolites that are absorbed by the organism comprise compounds that, at low doses, induce stress resistance mechanisms, including autophagy, DNA repair, and expression of detoxifying and antioxidant enzymes. We propose that these mechanisms improve cellular and organ function and can account for the promiscuous bioactivities of phytochemicals, despite their limited bioavailability and extremely varied chemical structures.
    MeSH term(s) Biological Availability ; Gastrointestinal Microbiome ; Humans ; Phytochemicals/pharmacokinetics ; Phytochemicals/pharmacology ; Prebiotics ; Stress, Physiological/drug effects
    Chemical Substances Phytochemicals ; Prebiotics
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Comprehensive organic profiling of biological particles derived from blood.

    Wu, Cheng-Yeu / Martel, Jan / Young, John D

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 11310

    Abstract: Mineral nanoparticles form in physiological and pathological processes occurring in the human body. The calcium phosphate mineral phase of the particles has affinity for proteins and lipids, but the complete profiling of the organic molecules that bind ... ...

    Abstract Mineral nanoparticles form in physiological and pathological processes occurring in the human body. The calcium phosphate mineral phase of the particles has affinity for proteins and lipids, but the complete profiling of the organic molecules that bind to the particles has not been described in detail. We report here a comprehensive analysis of organic components found in mineralo-organic particles derived from body fluids. Based on biological staining, fluorescent tagging, proteomics and metabolomics, our results indicate that the mineral particles bind to proteins, amino acids, carbohydrates, polysaccharides, phospholipids, fatty acids, DNA and low molecular weight metabolites. These results can be used to study the formation and effects of mineralo-organic particles in biological fluids.
    MeSH term(s) Amino Acids/chemistry ; Amino Acids/metabolism ; Calcium Phosphates/chemistry ; Calcium Phosphates/isolation & purification ; Carbohydrates/chemistry ; DNA/chemistry ; DNA/metabolism ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Humans ; Lipids/chemistry ; Metabolomics ; Minerals/chemistry ; Minerals/isolation & purification ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Phospholipids/chemistry ; Phospholipids/metabolism ; Polysaccharides/chemistry ; Polysaccharides/metabolism ; Proteins/chemistry ; Proteins/metabolism ; Proteomics
    Chemical Substances Amino Acids ; Calcium Phosphates ; Carbohydrates ; Fatty Acids ; Lipids ; Minerals ; Phospholipids ; Polysaccharides ; Proteins ; DNA (9007-49-2) ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2018-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-29573-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Gut barrier disruption and chronic disease.

    Martel, Jan / Chang, Shih-Hsin / Ko, Yun-Fei / Hwang, Tsong-Long / Young, John D / Ojcius, David M

    Trends in endocrinology and metabolism: TEM

    2022  Volume 33, Issue 4, Page(s) 247–265

    Abstract: The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic and extrinsic factors, including genetic predisposition, the ... ...

    Abstract The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic and extrinsic factors, including genetic predisposition, the Western diet, antibiotics, alcohol, circadian rhythm disruption, psychological stress, and aging. Chronic disruption of the gut barrier can lead to translocation of microbial components into the body, producing systemic, low-grade inflammation. While the association between gut barrier integrity and inflammation in intestinal diseases is well established, we review here recent studies indicating that the gut barrier and microbiota dysbiosis may contribute to the development of metabolic, autoimmune, and aging-related disorders. Emerging interventions to improve gut barrier integrity and microbiota composition are also described.
    MeSH term(s) Chronic Disease ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Microbiota
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2022.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Respiratory support in intensive care

    Sykes, Keith / Young, John Duncan

    (Principles and practice series)

    1999  

    Author's details Keith Sykes ; J. D. Young
    Series title Principles and practice series
    Keywords Respiration Disorders / therapy ; Respiration, Artificial ; Ventilators, Mechanical
    Language English
    Size X, 305 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher BMJ Books
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Old title 1. Aufl. u.d.T. Sykes, Keith: Respiratory support
    HBZ-ID HT013753161
    ISBN 0-7279-1379-4 ; 978-0-7279-1379-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3354 order for loan Magazin

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