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  1. Article ; Online: Dietary interventions to extend life span and health span based on calorie restriction.

    Minor, Robin K / Allard, Joanne S / Younts, Caitlin M / Ward, Theresa M / de Cabo, Rafael

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2010  Volume 65, Issue 7, Page(s) 695–703

    Abstract: The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently ...

    Abstract The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)-which is well known to improve both health and longevity in controlled studies-as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.
    MeSH term(s) Aging/physiology ; Animals ; Antioxidants/pharmacology ; Caloric Restriction ; Glucose/metabolism ; Health ; Humans ; Insulin/physiology ; Intracellular Signaling Peptides and Proteins/physiology ; Longevity/physiology ; Protein-Serine-Threonine Kinases/physiology ; Sirtuins/physiology ; TOR Serine-Threonine Kinases
    Chemical Substances Antioxidants ; Insulin ; Intracellular Signaling Peptides and Proteins ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Sirtuins (EC 3.5.1.-) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2010-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glq042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.

    Minor, Robin K / López, Miguel / Younts, Caitlin M / Jones, Bruce / Pearson, Kevin J / Anson, Robert Michael / Diéguez, Carlos / de Cabo, Rafael

    Aging cell

    2011  Volume 10, Issue 3, Page(s) 483–492

    Abstract: Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite ... ...

    Abstract Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite suppression using two models: neuropeptide Y (NPY) knockout mice and monosodium glutamate-injected mice. While CR was protective in control mice challenged with a two-stage skin carcinogenesis model, papilloma development was neither delayed nor reduced by CR in the monosodium glutamate-treated and NPY knockout mice. Adiponectin levels were also not increased by CR in the appetite-suppressed mice. We propose that some of CR's beneficial effects cannot be separated from those imposed on appetite, and that NPY neurons in the arcuate nucleus of the hypothalamus are involved in the translation of reduced intake to downstream physiological and functional benefits.
    MeSH term(s) 9,10-Dimethyl-1,2-benzanthracene/adverse effects ; Animals ; Appetite/drug effects ; Appetite/physiology ; Arcuate Nucleus of Hypothalamus/cytology ; Arcuate Nucleus of Hypothalamus/drug effects ; Arcuate Nucleus of Hypothalamus/physiology ; Caloric Restriction ; Female ; Hunger/drug effects ; Hunger/physiology ; Male ; Mice ; Mice, Knockout ; Neoplasms, Experimental/chemically induced ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Neuropeptide Y/deficiency ; Neuropeptide Y/genetics ; Papilloma ; RNA, Messenger/analysis ; Skin Neoplasms/chemically induced ; Sodium Glutamate/pharmacology ; Tetradecanoylphorbol Acetate/adverse effects
    Chemical Substances Neuropeptide Y ; RNA, Messenger ; 9,10-Dimethyl-1,2-benzanthracene (57-97-6) ; Tetradecanoylphorbol Acetate (NI40JAQ945) ; Sodium Glutamate (W81N5U6R6U)
    Language English
    Publishing date 2011-04-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/j.1474-9726.2011.00693.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

    Jimenez-Gomez, Yolanda / Mattison, Julie A / Pearson, Kevin J / Martin-Montalvo, Alejandro / Palacios, Hector H / Sossong, Alex M / Ward, Theresa M / Younts, Caitlin M / Lewis, Kaitlyn / Allard, Joanne S / Longo, Dan L / Belman, Jonathan P / Malagon, Maria M / Navas, Placido / Sanghvi, Mitesh / Moaddel, Ruin / Tilmont, Edward M / Herbert, Richard L / Morrell, Christopher H /
    Egan, Josephine M / Baur, Joseph A / Ferrucci, Luigi / Bogan, Jonathan S / Bernier, Michel / de Cabo, Rafael

    Cell metabolism. 2013 Oct. 1, v. 18, no. 4

    2013  

    Abstract: Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose ... ...

    Abstract Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.
    Keywords Macaca mulatta ; adipocytes ; animal disease models ; anti-inflammatory activity ; blood serum ; diet ; glucose tolerance ; humans ; inflammation ; insulin ; insulin resistance ; mice ; monkeys ; noninsulin-dependent diabetes mellitus ; obesity ; resveratrol ; transcription factor NF-kappa B ; white adipose tissue
    Language English
    Dates of publication 2013-1001
    Size p. 533-545.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2013.09.004
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 6169: Show issues Location:
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  4. Article ; Online: Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

    Jimenez-Gomez, Yolanda / Mattison, Julie A / Pearson, Kevin J / Martin-Montalvo, Alejandro / Palacios, Hector H / Sossong, Alex M / Ward, Theresa M / Younts, Caitlin M / Lewis, Kaitlyn / Allard, Joanne S / Longo, Dan L / Belman, Jonathan P / Malagon, Maria M / Navas, Placido / Sanghvi, Mitesh / Moaddel, Ruin / Tilmont, Edward M / Herbert, Richard L / Morrell, Christopher H /
    Egan, Josephine M / Baur, Joseph A / Ferrucci, Luigi / Bogan, Jonathan S / Bernier, Michel / de Cabo, Rafael

    Cell metabolism

    2013  Volume 18, Issue 4, Page(s) 533–545

    Abstract: Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose ... ...

    Abstract Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.
    MeSH term(s) Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Carbohydrates ; Cell Line ; Diet, High-Fat ; Inflammation/metabolism ; Insulin/blood ; Insulin/metabolism ; Macaca mulatta/metabolism ; Male ; Mice ; NF-kappa B/metabolism ; Obesity/etiology ; Obesity/metabolism ; Resveratrol ; Signal Transduction/drug effects ; Sirtuin 1/metabolism ; Stilbenes/pharmacology ; Transcriptome ; Viscera/metabolism ; Viscera/pathology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Carbohydrates ; Insulin ; NF-kappa B ; Stilbenes ; Sirtuin 1 (EC 3.5.1.-) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2013-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2013.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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