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  1. Article ; Online: Pathogenic signaling in multiple myeloma.

    Bolomsky, Arnold / Young, Ryan M

    Seminars in oncology

    2022  Volume 49, Issue 1, Page(s) 27–40

    Abstract: Multiple myeloma is a common hematological malignancy of plasma cells, the terminally differentiated B cells that secrete antibodies as part of the adaptive immune response. Significant progress has been made in treating multiple myeloma, but this ... ...

    Abstract Multiple myeloma is a common hematological malignancy of plasma cells, the terminally differentiated B cells that secrete antibodies as part of the adaptive immune response. Significant progress has been made in treating multiple myeloma, but this disease remains largely incurable, and most patients will eventually suffer a relapse of disease that becomes refractory to further therapies. Moreover, a portion of patients with multiple myeloma present with disease that is refractory to all treatments from the initial diagnosis, and no current therapeutic approaches can help. Therefore, the task remains to advance new therapeutic strategies to help these vulnerable patients. One strategy to meet this challenge is to unravel the complex web of pathogenic signaling pathways in malignant plasma cells and use this information to design novel precision medicine strategies to assist these patients most at risk.
    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Plasma Cells ; Precision Medicine ; Signal Transduction
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proximity Ligation Assay.

    Young, Ryan M

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1956, Page(s) 363–370

    Abstract: Many methods exist to study oncogenic signaling in lymphoma cells, each with certain strengths and weaknesses. The proximity ligation assay (PLA) is a technique used to examine protein-protein interactions in situ. PLA offers many advantages over ... ...

    Abstract Many methods exist to study oncogenic signaling in lymphoma cells, each with certain strengths and weaknesses. The proximity ligation assay (PLA) is a technique used to examine protein-protein interactions in situ. PLA offers many advantages over traditional biochemical approaches to signaling in that it can detect both transient interactions, which are hard to capture otherwise, as well as protein interactions within large supramolecular signaling platforms that are often intractable to traditional biochemical methodologies. In addition, PLA can be adapted for use in lymphoma biopsy samples to translate findings from the lab. Implementation of PLA can complement many types of lymphoma research, and the methods presented herein can be adapted to a number of experimental settings.
    MeSH term(s) Cell Line, Tumor ; Humans ; Immunoconjugates/metabolism ; Lymphoma/metabolism ; Microscopy, Confocal/methods ; Optical Imaging/methods ; Protein Interaction Mapping/methods ; Protein Interaction Maps ; Signal Transduction ; Staining and Labeling/methods ; Tissue Fixation/methods
    Chemical Substances Immunoconjugates
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9151-8_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mixed Electronic States in Molecular Dimers: Connecting Singlet Fission, Excimer Formation, and Symmetry-Breaking Charge Transfer.

    Young, Ryan M / Wasielewski, Michael R

    Accounts of chemical research

    2020  Volume 53, Issue 9, Page(s) 1957–1968

    Abstract: ConspectusChromophore aggregates are capable of a wide variety of excited-state dynamics that are potentially of great use in optoelectronic devices based on organic molecules. For example, singlet fission, the process by which a singlet exciton is down ... ...

    Abstract ConspectusChromophore aggregates are capable of a wide variety of excited-state dynamics that are potentially of great use in optoelectronic devices based on organic molecules. For example, singlet fission, the process by which a singlet exciton is down converted into two triplet excitons, holds promise for extending the efficiency of solar cells, while other processes, such as excimer formation, are commonly regarded as parasitic pathways or traps. Other processes, such as symmetry-breaking charge transfer, where the excited dimer charge separates into a radical ion pair, can be both a trap and potentially useful in devices, depending on the context. Thus, an understanding of the precise mechanisms of each of these processes is vital to designing tailor-made organic chromophores for molecular optoelectronics.These excited-state phenomena have each been well-studied in recent years and show tantalizing connections as the molecular systems and environments are subtly changed. These seemingly disparate phenomena can be described within the same unifying framework, where each case can be represented as one point in continuum of mixed states. The coherent mixed state is observed experimentally, and it collapses to each of the limiting cases under well-defined conditions. This framework is especially useful in demonstrating the connections between these different states so that we can determine the factors that control their evolution and may ultimately guide the state mixtures to the product state of choice. The emerging picture shows that tuning the electronic coupling through proper arrangement of the chromophores must accompany environmental tuning of the chromophore energies to produce a fully mixed state. Changes in either of these quantities leads to evolution of the admixture and ultimately collapsing the superposition onto a given state, producing one of the photophysical pathways discussed above.In our laboratory, we are utilizing covalent dimers to precisely arrange the chromophores in rigid, well-defined geometries to systematically study the factors that determine the degree of state mixing and its fate. We interrogate these dynamics with transient absorption spectroscopy from the UV continuously into the mid-infrared, along with time-resolved Raman and emission and magnetic resonance spectroscopies to build a complete and detailed molecular level picture of the dynamics of these dimers. The knowledge gained from dimer studies can also be applied to the understanding the dynamics in extended molecular solids. The insight afforded by these studies will help guide the creation of new designer chromophores with control over the fate of the excited state.
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.0c00397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Optical Initialization of Molecular Qubit Spin States Using Weak Exchange Coupling to Photogenerated Fullerene Triplet States.

    Mao, Haochuan / Young, Ryan M / Krzyaniak, Matthew D / Wasielewski, Michael R

    The journal of physical chemistry. B

    2022  

    Abstract: The ability to initialize an electron spin qubit into a well-defined state is an important criterion for quantum information applications. To achieve this goal, a chromophore photoexcited to its triplet state is used to strongly spin polarize a nearby ... ...

    Abstract The ability to initialize an electron spin qubit into a well-defined state is an important criterion for quantum information applications. To achieve this goal, a chromophore photoexcited to its triplet state is used to strongly spin polarize a nearby stable radical in a series of C
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c07096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quantum Gate Operations on a Spectrally Addressable Photogenerated Molecular Electron Spin-Qubit Pair.

    Mao, Haochuan / Pažėra, Gediminas J / Young, Ryan M / Krzyaniak, Matthew D / Wasielewski, Michael R

    Journal of the American Chemical Society

    2023  Volume 145, Issue 11, Page(s) 6585–6593

    Abstract: Sub-nanosecond photodriven electron transfer from a molecular donor to an acceptor can be used to generate a radical pair (RP) having two entangled electron spins in a well-defined pure initial singlet quantum state to serve as a spin-qubit pair (SQP). ... ...

    Abstract Sub-nanosecond photodriven electron transfer from a molecular donor to an acceptor can be used to generate a radical pair (RP) having two entangled electron spins in a well-defined pure initial singlet quantum state to serve as a spin-qubit pair (SQP). Achieving good spin-qubit addressability is challenging because many organic radical ions have large hyperfine couplings (HFCs) in addition to significant
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c01243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ultrafast Charge Transfer Dynamics in a Slip-Stacked Donor-Acceptor-Acceptor System.

    Lin, Chenjian / O'Connor, James P / Phelan, Brian T / Young, Ryan M / Wasielewski, Michael R

    The journal of physical chemistry. A

    2023  Volume 128, Issue 1, Page(s) 244–250

    Abstract: Photoexcitation of molecular electron donor and/or acceptor chromophore aggregates can greatly affect their charge-transfer dynamics. Excitonic coupling not only alters the energy landscape in the excited state but may also open new photophysical ... ...

    Abstract Photoexcitation of molecular electron donor and/or acceptor chromophore aggregates can greatly affect their charge-transfer dynamics. Excitonic coupling not only alters the energy landscape in the excited state but may also open new photophysical pathways, such as symmetry-breaking charge separation (SB-CS). Here, we investigate the impact of excitonic coupling on a covalent donor-acceptor-acceptor system comprising a perylene donor (Per) and two perylenediimide (PDI) acceptor chromophores in which the three components are π-stacked in a geometry that is slipped along their long axes (
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c07539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-Lived Charge Separation in Single Crystals of an Electron Donor Covalently Linked to Four Acceptor Molecules.

    Fisher, Jeremy M / Williams, Malik L / Palmer, Jonathan R / Powers-Riggs, Natalia E / Young, Ryan M / Wasielewski, Michael R

    Journal of the American Chemical Society

    2024  Volume 146, Issue 14, Page(s) 9911–9919

    Abstract: Crystalline donor-acceptor (D-A) systems serve as an excellent platform for studying CT exciton creation, migration, and dissociation into free charge carriers for solar energy conversion. Donor-acceptor cocrystals have been utilized to develop an ... ...

    Abstract Crystalline donor-acceptor (D-A) systems serve as an excellent platform for studying CT exciton creation, migration, and dissociation into free charge carriers for solar energy conversion. Donor-acceptor cocrystals have been utilized to develop an understanding of CT exciton formation in ordered organic solids; however, the strong electronic coupling of the D and A units can sometimes limit charge separation lifetimes due to their close proximity. Covalent D-A systems that preorganize specific donor-acceptor structures can assist in engineering crystal morphologies that promote long-lived charge separation to overcome this limitation. Here we investigate photogenerated CT exciton formation in a single crystal of a 2,5,8,11-tetraphenylperylene (PerPh
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c00201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: π-Stacking-Dependent Vibronic Couplings Drive Excited-State Dynamics in Perylenediimide Assemblies

    Kim, Taeyeon / Lin, Chenjian / Schultz, Jonathan D. / Young, Ryan M. / Wasielewski, Michael R.

    Journal of the American Chemical Society. 2022 June 14, v. 144, no. 25

    2022  

    Abstract: Vibronic coupling, the interplay of electronic and nuclear vibrational motion, is considered a critical mechanism in photoinduced reactions such as energy transfer, charge transfer, and singlet fission. However, our understanding of how particular ... ...

    Abstract Vibronic coupling, the interplay of electronic and nuclear vibrational motion, is considered a critical mechanism in photoinduced reactions such as energy transfer, charge transfer, and singlet fission. However, our understanding of how particular vibronic couplings impact excited-state dynamics is lacking due to the limited number of experimental studies of model molecular systems. Herein, we use two-dimensional electronic spectroscopy (2DES) to launch and interrogate a range of vibronic coherences in two distinct types of perylenediimide slip stacks─along the short and long molecular axes, which form either an excimer or a mixed state between the Frenkel exciton (FE) and charge transfer states. We explore the functionality of these vibronic coherences using quantum beatmaps, which display the Fourier amplitude signal oscillations as a function of pump and probe frequencies, along with knowledge of the characteristic signatures of the FE, ionic, and excimer species. We find that a low-frequency vibrational mode of the short-axis slip stack appears concomitantly with the formation of the excimer state, survives 2-fold longer than in the FE state in the reference monomer, and shows a phase shift compared to other modes. For the long-axis slip stacks, a pair of low-frequency modes coupled to a high-frequency coordinate of the FE state were found to play a critical role in mixed-state generation. Our findings thus experimentally reveal the complex and varying roles of vibronic couplings in tightly packed multimers undergoing a range of photoinduced processes.
    Keywords Americans ; couplings ; energy transfer ; frequency ; journals ; molecular models ; oscillation ; pumps ; quantum mechanics ; reaction mechanisms ; spectroscopy
    Language English
    Dates of publication 2022-0614
    Size p. 11386-11396.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c03993
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Controlling the Dynamics of Three Electron Spin Qubits in a Donor-Acceptor-Radical Molecule Using Dielectric Environment Changes.

    Mao, Haochuan / Young, Ryan M / Krzyaniak, Matthew D / Wasielewski, Michael R

    The journal of physical chemistry letters

    2021  Volume 12, Issue 9, Page(s) 2213–2218

    Abstract: Photogenerated entangled electron spin pairs provide a versatile source of molecular qubits. Here, we examine the spin-dependent dynamics of a covalent donor-acceptor-radical molecule, D-A- ... ...

    Abstract Photogenerated entangled electron spin pairs provide a versatile source of molecular qubits. Here, we examine the spin-dependent dynamics of a covalent donor-acceptor-radical molecule, D-A-R
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.1c00077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Crannenols A-D, Sesquiterpenoids from the Irish Deep-Sea Soft Coral

    Welsch, Joshua T / Young, Ryan M / Allcock, A Louise / Johnson, Mark P / Baker, Bill J

    Journal of natural products

    2022  Volume 85, Issue 10, Page(s) 2395–2398

    Abstract: Four undescribed sesquiterpenoids, crannenols A-D ( ...

    Abstract Four undescribed sesquiterpenoids, crannenols A-D (
    MeSH term(s) Animals ; Anthozoa/chemistry ; Sesquiterpenes/chemistry ; Magnetic Resonance Spectroscopy
    Chemical Substances Sesquiterpenes
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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