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  1. Article ; Online: Re: Estimating the Cardiovascular Disease Risk Reduction of a Quality Improvement Initiative in Primary Care: Findings from EvidenceNOW.

    Young, Richard A

    Journal of the American Board of Family Medicine : JABFM

    2024  Volume 36, Issue 6, Page(s) 1087–1088

    MeSH term(s) Humans ; Quality Improvement ; Cardiovascular Diseases/prevention & control ; Primary Health Care ; Health Services Research ; Risk Reduction Behavior
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2239939-2
    ISSN 1558-7118 ; 1557-2625
    ISSN (online) 1558-7118
    ISSN 1557-2625
    DOI 10.3122/jabfm.2023.230230R0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2626: Show issues Location:
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  2. Article ; Online: What do we mean, 'necessary'?-Achieving balance and recognizing limits in primary healthcare and universal healthcare.

    Young, Richard A

    Journal of evaluation in clinical practice

    2021  Volume 28, Issue 2, Page(s) 341–344

    Abstract: Sturmberg and Martin make a compelling case for primary healthcare (PHC) to be the foundation for universal healthcare (UHC). They state that a system should have necessary resources, but what does that mean? Basic economic theory postulates that all ... ...

    Abstract Sturmberg and Martin make a compelling case for primary healthcare (PHC) to be the foundation for universal healthcare (UHC). They state that a system should have necessary resources, but what does that mean? Basic economic theory postulates that all resources are limited and that choices must be made between competing options. For a UHC system to be successful and resilient, it must accept that healthcare is a limited right, there will always be inequalities in healthcare delivery and outcomes, primary care physicians and their teams must accept the added burden of balancing the needs of their personal patients with the greater system, leaders and observers of healthcare systems must accept that moderation and balance will often be the best outcome even though they are difficult to measure, and leaders of healthcare systems must accept that they cannot control the system, but contribute by providing context and limited constraints, information, and resources. A deeper understanding of complex adaptive systems will best guide these necessary changes.
    MeSH term(s) Delivery of Health Care ; Humans ; Primary Health Care ; Universal Health Care ; Universal Health Insurance
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1327355-3
    ISSN 1365-2753 ; 1356-1294
    ISSN (online) 1365-2753
    ISSN 1356-1294
    DOI 10.1111/jep.13545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4464: Show issues Location:
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  3. Article ; Online: Regulatory architecture of cell identity genes and housekeeping genes.

    Dall'Agnese, Alessandra / Young, Richard

    Trends in cell biology

    2023  Volume 33, Issue 12, Page(s) 1010–1013

    Abstract: Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through ... ...

    Abstract Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.
    MeSH term(s) Humans ; Genes, Essential/genetics ; Enhancer Elements, Genetic/genetics ; Gene Expression Regulation/genetics ; Promoter Regions, Genetic
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3410: Show issues Location:
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  4. Article ; Online: Would Medicare for All Be the Most Beneficial Health Care System for Family Physicians and Patients? No: Medicare for All Would Cause Chaos and Fail to Control Health Care Costs.

    Young, Richard A

    American family physician

    2020  Volume 102, Issue 7, Page(s) 392–393

    MeSH term(s) Family Practice ; Health Care Costs ; Humans ; Medicare ; United States ; Universal Health Insurance
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  5. Article ; Online: Increasing Spending on Primary Care to Reduce Health Care Costs.

    Young, Richard A

    JAMA

    2020  Volume 323, Issue 6, Page(s) 571

    MeSH term(s) Health Care Costs ; Health Expenditures ; Primary Health Care
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.20634
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  6. Article: Weight restoration in adolescent anorexia: parents' goal-directed processes.

    Socholotiuk, Krista D / Young, Richard A

    Journal of eating disorders

    2022  Volume 10, Issue 1, Page(s) 190

    Abstract: Background: Parent-led weight restoration is a key intervention of family-based treatment, an empirically supported treatment for adolescent anorexia. Successful outcomes in family-based treatment depend almost entirely on parental action, yet current ... ...

    Abstract Background: Parent-led weight restoration is a key intervention of family-based treatment, an empirically supported treatment for adolescent anorexia. Successful outcomes in family-based treatment depend almost entirely on parental action, yet current understandings of this intervention are primarily informed by professional theory and expert perspectives. Comparatively little is known about parents' goals and actions while implementing the treatment, despite goal-directed action being an explicit framework of family-based treatment. This study seeks to investigate parents' involvement in weight restoration from the perspective of the goal-directed actions they construct and engage in themselves and with others. This study focuses on the phenomenon of parent-led weight restoration as a project and addresses the following research question: "How do parents participate in the weight restoration of their adolescent as the adolescent recovers from anorexia nervosa?".
    Method: This multicase study used the action project method and conceptual framework of contextual action theory to examine four cases of five parents engaged in actions to help their adolescent regain weight and recover from anorexia. Data were collected using multi-part interviews and analyzed according to the action project method and the multicase approach.
    Results: Parents' weight restoration projects were identified and grouped based on three common a themes. The primary theme, progressing toward health and well-being, was supported by three key processes: maintaining a holistic focus, trusting, and monitoring progress. Two secondary themes captured actions that were integral to the parents' projects, but with less prominence. Secondary themes were creating capacity, which was supported by three processes (managing emotions to maintain a helpful focus, personal work, and resourcing time and finances), and coordinating and negotiating partnerships. The socio-cultural valuing of the thin ideal emerged as a unique process salient in one case. This study presents a goal-directed and contextual perspective on how parents translated the principles of family-based treatment into their daily lives. It joins a small but growing body of work concerned with generating new understandings and frameworks for practitioners and researchers to enhance the effectiveness of family-based treatment in community settings.
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699357-0
    ISSN 2050-2974
    ISSN 2050-2974
    DOI 10.1186/s40337-022-00676-w
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  7. Article ; Online: Attracting Medical Students to Family Medicine: An Historical View.

    Young, Richard A / Tinger, Sophia

    Family medicine

    2022  Volume 54, Issue 4, Page(s) 290–293

    Abstract: Background and objectives: In 2018, the 25 x 2030 Collaborative was created. Its goal is to "increase the proportion of US medical school graduates who choose family medicine (FM) to 25% by 2030." The purpose of this study was to take a deeper look at ... ...

    Abstract Background and objectives: In 2018, the 25 x 2030 Collaborative was created. Its goal is to "increase the proportion of US medical school graduates who choose family medicine (FM) to 25% by 2030." The purpose of this study was to take a deeper look at the history of medical student interest in FM from the earliest data to the present, both after the match and those who are FM interns after July 1.
    Methods: We used publicly available match data, primarily from the National Resident Matching Program website, a series of articles published for nearly 30 years in Family Medicine on match results, and the American Academy of Family Physicians website.
    Results: The total number of FM residents is growing (4,493 matched in 2021). After the managed care era in the mid-1990s, there was a collapse in interest among allopathic graduates that bottomed out at 6.8% graduates matching in FM by 2009; this rate has only slowly increased to 8.1% in 2021. Interest has been essentially flat for the last 10 years, and is lower than the percentage match rate prior to the managed care era (9.9% to 14.0%). There was more variability among osteopathic students, but interest has never been greater than 23%. Including the allopathic and osteopathic students who join FM residencies after the match does not appreciably alter these results.
    Conclusions: The 25 x 30 Collaborative will likely fail to reach its goal.
    MeSH term(s) Career Choice ; Family Practice/education ; Humans ; Internship and Residency ; Osteopathic Medicine/education ; Physicians, Family ; Schools, Medical ; Students, Medical ; United States
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639374-3
    ISSN 1938-3800 ; 0742-3225
    ISSN (online) 1938-3800
    ISSN 0742-3225
    DOI 10.22454/FamMed.2022.279855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2327: Show issues Location:
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  8. Article ; Online: Learning the chemical grammar of biomolecular condensates.

    Kilgore, Henry R / Young, Richard A

    Nature chemical biology

    2022  Volume 18, Issue 12, Page(s) 1298–1306

    Abstract: Biomolecular condensates compartmentalize and regulate assemblies of biomolecules engaged in vital physiological processes in cells. Specific proteins and nucleic acids engaged in shared functions occur in any one kind of condensate, suggesting that ... ...

    Abstract Biomolecular condensates compartmentalize and regulate assemblies of biomolecules engaged in vital physiological processes in cells. Specific proteins and nucleic acids engaged in shared functions occur in any one kind of condensate, suggesting that these compartments have distinct chemical specificities. Indeed, some small-molecule drugs concentrate in specific condensates due to chemical properties engendered by particular amino acids in the proteins in those condensates. Here we argue that the chemical properties that govern molecular interactions between a small molecule and biomolecules within a condensate can be ascertained for both the small molecule and the biomolecules. We propose that learning this 'chemical grammar', the rules describing the chemical features of small molecules that engender attraction or repulsion by the physicochemical environment of a specific condensate, should enable design of drugs with improved efficacy and reduced toxicity.
    MeSH term(s) Biomolecular Condensates ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-022-01046-y
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  9. Article ; Online: The Development of the World Anti-Doping Code.

    Young, Richard

    Medicine and sport science

    2017  Volume 62, Page(s) 11–21

    Abstract: This chapter addresses both the development and substance of the World Anti-Doping Code, which came into effect in 2003, as well as the subsequent Code amendments, which came into effect in 2009 and 2015. Through an extensive process of stakeholder input ...

    Abstract This chapter addresses both the development and substance of the World Anti-Doping Code, which came into effect in 2003, as well as the subsequent Code amendments, which came into effect in 2009 and 2015. Through an extensive process of stakeholder input and collaboration, the World Anti-Doping Code has transformed the hodgepodge of inconsistent and competing pre-2003 anti-doping rules into a harmonized and effective approach to anti-doping. The Code, as amended, is now widely recognized worldwide as the gold standard in anti-doping. The World Anti-Doping Code originally went into effect on January 1, 2004. The first amendments to the Code went into effect on January 1, 2009, and the second amendments on January 1, 2015. The Code and the related international standards are the product of a long and collaborative process designed to make the fight against doping more effective through the adoption and implementation of worldwide harmonized rules and best practices.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1662-2812 ; 0254-5020
    ISSN (online) 1662-2812
    ISSN 0254-5020
    DOI 10.1159/000460681
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  10. Article: Observations on the Report Lately Published by the Health of Towns' Commission, and on the Remedial Measures Therein Proposed for England and Wales.

    Young, Richard White

    Edinburgh medical and surgical journal

    2018  Volume 66, Issue 169, Page(s) 358–384

    Language English
    Publishing date 2018-10-17
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2793596-6
    ISSN 0963-4932
    ISSN 0963-4932
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