LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Second Nationwide Tuberculosis Outbreak Caused by Bone Allografts Containing Live Cells - United States, 2023.

    Wortham, Jonathan M / Haddad, Maryam B / Stewart, Rebekah J / Annambhotla, Pallavi / Basavaraju, Sridhar V / Nabity, Scott A / Griffin, Isabel S / McDonald, Emily / Beshearse, Elizabeth M / Grossman, Marissa K / Schildknecht, Kimberly R / Calvet, Helene M / Keh, Chris E / Percak, Jeffrey M / Coloma, Myron / Shaw, Tambi / Davidson, Peter J / Smith, Shona R / Dickson, Robert P /
    Kaul, Daniel R / Gonzalez, Annett R / Rai, Saroj / Rodriguez, Gretchen / Morris, Sandra / Armitige, Lisa Y / Stapleton, Jessica / Lacassagne, Michael / Young, Laura R / Ariail, Kiley / Behm, Heidi / Jordan, Hannah T / Spencer, Magdalene / Nilsen, Diana M / Denison, Brenda Montoya / Burgos, Marcos / Leonard, Juliet M / Cortes, Erick / Thacker, Tyler C / Lehman, Kimberly A / Langer, Adam J / Cowan, Lauren S / Starks, Angela M / LoBue, Philip A

    MMWR. Morbidity and mortality weekly report

    2024  Volume 72, Issue 5253, Page(s) 1385–1389

    Abstract: During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated ... ...

    Abstract During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated with a similar product manufactured by the same tissue establishment (i.e., manufacturer) occurred in 2021. Because of concern that these cases represented a second outbreak, CDC and the Food and Drug Administration worked with the tissue establishment to determine that this product was obtained from a donor different from the one implicated in the 2021 outbreak and learned that the bone allograft product was distributed to 13 health care facilities in seven states. Notifications to all seven states occurred on July 12. As of December 20, 2023, five of 36 surgical bone allograft recipients received laboratory-confirmed TB disease diagnoses; two patients died of TB. Whole-genome sequencing demonstrated close genetic relatedness between positive Mycobacterium tuberculosis cultures from surgical recipients and unused product. Although the bone product had tested negative by nucleic acid amplification testing before distribution, M. tuberculosis culture of unused product was not performed until after the outbreak was recognized. The public health response prevented up to 53 additional surgical procedures using allografts from that donor; additional measures to protect patients from tissue-transmitted M. tuberculosis are urgently needed.
    MeSH term(s) Humans ; United States/epidemiology ; Tuberculosis/epidemiology ; Tuberculosis/diagnosis ; Mycobacterium tuberculosis/genetics ; Tissue Donors ; Disease Outbreaks ; Allografts
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm725253a1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1827: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Response to CPAP withdrawal in patients with mild versus severe obstructive sleep apnea/hypopnea syndrome.

    Young, Laura R / Taxin, Zachary H / Norman, Robert G / Walsleben, Joyce A / Rapoport, David M / Ayappa, Indu

    Sleep

    2013  Volume 36, Issue 3, Page(s) 405–412

    Abstract: Background: Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), even those generally compliant with CPAP therapy, often intermittently discontinue CPAP.: Study objective: Examine the impact of CPAP withdrawal on sleep, sleep disordered ... ...

    Abstract Background: Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), even those generally compliant with CPAP therapy, often intermittently discontinue CPAP.
    Study objective: Examine the impact of CPAP withdrawal on sleep, sleep disordered breathing (SDB), and daytime function in subjects with varying severity of OSAHS.
    Patients and interventions: Forty-two subjects (26M/16 F) with OSAHS (AHI4% = 45.2 ± 35.5/h pretreatment) on CPAP for 4 months were evaluated on the second night of CPAP withdrawal. Sleep architecture, SDB indices, and subjective/objective daytime function were assessed pretreatment, on CPAP therapy, and after CPAP withdrawal. Comparisons were made between pretreatment and CPAP withdrawal for the entire group, and for subgroups of mild/moderate (AHI4% < 30/h, n = 22) and severe (AHI4% > 30/h, n = 20) SDB.
    Results: Overall, and for mild/moderate subjects, SDB indices returned to pretreatment values on CPAP withdrawal but with fewer apneas and more hypopneas/RERAs. For severe SDB, the event frequency (AI, AHI4%, and RDI) was lower and O2 desaturation was improved on CPAP withdrawal. Across SDB severity, sleep architecture showed lower %REM (15.6% vs 12.9%, P = 0.009) on the CPAP withdrawal compared to pretreatment. Stanford Sleepiness Score, MSLT, and PVT measures were not significantly different between pretreatment and CPAP withdrawal.
    Conclusions: Over a wide range of SDB severity CPAP withdrawal results in recurrence of SDB, albeit with less severe O2 desaturation. Subjective/objective daytime function returned to pretreatment levels. Sleep architecture changes on CPAP withdrawal (acute SDB) may reflect reduced sleep pressure compared to pretreatment chronic SDB. Our data suggest detrimental effects of even brief withdrawal of CPAP in subjects with both mild and severe OSAHS.
    Citation: Young LR; Taxin ZH; Norman RG; Walsleben JA; Rapoport DM; Ayappa I. Response to CPAP withdrawal in patients with mild versus severe obstructive sleep apnea/hypopnea syndrome. SLEEP 2013;36(3):405-412.
    MeSH term(s) Activities of Daily Living ; Continuous Positive Airway Pressure/methods ; Continuous Positive Airway Pressure/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Patient Compliance/statistics & numerical data ; Polysomnography/methods ; Recurrence ; Severity of Illness Index ; Sleep Apnea Syndromes/complications ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2013-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.5665/sleep.2460
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top